A new algorithm can predict which genes cause cancer without DNA sequence changes. Researchers have identified 165 previously unknown cancer genes using machine learning technology, interacting closely with well-known cancer genes.
Researchers found that chronic dietary exposure to RNAi pesticides enhances their efficacy in controlling pests, allowing for lower concentrations to be used for effective control. This breakthrough has implications for optimizing dsRNA spray approaches and developing genetically engineered crops with built-in pest control.
Researchers at the University of Texas MD Anderson Cancer Center have identified a new surface protein, MT1-MMP, as a promising therapeutic target for osteosarcoma. The protein is highly expressed on the surface of osteosarcoma cells but not in normal human tissues, making it an attractive target for antibody-drug conjugate therapy.
Researchers at the University of Cambridge have developed a technique to track individual atoms in real time, allowing for greater control over material growth. This breakthrough could enable more precise design and manufacture of materials with unique properties.
A study published in Nature Metabolism reveals that vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced energy-burning brown fat cells. This finding could lead to the development of new therapies targeting obesity and metabolic disorders by increasing overall energy expenditure.
New research suggests that HDL particles' anti-inflammatory properties may predict future cardiovascular events, improving risk assessment and prediction. The study found that individuals with lower anti-inflammatory activity in their HDL particles were more likely to experience cardiovascular events.
Researchers identified a novel drug duo that exploits a weakness in SCLC's reproduction process, increasing replication stress and damaging DNA. The berzosertib-topotecan combination helped improve symptoms in over one-third of patients in a clinical trial.
Researchers propose a novel therapeutic strategy combining temozolomide with dianhydrogalactitol to overcome resistance mechanisms in glioblastoma. The combination shows synergistic effects in slowing tumour growth, suggesting a promising new approach for treating aggressive brain tumors.
Research by Penn State found that parents reported higher levels of depression, anxiety, and behavioral problems in their children after the pandemic, with some experiencing 'clinically significant' symptoms. The study highlights the importance of a positive coparenting relationship for family well-being during times of stress.
Incorporating HIV screening into COVID-19 testing at an urban emergency department improved patient outcomes, according to a recent study. The study found that this integrated approach led to higher rates of HIV diagnosis and treatment, ultimately reducing the spread of both diseases.
Researchers at Marine Biological Laboratory found that replacing beef with chicken, swapping meat meals for vegetarian options, and upgrading lighting could reduce the institution's nitrogen footprint by up to 7.7%. These 'low-effort' solutions require no major changes or additional funding.
Researchers found that exercise training in mice with human breast cancer grew tumors more slowly and responded better to immunotherapy, with increased anti-tumor immune responses. Exercise also enhanced the activity of cytotoxic T lymphocytes (CD8+ T cells), which killed cancer cells.
Researchers used CRISPR to study tomato gene interactions, revealing a complex relationship between mutations and fruit size. The findings suggest that predicting the effects of mutations on different varieties is crucial for efficient crop breeding.
At EuroCMR 2021, experts presented novel research on using hypnosis to enable claustrophobic patients to undergo CMR, the effect of weight loss on heart function in obese people, and improving detection of cardiotoxicity in lymphoma survivors. CMR is also revealing sex differences in how the heart adapts after a myocardial infarction.
Researchers at Utrecht University and TU Wien have developed special light waves that can bypass scattering in complex media, enabling precise imaging of objects. This breakthrough could revolutionize biological experiments, such as studying cells, by controlling light distribution inside tissues.
A study by Princeton researchers found that universities adopting an 'instrumental rationale' for diversity, emphasizing benefits for all students, reflect the preferences of predominantly white Americans. This approach is associated with lower graduation rates and poorer outcomes for Black students.
A recent study has discovered a profound loss of ability to experience pleasure in people with early-onset dementia, known as frontotemporal dementia (FTD). Grey matter deterioration in the 'pleasure system' of the brain was found, distinct from those implicated in depression or apathy.
A recent study warns that moving endangered species to new locations can accidentally spread diseases and parasites, putting populations at risk of collapse. The researchers recommend stricter quarantine periods and relocation strategies to mitigate this risk.
Researchers from Singapore University of Technology and Design developed the largest range of silicone and epoxy hybrid resins for 3D printing wearable devices, biomedical equipment, and soft robotics. The new resins exhibit excellent interfacial toughness and mechanical properties.
New research from Duke University suggests that the SEC's growing emphasis on terrorism disclosures may come at the expense of financial reporting oversight. The study found that when SEC comment letters included references to terrorism, the agency's error-detection rate dropped significantly.
