Articles tagged with Chemical Biology
A flexible signal within TAF2 helps connect gene expression to RNA processing by guiding the protein to nuclear speckles. This mechanism enables targeted localisation and alternative splicing, modulating how information is processed at the RNA level.
Researchers at Washington University in St. Louis have made strides in removing selenium contamination from water using iron electrocoagulation, a process that generates iron-containing solids with large surface areas to bind selenium. The method removed more than 98% of selenium by flowing through an iron reactor for 11 seconds and se...
Rasika Dias, a renowned chemist at UTA, has been named a 2025 fellow of the Royal Society of Chemistry for his groundbreaking contributions to chemical sciences. He is the second chemistry faculty member to receive this honor.
A novel compound ML233 inhibits melanin production with no significant toxic side effects, offering a potential new strategy for treating pigment-related skin conditions. The study demonstrates promising results in reducing melanin synthesis and proliferation of melanoma cells.
A new microscopy technique, SIMIP, combines structured illumination with mid-infrared photothermal detection to achieve high-speed chemical imaging with superior resolution. The method outperforms conventional methods in terms of spatial resolution and chemical contrast.
A recent study reveals that tropical forests are home to an incredible diversity of chemical compounds, including terpenoids and alkaloids, which could have practical implications for human health. The researchers found that tree species in higher elevations tend to use similar chemicals to protect themselves from enemies.
Kyushu University researchers have successfully recreated the fluid dynamics of flowing biological cells using numerical simulations. The study reveals that capsule position depends on deformation and pulsation frequency, enabling precise cell manipulation in research and potential applications in artificial heart development.
A recent study suggests that Saturn's moon Titan could support simple, microscopic life forms due to its abundant organic content. However, the amount of biomass that can exist in this environment is likely to be extremely limited, possibly only a few pounds.
Isowalsuranolide activates autophagy-dependent cell death by targeting TrxR1/2, leading to ROS-mediated lysosomal biogenesis and reduced cell growth. The study reveals the TrxR1/2-p53-TFEB/TFE3 axis as a key regulator of cellular homeostasis in cancer.
A scientific initiative is underway to prevent harmful Prymnesium algal blooms from occurring in the Broads, which threaten fish stocks and local biodiversity. Researchers are working to identify environmental triggers and develop strategies to safeguard the waterways.
William Murphy, a genomicist at Texas A&M University, was named the 2025 SEC Professor of the Year. He studies genome structure, function and evolution to understand genetic basis of species traits and diseases.
A team of scientists has created a new method to selectively modify specific proteins in complex biological environments. They achieved this using aptamers and deoxyoxanosine, allowing precise conjugation of desired sites on target proteins. This breakthrough technology has the potential to revolutionize cancer diagnosis and treatment.
Researchers have identified a novel mechanism of intercellular communication involving mRNA transfer between different types of stem cells. This phenomenon enables cell fate conversion and reverts human pluripotent stem cells to an earlier embryonic stage.
Mesoscale eddies play a vital role in nutrient transport and the carbon cycle, trapping water masses and migrating into the open ocean. The study reveals that these eddies transport up to 10,000 tonnes of labile organic carbon each year.
Researchers have made progress in understanding how Streptococcus pneumoniae constructs its capsule, a critical target for vaccine development. The study identified three categories of transporters that facilitate sugar building block transport, with relaxed specificity transporters posing potential risks to bacterial growth.
Scientists at UC Riverside discovered a way to exploit parasitic plant hormones to induce
Researchers have uncovered a key mechanism involving Intermolecular Coulombic Decay (ICD) in aqueous environments initiated by heavy-ion irradiation, providing insights into the effectiveness of such irradiation. This process significantly increases the biological effectiveness of heavy-ion therapy.
A research team at Tokyo University of Science has identified two new tetranins in spider mite saliva that reduce reproduction and increase defense responses in plants. The findings have potential for organic farming techniques and more resilient crops, contributing to sustainable agriculture and enhanced food safety.
Scientists developed a novel solvatochromic fluorescent dye that enables high-precision temperature measurements through changes in fluorescence properties. The researchers achieved exceptional sensitivity and resolution, ideal for bioimaging applications.
Developing heart cells use filopodia to probe and grab onto potential partners, seeking stability through energy equilibrium. The model predicts how cells match and rearrange, mirroring real embryo outcomes.
