Articles tagged with Radiation
The NRG-RTOG 0712 trial demonstrated high efficacy rates for both gemcitabine and daily radiation regimens, with 79% and 85% distant metastasis-free rates at 3 years, respectively. The findings confirm the acceptance of these treatments as alternatives to cystectomy.
A new Penn study found administering radiation therapy to multiple myeloma patients waiting for CAR T cells to be manufactured was safe and did not interfere with cellular therapy. Patients who received radiation 34 days or fewer before infusion had similar rates of severe side effects as those who did not receive radiation.
A randomized phase III trial found that stereotactic radiosurgery reduces cognitive decline without compromising survival for patients with four or more brain metastases. Patients who received SRS had better preserved cognitive function compared to those who received whole-brain radiation therapy.
A randomized phase II/III trial found that SBRT reduced pain in patients with spinal metastases by 35% after three months, compared to 14% for conventional radiation. Patients treated with SBRT also experienced higher satisfaction rates related to financial considerations.
A phase II trial shows similar safety and efficacy with single- and multiple-fraction treatment for patients with limited oligometastases. The study found comparable survival rates, local control rates, and disease-free survival rates between the two treatment groups.
A randomized phase III trial found that image-guided intensity modulated radiation therapy (IMRT) improves long-term toxicity-free survival and reduces gastrointestinal side effects in women with cervical cancer. The study showed a significant reduction in moderate-to-severe gastrointestinal side effects compared to 3D-CRT, with improv...
The new guideline provides options for different treatments to improve survival rates and quality of life for patients with locally advanced rectal cancer. Recommendations address patient selection, pelvic radiation treatments, integration with chemotherapy and surgery, and follow-up care.
The American Society for Radiation Oncology (ASTRO) will highlight groundbreaking studies and discussions on cancer treatment advances, COVID-19, and racial representation in radiation therapy clinical trials at its upcoming Annual Meeting.
A high-fibre diet has been found to offset chronic gastrointestinal damage caused by radiotherapy, reducing radiation-induced inflammation in the digestive system. This contradicts long-held clinical recommendations that advise a restricted fibre diet for cancer patients undergoing radiotherapy treatment.
Research reveals continuous loess deposition over the past 3.6 million years, indicating a dry climate and desert conditions in midlatitude Asia. Global cooling is linked to this aridity, intensifying westerly winds and enhancing dust production.
Bob May, Jefferson Lab ES&H Deputy Director, has been named a fellow of the Health Physics Society for his 40-year career in health physics. He is recognized for his significant contributions to radiation safety and administration within the field.
Researchers found that targeting purine metabolism can disrupt DNA repair and increase sensitivity to radiation, offering a new approach to overcome resistance. A clinical trial is planned to test the effectiveness of an FDA-approved drug in human patients.
A new Oregon State University study using zebrafish found no significant health impacts from 5G radiofrequency radiation. Researchers exposed embryonic zebrafish to 3.5 GHz radiation and observed a modest impact on sound response, highlighting the need for further investigation.
Researchers developed a highly effective and safe nanocrystal to combat deadly radiation, increasing survival rates and reducing oxidative stress by five times compared to individual components.
The American Society for Radiation Oncology (ASTRO) has released its first clinical guideline on radiation therapy for cervical cancer. The guidelines address indications and best practices for external beam radiation therapy and brachytherapy in postoperative and definitive settings, including the use of chemotherapy and IMRT.
Photodynamic therapy has been shown to be effective in treating localized tumors, including ovarian cancer, through the introduction of photosensitizers that selectively accumulate in tumor tissue, producing singlet oxygen and other active radicals to destroy cells.
Glioblastoma cells acquire radiation resistance by dumping exosomal microRNA miR-603, leading to increased protein production and insensitivity to radiation. This study reveals a new therapeutic strategy for overcoming cancer cell resistance.
Researchers developed a post-processing algorithm to increase the quality of reconstructed CT images while reducing noise and radiation exposure. The new method enhances tissue discrimination by 60%, enabling better decision-making for further treatments.
Researchers at UCLA have found that adding a schizophrenia drug to traditional radiation therapy improved overall survival in mice with glioblastoma. The combination successfully delayed tumor growth and prolonged animal survival by over 200 days.
Researchers have developed a method using phononic crystals to generate tunable, time-variant sound fields that can trap and transport particles and cells in microchannels. This technology has potential applications in display technology, biomedical sensors, and diagnostic tools.
Researchers developed a new design to reduce energy loss in optical fiber communications by radiating light in a single direction. This breakthrough has the potential to improve data communications for commercial data centers and enable battery-powered photonic computers.
