Articles tagged with Alzheimer Disease
A Phase III randomized, placebo-controlled trial found that donepezil did not improve memory or other cognitive functions in breast cancer survivors. Despite this, researchers emphasize the need for further trials with different approaches to address cancer-related cognitive impairment.
A study by Duke and Columbia Universities found that non-white older adults with mild cognitive impairment reside in areas with more environmental injustices than their white peers. The study suggests that location, race, and environmental factors may interact to impact brain health.
Researchers found that boosting mitochondrial health can combat protein clumping linked to both aging and Alzheimer's. The study identifies a core insoluble proteome enriched with numerous proteins not previously considered, offering new targets for exploration.
A study by Netherlands Institute for Neuroscience found that certain individuals with Alzheimer's disease processes in their brains did not show clinical symptoms. Gene-expression profiling revealed higher expression of genes related to metallothionein and mitochondrial processes in these 'resilient' individuals.
FutureNeuro, a leading SFI Research Centre, is expanding its research programme with a focus on diagnostics, therapeutics, and digital health. The centre aims to develop precision diagnostics, future treatments, and systems using real-time health data.
A new biomarker, miR-519a-3p, has been discovered to detect Alzheimer's disease in its asymptomatic stages. The molecule is linked to the expression of cellular prion protein, which is deregulated in people with neurodegenerative diseases.
Researchers discovered the key role of protein Contactin-4 in shaping neurons and its interaction with APP, a gene strongly linked to Alzheimer's disease. The study found that CNTN4 regulates neural elongation and is co-dependent with APP for brain development.
A University of Saskatchewan researcher is building tiny pseudo-organs from stem cells to help diagnose and treat Alzheimer's disease. These 'mini-brains' more accurately reflect a fully-fledged adult human brain, allowing for closer examination of neurological conditions.
Engineers at the University of California San Diego used a new technique called MUSIC to map out interactions between chromatin and RNA in individual brain cells. The study found that some brain cells age faster and are more prevalent in individuals with Alzheimer's disease, particularly in women.
A study from North Carolina State University found that environmentally caused alterations in the genome may contribute to Alzheimer's disease risk, particularly in Black people. The research identified stable epigenetic features that distinguish Alzheimer's brains from those without the disease.
White and Hispanic people are most likely to be diagnosed with behavioral symptoms of dementia, but also receive potentially harmful drugs. The study found substantial racial disparities in dementia diagnosis and treatment, with non-white patients being underdiagnosed for treatable symptoms.
A study published by USTC reveals that age-dependent accumulation of Glu-5’tsRNA-CTC impairs mitochondrial protein translation, accelerating brain aging and Alzheimer’s disease. This abnormal accumulation disrupts cristae structure, resulting in reduced synaptic glutamate levels.
Researchers at PNNL have developed a method to control the handedness of peptoid helices, which can be used to design precise drug delivery agents or artificial enzymes. The team's discovery could provide insights into protein assembly and potentially lead to breakthroughs in treating protein folding-related diseases.
Researchers found a significant association between neighborhood deprivation and DNA methylation in brain tissue, which may be linked to immune response. The study identified one CpG site (cg26514961, PLXNC1 gene) significantly associated with neighborhood deprivation after controlling for covariates.
Purdue University researcher Hana Hall explores the role of R-loops in neurodegenerative diseases, including Alzheimer's, by investigating their impact on neuronal aging and DNA damage. Her work aims to understand how R-loop accumulation contributes to cellular stress and damage.
Researchers at UCLA Health discovered a novel, energy-efficient mechanism of working memory that reduces metabolic cost even during sleep. The discovery is published in Nature Communications and may provide an early diagnostic for Alzheimer's disease and related dementia.
A recent CU Anschutz study found that young people with youth-onset diabetes have a higher risk of developing neurodegenerative diseases like Alzheimer's. The study discovered specific blood biomarkers and elevated amyloid protein accumulation in the brains of participants, indicating an early onset AD risk trajectory.
Three FAU researchers have received $1M in FDOH grants to develop innovative approaches against Alzheimer's disease. Mare Cudic aims to explore the link between glycosylation and neuroinflammation, while Ruth Tappen develops an online screening tool for older drivers with cognitive decline.
Researchers created a corticolimbic index tool that categorizes Alzheimer's disease into three subtypes based on brain changes. The study found demographic and clinical differences among sex, age at onset, and rate of cognitive decline.
A study published in Nature Medicine reveals that individuals with two copies of the APOE4 gene develop signs of Alzheimer's disease, with over 95% showing biological characteristics at age 65. The findings suggest a new genetic form of Alzheimer's disease, potentially leading to personalized prevention and treatment strategies.
