A novel 'reporter' molecule has been developed to detect ER-related problems during protein synthesis, offering simplicity and robustness against environmental fluctuations. The tool uses a firefly luciferase-based system to identify defects in protein translocation and disulfide bond formation.
Teletrix's VIZRAD AR platform simulates ionizing radiation behavior using augmented reality technology, providing a safe and immersive way to learn about radiation without exposure. The platform offers improved training capabilities for workers in radiation-controlled areas.
A new study shows that coordinating the siting of solar farms, wind farms, and storage systems can improve efficiency and reduce costs by aligning renewable power generation with demand. The approach uses fine-grained weather data and energy system modeling to maximize utilization of renewable resources.
Scientists discover a highly specific CRISPR-Cas13 enzyme, ChCas12b-D496A, capable of distinguishing single-base mutations. This breakthrough expands targeting range for genome editing and offers promising prospects for treating genetic diseases.
Three Sanford Burnham Prebys faculty members, David A. Brenner, Randal J. Kaufman, and Tariq M. Rana, are recognized for their significant scientific influence. Their publications have been cited top 1% globally by number of citations.
Researchers Fernanda Morales-Calva and Stephanie Leal explored the three Ws of memory - what, where, and when - to understand why people remember certain things. They found that emotional content, personal significance, repetition, and attention can influence memory retention. The study highlights the importance of considering individu...
Researchers used CT scans to examine giant hailstones formed during a 2022 thunderstorm in Catalonia. The study revealed irregular internal shapes and heterogeneous growth patterns, overturning previous assumptions about hailstone formation.
A study investigates the balance characteristics of athletes in different sports, revealing distinct differences between gymnasts, swimmers, and others. The findings suggest that shorter stature, stronger knee extensors, and more acute foot sensation are related to better balance ability.
Researchers developed a novel cyclic molecule that selectively traps phosphate species through multi-point hydrogen bonding in harmony with water molecules. The findings provide guidelines to design new cyclic molecules for aqueous environments, significant for materials development.
A novel classification method for adult spinal deformity diseases has been developed using deep learning of gait data, achieving a correct response rate of 71.43% in testing, surpassing conventional methods.
This study reveals regional disparities in home healthcare use for older adults, with higher rates in areas with high population densities. Urban areas tend to have more enhanced clinics, leading to increased home visit rates, while less populated areas rely on conventional clinics and lower home visit rates.
A UT Health San Antonio study found that brain volume changes correlate with social behavior differences in psychiatric conditions such as autism spectrum disorder and schizophrenia. Tbx1 deficiency was associated with decreased brain volume in the amygdala and surrounding cortical regions, affecting desire for social interaction.
A recent study labels whiteness as a fundamental determinant of health in rural America, highlighting unique factors that contribute to poorer health outcomes. Rural white Americans face higher rates of heart disease, stroke, and cancer compared to their urban counterparts due to limited access to healthcare and socioeconomic disparities.
Researchers are developing a system to instantly conceal and anonymize voices through computer-generated speech. The technology will allow users to control factors like age, gender, and dialect in real-time conversations.
The BeginNGS platform uses genome sequencing and artificial intelligence to detect rare genetic diseases in newborns, achieving a 97% reduction in false positives. This technology has the potential to save thousands of lives by providing earlier diagnoses and treatment.
Researchers develop innovative hybrid control strategy to improve product yields in biosynthetic processes. The new approach combines model-based optimization with in-cell feedback control, outperforming traditional methods and promising reduced costs and environmental impact.
Recent advancements in electrocatalytic technologies address environmental pollution and health risks from nitrates and nitrites through sensor and catalysis innovations. The review explores the conversion of nitrogen pollutants into valuable compounds like ammonia and urea.
The NUS research team has developed flexible fibres with self-healing, light-emitting and magnetic properties. The Scalable Hydrogel-clad Ionotronic Nickel-core Electroluminescent (SHINE) fibre offers a more efficient, durable and versatile alternative to existing light-emitting fibres.
Neutrino research may hold the key to understanding the universe's origins and the imbalance between matter and antimatter. Scientists are exploring experimental anomalies and searching for a new 'sterile' neutrino flavor, which could provide answers to these deep questions.
Scientists warn that Alaska's Arctic Coastal Plain will experience unprecedented transformation due to the compounding effects of sea level rise, permafrost thaw subsidence, and erosion. By 2100, total land loss is expected to exceed erosional losses by up to eight times, posing new challenges to coastal communities.
