Articles tagged with Scars
Researchers from Monash University found that macrophages play a crucial role in salamander regeneration. Without them, salamanders lose their ability to regenerate and form scar tissue instead. The study brings scientists closer to understanding the conditions needed for human regeneration.
The American Society of Plastic Surgeons reports a 4,378% increase in upper arm lift procedures for women over the past decade, with over 15,000 procedures performed in 2012. Women's desire for toned arms is fueled by celebrity influence and sleeveless fashion, with Michelle Obama and Jennifer Aniston being top inspirations.
New study finds MR images taken during systole phase show more accurate detection of myocardial scars in ischemic cardiomyopathy patients. Systolic images revealed scars not visible on diastolic images, particularly in the left ventricle area prone to ischemic damage.
A study found that limited scar burden was linked to improved heart contraction and reversal of wall thinning in patients with coronary artery disease. Regional myocardial wall thinning may represent viable myocardium with potential for recovery, challenging current views on the condition.
Pulmonary fibrosis is a scarring of the lungs that causes shortness of breath and fatigue. Researchers identified a mechanosensitive cellular signaling pathway in myofibroblasts, which promotes survival and prevents normal cell disappearance after wound healing.
Researchers developed a method to reduce scar tissue and improve cardiac function in mice after a heart attack. The treatment uses microbubbles that oscillate with focused ultrasound, stimulating growth hormones and improving circulation.
Researchers are developing artificial blood platelets laced with regulatory chemicals that can be injected into the bloodstream to control bleeding and promote healing. The synthetic platelets have shown promise in animal models, reducing clotting time by approximately 30 percent.
The shift from four-footed walking to bipedalism has resulted in various physical challenges, including flat feet, bunions, and slipped discs. As humans adapted to upright walking, the spine developed an S-shaped structure, leading to conditions like lordosis and scoliosis.
A large, randomized trial found that angiotensin II blockade did not lessen tissue scarring or prevent kidney failure in kidney transplant recipients. The treatment was safe and well-tolerated but showed no benefit in slowing disease progression.
Mount Sinai researchers have developed a playbook for treating fibrotic diseases, which are responsible for 45% of all deaths in the industrialized world. They've identified promising experimental drugs and biomarkers that will facilitate testing of new treatments.
Researchers from Weill Cornell Medicine and others have successfully reprogrammed scar tissue in rats' hearts using a cocktail of three genes. The addition of a VEGF gene enhances this effect, improving heart function and reducing scar tissue.
Researchers discovered that basal cells initiate repair and serve as progenitor cells after chlorine gas exposure, helping restore new tissue in the airways. Understanding this process can aid in developing treatments to prevent scarring and asthma-like breathing problems.
Researchers found that both skeletal muscle MSCs and adipose tissue MSCs improved left ventricle function and reduced infarct size after injection into the heart of laboratory rats. The study suggests that these cells may be a potential treatment modality for patients with acute myocardial infarction.
Researchers at Northwestern University have implicated toll-like receptor 4 (TLR4) in the development of tissue fibrosis, a hallmark of scleroderma. The study found that mutations in the TLR4 gene made mice resistant to experimental scleroderma and that patients with scleroderma had abnormal TLR4 levels in affected tissues.
A new treatment method has been developed to reduce post-surgical scarring in glaucoma patients. The treatment uses a gel containing the anti-scarring drug 5-Fluorouracil, which is time-released over several days, resulting in fewer injections and less hospital visits.
Researchers at the University of Cincinnati have shown that pulsed-dye laser treatment improves burn scar appearance, texture, and elasticity. The study found significant improvements in redness, scar thickness, and biomechanical properties, with potential implications for further refining treatment options.
A new study published in the Canadian Medical Association Journal found that uncircumcised boys are at a higher risk of urinary tract infections. The researchers did not find a significant association between the degree of urethral visibility and infection risk.
Researchers found that blocking adenosine receptors can reduce scar size and improve skin quality, offering new hope for victims of burns, wounds, or illnesses. The discovery could lead to new agents diminishing scarring and disfigurement.
Researchers use bimodal dual AC mode microscopy to analyze eye tissue damaged by scarring in diabetic patients. The study provides detailed information on the composition and surface characteristics of these tissues.
Researchers at the University of Pittsburgh School of Medicine have identified an agent called E4 that can protect the skin and lungs from fibrosis, a process that can lead to organ failure and death. The agent may work by stalling the cross-linking of collagen needed to form thick scars.
Researchers at the Buck Institute have found that modifying scar tissue can potentially improve outcomes in chronic stroke. The study builds on spinal cord injury research and shows that treatments like chondroitinase ABC and glypican can reduce scar tissue size, stimulate neuron growth, and increase survival.
