Articles tagged with Neuropathology
A new study published in Anaesthesia has found no statistically significant differences in neurodevelopmental outcomes between children exposed to anaesthesia during pregnancy and those not exposed. The study, led by Professor Steffen Rex, comprehensively evaluated over 500 children aged 2-18 years using standardized tools.
Researchers found lower serum TDP-43 levels in patients with C9orf72 repeat expansion or motoneuron disease, distinguishing them from other FTD subtypes. This study suggests TDP-43 as a potential biomarker for diagnosing specific FTD subtypes, enabling patient-specific interventions.
The study used a weakly supervised deep learning algorithm to analyze human brain autopsy tissues and predict the presence or absence of cognitive impairment. The model identified a signal associated with decreasing myelin staining, which was linked to cognitive impairment in the white matter.
A multi-institutional team assessed the diagnostic criteria for canine glioma using the Comparative Brain Tumor Consortium's guidelines. The study found that consensus was achieved for 71 out of 85 cases (84%), with a moderate level of inter-pathologist agreement.
A new study introduces a novel epigenetic predictor, PCBrainAge, that captures aging heterogeneity across multiple brain regions. The tool demonstrates stronger associations with AD dementia and pathologic AD compared to existing age predictors.
Researchers at City University of Hong Kong discovered a new neural mechanism that enables animals to perceive and integrate environmental cues, such as air puffs and sounds, to initiate defensive behavior. This finding has implications for understanding schizophrenia patients' auditory hallucinations.
Researchers found that biomarkers of Alzheimer's disease pathology, such as amyloid-beta and tau proteins, were associated with increased anxiety and apathy in cognitively unimpaired older adults. Higher levels of apathy were also linked to a more rapid cognitive decline.
Researchers discovered that inhibiting the breakdown of a neuroprotective molecule called 2-arachidonoylglycerol (2-AG) in astrocytes promotes recovery from traumatic brain injury. The study suggests that targeting this molecule could lead to the development of new therapies for TBI-induced disease.
A study at the University of Helsinki found that the APOE4 allele may increase cerebral microhaemorrhages and mental fatigue in COVID-19 patients. The risk of developing severe COVID-19 more than doubled in carriers of this allele.
Researchers from Tel Aviv University have identified the biological mechanism causing nerve destruction in ALS, a fatal neurodegenerative disease. They found that TDP-43 protein accumulation in neuromuscular junctions inhibits local protein synthesis and mitochondrial activity, leading to degeneration and death of motor neurons.
The USC Stevens INI is partnering with Vanderbilt University Medical Center and the University of Miami to merge Alzheimer's disease data from over 30 datasets, producing a large-scale, standardized set of clearly defined data. This harmonization will enable large-scale machine learning analysis to better characterize the genetic basis...
Researchers at the University of Helsinki have identified two distinct patterns of alpha-synuclein accumulations in the olfactory bulb, associated with differing disease types of dementia with Lewy bodies. These findings support the classification of the disease into two distinct forms, one progressing to the amygdala and another to th...
Researchers have shown that microglia play a central role in maintaining normal brain function and can fail to do so, leading to serious brain disorders. This new understanding has the potential to develop better diagnostics and treatments for these diseases.
A new study from Northwestern University found that individuals with higher conscientiousness tend to have greater cognitive resilience in older age. In contrast, those with higher neuroticism are more likely to experience worse cognitive function despite similar levels of neuropathology.
Researchers developed a machine-learning approach to distinguish critical markers of Alzheimer's disease using computer-aided analysis. The tool can process large amounts of data quickly and accurately, enabling neuropathologists to analyze thousands of times more samples than before.
Researchers have discovered a potential new treatment for Alzheimer's disease by inhibiting the 12/15-lipoxygenase enzyme, which is elevated in patients with the condition. The study found that this inhibitor reverses cognitive decline and neuropathology in an AD mouse model, even after symptoms have already developed.
Researchers at Rush University Medical Center found that moderate seafood consumption was associated with less Alzheimer's disease pathology, including lower amyloid plaques and tangles. Seafood intake was only linked to reduced harm when individuals had a specific genetic profile, highlighting the need for personalized nutrition advice.
A study of deceased individuals found that moderate seafood consumption was correlated with lesser Alzheimer disease neuropathology, despite higher brain levels of mercury. The study suggests that selenium, an essential nutrient in seafood, may reduce mercury toxicity and its negative effects on the brain.
The Journal of Neuropathology & Experimental Neurology will now be published by Oxford University Press USA, publishing original articles on neuropathology and experimental neuroscience since 1942. The journal is the official publication of the American Association of Neuropathologists, Inc.
A consensus panel of neuropathologists confirms CTE has a distinct pathognomonic signature in the brain, differentiating it from other tauopathies. The criteria define progressive degeneration of brain tissue, including abnormal protein buildup, leading to memory loss and dementia.
Researchers have discovered strong evidence that epigenetic changes play a role in Alzheimer's disease, with specific DNA modifications linked to neuropathology. The study provides potential hope for understanding the mechanisms involved in dementia and highlights the importance of epigenetics research.
Nicolas G. Bazan, MD, PhD, receives the Polish Academy of Sciences' Professor Miroslaw M. Mossakowski Medal for his groundbreaking work on neurodegenerative diseases. Bazan's contributions to research on Alzheimer's, stroke, and other conditions have led to the development of multiple patented therapies.
Manuela Neumann has been recognized with a Euro 150,000 award from the French Alzheimer's Foundation for her groundbreaking research on abnormal proteins in neurodegenerative diseases. The award aims to support further investigations into mechanisms and causes of these diseases.
A new study found that moderate consumption of Cabernet Sauvignon reduces AD-type â-amyloid neuropathology and memory deterioration in mice. The findings support epidemiological evidence suggesting moderate wine consumption may help prevent Alzheimer's clinical dementia.
Researchers found that young intravenous drug users, mainly heroin and methadone abusers, show brain damage linked to Alzheimer's disease. The study suggests increased risk of brain damage associated with opiate abuse, particularly among young individuals.