A study found that an organ transplant drug, rapamycin, can regulate over-excited neurons and preserve cognitive function in mouse models of Alzheimer's disease and seizures. The research suggests that seizures may accelerate AD progression and that targeting neuron excitability could slow the disease.
A study led by Universitat Rovira i Virgili reveals the mechanism behind a diet high in saturated fats and Alzheimer's disease, showing that a high-fat diet can worsen insulin-related miRNAs and lead to brain damage.
A commentary highlights the importance of including nursing home residents in clinical trials to address health equity concerns. The authors propose key elements for successful nursing home clinical trials and emphasize the benefits of conducting research in this setting.
Researchers identify TRMT10C enzyme causing methylation of ND5 mRNA, leading to mitochondrial dysfunction and reduced energy supply to the brain. Impairment of complex I in the respiratory chain contributes to Alzheimer's disease pathology.
A new nanomaterial has been developed to mimic the behavior of proteins and may lead to effective treatments for Alzheimer's and other neurodegenerative diseases. The nanomaterial alters the interaction between two key proteins in brain cells, potentially providing a powerful therapeutic effect.
Researchers at KTH Royal Institute of Technology have developed a microfluidic device that converts skin cells into neural stem cells, speeding up the process and reducing costs. This advance brings personalized cell-based therapies for Alzheimer's and Parkinson's closer to reality.
A global consortium has studied the connection between a specific gene variation and Pick's disease, a rare form of early-onset dementia. The research found that the MAPT H2 genetic variant is associated with an increased risk of Pick's disease in people of European descent.
The Alzheimer's disease treatment landscape is experiencing a significant shift, with numerous potential drugs making their way through clinical trials. Biomarkers have also emerged as a key area of focus, providing valuable information on the drug's impact and allowing for more precise guidance in future trials.
Researchers used state-of-the-art imaging techniques to discover the metabolism driving Alzheimer's disease, suggesting new treatment strategies. Lipid droplet metabolism can malfunction in Alzheimer's, leading to a cycle of stress and inflammation that worsens the disease.
Researchers used machine learning to analyze over 1.09 million potential metabolite-receptor pairs and predict the likelihood that each interaction contributed to Alzheimer's disease. The study found a protective metabolite called agmatine interacting with a receptor called CA3R in brain cells, reducing CA3R levels and lowering phospho...
Depletion of axonal mitochondria disrupts autophagy, leading to abnormal protein build-up in neurons. Restoring mitochondrial levels restores autophagy and recovers impaired neuron function.
Researchers at Gladstone Institutes have identified a blood coagulation protein, fibrin, as the culprit behind toxic inflammation and neuron loss after a major head injury. This finding can inform new treatment strategies for traumatic brain injuries, which often lead to dementia, depression, and difficulty concentrating.
The Association for Chemoreception Sciences (AChemS) 46th annual meeting features 62 presentations and 184 accepted posters on various topics including taste transduction, olfactory dysfunction, and social behavior. The conference promises a comprehensive exploration of cutting-edge research with keynote presentations and symposia.
Scientists at Salk Institute explore the clinical potential of cannabinol (CBN) in treating traumatic brain injury, Alzheimer's disease, and Parkinson's disease. They identify four CBN analogs with improved neuroprotective ability and drug-like efficacy.
Researchers found that ketogenic diets reduced plasma levels of total Tau in females, mitigated elevations in plasma lipids, and improved circulating lipids. However, neither continuous nor intermittent ketogenic diets improved measures of cognitive or motor behavior in the TgF344-AD rat model.
Researchers found that individuals from certain racial and ethnic groups are less likely to be eligible for Alzheimer's disease clinical trials due to lower amyloid levels at early stages of the disease. Amyloid buildup in the brain varies across different populations, contributing to underrepresentation in clinical trials.
Scientists at Sanford Burnham Prebys have identified promising links between common HIV drugs and a reduced incidence of Alzheimer's disease. The study analyzed over 225,000 medical records and found that RT inhibitor exposure was associated with a statistically significant reduced incidence and prevalence of AD.
Researchers investigate how early-stage Alzheimer's disease affects memory formation by examining synaptic connections and amyloid beta. The study aims to understand the role of NMDA receptors in synaptic plasticity and how they might be hijacked by amyloid beta, leading to memory dysfunction.
Researchers aim to understand mechanisms behind high ADRD rates among MENA immigrants, a growing demographic. The study will investigate daily living, stress, genetics, brain health, and cognitive ability, using MRI-based imaging and cognitive assessments.
A new study reveals that people with Down syndrome are more prone to developing Alzheimer's disease due to the presence of an extra chromosome 21, which leads to increased amyloid deposits. As a result, cognitive decline occurs in their 50s, whereas autosomal dominant Alzheimer's typically starts later in life.
