A systematic review suggests that published studies on burnout and patient care quality may exaggerate the magnitude of the effect. The review analyzed 145 study populations and found that many results were due to biases in measurement and analysis, leading to overestimation of the relationship between burnout and poor quality care.
Researchers at Baylor College of Medicine developed a reliable molecular profile for meningiomas, predicting tumor recurrence with high accuracy. The study identified a unique characteristic of aggressive meningiomas, the dysfunction of the DREAM complex, which contributes to malignant transformation.
New research from Boston Medical Center's Grayken Center for Addiction found that community members responding to an overdose with naloxone are more likely to seek emergency help. The study analyzed overdose rescue reports and identified factors associated with calling emergency services when helping someone with naloxone.
A new research project will improve solar cell technology and explore new uses for photovoltaic devices. The collaboration includes five universities in three countries, with a focus on additive manufacturing and 3D printing for low-cost solar cell production.
Seabirds (Manx shearwaters) use spatial cognition to navigate back to their home colonies with accurate directional knowledge. However, they do not encode specific routes or anticipate obstacles encountered during foraging trips.
A recent study reveals that early hunter-gatherers on opposite sides of North America interacted much sooner than previously believed. Analysis of human remains, stone tools, and a copper band found in an ancient burial pit in Georgia suggests direct trade networks between the Great Lakes region and the coastal southeast United States....
A team of researchers found that Peruvian glaciers have retreated by 30% since 2000, with the rate of retreat accelerating since 2013. The increased melting is linked to El Niño events and has significant implications for water supply, agriculture, and natural hazards.
A new compound has been developed that can prevent unwanted cell death, which could improve recovery from medical emergencies and procedures. The study's findings suggest the potential for using this 'cell death blocker' to treat conditions like cardiovascular diseases and degenerative disorders.
The Carnegie Mellon and Yale research team will scale up production of PNAs, improve DNA binding properties, and develop new nanoparticle formulations for enhanced in vivo editing. The goal is to move the technique closer to clinical therapeutic applications.
Researchers have identified a novel compound that selectively inhibits the cyclin-dependent-like protein kinase PfCLK3 in Plasmodium falciparum, disrupting its lifecycle. The molecule TCMDC-135051 has shown promise in treating malaria and preventing transmission to vector insects.
A study by Oregon State University found that the state's accountable-care model led to decreases in unscheduled, preventable hospitalizations among Medicaid enrollees. The model emphasizes primary care, disease prevention, and population health measurements, which may promote more efficient healthcare resource use.
A new study published in Health Affairs found a 10% increase in behavioral health workforce jobs is associated with a 1.2% decrease in firearm suicide rates. The researchers suggest that investing in gun safety initiatives may be more effective in reducing suicides, highlighting the need for additional measures to curb gun-related deaths.
A new study from the University of Eastern Finland found that people with Alzheimer's disease who used antipsychotic drugs accumulated more hospital days over a two-year period. The study, based on the MEDALZ cohort, found that antipsychotic initiators had approximately eleven more hospital days per person-year compared to non-initiators.
A study published in Neurology found that young adults experiencing annual income drops of 25% or more are at risk of having thinking problems and reduced brain health in middle age. Participants with higher income volatility during peak earning years showed worse brain aging, including smaller total brain volume and reduced connectivity.
A study found that e-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice. Exposure to e-cigarette juice led to a high incidence of tumors, while filtered air exposure had minimal effects.
A new study reveals a stark mismatch between the number of US child firearm injuries and funding for research to understand and prevent them. Funding for pediatric firearm research is 30 times lower than needed to keep pace with other child health threats, resulting in less new knowledge and fewer discoveries.
The study reveals that the compound eyes of fruit flies play a crucial role in synchronizing their circadian clocks with light exposure. As daylight periods increase, the evening activity peak is delayed and the 'siesta' period is extended, highlighting the flexibility of the circadian clock mechanism.
Exercise can counteract the negative effects of cancer treatments on the cardiovascular system and relieve symptoms such as nausea and fatigue. A tailored exercise prescription is recommended for each patient based on individual characteristics, personal history, and cancer treatment.
USC researchers have successfully grown human testosterone-producing cells in the lab, paving the way to treat low testosterone with personalized replacement cells. The breakthrough could potentially bypass side effects associated with current treatments, such as infertility and increased risk of prostate cancer.
Researchers analyze data on international emergency events between 1960 and 2015, revealing growing hazards posed by severe events linked to climate change. Economic damages rise sharply worldwide, including in temperate areas, as death tolls from extreme temperature events increase in poor and rich countries.
