Articles tagged with Radiation
Glioblastoma cells acquire radiation resistance by dumping exosomal microRNA miR-603, leading to increased protein production and insensitivity to radiation. This study reveals a new therapeutic strategy for overcoming cancer cell resistance.
Researchers developed a post-processing algorithm to increase the quality of reconstructed CT images while reducing noise and radiation exposure. The new method enhances tissue discrimination by 60%, enabling better decision-making for further treatments.
Researchers at UCLA have found that adding a schizophrenia drug to traditional radiation therapy improved overall survival in mice with glioblastoma. The combination successfully delayed tumor growth and prolonged animal survival by over 200 days.
Researchers have developed a method using phononic crystals to generate tunable, time-variant sound fields that can trap and transport particles and cells in microchannels. This technology has potential applications in display technology, biomedical sensors, and diagnostic tools.
Researchers developed a new design to reduce energy loss in optical fiber communications by radiating light in a single direction. This breakthrough has the potential to improve data communications for commercial data centers and enable battery-powered photonic computers.
This study found that HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) cells exhibit enhanced radiosensitivity and increased cell motility after radiation therapy. In contrast, HPV-negative OPSCC cells show decreased radiosensitivity and reduced cell motility.
Researchers at UCLA Jonsson Comprehensive Cancer Center identified a possible new drug, NSPP, that prevents cognitive decline in mice after radiation therapy for brain tumors. The study found the drug did not reduce radiation treatment efficacy.
The NETTER-2 study is a Phase III clinical trial evaluating Lutathera's efficacy and safety in treating Grade 2 and 3 advanced GEP-NETs. The primary objective is to prolong Progression Free Survival in patients with high proliferation rate tumors.
A new phase II trial found a combination of radiation therapy and pembrolizumab to be effective in treating locally advanced head and neck squamous cell carcinoma, particularly for patients ineligible for cisplatin chemotherapy. The treatment showed encouraging survival outcomes and acceptable toxicity.
A new international advisory system is working to keep aircraft crew and passengers safe from space weather impacts. The system predicts disruptions from solar activity and helps airlines adjust flight paths to minimize impacts on navigation and communications systems.
Researchers at UCLA Jonsson Comprehensive Cancer Center found a condensed five-day radiation regimen to be as effective as traditional five-week treatment in treating soft tissue sarcoma. The new approach showed lower wound complication rates and improved cancer control without increasing side effects.
This study found that the addition of nimotuzumab to weekly cisplatin-radiation significantly improves outcomes, including overall survival, in locally advanced head and neck cancer patients with HPV negative oropharyngeal cancers. The study compared these outcomes with a control group receiving only cisplatin-radiation.
A five-year follow-up study of over 2,000 U.S. men with localized prostate cancer found that radiation therapy was associated with significant declines in erectile function, while surgery improved function over time. Prostatectomy also resulted in worse urinary incontinence compared to other treatments.
A new synthesis method has been developed to unlock the secrets of 'strange metals', which exhibit unusual temperature behavior. The research team's findings confirm that quantum-critical charge fluctuations play a key role in their behavior.
A new study found that a disrupted biological clock increases the risk of heart disease in mice treated with radiation therapy, highlighting the potential role of protein Bmal1 in protecting the heart. The research could lead to personalized medicine approaches and optimized timing for radiation therapy to minimize side effects.
A new study suggests that monitoring patients' activity levels prior to chemoradiation therapy for lung cancer can predict treatment outcomes. Inactive patients are more likely to experience hospitalization, treatment delays, and disease recurrence, while active patients have better survival rates.
A new species of wasp-mimicking fly from South Korea has been discovered, with members twice the size of common house flies. The ancient insect, named after PSY's 'Gangnam Style', had distinct yellowjacket-like patterns on its abdomen.
The study found that higher doses of radiation and adding the drug cetuximab did not improve patient survival compared to standard of care chemoradiation. The 5-year overall survival estimate for the standard radiation dose arm was 32.1%, amongst the highest for Stage III NSCLC.
Researchers found that radiation triggers an immune response that severs connections between nerve cells, leading to damage and cognitive problems. The study suggests two potential approaches to prevent this damage: blocking a receptor responsible for synapse removal or tamping down the brain's immune response.
Researchers found that bumblebees consuming more nectar due to sub-lethal radiation exposure may impair colony growth. This effect could have significant consequences for pollinator ecosystem services in the Chernobyl Exclusion Zone.
