A cross-sectional analysis found significant delays in treatment initiation for early-onset colorectal cancer in all-urban populations, with young male, Asian or Pacific Islander, Black, or Hispanic patients disproportionately affected. These delays, exceeding 90 days, challenge assumptions of uniformly timely access in urban settings.
A clinical trial found that weekly injectable extended-release buprenorphine treatment resulted in higher rates of illicit opioid abstinence during pregnancy compared to sublingual buprenorphine. Serious adverse events were also less common in the extended-release group.
Researchers developed a comprehensive genetic risk calculator for metabolic disease by integrating genetic data from hundreds of thousands of people worldwide. The polygenic risk score outperformed existing disease-prediction models and predicted downstream morbidity and clinical interventions, particularly in non-European populations.
Febrile neutropenia is a chemotherapy complication that Traditional Chinese Medicine (TCM) can help alleviate. TCM combines tonifying qi and blood, warming yang, and strengthening the spleen and kidney to treat FN. Combining TCM with standard therapy significantly improves outcomes.
Dr. Sara Simblett brings expertise in digital health innovation, patient engagement, and technology integration to JMIR Neurotechnology. Her research focuses on improving access, quality, and outcomes of care through digital interventions.
Researchers discovered that acetylcholine can directly trigger the release of serotonin in the brain, promoting coordinated chemical signaling. This finding suggests that brain disorders may involve the internal coordination system being pushed into overdrive, leading to pathological increases in serotonin levels.
Researchers developed novel tantalate high-entropy ceramics coatings that surpassed 1500 °C thermal barrier performance. The coatings showed excellent structural integrity and stable fluorite crystal structure under rigorous thermal measurements.
A research team developed a machine learning accelerated design strategy to screen optimal BaTiO3-based high-entropy ceramic compositions, achieving ultrahigh energy storage performance and high efficiency. The designed ceramic exhibits excellent environmental stability and pulsed charge-discharge performance, paving the way for practi...
SwRI is using low frequency eddy current testing to detect and characterize subsurface flaws and cracks in bolt holes. This method will allow aircraft maintainers to assess damage progression and make repair decisions to keep the aircraft flying safely.
Researchers found that reforestation in tropical regions, such as the Amazon basin and West and South-East Africa, can have a significant cooling effect due to high evapotranspiration rates. This approach can be more efficient than previously thought, especially when combined with other climate protection strategies.
Researchers developed lead-free relaxor ferroelectric ceramics with enhanced energy storage and ultrafast discharge capabilities. The high-entropy approach and bandgap engineering enabled grain refinement, increased resistivity, and a broader bandgap, contributing to a significantly enhanced breakdown electric field.
Researchers tested ChatGPT with over 700 hypotheses, finding the AI was accurate 76.5% of the time, but struggled to identify false statements and was inconsistent in its answers. The study highlights the need for skepticism and caution when using AI for critical tasks, particularly those involving nuance or complex reasoning.
A recent study on sheep genome sheds light on regulatory elements that influence gene expression, providing tools for breeders to select beneficial traits and avoid disease. The study mapped gene promoters and enhancers in various tissues, offering a platform for exploring future research across multiple animal species.
A concerning rise in adolescent obesity has been found, with overall rates climbing to 15.9% in 2023. Obesity patterns also reveal a decline in weight-loss attempts, with females more likely to attempt weight loss but fewer adolescents reporting efforts in 2023.
Researchers found that nearly 80% of patients with elevated Lp(a) >50 mg/dL did not initiate lipid-lowering therapy, highlighting selective responses to elevated Lp(a). PCSK9 inhibitors and aspirin initiation were also less common among patients with elevated Lp(a).
The new framework groups stations with similar hydrological behavior, reducing computational cost while maintaining high predictive accuracy. This approach enables scalable, data-efficient AI systems for water level forecasting, supporting flood early-warning systems, optimized reservoir and irrigation management, and improved decision...
Climate mitigation policies may increase hunger risk due to land use competition, but ozone reduction benefits partially offset these effects. Ozone-driven yield gains reduce food prices and increase food availability, particularly in regions with severe hunger.
A new clinical trial will investigate whether adding the oral medication vorasidenib to standard chemotherapy improves progression-free survival for people with newly-diagnosed, grade 3 IDH-mutant astrocytoma. The study aims to recruit 400 individuals with this type of brain cancer and evaluate the safety and side-effect profile of the...
A new class of molten planet has been discovered, with a permanent ocean of magma and a unique composition of heavy sulphur molecules. This exoplanet, L 98-59 d, is unlike any known planet in our Solar System and may be the first of its kind in the galaxy.
Researchers at the University of Edinburgh have developed a method to transform post-consumer plastic into L-DOPA, a frontline medication for Parkinson's disease. The process harnesses the power of bacteria to break down PET waste and produce L-DOPA, providing a sustainable solution to the production of pharmaceuticals.