A study found that adequate levels of five antioxidants may reduce infection with high-risk human papillomavirus (HPV) strains associated with cervical cancer. Lower levels of serum albumin and four dietary antioxidants were linked to a higher risk of HPV infection, suggesting a potential nutritional strategy for prevention.
Researchers at CU Cancer Center have discovered that tumor-suppressing genes MAP3K7 and CHD1 deletion increases androgen receptor signaling, making patients less responsive to anti-androgen therapy. This knowledge could lead to personalized treatment approaches for men with aggressive prostate cancer.
Scientists at EMBL Hamburg use X-ray beams to study artificial protein nanostructures, confirming their ability to fold into desired shapes. The findings advance understanding of synthetic origami-like protein folding for therapeutic applications.
A study published in International Journal of Environmental Research and Public Health found that exercise can alter the oral environment, favoring less harmful bacteria in people with NAFLD and gum disease. This shift may help reduce inflammation and improve overall health outcomes.
A modeling study estimates COVID-19-related changes in colorectal cancer screenings and associated outcomes. Expanded fecal immunochemical testing may help mitigate these outcomes during the pandemic.
A new study finds that convenience and access outweigh reputation when older adults choose a doctor, with online ratings playing an important role. The study also reveals disparities in the perceived importance of online ratings among different demographic groups.
Scientists develop a generic approach to generate arbitrary vectorial optical fields (VOFs) using metasurfaces, offering improved efficiency and control over polarization. They experimentally demonstrate the generation of VOFs in both far-field and near-field regimes with tailored wave fronts and inhomogeneous polarization distributions.
Researchers have discovered a new potential mechanism for age-related macular degeneration, suggesting that the structural organization of light-sensing cells may be affected by the disease. This finding offers hope for identifying new molecular targets to treat the condition and potentially reversing its effects.
A new study found that solar panels can increase flower abundance and delay bloom timing, benefiting pollinators. The research suggests that using solar panels for pollinator habitat restoration could aid the agricultural community and provide important ecosystem services.
Research reveals that household water consumption shifted from predominantly morning usage to multiple peaks during the lockdown period. The study found a sharp increase in consumption in March and April, with the number of households in the multiple peak cluster rising by 93% between March and May.
A study of over 42,000 children found that mothers who took antidepressants during pregnancy were more likely to have children with affective disorders, but not due to the medication itself. The research suggests that parental mental illness may be the underlying cause.
A team of researchers has developed a computational framework that captures cell interactions and their impact on embryonic tissue dynamics. They found that dynamic forces and tension fluctuations are responsible for the fluid state of tissues during development.
A research consortium led by City's Professor Nabil Aouf will develop next-generation AI-based GNC systems for space exploration. The study aims to make a formal link between AI-based machine learning and control theory-based reasoning.
A new study finds that pre-pandemic children have higher frequencies of convergent B cell clones for SARS-CoV-2 and its variants, while adult blood shows few such clones. The research suggests that early childhood B cell clonal expansions may stimulate cross-reactive memory, leading to better responses to novel pathogens.
Researchers have identified 19 genes and 25 corresponding proteins that may contribute to the cause of depression. These findings offer promise as potential targets for new depression treatments and could serve as biomarkers for depressive symptoms.
A new study reveals that gray wolves adapted their diet over thousands of years, shifting from a reliance on horses during the Pleistocene to caribou and moose today. The researchers found that horses accounted for half of the ancient wolf diet, while modern diets consist mainly of caribou and moose.
A shared set of brain regions play an important role in controlling the successful retrieval of weak memories, according to a new University of York study. The research may have implications for treating memory disorders like dementia and developing more advanced artificial intelligence systems.
A study finds that institutions' use of instrumental rationale for diversity and inclusion is associated with increased disparities in graduation rates between White and Black students. This rationale, sanctioned by the US Supreme Court, emphasizes compelling educational benefits over moral values.
A new study found that people who rely on television and Facebook for COVID-19 news are less knowledgeable about the virus. The survey of 5,948 adults in Pennsylvania revealed a clear relationship between trusted news sources and knowledge of coronavirus.
A team from Osaka University and Hokkaido University has developed a quick PCR-based reverse genetics system for analyzing SARS-CoV-2 mutations. This system allows for the examination of biological features of mutations in a matter of two weeks, significantly faster than previous methods that took several months.