Researchers discovered re-entrant superconductivity in uranium ditelluride, a phenomenon where a superconducting state arises, breaks down, and then re-emerges. High magnetic fields induced the rare 'Lazarus' behavior, which has implications for quantum computing.
The article discusses how the rise of AI will shift jobs towards feeling tasks, making emotional intelligence and interpersonal skills vital for success. Research by the University of Maryland suggests that companies and individuals must adapt to this new economy, where firms need to recruit people who excel in feeling tasks.
Researchers discovered large-scale polycultural agricultural systems for growing crops like avocado and maize in Maya wetlands. The findings suggest these fields were adaptations to major shifts in Maya civilization as food demand increased during the Late Classic period.
Researchers found that dockless bike-share programs outperformed Pronto due to their high density and accessibility. The study suggests service providers should deploy large-scale systems with plenty of bikes or stations to achieve highest ridership.
Researchers discovered that bioelectricity plays a crucial role in developing embryos, specifically in the formation of cartilage and bone. The study found that voltage gated calcium channels initiate molecular changes that lead to differentiation into mature cartilage cells.
Researchers at MIT have developed a mathematical approach to understanding zeolites, revealing why only a small subset has been discovered or made. The graph-based model predicts which pairs of zeolite types can be transformed from one to the other, opening doors for new pathways in production and potential discoveries of novel materials.
Under climate warming up to 1.7 °C, sedge plants prioritize root growth over shoot growth due to nitrogen supply limitations; however, as warming intensifies, shoots become more prominent, indicating nitrogen supply now outpaces plant demand.
A new analysis found that the current annual US sales of new antibiotics to treat carbapenem-resistant Enterobacteriaceae (CRE) is $101 million, significantly short of the needed $1 billion. This shortfall threatens the financial viability of new antibiotic development and may lead to reduced treatment options for patients. Researchers...
A new phylogenomic tree reveals the early evolution of stick insects was likely triggered by birds and mammals. The study suggests that their remarkable camouflage abilities evolved as an adaptation to avoid predators, with most old lineages emerging after the dinosaurs became extinct 66 million years ago.
Researchers developed ptychographic x-ray laminography to validate chip integrity without damaging them. The method generates high-resolution 3D images of chips from diffraction patterns, allowing companies to verify design specifications and detect manufacturing errors.
A new mathematical optimization model introduced in the INFORMS journal Transportation Science can reduce extreme flight delays by as much as 20-30% on average, while increasing crew salary costs by only 2-3%. This approach allows airlines to balance delay reduction with buffer placement costs.
Researchers at Yale University are developing new materials that can mimic neurons, compute with magnets, and calculate using quantum mechanics. The team used a precision measurement technique to create artificial crystals composed of elements from the periodic table.
Vibrio cholerae uses its type VI secretion system (T6SS) to compete with other bacteria and acquire new genetic material, leading to rapid evolution and pathogen emergence. The bacterium can steal up to 150,000 nucleic acid base pairs, or roughly 150 genes, in a single attack.
A new study by Duke University and Fudan University suggests that local conservation efforts can significantly buffer the impacts of climate change, buying cities time to adapt. Local interventions have promoted coral recovery in Florida Keys and restored seagrass beds in Chesapeake Bay.
Physicists at Mainz University have developed a new method to detect dark matter using cesium atom vapor and atomic spectroscopy. By searching in a previously inaccessible frequency range, they were able to formulate new restrictions on the nature of dark matter.
Researchers studied histone modifications in zebrafish development, finding that H3K27 acetylation awakens the genome for transcription. This epigenetic factor determines gene function and is conserved across species, including mammals.
Researchers have identified a key mechanism underlying atopic dermatitis, a chronic inflammatory skin disease affecting 20% of children and 5% of adults. The study reveals that mast cells and sensory neurons interact in 'sensory neuroimmune units' to detect allergens, triggering inflammation.
George Mason University researchers have discovered the exact location where two proteins responsible for hiding cancer cells from the immune system bind. The protein painting technology enables rapid performance testing of drugs, producing results in several days instead of years.
A new study from OIST and RIKEN has developed a computational model that demonstrates the importance of inhibitory circuits in brain function. The model shows that inhibitory neurons play a key role in associative memory, allowing patterns to be stored in memory for longer periods.
A virtual town called 'Neuralville' was created to test brain function, revealing specialized cortical scene-selective regions for recognizing places and navigating through environments. The study has implications for brain rehabilitation methods and improving computer vision systems.