A Duke University Medical Center team has developed a method to convert scar tissue in the heart into functioning heart muscle cells using microRNAs. This approach eliminates the need for stem cell transplantation, potentially treating millions of people with heart failure caused by scar tissue after a heart attack.
Researchers have diagnosed Frida Kahlo's infertility as Asherman's syndrome, a condition caused by scarring in the uterus following a traumatic injury. The diagnosis is supported by Kahlo's medical history and artwork, which show images of reproductive organs and fertility issues.
Scientists have made breakthroughs in reprogramming scar tissue from myocardial infarction (MI) into viable heart muscle cells using viral vectors. The new approach has shown promising results in adult mice and offers a potential solution to the major problem of cardiac regeneration after MI.
The RESTORE-2 trial found high rates of investigator and patient satisfaction with autologous adipose-derived regenerative cell (ADRC)-enriched fat grafting for breast reconstruction after cancer surgery. The procedure also showed improved breast contour and no local cancer recurrences or serious adverse events.
A new ecosystem has been discovered in the deep sea, featuring a blend of hot and cold environments. The Jaco Scar site, located off Costa Rica, supports a vast array of species that thrive in both hydrothermal vents and cold methane seeps.
Keloids are raised, irregularly shaped scars that do not subside over time. African Americans are 7 times more likely than Caucasians to develop keloids following head and neck surgery, according to a new study from Henry Ford Hospital.
A UCSF stem cell study conducted in mice suggests a novel strategy for treating damaged cardiac tissue after a heart attack. The approach potentially improves cardiac function, minimizes scar size, and avoids tissue rejection.
A study published in The Lancet found that infusing patients' own cardiac stem cells into the heart after a heart attack reduces scar tissue by 50%. This breakthrough suggests that healthy heart muscle can be restored after previously thought-to-be irreparable damage.
A Cedars-Sinai Heart Institute clinical trial has demonstrated that treating heart attack patients with their own heart-derived cells can help damaged hearts regrow healthy muscle. The study found a significant reduction in scar size and an increase in healthy heart muscle following the stem cell treatments.
Researchers found that hydrogen sulfide decreases the production of scarring proteins in kidney cells exposed to high glucose levels. The study paves the way for future research in animal models of diabetic kidney disease.
Multiple sclerosis may not be an autoimmune disease, but rather a metabolic disorder. This new framework could help guide researchers toward new treatments and ultimately a cure for the disease. The lipid hypothesis proposes that MS is caused by disruption of lipid homeostasis in the central nervous system.
Researchers at Stanford University School of Medicine have identified the molecular pathway through which physical force contributes to scarring in mice. They found that blocking this enzyme can reduce inflammation and fibrosis, offering a potential new approach for treating fibrotic diseases such as pulmonary fibrosis and rheumatoid a...
Researchers found that extreme endurance exercise can cause damage to the right ventricle of the heart, which can lead to arrhythmias and reduced performance. While the damage is reversible in most athletes, five out of 40 studied showed permanent scarring, suggesting a susceptibility to long-term effects.
A team of researchers from Duke University Medical Center used genetic lineage tracing to study the origin of fibrotic cells in lung tissue. They found that pericytes, a previously unknown population of cells, are present in fibrotic areas and may play a role in the scarring process.
Researchers at Newcastle University discovered that manipulating serotonin's actions can tip the balance towards healthy tissue regeneration and block scarring in mouse models of chronic liver disease. This approach targets the 5-HT2B receptor, which instructs scar-forming cells to switch off regeneration.
Researchers found that scarring after a heart attack can help prevent further damage, but interrupting the process weakens heart function. The study suggests that timing is essential in manipulating cells to decrease scarring and enhance regeneration.
Researchers at Case Western Reserve University have developed a brain probe that softens after insertion, inducing less scarring and enabling the brain to heal faster. The nanocomposite probe, inspired by the skin of the sea cucumber, changes its mechanical properties in response to water, reducing damage to surrounding brain tissue.
A new ultrasound-based diagnostic tool could allow doctors to accurately distinguish between intestinal fibrosis and inflammation, enabling targeted treatment. The method has shown promising results in animal models and pilot human studies, paving the way for a long-term clinical trial.
Researchers found that bortezomib inhibits transforming growth factor beta, a protein essential for scar tissue growth, preventing its development in human cells and mouse models. The drug also prevented expression of proteins necessary for scarring in fibroblast cells from scleroderma patients
A study of seven patients found that wearing a custom-designed pressure device on the ear at night supplemented surgical excision and steroid injection to effectively treat auricular keloids. The device showed safety and efficacy, with no itch, pain or abnormal sensations reported by treated patients.
