Articles tagged with Research Management
Researchers have identified CAR-T cell therapy as a potential treatment for autoimmune diseases such as rheumatoid arthritis, SLE, and type 1 Diabetes Mellitus. Early studies have shown promising results in reducing disease activity and improving patients' quality of life, but long-term data on safety and efficacy is limited.
A group of 350 scientists from over 60 countries call for a legally binding global treaty to prohibit the production of hazardous plastics chemicals and adopt science-based approaches. They advocate for an independent scientific body with robust conflict of interest policy and regional representation.
Researchers have developed an active learning strategy to accelerate the synthesis of high-performance engineered biochar with enhanced CO2 uptake. The approach nearly doubled CO2 capture performance, showcasing its transformative impact.
A new study from Colorado State University suggests that transitioning to green wastewater-treatment approaches, financed through carbon markets, could save $15.6 billion and reduce CO2-equivalent emissions by 30 million tonnes over 40 years. The research explores the potential economic tradeoffs of switching to green infrastructure an...
Researchers from the University of Cincinnati presented findings on the effectiveness of a two-component enzyme replacement therapy for late-onset Pompe disease. The study showed that patients treated with this regimen experienced improvement or stability in motor function, pulmonary function, and muscle strength. Additionally, experts...
A new study published in PNAS found that AI-generated messages made recipients feel more 'heard' than messages generated by untrained humans, and that AI was better at detecting emotions. However, recipients reported feeling less heard when they learned a message came from AI.
A new study has identified alpha-1-antichymotrypsin as a blood protein marker that can predict delayed recovery of concussion in children. The study found that children with low levels of alpha-1-antichymotrypsin were more likely to experience delayed recovery, highlighting the potential for early diagnosis and targeted treatment.
A new statistical-modeling workflow can quickly identify molecular structures of products formed by chemical reactions, accelerating drug discovery and synthetic chemistry. The workflow also enables the analysis of unpurified reaction mixtures, reducing time spent on purification and characterization.
A study from Colorado State University explores how human activity is altering the atmospheric water cycle, leading to changes in precipitation distribution and cloud formation. The research uses science fiction narratives to imagine possible futures and spark conversations around water management policies.
A study led by Michigan Medicine found that around 10% of deaths following percutaneous coronary intervention are potentially preventable. Complications during procedures contributed to 20% of the nearly 1,200 deaths reported during the study period.
Researchers at Tohoku University developed a high-performance magnesium-air battery that utilizes water activation and carbon cathodes. The paper-based battery achieved impressive performance results and demonstrated its versatility in wearable devices such as pulse oximeters and GPS sensors.
Researchers from the University of Houston used spaceborne-monitoring to detect movements and deformations in the Kakhovka Dam years before its collapse. The study highlights the importance of proactive monitoring and remote sensing in ensuring infrastructure safety and integrity.
The journal features five original articles from Kennedy Krieger faculty members, providing actionable insights on caring for children with autism. The volume addresses a significant gap in resources for pediatric clinicians and researchers globally.
Researchers discovered compounds with untapped therapeutic potential for treating BPH, melanogenesis, and nerve damage. Metformin restored sex hormone homeostasis, epimedin B stimulated pigmentation function, and hydralazine suppressed ferroptosis to aid in axon regeneration.
Researchers found that chlorogenic acid enhances osteoblast proliferation and differentiation, while inhibiting RANKL-induced osteoclastogenesis. Administration of chlorogenic acid antagonizes ovariectomized-induced bone loss in rats.
A WVU study found that treating work like a game improves workers' productivity and engagement, but also increases stress levels. Gamification can boost completion times for repetitive tasks, but may push employees past their tolerance threshold, leading to frustration and physical demands.
Researchers from Tokyo University of Science found that rose essential oil increases the transcript levels of PIR1 and PIN2, key plant defense genes, in tomato plants. The study also showed that REO reduces leaf damage caused by pests and attracts beneficial predators to protect against herbivores.
The T2oFu method offers a new approach to quantitative phase and polarization-sensitive tomography, enabling high-contrast images of muscle fibers with implications for diagnosing skeletal myopathies. The technique has been successfully tested on heart tissue samples with cardiac amyloidosis, providing promising results.
Reducing surgeon manipulation of predicted operating room time improved overall scheduling accuracy, with a significant decrease in underscheduled operations and manipulations. The study found that educating surgeons about the importance of accurate OR planning increased accuracy rates by 6.2 percentage points.
A novel risk score predicts cardiovascular complications after bone marrow transplant with high accuracy, helping guide patient selection and post-transplant management. Patients with preexisting cardiovascular conditions are more likely to experience long-term complications.