This study found that HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) cells exhibit enhanced radiosensitivity and increased cell motility after radiation therapy. In contrast, HPV-negative OPSCC cells show decreased radiosensitivity and reduced cell motility.
Researchers at UCLA Jonsson Comprehensive Cancer Center identified a possible new drug, NSPP, that prevents cognitive decline in mice after radiation therapy for brain tumors. The study found the drug did not reduce radiation treatment efficacy.
The NETTER-2 study is a Phase III clinical trial evaluating Lutathera's efficacy and safety in treating Grade 2 and 3 advanced GEP-NETs. The primary objective is to prolong Progression Free Survival in patients with high proliferation rate tumors.
A new phase II trial found a combination of radiation therapy and pembrolizumab to be effective in treating locally advanced head and neck squamous cell carcinoma, particularly for patients ineligible for cisplatin chemotherapy. The treatment showed encouraging survival outcomes and acceptable toxicity.
A new international advisory system is working to keep aircraft crew and passengers safe from space weather impacts. The system predicts disruptions from solar activity and helps airlines adjust flight paths to minimize impacts on navigation and communications systems.
Researchers at UCLA Jonsson Comprehensive Cancer Center found a condensed five-day radiation regimen to be as effective as traditional five-week treatment in treating soft tissue sarcoma. The new approach showed lower wound complication rates and improved cancer control without increasing side effects.
This study found that the addition of nimotuzumab to weekly cisplatin-radiation significantly improves outcomes, including overall survival, in locally advanced head and neck cancer patients with HPV negative oropharyngeal cancers. The study compared these outcomes with a control group receiving only cisplatin-radiation.
A five-year follow-up study of over 2,000 U.S. men with localized prostate cancer found that radiation therapy was associated with significant declines in erectile function, while surgery improved function over time. Prostatectomy also resulted in worse urinary incontinence compared to other treatments.
A new synthesis method has been developed to unlock the secrets of 'strange metals', which exhibit unusual temperature behavior. The research team's findings confirm that quantum-critical charge fluctuations play a key role in their behavior.
A new study found that a disrupted biological clock increases the risk of heart disease in mice treated with radiation therapy, highlighting the potential role of protein Bmal1 in protecting the heart. The research could lead to personalized medicine approaches and optimized timing for radiation therapy to minimize side effects.
A new study suggests that monitoring patients' activity levels prior to chemoradiation therapy for lung cancer can predict treatment outcomes. Inactive patients are more likely to experience hospitalization, treatment delays, and disease recurrence, while active patients have better survival rates.
A new species of wasp-mimicking fly from South Korea has been discovered, with members twice the size of common house flies. The ancient insect, named after PSY's 'Gangnam Style', had distinct yellowjacket-like patterns on its abdomen.
The study found that higher doses of radiation and adding the drug cetuximab did not improve patient survival compared to standard of care chemoradiation. The 5-year overall survival estimate for the standard radiation dose arm was 32.1%, amongst the highest for Stage III NSCLC.
Researchers found that radiation triggers an immune response that severs connections between nerve cells, leading to damage and cognitive problems. The study suggests two potential approaches to prevent this damage: blocking a receptor responsible for synapse removal or tamping down the brain's immune response.
Researchers found that bumblebees consuming more nectar due to sub-lethal radiation exposure may impair colony growth. This effect could have significant consequences for pollinator ecosystem services in the Chernobyl Exclusion Zone.
The American Society for Radiation Oncology (ASTRO) has released a new clinical guideline for the use of radiation therapy in treating basal and cutaneous squamous cell carcinomas. The guideline provides recommendations on when to use radiation as stand-alone therapy or following surgery, as well as dosing and fractionation schedules.
A new clinical trial has found that patients with limited-stage, aggressive non-Hodgkin's lymphoma who have a clear PET scan can skip radiation therapy and still achieve excellent results. The study showed that 91% of patients who received no radiation were alive five years after treatment.
A multi-centre trial led by McMaster researchers found that accelerated partial breast irradiation (APBI) is as effective as whole breast radiation in reducing breast cancer recurrence, with similar recurrence rates after one week of treatment. However, APBI was associated with higher late toxic effects and worse cosmetic outcomes.
High-dose-rate brachytherapy offers excellent cure rates and cosmetic outcomes for elderly patients with common skin cancers, including squamous cell carcinoma and basal cell carcinoma. The treatment delivers a precise dose of radiation directly to the tumor while sparing healthy tissue nearby.