A recent study published in Science has discovered that the majority of scar cells in spinal cord injuries are derived from pericytes, not glial cells. This finding suggests that modulating pericyte activity could potentially stimulate functional recovery after CNS damage.
Researchers at Case Western Reserve University found that mesenchymal stem cells can inhibit an overactive immune system and promote tissue repair. These cells have shown potential in treating conditions such as acute heart attack, stroke, kidney failure, and juvenile diabetes.
A new minimally invasive procedure called hidden incision endoscopic surgery (HIdES) eliminates visible scarring in kidney surgeries. The technique, developed by Dr. Patricio Gargollo, offers greater technical flexibility than laparoscopic surgery and has been shown to provide higher satisfaction rates among patients.
A genetic biomarker has been identified that can predict the likelihood of successful restoration of blood flow after leg bypass surgery. Patients who inherit a specific DNA variation are 2.5 times more likely to maintain adequate blood flow through their surgically repaired blood vessels.
Researchers at Stanford University developed a special wound dressing that significantly reduced scar tissue caused by incisions in animal tests and early clinical trials. The novel 'stress-shielding device' provides uniform compression across the wound, reducing scarring and potentially making surgical revisions more appealing.
A new study published in American Journal of Transplantation found that progressive damage to kidney transplants is less common and less severe than previously reported. The study, involving 797 patients, showed that 87% of patients had mild or no signs of progressive scar damage at one year after transplant.
A team at the Kennedy Institute of Rheumatology found that tiny pieces of a protein called tenascin-C can bind to specific sites on another protein, helping to construct tissue. These small domains may help stop uncontrolled matrix deposition in conditions like fibrosis, making them potential tools for controlling diseases.
Researchers have shown that stem cell injections can reduce heart size, scar tissue, and improve function to injured heart areas. The therapy has been found to be beneficial for patients with chronically enlarged hearts due to damage from heart attacks.
Researchers reconstructed a 226-year fire history in southern Illinois by analyzing fire scars on post oak trees. The study found that repeated fires dating back to early European settlement permanently altered the region's ecology.
Corinne Hartin, a University of Miami Ph.D. student, received the best oral presentation award at the SCAR Open Science Conference in Buenos Aires. Her research focuses on understanding ocean water's role in climate change, particularly Subantarctic Mode Water and Antarctic Intermediate Water.
Researchers found that Taxol, a cancer drug, can aid in the regeneration of nerve cells after spinal cord injuries. The drug stabilizes microtubules and prevents the production of inhibitory substances in scar tissue, allowing for better nerve cell growth.
A study found that vitamin D deficiencies are prevalent among patients with autoimmune lung diseases, particularly those with connective tissue disease. The study suggests a potential role for vitamin D in the development of these diseases and improving lung function.
A Canadian researcher has identified a small peptide, 15-1, which blocks fragments of the ubiquitous sugar molecule hyaluronan and promotes robust healing and less scarring in deep wounds. The study found that this peptide effectively reduced wound contraction, collagen deposits, inflammation, and growth of unwanted new blood vessels.
Researchers at Duke University Medical Center discovered a stem cell secreted protein that improves heart muscle repair after a heart attack. The protein, sfrp2, reduces collagen layering and prevents heart failure in study rats.
Research led by Dr. James White has developed a novel 3D imaging technique to visualize myocardial scar tissue and coronary blood vessels in a single image. This breakthrough may improve targeting of blood vessels for therapy in patients requiring pacemakers, bypass surgery or angioplasties.
Researchers at the University of Louisville have developed a new technology that prevents scar tissue from forming around implanted devices, allowing them to function longer. The technology uses tiny blood vessel fragments suspended in collagen gel to create an environment that resists scarring.
Researchers developed a novel 3D imaging approach that combines CT images with conventional ablation techniques to improve the accuracy of ventricular tachycardia treatment. The new method successfully predicted areas of abnormal electrical activity in 81.7% of heart segments analyzed.
Researchers from the University of Illinois at Chicago have discovered a cellular response that breaks down and inhibits excess scar tissue in wound healing. Fibroblasts recruited to the wound site enter a state of reproductive dormancy called senescence, which accelerates collagen breakdown and limits scar tissue formation.
The University of Pittsburgh will conduct human trials for three innovative regenerative medicine programs aiming to replace scars and defects with healthy tissues. The projects, if successful, could lead to interventions benefiting civilians as well.