Articles tagged with White Adipose Tissue
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A new study found that adipose-derived extracellular vesicles, tiny cell messengers in obese individuals, accelerate the buildup of amyloid-β plaques in the brain, a hallmark of Alzheimer's disease. Researchers hope targeting these tiny cell messengers could reduce the risk of Alzheimer's disease in people with obesity.
Researchers developed a dual-action nanotherapy that converts white fat into beige fat and reduces obesity-related inflammation, significantly improving metabolic health without detectable toxicity.
Researchers found that CD44-deficient mice stayed lean despite a high-fat diet, while control mice developed obesity. The study suggests CD44 inhibitors could serve as a complementary treatment for obesity and related metabolic disorders.
Researchers discovered novel regulatory molecules in adipogenesis, specifically membrane receptors like GPCRs. ADGRD1 promotes differentiation of adipose progenitor cells while GPR39 inhibits this process.
Researchers found that brown adipose tissue enhances exercise endurance and supports healthy aging by improving blood circulation and reducing cellular stress. The study suggests that treatments mimicking BAT's benefits could lead to innovative therapies for improved energy levels and heart health.
Researchers from Kumamoto University identified SerpinA1 as a key regulator in combating obesity and enhancing glucose metabolism. The study found that activating brown adipose tissue could pave the way for innovative treatments for diabetes and metabolic disorders.
Adipo Therapeutics' lead product ADPO-002NP shows promising results in increasing energy expenditure and improving insulin resistance by browning white adipose tissue. The company is now raising $8 million to move the treatment to first-in-human Phase I clinical trials.
Researchers at Terasaki Institute have developed simvastatin-loaded nanoparticles to target adipose tissue inflammation, promoting fat tissue browning and weight loss. The treatment effectively inhibits obesity-related inflammation, controlled white fat production, and demonstrated strong anti-inflammatory effects.
The EAT2 study, led by Dr. Ursula White, investigates the lasting health effects of short-term weight gain and loss on fat tissue and overall health. Participants will undergo a dietary intervention program followed by an eight-week weight loss treatment.
Researchers discovered that blocking Cxcr4 in mice reduced white fat tissue, while estrogen therapy could be effective with lower doses. The study offers promising avenues for understanding healthy and unhealthy fat tissue development.
Researchers found that Kallistatin expression increases after weight loss in individuals with overweight and obesity. Additionally, human Kallistatin improves hepatic insulin sensitivity in diet-induced obese mice. The study suggests that Kallistatin may be an interesting therapeutic target for people with obesity and type 2 diabetes.
Researchers found that male rats burn fat for energy while female rats preserve their fat mass after vigorous exercise. This sex-dependent difference was attributed to various molecular responses in fat tissue. Exercise made the fat stores of both sexes healthier, with fewer signals associated with obesity.
Researchers found that spinal cord injury triggers abnormal neuronal activity that causes abdominal fat tissue compounds to leak and pool in the liver and other organs. A short course of gabapentin, commonly prescribed for nerve pain, prevented this damaging metabolic effect.
Researchers found that Kallistatin expression increases after weight loss, improving hepatic insulin sensitivity in obese mice. This protein may be an interesting therapeutic target for treating obesity and type 2 diabetes.
Scientists at the University of Copenhagen discovered a new type of fat cell called SWAT cells that provide structural integrity to adipose tissue. These flexible cells can differentiate into various types, including fat cells and progenitor cells, suggesting a crucial role in adapting to metabolic conditions.
Researchers found that women with higher-quality cardiovascular fat during midlife had stronger long-term memory and lower inflammation, while those with lower-quality fat had worsening working memory. The study suggests that taking care of heart health during menopause may protect brain health and reduce dementia risk.
A new study reveals the molecular structure of UCP1, allowing scientists to develop therapeutics that activate it to burn excess calories. This breakthrough could combat obesity and related diseases like diabetes by activating brown fat tissue.
Researchers have unlocked insights into how brown fat tissue can be harnessed to combat obesity and remove glucose from the blood. The study used a cryogenic electron microscope to view mitochondrial uncoupling protein 1 in atomic detail, revealing potential new ways to promote weight loss.
New research suggests a way to ward off age-related weight gain by stimulating beige fat cells. Beige fat has thermogenic properties that can reduce blood sugar and fatty acids causing heart disease. The study identifies a specific signaling pathway responsible for suppressing beige fat formation in older mice.
Researchers at Salk Institute discover thousands of previously unknown microproteins in brown and white fat tissue, finding that one, Gm8773, increases feeding activity in mice. This discovery could lead to the development of a therapeutic to promote weight gain in certain disease situations.
Researchers at Karolinska Institutet discovered that SARS-CoV-2 infection triggers blood vessel formation in fat tissues, leading to thermogenic metabolism and significant weight loss. Blocking this process with an antiangiogenic drug restored weight loss in mice and hamsters infected with the virus.
Researchers explore the interactions between adipose tissues and surrounding blood vessels in connection with lipid metabolism and associated diseases. Targeting angiogenesis may provide a gateway for treating obesity, while its inhibition or promotion depends on the specific disease context.
A new study in mice has mapped the cells, genes, and pathways that respond to exercise and diet, offering potential targets for drugs that mimic exercise's benefits. Exercise was found to push these systems in the opposite direction of high-fat diets.
A scientific review found that cold water swimming can reduce 'bad' body fat and improve insulin sensitivity. However, the health benefits are uncertain due to limited study quality and variability in participant profiles.
Researchers at IRB Barcelona have discovered a key mechanism behind the formation of brown adipose tissue, which is essential for preventing obesity. The study found that the NCOR1 protein is degraded through autophagy to ensure correct development of brown adipose tissue cells.