The latest release of Wiley's AntiBase Library adds 9,500 compounds, increasing the total number of compounds in the database to over 105,000. This expanded database provides a powerful screening tool for discovering novel compounds with antimicrobial, antitumor, or other desired effects.
The TTUHSC Graduate School of Biomedical Sciences hosted the 37th Student Research Week, showcasing student researchers' work and presentations from distinguished national speakers. The event featured an increase in abstract submissions and lightning talk sessions.
Researchers used X-ray light to analyze the structure of 2-thiouracil, a substance with medically relevant properties. The study found that UV radiation causes the molecule to bend, resulting in the protrusion of the sulfur atom and making it reactive.
Core-shell nanoparticles offer effective drug encapsulation, shielding from degradation, and controlled release. This innovation enables targeted drug delivery, improving treatment outcomes and reducing side effects. The versatility of these nanoparticles allows for tailored materials to suit different therapeutic needs.
A new University of Texas at Arlington study reveals high concentrations of microplastics in bird lungs, with average particles per species and gram of lung tissue measured. The study highlights the urgent need to address plastic pollution and its far-reaching impacts on ecosystem health and human health.
Researchers at POSTECH developed a super-photostable organic dye, PF555, to track proteins in cells over extended periods. This breakthrough enables observation of endocytosis and protein interactions, revealing EGFR's active navigation in its environment.
UTA's expansion of its undergraduate research program has enabled students to present their work at major symposiums, including the American Institute of Aeronautics and Astronautics conference. The program has strengthened students' commitment to pursuing graduate studies in various fields.
The newly synthesized monolayer Ti3C2Tx transforms photocatalytic bioaerosol disinfection at the catalyst-cell interface. The material achieves a sterilization efficiency of 3.3 log in just 12.8 seconds, far exceeding traditional TiO2.
Lauren Albrecht, a UC Irvine assistant professor of pharmaceutical sciences, has been recognized as a 2025 Sloan Research Fellow for her groundbreaking work in cell and chemical biology. Her research on methylation in lysosomal proteolysis holds promise for new therapeutic strategies and implications in genetic heart disease.
Researchers at UNIGE have developed a system that uses light to activate targeted molecules, enabling spatial and temporal control over the activity of a molecule in a living organism. This technology has vast potential applications in both basic research and improving existing medical treatments, such as those for skin cancer.
Researchers discovered a novel mechanism of intercellular communication through mRNA transfer between stem cells, allowing for biologically significant effects such as cell fate conversion and pluripotent state maintenance.
A new study explores how chemical mixtures transform under shifting environmental conditions, shedding light on prebiotic processes that may have led to life. The research finds that environmental factors played a key role in shaping the molecular complexity needed for life to emerge.
Biomedical engineers at Duke University have developed a new technique that traps together cellular machinery to increase protein production rates. This approach uses synthetic disordered proteins to form compartments called biological condensates, which enhance the rate of protein production by bringing together biomolecular machinery...
A team from Tokyo University of Science developed a novel trivalent platform for triple click chemistry, allowing for the efficient synthesis of complex compounds. The approach utilizes simple initial materials and promotes sustainable pharmaceutical synthesis.
Researchers develop new method to study glycosylation in proteins, discovering that gut bacteria can alter molecular signatures in the brain. The study found over 150,000 glycosylated protein forms in brain tissue samples from mice.
Marshall University researcher Brandon Henderson has secured a $1.85 million NIH grant to study the impact of synthetic coolants in vaping products on nicotine addiction. The five-year research project will explore how synthetic coolants influence addiction-related behaviors, particularly among adolescents.
New study reveals quantum mechanical processes facilitate energy transfer and charge separation in photosynthetic organisms. This understanding can inform the design of artificial photosynthesis units for unprecedented solar energy efficiency.
Researchers at Queensland University of Technology have developed a novel biosensor that can selectively detect rare earth elements. The biosensor is based on molecular nanomachines engineered by the team, which produce easily detectable signals when binding to lanthanides.
A study on fruit fly larvae revealed the presence of neurons with mechanoreceptors in their peripheral taste organs, allowing them to sense food texture. This discovery sheds light on the complex process of tasting texture and highlights the importance of multisensory contributions in food perception.
Southwest Research Institute's Risk Evaluation & Medical Decision Efficacy (REMEDY) tool supports agile medical decisions on countermeasures for chemical and biological threats. The REMEDY mission risk evaluations quantify risks and benefits of medical countermeasures, enabling operational planners to make informed decisions.