A new trial found that infants and toddlers with unilateral cerebral palsy show significant improvements in hand and arm function when receiving early, high-dose therapy. The study suggests that multiple approaches can help children build critical motor skills, providing families and clinicians with evidence-based options.
Researchers have uncovered unusual clustering of endothelial cells around immune cells, signaling the start of excessive collagen production and scarring. This discovery could lead to new treatments for fibrosis, a common complication in Crohn's Disease affecting 10-20% of patients.
A national poll finds 1 in 3 parents worry their teen or young adult driver could cause an accident, with most witnessing unsafe driving behaviors. Despite concerns, most parents rate their child's driving as average or better, and relatively few impose consequences for risky behaviors.
A novel drug delivery system developed by Osaka Metropolitan University improves Paclitaxel absorption by binding to the lipocalin-type prostaglandin D synthase enzyme, enabling selective delivery to cancer tissues. The system demonstrates significant tumor suppression effects even after administration cessation.
The new guidelines, based on 137 systematic reviews, emphasize the importance of consistency and effort in resistance training. The primary goal for most adults should be to build a consistent routine, which can be achieved with elastic bands, bodyweight training, or home-based routines.
A large study found that Asian mothers experience a 1.5-fold higher rate of obstetric trauma, while Black immigrant and refugee mothers have a 20-30% higher risk. The study also found that immigrants with shorter duration of residence had higher initial risk of obstetric trauma, which declined with increasing time in Canada.
A study extending pregnancy monitoring from conception to 6 weeks postpartum found nearly 10,000 cases of severe maternal complications in Canada each year. This reveals significant cases were previously missed, emphasizing the importance of postpartum care and timely interventions.
A new framework, DUPGT-CDR, uses gating networks to effectively incorporate both positive and negative feedback in cross-domain recommendation systems, achieving lower prediction errors and improved convergence speed. The framework offers more precise product recommendations and personalized learning resources across various domains.
A team of international researchers successfully demonstrates time-bin QKD over 120 km with an on-demand telecom semiconductor QD device. The system achieves exceptional stability and maintains high security key rates, making it suitable for real-world text message encryption applications.
The study reveals that bonding heterogeneity, rather than geometric similarity, governs relaxation dynamics in glasses. By incorporating electronic structure and chemical interactions, researchers establish a new physical framework for understanding structure-relaxation coupling in glasses.
Prof. Yanquan Geng's team has devised a way to carve variable-depth, three-dimensional trenches into gallium antimonide using a microscopic tip vibrating thousands of times per second. This process improves the crystal's structural integrity and enables the creation of pristine 3D nanogrooves with controlled depths and widths.
Researchers used microwave-based 3D printing to create ceramic components with near-zero porosity and improved strength. The hybrid technique eliminates microscopic holes and traps gas bubbles, allowing for more bending force before breaking.
A recent study found that women have a 21% lower risk of death compared to men, but a 12% higher risk of severe side effects from cancer treatment. The research, conducted in partnership with international collaborators, analyzed data from over 20,000 cancer patients and identified sex-based differences in survival and treatment toxicity.
Researchers reveal that coronaviruses hijack specific cellular protein to build large compartments for viral assembly, leading to reduced viral production in cells lacking the HGS protein. The discovery opens new avenues for antiviral therapy by targeting the interaction between HGS and viral proteins.
Researchers developed a new eDNA sampling membrane that captures DNA fragments with high efficiency, detecting multiple tropical coral reef fish species. The membrane, coated with molybdenum disulfide nanosheets, enables preferential interactions with DNA bases, improving the capture of trace eDNA from large volumes of seawater.
Researchers have developed bioengineered extracellular vesicles with enhanced therapeutic functionality, which can precisely target injured cardiac tissue and deliver therapeutic cargos. These bioengineered EVs have shown promising results in preclinical models of myocardial infarction, heart failure, and pulmonary arterial hypertension.
Researchers have developed an 'ECI patch' that reads brain signals and controls cars with 93.5% accuracy. The patch, powered by ultra-thin sheets called MXene, detects fatigue and mental states without causing skin irritation.
A research team has pioneered a novel optical neural network that physically 'learns' through associative light exposure, eliminating the need for traditional computing algorithms. The system successfully recognized letters and demonstrated capability in handwritten digit recognition.
A new study found that A&E patients with visible blood in their urine who receive a scan within 48 hours are 2.5% less likely to die within three months. The study also showed that patients with cancer are diagnosed significantly faster when they receive prompt investigation.
Researchers compare prostate cancer screening to breast cancer screening, finding similarities in identifying significant cancers and reducing mortality. The study suggests that prostate cancer screening should be reconsidered, offering benefits over harms, and highlights the need for further analysis on costs.