A new study published in Redox Biology reveals that white adipose tissue is the most vulnerable organ to obesity-related metabolic changes. The study shows that when physiological stress exceeds the capacity of white adipose tissue to respond, it loses its metabolic plasticity, leading to a snowball effect on metabolic dysfunctions.
Researchers at Beth Israel Deaconess Medical Center have identified a key enzyme involved in producing a new class of lipids with therapeutic effects for patients with diabetes. The discovery, published in Nature, could pave the way for new treatments to protect insulin-producing cells and improve blood sugar control.
Researchers investigate how enzymes regulate metabolism, weight gain, and liver disease, revealing diet's significant role in obesity and altered lipid profiles. The study also shows that age affects metabolic processes, leading to weight gain, increased fat storage, and unhealthy liver changes.
A breakthrough discovery has identified a novel approach to tackle metabolic diseases by inhibiting a liver enzyme that regulates appetite and energy expenditure. The treatment, which stabilizes key proteins in the blood, resulted in significant weight loss and improved insulin sensitivity in obese mice.
Scientists have generated an atlas of cell types in white adipose tissue, identifying novel subpopulations linked to increased risk of metabolic disease. The study provides a comprehensive resource for translational research into human metabolic diseases.
Researchers found that dietary intake of flavan-3-ols activates brown adipose tissue, leading to increased heat production and fat burning. Long-term consumption of flavanol-rich foods may also lead to the development of a healthier metabolism.
Scientists at Nanyang Technological University have developed a novel therapeutic approach to tackle obesity, reducing body fat and improving blood markers through a hydrogel injection and near infrared light treatment. The treatment shows significant promise in lab trials, with mice experiencing reduced body mass and improved metabolism.
Researchers found that flavanols activate brown adipose tissue, causing it to burn calories and produce heat. Long-term consumption of flavanols increased the levels of heat-related proteins in mice, suggesting a potential therapeutic effect against obesity-related diseases.
Researchers at Karolinska Institutet discovered three different subtypes of mature fat cells in white adipose tissue, with only one subtype, Adipo PLIN, responding to insulin. The study suggests that changes in this specific subtype may contribute to metabolic diseases like Type 2 diabetes.
Researchers discover adolescent adipose tissue differs from adult white fat in terms of precursor cell properties. Modulating Asc-1 function may help obese patients maintain a healthy metabolism and delay obesity treatment.
Researchers have identified a genetic program controlling the development of beige fat cells, which can convert energy into heat. The study's findings suggest that people with more thermogenic fat cells may be less likely to develop obesity and related metabolic disorders.
Researchers have identified several classes of adipocyte progenitor cells that give rise to fat tissue in mice and humans. The discovery provides insight into the complex mechanisms underlying fat tissue formation and highlights the importance of targeted approaches to prevent metabolic diseases.
Researchers discovered a sex-specific obesity locus for the Lyplal1 gene, finding that females have a higher mitochondrial activity and produce more brown adipose tissue, reducing fat mass and insulin resistance. In contrast, males exhibit low mitochondrial activity and increased weight and insulin resistance.
A new method, DITE, has been developed to accurately measure temperature in fat-containing tissues. The method was tested using fluorescent thermometers and achieved precise results, providing potential insights into the characterization of brown adipose tissue in vivo.
Researchers have discovered an enzyme called SNRK that regulates inflammation in white fat tissue and promotes brown fat metabolism. This finding suggests a potential new target for therapies aimed at curbing obesity and its complications.
Researchers developed a non-invasive MRI-based method to quantify dermal fat, total WAT volume and BAT activation in mice and humans. Studies showed that dWAT thickness was highly variable between subjects and increased in genetically obese mice and those fed high-fat diets.
Researchers at McGill University have found a way to reprogram white fat cells into energy-burning beige or brown fat cells. This 'browning' process can help manage obesity and other metabolic disorders by burning excess energy instead of storing it.
Researchers found that increasing energy expenditure with brown or brite/beige fat cells could be an effective way to fight obesity. The study suggests harnessing the body's natural mechanism of converting white fat cells into beige fat cells by using heat production and increasing the sympathetic nervous system's supply of blood vessels.
A team of researchers from the University of Southern Denmark has successfully reprogrammed white adipose tissue cells to become 'brite' (brown-in-white) fat cells, increasing energy consumption and potentially treating obesity. The study identified KLF11 as a key gene required for this process, paving the way for future treatments.
A new study published in Cell Metabolism suggests that cold exposure can accelerate the growth of atherosclerotic plaque in blood vessels, leading to increased risk of heart disease-related deaths. Brown fat activation has been linked to the formation of unstable plaques that can rupture and cause blockages in the heart and brain.
A study by the Helmholtz Association found that COX-2 inflammation enzyme increases in white fat tissue after cold exposure, stimulating the formation of brown fat cells. The scientists also discovered that boosting COX-2 production in mice leads to a 20% reduction in body weight.
Researchers have discovered novel prion infectivity in white and brown fat tissues of mice, shedding new light on the pathogenesis of prion diseases. This finding may have significant implications for preventing prion infection in animals and humans, particularly in ruminants suspected of exposure to or infection with prions.
A recent study published in the Journal of Clinical Investigation reveals that a diabetes drug called rosiglitazone enhances fat cell energy production by remodelling mitochondria. This finding suggests a potential new approach to treating obesity, which is a major risk factor for developing type 2 diabetes.
Researchers found that even a moderate loss of fat leads to decreased amounts of infection-fighting IgG antibodies, increasing disease susceptibility. Immune system function improved after regrowth of removed fat tissue.
Researchers at the University of Washington have created a genetic mutation in mice that prevents them from storing fat even on a high-fat diet. The study suggests a potential new approach for treating obesity by targeting the cells' internal signaling pathways.