The American Society for Radiation Oncology (ASTRO) has released a new clinical guideline for the use of radiation therapy in treating basal and cutaneous squamous cell carcinomas. The guideline provides recommendations on when to use radiation as stand-alone therapy or following surgery, as well as dosing and fractionation schedules.
A new clinical trial has found that patients with limited-stage, aggressive non-Hodgkin's lymphoma who have a clear PET scan can skip radiation therapy and still achieve excellent results. The study showed that 91% of patients who received no radiation were alive five years after treatment.
A multi-centre trial led by McMaster researchers found that accelerated partial breast irradiation (APBI) is as effective as whole breast radiation in reducing breast cancer recurrence, with similar recurrence rates after one week of treatment. However, APBI was associated with higher late toxic effects and worse cosmetic outcomes.
High-dose-rate brachytherapy offers excellent cure rates and cosmetic outcomes for elderly patients with common skin cancers, including squamous cell carcinoma and basal cell carcinoma. The treatment delivers a precise dose of radiation directly to the tumor while sparing healthy tissue nearby.
A nationwide survey of over 400 US adults with cancer found that nearly all patients felt confident in their treatment decisions but had gaps in knowledge about potential side effects. The study highlights the need for more informed patient counseling and coordination between oncology disciplines to manage treatment-related side effects.
The SRNL-designed radiation detection system has been successfully implemented at the Port of Tacoma and NY/NJ, detecting illicit radioactive material in intermodal cargo containers. The system is expected to save significant time and space requirements for scanning these containers, increasing operational efficiency.
Researchers at the University of Seville have developed a procedure for producing boron carbide phase B6C, an ultra-resistant material with a hardness of 52 GPa and Young modulus of 600 GPa. The material is resistant to radioactivity and surpasses diamond in hardness.
Tardigrades' protein Dsup protects cells from X-rays and hydroxyl radicals by binding to chromatin and forming a shield. This mechanism may help develop animal cells that can live longer under extreme conditions.
A phase II trial found that adding radiation therapy to immunotherapy increases progression-free survival for patients with metastatic non-small-cell lung cancer. T cells played a key role in the immune response, with certain markers predicting longer disease-free periods.
Researchers found that adding durvalumab to radiation and chemotherapy significantly decreased the recurrence of lung cancer in both chest and distant sites, with new lesions occurring primarily in the brain. This suggests that aggressive local therapies may further extend survival for patients with non-small cell lung cancer.
A machine-learning model has been developed to predict significant weight loss and need for feeding tube placement in head and neck cancer patients undergoing radiation therapy. The model showed high accuracy in predicting these two endpoints, allowing clinicians to take preventive measures.
A new trial analysis found that women diagnosed with early stages of cancer who undergo lumpectomies and receive either partial or whole breast radiation have equivalent cosmetic outcomes, according to patient and physician ratings. The study's findings aim to guide women seeking breast-conserving therapy for early-stage disease.
A noninvasive radiation therapy called ENCORE has been shown to dramatically reduce episodes of rapid, abnormal heartbeats for more than two years. The treatment, which uses stereotactic body radiation therapy, has also led to a reduction in medication side effects and improved quality of life.
A randomized clinical trial found that high-dose radiation therapy can generate an immune system response similar to vaccination, sparking a systemic immune reaction against cancer. Patients treated with stereotactic ablative radiotherapy lived significantly longer without disease progression.
The closure of nearly 100 women's health clinics in the US was associated with fewer cervical cancer screenings, more advanced diagnoses, and increased mortality rates. States with clinic closures saw a 2% drop in screenings, particularly among uninsured women, Hispanic women, and young adults.
A new study from the University of Pennsylvania found that radiation therapy given 30 days or less before CAR T infusion reduces the risk of serious cytokine release syndrome and neurotoxicity. The therapy may also have potential benefits for NHL patients, according to researchers.
A phase one/two study found that a single high dose of radiation significantly reduces ventricular tachycardia episodes, with a 72% overall survival rate at one year and 52% at two years. The noninvasive procedure is a last line of defense for patients who have exhausted other treatments.
A recent study found that a standardized medical school exam can bias the entry of diverse and qualified candidates into radiation oncology residency programs. The researchers suggest that using a holistic approach to evaluate applicants could help address these biases, incorporating emotional intelligence and other core competencies.
The American Society for Radiation Oncology (ASTRO) has released a new clinical guideline recommending the use of radiation therapy in pre-surgical, post-surgical, definitive and palliative settings. The guideline emphasizes a patient-centered approach integrating patients' values and preferences into treatment decisions.
Researchers developed a new mathematical model to optimize radiation therapy for brain tumors by targeting the densest areas. This approach has shown promise in increasing the number of tumor cells killed during treatment.
