Articles tagged with Memory Formation
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Researchers have identified PDE4B as a potential target for treating Alzheimer's disease, where reducing its activity shows promise in improving memory and glucose metabolism. The study suggests that this approach may also protect against other forms of dementia, such as Huntington's disease.
Researchers developed a new model that highlights the crucial role of interactions among neighboring contact sites of nerve cells for brain plasticity. Synaptic plasticity, the brain's method for learning, is shaped by the strength and stability of neuronal connections, which are influenced by both excitatory and inhibitory synapses.
A recent study by Boston Children's Hospital researchers found that activity in the dentate gyrus helps keep us focused on our environment when our mind wanders. This neural activity also aids in forming memories.
Research suggests that magnetite particles, found in air pollution, can induce signs and symptoms of Alzheimer's disease. The study exposed mice to fine particles of iron, magnetite, and diesel hydrocarbons, finding that magnetite induced Alzheimer's disease pathologies, including neuronal cell loss and amyloid plaque formation.
Researchers found that individuals with mild cognitive impairment (aMCI) struggle with ambiguous sentences, indicating a key deficit in processing complex language. This deficit is independent of memory loss and may serve as an additional 'cognitive biomarker' for early detection.
Researchers found that lower activity of the Snhg11 gene in brains with Down syndrome contributes to memory deficits. The study suggests a key role for non-coding RNAs in regulating gene activity and influencing complex traits.
A new brain stimulation technique called Patterned Low-Intensity Low-Frequency Ultrasound (LILFUS) has been developed by researchers at the Institute for Basic Science. This non-invasive method uses ultrasound to induce long-lasting changes in brain function and has shown promise in treating various neurological disorders.
Researchers discovered a single population of neurons in the CA2 area of the hippocampus can use different codes to represent familiar and unfamiliar individuals. This finding may shed light on disorders affecting memory such as schizophrenia and Alzheimer's.
Researchers have identified the molecular mechanism behind memory creation and found that saturated fatty acids interact with a protein called STXBP1. This interaction coordinates the release of fatty acids and directs communication at synapses in the brain.
Researchers found that handwriting by hand increases brain connectivity, promoting better memory formation and encoding of new information. This discovery highlights the need for more handwriting activities in schools, potentially leading to improved learning outcomes.
Researchers have discovered a new function for the protein RPT6, which helps form memories. RPT6 binds to DNA and increases gene expression during memory formation, playing a dual role in memory processing.
Researchers found that memory cells become more stable over time, improving ability to distinguish between similar experiences. This process could lead to new treatments for memory disorders like Alzheimer's disease.
New research from the University of Copenhagen shows that physical exercise improves ability to learn and remember motor skills, such as riding a bike or driving a car. Exercise before or after practicing new skills can lead to up to 10% improvement in memory, with enhanced effects when done both times.
Researchers found that traumatic memories immediately following a distressing event are more memorable than the moments leading up to it. This discovery has implications for eyewitness testimonies, therapies for PTSD, and understanding memory decline in brain disorders like Alzheimer's disease.
Growth hormone influences regulation of anxiety via a specific group of neurons, according to researchers at the University of São Paulo. The study identified somatostatin-expressing neurons as key players in modulating GH's anxiolytic effect, with increased anxiety observed in mice lacking these neurons.
Researchers discovered a striking similarity between AI models and the human brain's hippocampus, which enables powerful AI systems. By mimicking the NMDA receptor's gating process, they improved long-term memory in Transformer models.
A two-week yoga nidra intervention increased sleep efficiency and percentage of delta-waves in deep sleep, leading to improved cognitive abilities such as decision-making and abstraction. Cognitive tests revealed faster responses with no loss in accuracy.
Researchers found lower levels of serotonin transporter and higher levels of amyloid-beta protein in brains of people with mild cognitive impairment, a potential target for treatments to slow or stop disease progression. Further research is needed to study the role of serotonin in disease progression.
A new study found that traumatic memories in people with PTSD are represented in the brain in a distinct way, deviating from regular memory processing. The hippocampus and posterior cingulate cortex regions showed different neural responses to traumatic and sad autobiographical memories.
Researchers from the University of Queensland have identified a noncoding RNA called Gas5 that coordinates neuronal excitability in real time, contributing to learning and memory. The study found that this RNA is uniquely required for fear extinction memory, a type of critical input processing that leads to the formation of memory.