A West Virginia University legal scholar argues that current laws favor biologic drugs with longer exclusivity periods, affecting their pricing. The scholar suggests reducing exclusivity for biologics to bring them in line with small-molecule drugs, which could lower drug costs.
Researchers will focus on novel non-plastic materials used for oyster reef restoration, evaluating their impact on surrounding marine habitats. The project aims to find solutions that bring the natural environment back after degradation from storms or human impact.
Researchers developed a 'volume dial' to amplify weak signals in the human body and environment. The system, called ROSALIND, can detect contaminants like E. coli and heavy metals at lower concentrations than previous models.
The study found that clouds contain significantly more arsenic on average than rainwater, and biological processes play a key role in the global distribution of arsenic. The researchers also detected various types of arsenic compounds in rainwater samples, including methylated forms formed by bacteria and plants.
Researchers propose using Exo-AUVs to detect life on Icy Worlds like Europa by identifying micro-zones with high biological potential. The strategy guides the Exo-AUV to collect diverse robust biosignatures and potentially detect extant life in various dimensions.
A new AI-driven approach identifies potentially harmful chemical substances in rivers by monitoring their effects on tiny water fleas, providing insights into complex mixtures and aquatic life. The study enables more comprehensive environmental monitoring and supports better-informed regulations for chemical discharge into waterways.
Researchers at St. Jude Children's Research Hospital have developed a novel solution to analyze the vast amounts of data generated by synthesizing large collections of new molecules. By using fragmentation patterns as universal barcodes, they can remove a key bottleneck in small molecule synthesis and screening.
Insilico Medicine has successfully integrated cutting-edge generative AI models into its platform, achieving significant increases in accuracy and speed. The company's AI-powered solutions have shown promising results in preclinical candidates and Phase II clinical trials.
A study by Chiba University researchers has identified 106 compounds in pregnant women's serum samples, including phthalates, nitrogenous compounds, and parabens, which may impact biological pathways. The study proposes a non-targeted approach for detecting foreign chemicals and evaluating their potential health effects.
Researchers developed a new tool called SigRM to analyze single-cell epitranscriptomics data, enabling the study of RNA modifications in individual cells. This can provide valuable insights into gene regulation and its impact on health and disease, particularly in complex conditions like cancer.
Insilico Medicine has developed an innovative platform using generative AI to discover novel molecules. The company has nominated over 20 preclinical candidates and received IND clearance for 10 molecules.
Rice scientists develop new nanomaterial that kills bacteria in biofluids under visible light, with minimal degradation and low lead leaching. The findings suggest potential applications in water treatment and therapeutics.
A new COF sensor can detect pH changes in plant xylem tissues, providing early warning of drought stress up to 48 hours before traditional methods. This technology enables timely detection and management of drought stress, optimizing crop production and yield.
Insilico Medicine has been selected by Fortune as one of the top AI innovators, leveraging its generative AI platform to develop novel drugs and treatments. The company's lead drug pipeline, ISM001-055, has shown promising results in Phase IIa trials, offering new hope for patients with idiopathic pulmonary fibrosis.
A ground-breaking study found that war exposure causes adverse biological changes in children's DNA, leading to lifelong health impacts. The study discovered unique epigenetic responses to trauma, highlighting the need for further research into the long-term effects of war on children's development.
Researchers at Institute of Science Tokyo develop an innovative strategy to produce β- and γ-naphthocyclinones, challenging compounds that have potential for medical and biological applications. They successfully synthesize the molecules using a retrosynthetic analysis approach, achieving yields of over 70%.
Irene Coin's lab has developed a comprehensive overview of genetic code expansion technology and its application in membrane proteins. The technology allows for the modification of proteins directly in living cells, enabling the production of novel protein therapeutics and a deeper understanding of natural proteins.
Researchers found that plants have multiple enzymes for adding methyl groups to DNA, allowing them to override genetic instructions. The study reveals the evolutionary history of these enzymes and their unique structures, providing insights into plant resilience to environmental changes.
Researchers developed a method to visualize AMPA receptors using PET scans, revealing differences in density and distribution between healthy subjects and those with psychiatric disorders. This discovery may lead to new diagnostic and therapeutic approaches for conditions like schizophrenia, bipolar disorder, and autism spectrum disorder.
A study of human skeletal remains from the Tudor warship Mary Rose reveals that handedness may influence clavicle bone chemistry as people age. The analysis found increased mineral content and decreased protein content in right clavicles compared to left, suggesting repeated stress on the right side during activities like sailing.