Researchers at Moffitt Cancer Center have developed a model called GARD that uses genomic data to predict the risk of local tumor recurrence and optimize radiation doses for breast cancer patients. The study found that a personalized approach to radiation therapy can reduce overdosing certain patients and improve treatment outcomes.
A new Northwestern University study discovered that spaceflight consistently changes the abundance and diversity of gut bacteria in mice. Using a novel analytical tool called STARMAPS, researchers found that spaceflight causes a specific change on the microbiome, but ruled out radiation as the cause.
Researchers found that tumor cells depleted of ARID1A become highly sensitive to PARP inhibitor drugs after radiation treatment. This discovery could advance efforts to treat cancers resistant to current standard treatments.
Researchers have developed a drug that speeds up blood stem cell regeneration after exposure to radiation, accelerating the recovery of cancer patients. The new compound, DJ009, lifts molecular 'brakes' on blood stem cells, enabling them to recover faster and reducing the risk of infections.
A study published in JAMA Oncology found that introducing a default physician order into electronic health records reduced daily imaging for cancer patients with advanced cancer by half. This change also saved an average of two minutes per session, resulting in faster treatment courses.
A new AI framework developed by Cleveland Clinic researchers can now use medical scans and health records to personalize the dose of radiation therapy used to treat cancer patients. The framework has been shown to reduce treatment failure probability to less than 5 percent.
A new blood test may help personalize treatment for patients with HPV-linked head and neck cancer. Characteristics such as high circulating tumor HPV DNA levels before treatment and rapid clearance of the virus were linked to improved outcomes.
A study led by Northwestern University found that radiation combined with chemotherapy did not increase recurrence-free survival in women with stage III/IVA endometrial cancer. Chemotherapy alone remains the standard of care for this type of cancer.
A retrospective study of 748 NSCLC patients found that the average radiation dose delivered to the heart was associated with an increased risk of major adverse cardiovascular events and death. The team's findings highlight the need for more stringent avoidance of high cardiac radiotherapy doses and collaboration with cardiologists to m...
The seven-year ORATOR trial found no difference in survival between robotic surgery and radiation therapy, but patients receiving radiation experienced better swallowing outcomes. Participants in the surgery group were at risk for complications such as pain, bleeding, and hearing loss.
A new technique using laser angiography illuminated blood flow during laryngectomy surgery, identifying patients at highest risk of wound healing issues. This approach may enable surgeons to adjust during surgery or recovery to improve outcomes, with potential interventions including wider tissue removal and extended hospital stays.
A new study found that black men with low-risk prostate cancer are 16% less likely to adopt active surveillance than non-black men, despite similar rates of overall active surveillance. The disparity is attributed to socioeconomic and insurance barriers that deter black patients from accessing follow-up care.
A clinical trial at the University of Cincinnati is investigating the use of targeted proton radiation in early-stage breast cancer. The study aims to evaluate the effectiveness and cosmetic outcomes of this treatment, as well as its side effects and cancer recurrence rates.
Researchers have developed a system to accurately deliver precise doses of radiation to cancer tissues while minimizing exposure to healthy ones. The new system uses specialized polymer gel to visualize the spatial location and dose of treatment in real-time.
A new study presents evidence that pencil beam scanning proton therapy offers the best hope of preserving cognitive functions in children with brain tumors. The treatment delivers low doses of radiation to critical areas of the brain, including the temporal lobes and hippocampus.
Radiation oncologists provide guidance on preparing for and responding to natural disasters, including creating emergency operations plans, providing patients with access to treatment plans via flash drives, and identifying alternative sources of power. The tips aim to minimize treatment delays during a disaster.
The new technology provides a 360-degree, three-dimensional view of surgical tools and surrounding tissue for more precise needle placement. This allows for improved dose pattern distribution to the tumour and surrounding tissue, reducing complication rates.
A new study published in the American Journal of Roentgenology reviews historical rationale for patient shielding and concludes that its benefits outweigh its risks. The practice, which has been in place since 1976, poses little benefit while increasing radiation exposure and decreasing image quality.
A recent commentary suggests that treatment guidelines recommended by medical specialist organizations are more likely to lead to overdiagnosis, overtreatment, and increased healthcare costs. The authors argue that specialty bias and fee-for-service compensation models contribute to this issue.
Researchers used Raman spectroscopy to map biomolecular changes in radiation-resistant and radiation-sensitive human lung tumors and head and neck tumors. They found statistically significant differences in lipid and collagen content that could potentially identify treatment-resistant tumors early.