A world-first report found that alternative reporting options could help increase the number of women who report sexual assaults to police. Trauma-informed interviews designed in line with best-practice techniques can improve outcomes for victim-survivors of sexual assault who use them.
Researchers found that learning occurs through continuous formation of new connections between specific engram cells in different regions of the brain. This process allows us to form and store memories, with changes in synaptic wiring connectivity between these cells being a key mechanism for memory storage.
Researchers have identified a shared network of brain regions involved in various types of long-term memory, including general semantic, personal semantic, and episodic memory. The study found that these memory types rely on activating the same areas of the brain at differing magnitudes.
A study published in Nature Communications found that music-evoked emotions create boundaries between episodes, making them easier to remember. Fluctuating emotions help form separate and durable memories, even from neutral experiences. The research has great therapeutic promise for helping people with PTSD and depression.
A small molecule called YM022 has been discovered to block aversive memory formation in mice, offering a new direction for developing anti-depressants. The study found that YM022 suppressed neuroplasticity-caused aversive memory formation and reduced depressive behaviors in mice.
Researchers tested EMDR, a therapy proven to treat PTSD and depression, to reduce addiction cravings. The study found Addiction-focused EMDR was as effective as cognitive behavioral therapy for cravings, reducing symptoms by clinically significant amounts.
A newly developed labeling method allows for visualization of intraregional synaptic connections between inhibitory interneurons and excitatory engram cells. Researchers have identified the role of inhibitory interneurons in memory expression, suggesting that they suppress fear expression by inhibiting fear engram cells.
Researchers at Trinity College Dublin discovered that autism-induced maternal immune response alters brain development and prevents infantile amnesia. Memories formed during infancy can be permanently reinstated through light-activated neural pathways in adults.
A Cornell University-led study has separated the role of the hippocampus in two functions of memory, which are crucial for associating time, place, and past experiences with future actions. The breakthrough has significant implications for treating memory and learning issues found in Alzheimer's disease and dementia.
Researchers have discovered that traumatic memories create new neural networks and associations between distinct networks, enabling fear-based learning and recall. The study used optical and machine-learning approaches to visualize the dynamics of brain activity during memory formation.
Researchers found that the medial septum, a brain area in the center of the forebrain, plays a key role in encoding and retrieval processes. It helps generate gamma oscillations, which are faster for storing and slower for recalling memories.
A new study published in Neuron reveals that pericytes, a type of vascular cell, play a vital role in teaming up with neurons to form and store long-term memories. The research found that insulin-like growth factor 2 (IGF2) produced by pericytes enhances memory formation and storage.
A recent study by Ohio State University researchers found that saturated fats can interfere with the creation of new memories in aged brains. However, omega-3 fatty acids, particularly DHA, may help protect brain cells from fat-related inflammation. The study used cell cultures and brain tissue from aging mice to explore the effects of...
A study of 1,500 participants found that certain brain regions, including the hippocampus, exhibit stronger activation in individuals with better memory performance. The researchers identified functional networks in the brain linked to memory performance, shedding light on individual differences in memory recall.
A recent study published in Journal of Advertising sheds light on the effects of in-stream video advertising on ad information encoding. The research found that mid-roll ads elicit negative emotions but do not affect viewers' purchase intention. In contrast, pre- and post-roll ads have a significant impact on memory formation, highligh...
Caribbean box jellyfish have demonstrated complex learning capabilities, including associative learning and memory formation, despite having only one thousand nerve cells. This discovery sheds new light on the evolutionary success of jellyfish and raises questions about the universality of advanced learning mechanisms in animals.
A cluster of neurons in the fruit fly brain transforms memories about past rewards into actions, guiding the fly's navigation. The UpWiNs also send signals to dopaminergic neurons for higher-order learning, shedding light on parallel neural circuit mechanisms.
A new approach to PTSD treatment may involve targeting cerebellar inhibitory interneurons, which play a critical role in fear memory formation. The research found that these interneurons drive fear memory consolidation via learning-induced HCN plasticity.
Researchers found that insects like American cockroaches use the mushroom body to encode behavioral decision-making based on sensory information. The study challenges the prevailing view of insect cognition, suggesting a more complex brain function than previously thought.
The Wang Lab at MPFI will investigate neural circuits underlying Alzheimer's disease with a new $1.038M NIH grant. The research aims to shed light on how the brain forms and maintains memories, particularly in patients with declining cholinergic inputs.