The West Virginia Prevention Research Center will receive $750,000 in funding from the Centers for Disease Control and Prevention to address vaping and substance abuse issues. The grant aims to reduce rates of youth substance use and foster community resilience through a prevention model focused on building local capacity.
A recent analysis reveals that treatment of male breast cancer has evolved over the years, with certain patient- and tumor-related factors linked to better survival. The study found that older age, black race, multiple comorbidities, high tumor grade, and undergoing total mastectomy were associated with worse overall survival.
Breast cancer researchers at the University of Notre Dame have identified a pair of proteins, CXCL5 and CXCR2, critical for spreading breast cancer to bone. These proteins cause cancer cells to rapidly reproduce and spread throughout the bone and marrow.
A national essential medicines list in Canada could reduce inequitable access to medication, improve health outcomes, and optimize spending on medicines. The study highlights the importance of an independent decision-making body, selection criteria based on clinical and cost-effectiveness, and clear communication with stakeholders.
A research team has identified a protein called Meflin in cancer-suppressing cells surrounding pancreatic cancer. Increasing Meflin levels can restrain cancer progression and may lead to new therapies against the disease.
Researchers developed a new metabolic thyroid test that is faster and more accurate than current diagnostic tests. The test uses mass spectrometry imaging to identify diagnostic fingerprints produced by cancerous cells, preventing thousands of unnecessary surgeries each year.
Researchers at the University of Toronto have created a miniature soft robot that can crawl with inchworm-like motion using electrothermal actuators. The technology could revolutionize industries such as manufacturing, security, and wearable electronics.
A new study using big data reveals that many fundamental features of life, such as metabolism and growth, follow consistent relationships with body size across all creatures. This challenges the Metabolic Theory of Ecology and suggests a deep understanding of universal laws governing life's diversity.
A new model accurately estimates terror group lifetime lethality from initial attacks, potentially identifying highly destructive groups before they mature. The model conceptualizes terror groups as businesses constrained by resources, explaining lethality better than standard models.
A new study quantifies the strength of relationship between playing American football and chronic traumatic encephalopathy (CTE) severity. The study found that each additional year played increased CTE risk by 30% and severe CTE odds doubled for every 5.3 years played.
Heriberto Pérez's research developed deterioration models using International Roughness Index (IRI) and Coefficient of Transverse Friction (skid resistance), enabling predictions on road conditions after vehicle use. The models provide a strategic approach to optimize repair costs and improve pavement durability.
A new study from Northwestern University suggests that human ecology has played a more significant role in shaping the human gut microbiome than genetic relationships. The research found that the human gut microbiome is more similar to that of Old World monkeys like baboons than apes like chimpanzees.
A study found that around 17% of teachers in Northern Ireland are currently working in schools outside their community of origin. This is a higher percentage than previous studies and suggests that efforts to foster reconciliation between Catholic and Protestant communities may be paying off.
A massive explosion occurred in the center of the Milky Way 3.5 million years ago, creating two enormous 'ionisation cones' that sliced through the galaxy and impacted the Magellanic Stream. The blast was so powerful it lasted for 300,000 years and was triggered by nuclear activity associated with the black hole.
Despite a significant increase in antidepressant use, the number of older people diagnosed with depression remains largely unchanged. Research suggests that depression affects one in 15 people aged over 65, and its impact is felt by individuals, families, and friends.
A new type of drug that blocks one of cancer's key evolutionary escape routes from chemotherapy has been shown to reinvigorate the response to chemotherapy in cancers that had become resistant. The drug, BOS172722, works by forcing cancer cells through cell division too quickly, leading to fatal errors.
Researchers identified a specific subgroup of helper T cells driving MS and found that targeting the CXCR6 protein prevented and reversed the disease in mouse models. Elevated levels of CXCR6-positive cells were also found in inflamed joints of patients with inflammatory autoimmune arthritis.
Researchers have identified FGFR3 mutations in a subset of meningioma patients with favorable prognoses, suggesting potential for targeted therapy. These mutations may enhance diagnostic accuracy and clinical decision-making.
Researchers have created a new measurement method to determine the electrochemical activity of individual noble-metal-free nanoparticle catalysts. This breakthrough could lead to more efficient hydrogen production through water electrolysis by using affordable alternatives to precious metal catalysts.
Researchers developed a new non-invasive optical imaging system to diagnose and treat dry eye disease. The Tear Film Imager images layers of the tear film with speed and precision, providing nanometer-level insight into subtle changes in each layer.