A new monitoring system uses 'virtual sensing' to accurately estimate CO₂ and NOx emissions based on driving behavior. The system provides personalized environmental impact assessments, empowering drivers to manage their emissions.
Scientists at St. Jude Children's Research Hospital found a link between the chromosomal disorder 22q11.2 deletion syndrome and schizophrenia, with malformations in the cerebellum causing Tbx1 gene loss leading to improper skull formation.
A study by University of Copenhagen researchers highlights the challenges in investing in green hydrogen projects, citing market risks, regulatory uncertainty, and high costs. Oil and gas companies are better positioned to finance large-scale hydrogen projects due to their expertise and infrastructure.
A study published in Environmental Epigenetics found that pregnant women with preeclampsia had distinct epigenetic modifications, potentially serving as a biomarker. The researchers hope to develop a cheek swab test to detect these risks earlier, allowing for preventative medicine treatments.
Scientists at UCSF have developed engineered T cells that act as immune referees to soothe overreacting immune responses and mope up inflammatory molecules. These cells could improve treatment for organ transplants, type 1 diabetes and other autoimmune conditions by reducing the need for harsh immunosuppressant drugs.
Researchers enhanced the Elixhauser Comorbidity Model to better predict key outcomes such as hospital length of stay, mortality, readmission, and escalated care. The improved model has broad implications for healthcare decisions and patient outcomes.
A team of researchers has discovered that subtle changes in a lipid-binding region can dramatically alter the function of transcription factors in plants. By swapping the START domains of two near-identical paralogs, PHB and CNA, the researchers demonstrated that this single change could rewrite developmental instructions.
German physicist Christian Schneider has been awarded a European Research Council Consolidator Grant to study the optical properties of two-dimensional materials. His team plans to develop experimental set-ups to investigate the unique properties of these materials, which could lead to new applications in quantum technologies.
An international team of researchers warns that climate change could lead to widespread food shortages and famine if rapid changes are not made to develop climate-resilient crops. The group emphasizes the need for unprecedented collaboration between scientists, farmers, policymakers, and the public to address this crisis.
A CU Anschutz study found that using a decision aid led to less personal uncertainty and distress among older adults, but not reduced depression. The online tool helped participants feel more confident in their decisions.
The study reveals a high degree of technical mastery in the use of animal tendons, reed wood, and birch bark pitch to create bows and arrows. The findings shed new light on Neolithic archery techniques and materials in Europe.
Thyrotropin-releasing hormone (Trh) plays a crucial role in zebrafish hatching by activating a transient neuroendocrine circuit. The hormone stimulates the release of enzymes that break down the chorion, initiating hatching.
Fossil evidence from Australia and South America challenges prevailing narrative that eucalypt forests are under siege from expanding rainforests. The study suggests that fire became a feature of these vegetation interactions in Australia around five million years ago, making large-scale fire interventions unnecessary.
Astronomers have used the Hubble Space Telescope to study a quasar up close, revealing complex structures around a supermassive black hole. The observations show a mysterious L-shaped filamentary structure and small satellite galaxies falling into the black hole, offering insights into quasar formation and galaxy interactions.
Researchers develop a computational method to determine the crystal structures of multiphase materials directly from powder X-ray diffraction patterns. This approach can analyze existing experimental data that was previously difficult to decipher, leading to potential discoveries of new material phases.
A panel of international experts has drawn up guidelines to standardize the analysis and use of gut microbiota tests. The consensus paper aims to reduce the use of inappropriate tests and pave the way for evidence-based development of human microbiota diagnostics in medicine.
A new implantable device, inspired by a tree branch, uses DNA sensors to continuously monitor inflammation biomarkers in the body. The device accurately measures protein biomarkers of inflammation in diabetic rats and has potential applications for managing acute and chronic conditions.
A research team at DGIST has developed a breakthrough technology that improves fuel cell durability by incorporating nitrogen into alloy catalysts. The new method significantly enhances stability and reduces platinum usage, leading to more efficient and sustainable energy solutions.
Researchers link global warming spike in 2023 to reduced low-level cloud cover, which limits Earth's ability to reflect solar radiation. This decline in planetary albedo could explain the 'missing' 0.2 degrees Celsius of warming.
A phase 3 study demonstrated nearly 75% complete cancer remission in patients with high-risk bladder cancer unresponsive to BCG therapy. The novel treatment, cretostimogene grenadenorepvec, was well-tolerated and did not require bladder removal surgery.
Higher levels of satellite-based greenness and street-level green components are associated with lower adiposity in US children. The study suggests that increasing residential green space levels could be a viable urban planning strategy to combat childhood obesity.