Researchers from Sophia University found that melatonin and its derivatives, such as ramelteon and N1-acetyl-5-methoxyquinuramine, facilitate the formation of long-term memory in male mice. The study suggests that melatonin modulates the phosphorylation levels of key proteins involved in long-term memory formation.
Researchers found that natural forgetting can be reversed in certain circumstances, with memories stored in engram cells still intact but inaccessible. Competition between engrams affects recall, and forgotten memory traces can be reactivated by cues or updated with new information.
Glycosaminoglycans, complex sugars in the brain's extracellular matrix, regulate neural connectivity through sulfation patterns. This discovery could lead to treatments for neurodegenerative diseases and psychiatric disorders by manipulating these patterns.
A University of Massachusetts Amherst kinesiologist is implementing a physical activity program for young children in preschools with low socioeconomic status. The pilot study aims to measure the impact on cognitive development and gross motor skills, with potential long-term implications for health disparities.
Research reveals a local mechanism in neurons that enables insulin-like growth factors to facilitate brain plasticity. IGF release is necessary for activating the IGF1-Receptor during synaptic plasticity, leading to neuron growth and strengthening.
Researchers found that Period 1 gene becomes more active in memory-forming region of brain in daylight hours after learning, playing crucial role in consolidating memories. Mice exhibit improved daytime memory performance compared to nighttime.
Researchers found that people who imagined planning a heist had better memory the next day compared to those who imagined executing it. Curiosity supercharges memory for paintings seen while pretending to be an art thief.
A new study published in Aging (Albany NY) suggests that prior training can rescue cognitive decline in aging by improving task performance and strengthening memory processes. The research, conducted on rats, found that prior training enhanced short-term and intermediate memory, while also enabling encoding-boosted long-term memory.
Researchers at MSU have developed a state-of-the-art imaging system that can capture brain activity in real-time, revealing the intricate processes of memory formation. The system has the potential to image 10,000 to 20,000 neurons simultaneously, offering unprecedented insights into how memories are created and recalled.
New research shows that electric fields drive neural activity and coordinate memory across two key brain regions. The findings could lead to improved brain-controlled prosthetics for people with paralysis.
A Stanford Medicine-led study found that children with autism have impaired memory beyond poor facial recognition, affecting other types of information. The research also revealed distinct brain wiring patterns reflecting these memory challenges.
Scientists have used high-speed atomic force microscopy to observe the structural dynamics of CaMKII protein, shedding light on its role in modulating neural connections. The study reveals that the protein's structure changes in response to calcium and calmodulin binding, leading to a form of molecular memory.
Researchers establish a direct link between Covid-19 and Alzheimer's disease, attributing the connection to RAS overactivation caused by SARS-CoV-2 virus. This dysfunction leads to increased b-amyloid protein accumulation, impairing brain cell synaptic connections and cognitive functions.
A study found that social isolation is associated with a decrease in hippocampal volume, poorer cognitive performance, and an increased risk of developing conditions like Alzheimer's dementia. Conversely, maintaining a healthy social network can help preserve brain structure and function.
Researchers at the Institute for Basic Science have identified specific neurons in the hippocampus that allow us to recognize individual social counterparts and update their value through interactions. The dorsal CA1 region plays a crucial role in this process, enabling long-term memories of individuals to be formed.
Researchers discovered a specific form of ubiquitin protein selectively involved in forming fear memories in female brains, providing a potential target for therapeutic treatments. The finding could lead to more effective treatment options for post-traumatic stress disorder (PTSD) in females.
Researchers have identified a molecular mechanism underlying the change from gist-like to episodic memory in mice, suggesting that as interneurons mature, they enable memory specificity. This finding has implications for understanding child development research and conditions affecting the brain, such as autism spectrum disorder.
The gene LRRC4 regulates synapse formation, stability and excitatory transmission, playing a crucial role in learning, memory formation and storage. It also has key implications in neuronal disorders and aggressive brain and spinal cord cancer.
Researchers used AI to study how the hippocampus produces varied replay types efficiently and their purpose. The model showed that sequences are prioritized stochastically according to familiarity and reward positions.
A study published in Current Biology reveals that the hippocampus uses a specific neural mechanism to alternate between forming new memories and retrieving existing ones. The researchers found that gamma oscillations are coupled to theta waves, with different frequencies associated with encoding and retrieval processes.