Articles tagged with Neuropathology
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have shown that microglia play a central role in maintaining normal brain function and can fail to do so, leading to serious brain disorders. This new understanding has the potential to develop better diagnostics and treatments for these diseases.
A new study from Northwestern University found that individuals with higher conscientiousness tend to have greater cognitive resilience in older age. In contrast, those with higher neuroticism are more likely to experience worse cognitive function despite similar levels of neuropathology.
Researchers developed a machine-learning approach to distinguish critical markers of Alzheimer's disease using computer-aided analysis. The tool can process large amounts of data quickly and accurately, enabling neuropathologists to analyze thousands of times more samples than before.
Researchers have discovered a potential new treatment for Alzheimer's disease by inhibiting the 12/15-lipoxygenase enzyme, which is elevated in patients with the condition. The study found that this inhibitor reverses cognitive decline and neuropathology in an AD mouse model, even after symptoms have already developed.
A study of deceased individuals found that moderate seafood consumption was correlated with lesser Alzheimer disease neuropathology, despite higher brain levels of mercury. The study suggests that selenium, an essential nutrient in seafood, may reduce mercury toxicity and its negative effects on the brain.
Researchers at Rush University Medical Center found that moderate seafood consumption was associated with less Alzheimer's disease pathology, including lower amyloid plaques and tangles. Seafood intake was only linked to reduced harm when individuals had a specific genetic profile, highlighting the need for personalized nutrition advice.
The Journal of Neuropathology & Experimental Neurology will now be published by Oxford University Press USA, publishing original articles on neuropathology and experimental neuroscience since 1942. The journal is the official publication of the American Association of Neuropathologists, Inc.
A consensus panel of neuropathologists confirms CTE has a distinct pathognomonic signature in the brain, differentiating it from other tauopathies. The criteria define progressive degeneration of brain tissue, including abnormal protein buildup, leading to memory loss and dementia.
Researchers have discovered strong evidence that epigenetic changes play a role in Alzheimer's disease, with specific DNA modifications linked to neuropathology. The study provides potential hope for understanding the mechanisms involved in dementia and highlights the importance of epigenetics research.
Nicolas G. Bazan, MD, PhD, receives the Polish Academy of Sciences' Professor Miroslaw M. Mossakowski Medal for his groundbreaking work on neurodegenerative diseases. Bazan's contributions to research on Alzheimer's, stroke, and other conditions have led to the development of multiple patented therapies.
Manuela Neumann has been recognized with a Euro 150,000 award from the French Alzheimer's Foundation for her groundbreaking research on abnormal proteins in neurodegenerative diseases. The award aims to support further investigations into mechanisms and causes of these diseases.
A new study found that moderate consumption of Cabernet Sauvignon reduces AD-type â-amyloid neuropathology and memory deterioration in mice. The findings support epidemiological evidence suggesting moderate wine consumption may help prevent Alzheimer's clinical dementia.
Researchers found that young intravenous drug users, mainly heroin and methadone abusers, show brain damage linked to Alzheimer's disease. The study suggests increased risk of brain damage associated with opiate abuse, particularly among young individuals.