Researchers identified a novel mechanism where APP-CTFs disrupt organellar communication, interfering with cellular homeostasis and leading to endolysosomal dysfunction. This finding suggests that preventing APP-CTF accumulation could be crucial for developing new AD treatments.
A recent Mayo Clinic study investigated lucid episodes in people living with later stages of dementia, revealing that 75% were reported to have Alzheimer's Disease. The researchers identified distinct patterns or types of lucid episodes, suggesting they may be related to the level of cognition and circumstances surrounding the episode....
Researchers found that geraniol reduces oxidative stress and neuroinflammation-mediated cognitive impairment in a mouse aging model. Geraniol treatment improved spatial learning and memory by enhancing anti-oxidant and anti-inflammatory effects.
A new study found a link between midlife racial discrimination and increased levels of Alzheimer's disease markers, including phosphorylated tau181 and neurofilament light, in older age. Researchers analyzed data from 255 Black Americans over 17 years, revealing that chronic stress from racism contributed to dementia risk.
Researchers at Columbia University Irving Medical Center have discovered a genetic variant in the fibronectin gene that protects against Alzheimer's disease. The variant, found in APOEe4 carriers, reduces the odds of developing Alzheimer's by up to 70% and may help prevent or treat the disease.
Concordia researchers use network analysis to study cognitive decline, identifying key variables that predict subtle changes in brain function. Executive function and processing speed are found to be strongly influential, with age affecting cognition differently for those with mild cognitive impairment or Alzheimer's disease.
Scientists discovered that tiny brain bubbles called small extracellular vesicles carry more complete instructions for altering cellular function than previously thought. Researchers found nearly 80% of identified mRNAs were full-length, allowing them to be transcribed by recipient cells into viable proteins.
A traumatic brain injury quadruples the risk of developing dementia and neurodegenerative diseases like ALS. USC scientists used lab-grown human brain structures called organoids to study TBI's effects. They identified a gene, KCNJ2, that helps protect nerve cells against injury.
A study published in PNAS reveals the structure of a protein linked to neurodegenerative disease Niemann-Pick type C, which accumulates cholesterol within cellular compartments. The research sheds light on the complex mechanism of cholesterol distribution and its role in maintaining optimal levels.
A new study published in Neurology found that earlier menopause and higher cardiovascular risk are associated with increased risk of thinking and memory problems later. Women who experienced earlier menopause had lower cognitive scores compared to their male counterparts, especially those with high cardiovascular risk.
A recent study published in Annals of Neurology suggests that midlife stressful events may be a risk factor for developing Alzheimer's disease in older ages. Researchers found associations between stress and higher levels of beta-amyloid protein, neuroinflammation, and brain atrophy, particularly in men.
A Rice University research project aims to provide new insights into biological fibrillar nanostructures with potential implications for the treatment and diagnosis of Alzheimer’s and Parkinson’s diseases.
A new study found similarities in protein structures of Aβ and tau filaments between individuals with Alzheimer's disease and those with both conditions. This knowledge is crucial for understanding Alzheimer's disease in people with Down syndrome and assessing clinical trial inclusion.
A new bioluminescence imaging technique allows for real-time monitoring of oxygen concentration in the brain, revealing previously undetected areas of temporary hypoxia. The method enables researchers to study diseases associated with hypoxia, such as Alzheimer's and vascular dementia.
A new bioluminescence imaging technique allows researchers to observe oxygen movement in the brains of mice in real-time, providing insights into diseases such as Alzheimer's and strokes. The method reveals that small areas of the brain, called 'hypoxic pockets,' can be denied oxygen for brief periods, increasing risk for these diseases.
Researchers successfully transmitted familial Alzheimer's disease to normal lab mice through bone marrow stem cell transplant. The recipients developed cognitive decline and amyloid buildup at an accelerated rate, highlighting the systemic nature of Alzheimer's disease.
Researchers developed an app to detect mild cognitive impairment, a potential indicator of Alzheimer's disease. The study used data from 199 older adults and found that the app detected MCI with high accuracy, comparable to in-clinic assessments.
A study using a xenotransplantation model has revealed that human microglia respond to amyloid-β plaques with a complex immune response, influencing the disease course. The research highlights the importance of considering genetic factors in microglia-targeted therapies for Alzheimer's disease.
Researchers have identified PDE4B as a potential target for treating Alzheimer's disease, where reducing its activity shows promise in improving memory and glucose metabolism. The study suggests that this approach may also protect against other forms of dementia, such as Huntington's disease.
A large-scale animal study reveals that brain pH and lactate levels are a common feature across various neuropsychiatric conditions, including schizophrenia, bipolar disorder, autism, depression, epilepsy, and Alzheimer's disease. Changes in brain energy metabolism are linked to cognitive impairment, particularly working memory.