A nationwide survey of over 400 US adults with cancer found that nearly all patients felt confident in their treatment decisions but had gaps in knowledge about potential side effects. The study highlights the need for more informed patient counseling and coordination between oncology disciplines to manage treatment-related side effects.
The SRNL-designed radiation detection system has been successfully implemented at the Port of Tacoma and NY/NJ, detecting illicit radioactive material in intermodal cargo containers. The system is expected to save significant time and space requirements for scanning these containers, increasing operational efficiency.
Researchers at the University of Seville have developed a procedure for producing boron carbide phase B6C, an ultra-resistant material with a hardness of 52 GPa and Young modulus of 600 GPa. The material is resistant to radioactivity and surpasses diamond in hardness.
Tardigrades' protein Dsup protects cells from X-rays and hydroxyl radicals by binding to chromatin and forming a shield. This mechanism may help develop animal cells that can live longer under extreme conditions.
A randomized clinical trial found that high-dose radiation therapy can generate an immune system response similar to vaccination, sparking a systemic immune reaction against cancer. Patients treated with stereotactic ablative radiotherapy lived significantly longer without disease progression.
The closure of nearly 100 women's health clinics in the US was associated with fewer cervical cancer screenings, more advanced diagnoses, and increased mortality rates. States with clinic closures saw a 2% drop in screenings, particularly among uninsured women, Hispanic women, and young adults.
A phase II trial found that adding radiation therapy to immunotherapy increases progression-free survival for patients with metastatic non-small-cell lung cancer. T cells played a key role in the immune response, with certain markers predicting longer disease-free periods.
Researchers found that adding durvalumab to radiation and chemotherapy significantly decreased the recurrence of lung cancer in both chest and distant sites, with new lesions occurring primarily in the brain. This suggests that aggressive local therapies may further extend survival for patients with non-small cell lung cancer.
A machine-learning model has been developed to predict significant weight loss and need for feeding tube placement in head and neck cancer patients undergoing radiation therapy. The model showed high accuracy in predicting these two endpoints, allowing clinicians to take preventive measures.
A new trial analysis found that women diagnosed with early stages of cancer who undergo lumpectomies and receive either partial or whole breast radiation have equivalent cosmetic outcomes, according to patient and physician ratings. The study's findings aim to guide women seeking breast-conserving therapy for early-stage disease.
A noninvasive radiation therapy called ENCORE has been shown to dramatically reduce episodes of rapid, abnormal heartbeats for more than two years. The treatment, which uses stereotactic body radiation therapy, has also led to a reduction in medication side effects and improved quality of life.
A new study from the University of Pennsylvania found that radiation therapy given 30 days or less before CAR T infusion reduces the risk of serious cytokine release syndrome and neurotoxicity. The therapy may also have potential benefits for NHL patients, according to researchers.
A phase one/two study found that a single high dose of radiation significantly reduces ventricular tachycardia episodes, with a 72% overall survival rate at one year and 52% at two years. The noninvasive procedure is a last line of defense for patients who have exhausted other treatments.
A recent study found that a standardized medical school exam can bias the entry of diverse and qualified candidates into radiation oncology residency programs. The researchers suggest that using a holistic approach to evaluate applicants could help address these biases, incorporating emotional intelligence and other core competencies.
Researchers developed a new mathematical model to optimize radiation therapy for brain tumors by targeting the densest areas. This approach has shown promise in increasing the number of tumor cells killed during treatment.
The American Society for Radiation Oncology (ASTRO) has released a new clinical guideline recommending the use of radiation therapy in pre-surgical, post-surgical, definitive and palliative settings. The guideline emphasizes a patient-centered approach integrating patients' values and preferences into treatment decisions.
Researchers at Moffitt Cancer Center have developed a model called GARD that uses genomic data to predict the risk of local tumor recurrence and optimize radiation doses for breast cancer patients. The study found that a personalized approach to radiation therapy can reduce overdosing certain patients and improve treatment outcomes.
A new Northwestern University study discovered that spaceflight consistently changes the abundance and diversity of gut bacteria in mice. Using a novel analytical tool called STARMAPS, researchers found that spaceflight causes a specific change on the microbiome, but ruled out radiation as the cause.
Researchers found that tumor cells depleted of ARID1A become highly sensitive to PARP inhibitor drugs after radiation treatment. This discovery could advance efforts to treat cancers resistant to current standard treatments.
Researchers have developed a drug that speeds up blood stem cell regeneration after exposure to radiation, accelerating the recovery of cancer patients. The new compound, DJ009, lifts molecular 'brakes' on blood stem cells, enabling them to recover faster and reducing the risk of infections.