Researchers developed a new authentication technology that uses Ge2Sb2Te5 thin films to encode covert information, which can be revealed using a simple reading device. The technology has potential applications in various industries and shows promise for widespread use.
Researchers at the University of Konstanz have discovered that different mutations of the tumour suppressor p53 affect pancreatic carcinomas differently. The study found that two variants of p53 selectively control distinct metabolic pathways, providing new insights into cancer development.
Researchers propose a new model for understanding how information is transmitted in the brain by describing a unique axon morphology that changes size and modulates action potential speed
New research from the University of Pittsburgh found that opioids can suppress the immune system and reduce the effectiveness of immunotherapy for head and neck cancer. However, peripherally restricted OPRM1 antagonists (PAMORAs) may block opioid-induced immunosuppression and improve response rates to immune checkpoint inhibitor therapy.
A groundbreaking phase one clinical trial explores a novel cell-based immunotherapy for breast cancer, demonstrating significant shrinkage of tumors and minimal side effects. The treatment leverages dendritic cells to trigger an organized immune system attack on cancer, offering hope for replacing or reducing the need for chemotherapy.
Researchers found that women who had both ovaries surgically removed before age 50 are at high risk of late-life Alzheimer's disease, with a fourfold increase in risk linked to the APOE4 allele. Hormone therapy reduces this risk by half in these women.
A new Simon Fraser University study finds that antidepressants are associated with reduced genital sensitivity in 13% of users, compared to 1% of other psychiatric medication users. The study highlights the need for better patient education and warnings about potential side effects.
Researchers have developed a new coronary risk score specifically for women, accurately predicting and categorizing the risk of major adverse cardiovascular events. The findings suggest that this novel approach can help identify high-risk women earlier, reducing the risk of heart attacks and sudden cardiac death.
A new deep learning model enhances railroad condition monitoring by combining Convolutional Neural Networks (CNNs) and Long Short-Term Memory (LSTM) networks, achieving 97% accuracy in detecting train positions and conditions. The model's real-time processing capabilities enable swift intervention and mitigation of potential hazards.
Researchers discovered a single amino acid mutation in the H5N1 'bird flu' virus that enhances its ability to attach to human cells, potentially increasing the risk of person-to-person transmission. The finding highlights the need for ongoing surveillance of H5N1 mutations that pose risks to public health.
A new study highlights the critical role of mangroves in coastal resilience, providing $855 billion in flood protection services worldwide. Mangroves offer cost-effective protection to coastal communities and support national wealth by preserving lives, livelihoods, and infrastructure.
Researchers found that burned rice hulls can provide a nearly doubling of energy density in typical lithium-ion or sodium-ion batteries. The process is more sustainable than producing graphite from biomass, which requires heating to high temperatures and produces significant CO2 emissions.
Researchers found that EZH2 inhibition boosts T-cell immunotherapies' effectiveness by making cancer cells more visible and reducing immunosuppressive regulatory T-cells. This combination therapy showed improved survival rates in mice with lymphomas, suggesting a potential new approach to treating certain cancers.
A recent study found that when employees are given information on their colleagues' performance, many continue to operate in a way that is not necessarily more efficient or innovative. Instead, they may ignore negative feedback or reinterpret it in a positive light due to their own self-image and tendency towards self-enhancement. To f...
A USC-led study found that neurogenesis in adults supports verbal learning and memory, enabling people to have conversations. The discovery could lead to new approaches to restore cognitive function in patients with epilepsy and other conditions.
Researchers at Sanford Burnham Prebys found that pancreatic cancer cells rely on a specific nutrient, glutamine, to fuel their unchecked growth. The study identified two enzymes, aPKC zeta and iota, that play a regulatory role in the process of macropinocytosis, allowing cancer cells to scavenge alternative resources.
Research reveals a novel strategy for improving organic solar cells by combining insulators, boosting electron mobility up to 100 times. The discovery, known as insulator-donor electron wavefunction coupling, could lead to more efficient and powerful solar cells.
A team of UNC-Chapel Hill researchers will develop an oncology health learning system using AI-ready data to generate real-time identification of new cancer cases and support personalized treatments. The project aims to improve cancer diagnosis, care equity, and quality by creating accessible tools for health providers.
Margherita R. Fontana, Julie Frantsve-Hawley, and Ariadne Letra were elected as Vice-president, Treasurer, and Representative to the IADR/AADOCR Publications Committee respectively. Their terms commence at the 54th Annual Meeting of AADOCR in March 2024.