ToxIndex integrates three tiers of New Approach Methodologies, leveraging AI agents to access and orchestrate toxicological resources, and providing comprehensive, source-traceable risk assessments in a fraction of the time required by traditional methods.
The RESIL-Card tool helps hospital cardiovascular professionals and stakeholders assess and strengthen care pathways, ensuring continuity of care during crises. The tool offers a structured self-assessment framework, identifying concrete actions to maintain care continuity and patient safety.
A team from Tokyo Metropolitan University successfully detects laser-assisted electron scattering using circularly polarized light, shedding light on atomic scale helicity and its impact on electron-matter interaction. The signal agrees with theory, but further work is needed to improve detection efficiency and accuracy.
A new smartphone app has been shown to significantly improve sex life and delay ejaculation in men with premature ejaculation. The app, developed by urologists and psychologists, teaches men therapeutic techniques and exercises to manage arousal and control ejaculation.
A young female fisher traveled 118 kilometers from Durham to the White Mountains in New Hampshire, the longest recorded dispersal for the species. This journey, documented over winter with deep snow, underscores the fisher's adaptability and highlights the need for further research into movement patterns.
A new study by PSU researchers finds that abusive supervision can fundamentally alter how employees perceive their humanity, leading to severe burnout and decreased collaboration. In contrast, employees with a strong sense of self-efficacy are less susceptible to the dehumanizing effects of a toxic manager.
The photonics technology can detect molecular signals long before symptoms emerge, enabling earlier diagnosis and treatment. The technology uses nanomaterials and photonics to interact with microRNAs and detect cancer signals.
A new RNA therapy has been developed to enhance the heart's own ability to protect and repair itself after a heart attack. The therapy, which involves injecting particles into the arm, significantly reduced scarring and improved heart function in lab experiments, offering a potential breakthrough for heart patients.
The new law, House Bill 1266, guides curriculum and teacher training to prepare students for a data-rich world. By integrating data science across K–12 subjects, Indiana aims to develop critical thinking and problem-solving skills for future success.
Researchers at Rice University developed a safe bioelectronic sensor using naturally occurring polymer chitosan to effectively communicate with bacteria. The system uses a hydrogel to trap bacteria near an electrode, generating a stable electronic current when exposed to target substances.
A new University of Arizona study found that exposure to certain pesticides before pregnancy is associated with lower Apgar scores, a measure of newborn health. The study suggests that pesticides can affect the next generation, highlighting the importance of regulating pesticide use to improve maternal and child health.
Researchers transformed waste into high-performance porous carbon materials for soil and water conservation. The study identified top-performing materials from agricultural wastes, which exhibited high surface areas and favorable pore structures, enhancing adsorption capacity and water retention.
Insilico Medicine's inclusion in the Hang Seng Index and Stock Connect program is expected to enhance stock liquidity and market attention, strengthening the company's capital market influence. The company has achieved multiple drug development milestones, including 12 IND-enabling programs and preclinical candidates ISM0676 and ISM5059.
Insilico Medicine's Alex Zhavoronkov chairs precision aging discussion and presents Luminary Award to OpenAI president Greg Brockman. The company's AI-driven approaches accelerate drug discovery and advance precision medicine for aging and age-related diseases.
Researchers at Duke University have developed a technique using microbubbles and ultrasound to deliver large cancer drugs into cells, causing them to self-destruct. The technology, called SonoPIN, shows promise in precisely delivering therapeutics to cancer cells with minimal off-target effects.
Researchers found that seniors are willing to travel more than an hour for routine or specialized medical care, but this willingness varies by socioeconomic status, mobility, and location. The study's findings have implications for telehealth expansion and transportation policy, suggesting that programs offering ride services, improved...
Engineers from the University of Colorado Boulder have discovered the mathematical rules that fireflies follow to sync up their flashes in a South Carolina swamp. The team's findings could lead to new designs for robots that move in swarms and help scientists understand other examples of synchrony in biology.
A study in ferrets demonstrates that immunity to two proteins on the surface of the influenza virus can reduce transmission and viral evolution. Targeting both hemagglutinin and neuraminidase proteins can effectively curb the spread of the virus, with transmission rates dropping by half in animals with immunity to both.
Researchers at Albert Einstein College of Medicine have developed a new strategy to engineer immune cells that prolong their effectiveness, addressing a major limitation of current treatments. The new method generates longer-lasting immune cells that provide more sustained control of human blood cancers and suppression of HIV-infection.
A systematic review found a significant association between excessive smartphone use and eating disorder symptom severity in young people, including disordered eating and food addiction. The study highlights the need for early intervention strategies to address excessive phone use in young people displaying eating disorder symptoms.