Researchers at the University of Virginia Health System are developing a technique to 'paint' tiny nanoparticles on transplanted veins to prevent blockages, potentially sparing patients from repeated surgeries. This approach could significantly reduce the number of vascular reconstructions performed annually in the US.
A new study finds that Latinx children with unreliable access to food at age 4 are nearly four times more likely to develop fatty liver disease later. The researchers recommend earlier screening for metabolic dysfunction-associated steatotic liver disease (MASLD) and ensuring public meal programs offer nutritious meals.
A landmark study published in JAMA Pediatrics found that COVID vaccines are safe to administer during pregnancy, with no abnormal delays in infants when tested at 12 months and 18 months. The study of over 2,200 infants from across the country also found an increased risk of delay among male infants at 12 months but not at 18 months.
A new study projects that as many as 500,000 people could be affected and 1 in 35 properties damaged by flooding in 32 US coastal cities by 2050. The research highlights racial and socioeconomic demographics of those potentially affected.
A University of Cincinnati study found liraglutide to be efficacious and safe for weight loss in individuals with stable bipolar disorder, without destabilizing the illness. The drug reduced binge eating behavior and significantly lowered hemoglobin A1C levels.
The Zero-Energy Switchable Radiative Cooler (ZESRC) is a temperature-responsive solution that balances building temperatures sustainably. Field experiments demonstrate its effectiveness across seasons, reducing energy consumption by 14.3% compared to other devices.
Researchers developed an oxidative stress-based prognostic model for bladder cancer, identifying distinct molecular subtypes and predicting patient outcomes. The model shows promise in tailoring personalized treatment approaches, particularly for patients with low-risk profiles.
A new rapid test has been developed to identify hantavirus in South Korea, paving the way for early outbreak control. The Flongle sequencing-based diagnostic is cost-efficient and can detect HTNV genomes within 3 hours.
Researchers have discovered a new mechanism by which 5-aminolevulinic acid (ALA) improves cold resistance in tomato plants. The study found that ALA regulates the SlMYB4/SlMYB88-SlGSTU43 module to remove reactive oxygen species, enhancing the plants' tolerance to low-temperature stress.
Researchers found that SlWRKY80 positively regulates tomato resistance to saline-alkali stress by enhancing spermidine content and stabilizing Na+/K+ homeostasis through the JA metabolic pathway. Exogenous MeJA application increased endogenous MeJA and JA contents, reducing stress sensitivity in SlWRKY80 knockout lines.
Researchers decode underlying mechanisms of DCM, hippocampal neurotoxicity, and dysbiosis mediated AD progression using mass spectrometry imaging. The studies found metabolic changes in DCM rat hearts and regulation of CYPs in the hippocampus, providing new perspectives on treatment strategies.
Researchers have created a computer using an array of VCSELs that leverages optical feedback to efficiently solve complex optimization problems. The system encodes information in linear polarization states, minimizing interactions between variables and overcoming the von Neumann bottleneck.
A new study found that severe maternal grief, particularly the loss of a partner or child, is associated with an increased risk of heart failure in children up to middle age. The research suggests that prenatal stress may lead to adverse changes in mental and physical health, impacting fetal heart development.
A study led by UMass Amherst found that increased temperatures do lead to decreased body size in fish, but gill surface area does not explain the change. The researchers challenged widely cited model projections of drastic reductions in future global fisheries yields, suggesting that models need to be reconsidered.
Women with high-status contacts actually lose status, whereas men benefit from their networks. Researchers found that women who form ties with higher-status people are seen as dominant and subject to social penalties. Organizations can take steps to reframe network building activities to protect the status perception of women.
A study published in Global Change Biology found that low deep-water oxygen concentrations lead to increased algae growth and further oxygen declines. This positive feedback cycle can result in frequent algal blooms, disrupting lake ecosystems and human health.
A new study by Norwegian University of Science and Technology has developed a tool to identify individuals at high risk of burnout. The Burnout Assessment Tool (BAT) measures four main groups of risk factors, including exhaustion, mental distancing, cognitive impairment, and emotional impairment.
A recent study by the University of Surrey analyzed articles published in the Journal of Management Studies over the last decade and found that diverse research teams lead to more citations. The study reveals that internationality, interdisciplinarity, and gender diversity among authors all contribute to increased citation rates.
Researchers document various reasons for long-term clinical symptoms in patients infected with SARS-CoV-2. Key findings include immune system alterations, chronic inflammation, endothelial dysfunction, and mitochondrial issues contributing to post-COVID syndrome.
Chemical simulations can be sped up by resetting them, a new study from Tel Aviv University found. This technique, called stochastic resetting, overcomes the timescale problem, allowing for more accurate predictions of slow processes.