A new study found that Americans generally consume poor-quality food from restaurants, grocery stores, and other sources, except at school. However, significant improvements were observed in the nutritional quality of school meals over a 16-year period, particularly among low-income, Black, and Latinx children.
A new study estimates that FAFSA verification costs public colleges and universities nearly $500 million annually, with community colleges spending 22% of their financial aid office budget on verification. The burden falls disproportionately on these institutions, which enroll nearly half of all undergraduates.
Researchers found that family history of premature heart attacks, strokes, or angina poses major risks to close relatives, with shorter survival times reported among those with first-degree relatives. The study suggests a complex interplay between genetic and environmental factors in cardiovascular disease.
Researchers found that excess nitrogen deposition increases soil carbon and nitrogen concentrations in tropical forests, accelerating acidification and physical protection. However, this sink cannot offset human-induced carbon emissions, highlighting the need for sustainable land management practices.
Researchers developed a new test to measure inactive HIV viruses in patients' genes, providing more accurate information on drug effectiveness. This test could help track the size of the HIV reservoir and predict how long it takes to eliminate the virus from the body.
New research published in JNeurosci suggests that stress alters brain activity in self-inhibition areas but doesn't trigger binge-eating. This challenges the long-held theory that stress impairs inhibitory control and leads to binge-eating, indicating a more complex underlying mechanism.
Research found that ABC transporters in plants can confer glyphosate resistance by moving the herbicide out of cells. This is achieved through the EcABCC8 transporter, which was shown to exhibit higher expression levels in resistant weed species.
A novel adhesive patch platform has been developed by a research team at Pohang University of Science & Technology (POSTECH) to efficiently deliver blood vessel-forming growth factors using mussel adhesive protein. The platform demonstrated effective neovascularization in rat models for myocardial infarction and excisional wounds.
Research finds a significant decrease in greenhouse gas emissions from Chinese inland waters over the past three decades, primarily driven by environmental alterations. The study suggests that ignoring these emissions will result in overestimating China's terrestrial carbon sink capability.
Researchers at Uppsala University discovered that the surface layer of the intestinal mucosa can contract in response to bacterial attack, preventing damage and promoting healing. This finding offers a potential solution to treating bacterial gut infections, which affect hundreds of millions worldwide.
A new analysis found that younger age and specific types of cancer, such as melanoma and kidney cancer, increase the risk of severe side effects. Patients receiving multiple immune checkpoint inhibitors also faced a higher risk.
The cancer burden in China has undergone a paradigm shift, with rising cases of breast and lung cancers. The country's high incidence rate makes it a priority for policymakers to implement tailored preventive measures, including health education, vaccination programs, and tobacco-control policies.
Researchers found that 84% of atmospheric microplastics originated from road dust, while 11% came from sea spray and 5% from agricultural soil. Microplastics can re-enter the atmosphere even after settling on land or in water, highlighting a complex plastic cycle.
Researchers from NUST MISIS have created innovative multilayer coatings that synthesizes protective properties of nanoparticles, biopolymers, anticoagulants, and antibiotics. The coatings demonstrated excellent bactericidal efficacy against antibiotic-resistant bacterial strains with a prolonged antibacterial effect up to 7 days.
A study analyzing NYC jail admissions from 2008 to 2017 found that nearly 27% of Black men were jailed by age 38, compared to 3% of White men. The cumulative risk of incarceration disproportionately affected Latino men, particularly in poor neighborhoods.
Researchers found that almonds contain approximately 20% unabsorbed calories after digestion, which can result in reduced energy absorption and potential weight loss. This finding could alleviate concerns about nuts contributing to weight gain, allowing for healthier snacking options.
Researchers are developing a new therapy to alleviate painful side effects of chronic drug treatment in Parkinson's patients. They're also working on a technology to safely locate abandoned oil and gas wells using drones, addressing an environmental hazard across the US.
Researchers at KAUST developed a new technology that increases machine learning speed on parallelized computing systems by five-fold. This 'in-network aggregation' method uses readily available programmable network hardware to provide dramatic speed improvements.
Researchers uncover a new fossil beetle species from mid-Cretaceous amber, shedding light on the earliest pollinators of flowering plants. The discovery shows that short-winged flower beetles visited angiosperms in the Cretaceous, leading to a direct link between early flowering plants and their insect visitors.
A team from TUM and Max Planck Institute analyzed over 1200 samples of human lung cells reacting to SARS-CoV-2 proteins, identifying 1484 interaction points between viral and cellular proteins. This knowledge will help identify vulnerability hotspots for new therapies.