Researchers propose a novel augmentation regimen, IPIAD, combining five generic non-oncology drugs with standard chemotherapy for pancreatic ductal adenocarcinoma. The IPIAD regimen uses repurposed drugs like irbesartan and azithromycin to potentially slow disease growth and improve outcomes.
Researchers discovered two new genetic pathways associated with worse ICH outcomes, including a pathway affecting blood coagulation and cellular interactions. Population data showed a decrease in aneurysmal SAH strokes and a rise in non-aneurysmal subarachnoid hemorrhages, offering encouraging evidence for intervention success.
Scientists found that short-chain fatty acids produced by gut bacteria suppress allergic reactions by modulating mast cell activation and epigenetic modifications. This study provides new insights into the relationship between diet and immune system regulation, with potential applications in allergy treatment.
A global study review found negative indirect impacts of the pandemic on people with diabetes, including a rise in non-COVID-19-related deaths, diabetic ketoacidosis among children and adolescents, and sight loss. Pediatric ICU admissions were also significantly increased.
Researchers from Cleveland Clinic and IBM have developed an AI strategy to identify new targets for immunotherapy treatments. The study, published in Briefings in Bioinformatics, reveals how artificial intelligence can be designed to accurately depict how immune systems recognize target antigens.
Gabapentinoid usage has continued to rise in the US, increasing from 4.0% in 2015 to 4.7% in 2021, according to a recent report. The study found that users continue to take these medications despite FDA warnings against combining them with other sedating medications.
A study found that primary care physicians spent nearly 30 minutes more on EHR tasks between pre-pandemic and final year, with time spent outside of scheduled hours increasing significantly. This growth in EHR workload may contribute to burnout and affect decisions to cut back on clinic time or leave the profession.
This study explores the perspectives of primary care physicians (PCPs) and urologists on active surveillance (AS) care for men with low-risk prostate cancer. Key findings include the importance of patient education and clear communication among care team members to prevent loss to follow-up.
A recent study reveals that solar energy facilities planted with native grasses and wildflowers can rapidly support thriving insect populations. Total insect abundance tripled at the studied sites, providing additional pollination services to adjacent agricultural fields.
A new study reveals a surprising trend in global fishing industries: the decline of catch per fisher since the 1990s, despite increasing numbers of fishermen. This decrease has significant implications for food production efficiency, marine ecosystems, and fishing communities.
AI models predict patient outcomes with high accuracy within their training data, but their performance deteriorates when used outside the original trial or in different clinical settings. Researchers aim to improve accuracy by examining large patient groups and exploring new data modalities.
Researchers have developed a thermal management technique for photonic packages using glass substrates and thermoelectric vias, enabling precise temperature control. The technology, termed SimTEC, combines through glass vias partially filled with copper and thermoelectric materials to reduce thermal resistance between chips.
A new computational model, IRMMa, predicts personalized prognosis for newly diagnosed multiple myeloma patients based on tumor genomics and treatments. The model improves on previous prognostic tools by taking into account individualized risk and distinct subtypes of the disease.
Researchers at Pohang University of Science & Technology developed an uncrewed surface vehicle to measure nitrate concentration and water depth in a reservoir. The study reveals seasonal variations in nitrate levels and the importance of considering timing and weather conditions in water quality assessments.
A new study published in The Journal of Head Trauma Rehabilitation found that approximately 60% of people living with traumatic brain injury (TBI) experience chronic pain, even up to 30 years after injury. Chronic pain can significantly worsen outcomes for individuals with TBI, and medications are often the most frequently used treatment.
A University of Queensland study found humans can correctly identify the emotional context of chickens' clucks, with 69% accuracy. The ability to detect emotional information from vocalisations could improve the welfare of farmed chickens.
A study found that 64% of students did not engage in problematic behaviors, while 26% let participants take part despite knowing the hypothesis. Supervisors underestimated the prevalence of certain behaviors, highlighting the need for improved communication and Open Science education.
Recent urology treatment studies have improved the reporting of harms in randomized trials, addressing adverse events, side effects, and complications. The analysis found a significant increase in reporting harms criteria from 2012 to 2020, with more than three-fourths of items addressed by 2020.
A recent study published in Cerebral Cortex found that participants exposed to 18-Hz beta binaural beats had significantly higher accuracy and faster response times during comprehension tasks. This suggests that binaural beat stimulation at this frequency may be a potential tool for improving language skills.
A new study from the University of Ottawa and Copenhagen Business School finds that removing human bias from organizational processes can lead to autonomous systems that create their own environments. This could limit human ability to recognize automation biases, notice environmental shifts, and take action.