A study found that most persistent viral detection despite effective therapy is due to defective, non-infectious virus copies. The 5'-leader region of the virus is responsible for producing infectious particles, but defects in this area prevent the generation of functional viruses.
The Pan European One Health Network will harmonise the European response to infectious diseases by integrating human, animal, and environmental health. The network aims to develop a coordinated preventative response through collaborative innovation and knowledge sharing.
Monash University researchers have made a breakthrough in using phage therapy to treat life-threatening infectious diseases. The treatment involves injecting viruses called bacteriophages to kill bacterial infections that have not responded to other treatments.
A new study found that pediatric patients with long-COVID experience a high symptom burden, including sleep disturbance, anxiety, depression, and fatigue. The study describes an interdisciplinary care approach that incorporates integrative medicine, nutrition, and lifestyle modifications to manage symptoms.
A Finnish registry study found that severe infections, such as cystitis and bacterial disease, are associated with an increased risk of dementia. The study examined nationwide health registry data and identified 29 diseases linked to dementia risk, including mental disorders, Parkinson's disease, and alcohol-related mental disorders.
Researchers at the Wyss Institute developed DoriVac, a DNA nanotechnology-enabled vaccine platform that induces broad immunity against infectious viruses, including SARS-CoV-2, HIV, and Ebola. The platform produces potent antigen-specific immune responses and is more stable and easier to manufacture than traditional vaccine platforms.
Researchers found that silencing bacteria can worsen heart infections by promoting aggressive biofilm growth and reducing antibiotic effectiveness. The study highlights the need for targeted therapeutic strategies against infectious endocarditis.
Research by ASU professor Anne Stone examines the evolutionary history of infectious disease, tracing tuberculosis from ancient DNA. She identifies recurring patterns in ecological and social conditions that facilitate widespread transmission of pathogens.
Researchers developed a self-assembling peptide-based vaccine to create a localized immune niche, demonstrating its remarkable efficacy in inducing durable and potent immunity. The vaccine served as a reservoir for antigens and adjuvants, recruiting antigen-presenting dendritic cells to accumulate within the scaffold.
The new platform developed by UVA Health scientists can produce vaccines much faster, cheaper, and more easily than traditional approaches. The platform's proof-of-concept demonstrates its ability to produce highly immunogenic vaccines that can be manufactured at extremely low cost.
A new database, CANDID, brings together over a century of historical epidemiological data from across Canada. The dataset reveals the ecology and evolution of infectious diseases in Canada's history, enabling better understanding of past outbreaks and preparation for emerging diseases.
A study published in the International Journal of Infectious Diseases found that delafloxacin inhibits Legionella replication more effectively than levofloxacin. The antibiotic demonstrates promising intracellular activity, which could support further clinical investigation as a potential treatment for Legionnaires' disease.
The 2025 European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE) brings together over 3,000 participants to exchange knowledge and strengthen collaboration in infectious disease prevention and control. The conference highlights urgent priorities such as building trust in science, demonstrating science-based ...
The Gladstone Infectious Disease Institute is broadening its research scope to tackle pressing health challenges beyond viruses. Scientists are discovering new ways to combat antibiotic-resistant bacteria and explore the interconnectedness of viruses and bacteria in causing chronic diseases.
The article explores the fundamental principles and applications of current oral anti-tumor and anti-infective vaccines, discussing considerations necessary for designing future oral vaccines. Oral vaccines can be used for tumor therapy and prevention of various infectious diseases, improving immune defense.
Researchers at SMART Alliance for Research and Technology developed a powerful tool to scan thousands of biological samples and detect transfer ribonucleic acid (tRNA) modifications, which help control cell growth and response to diseases. The tool opens up new possibilities for disease research, diagnostics, and treatment development.
Researchers found that individuals affected by infectious disease outbreaks show significantly less trust in the political establishment. The study suggests that policymakers should integrate trust-preservation strategies into their epidemic response plans to maintain democratic norms.
A new study has mapped the history of infectious diseases across millennia, offering insights into how human-animal interactions transformed our health landscape. The research analyzed ancient DNA from over 1,300 prehistoric individuals, revealing that zoonotic diseases became more widespread around 5,000 years ago.
Fungicides used in agriculture linked to rising resistance to antifungal medical treatments, experts call for a 'One Health' approach to combat pathogens. The use of pesticides in plants may increase fungal resistance to treatments in humans and animals.
A new AI tool predicts infectious disease risk using large language modeling, consistently outperforming existing methods. The model uses real-time information to predict disease patterns and hospitalization trends, filling a gap in pandemic prediction tools.
Researchers at NYU Abu Dhabi have developed a breakthrough paper-based diagnostic device that can detect COVID-19 and other infectious diseases in under 10 minutes. The Radially Compartmentalized Paper Chip (RCP-Chip) is a fast, affordable, and portable solution for on-site screening of infectious diseases.
A new study found that routine testing for multiple infectious diseases among migrants can identify key infections earlier, improving health outcomes and reducing onward transmission. The Leicester screening programme, which tested 4004 migrant patients, revealed new diagnoses of TB, Hepatitis B and C, and HIV.
A new film series, 'The Deadly Five,' is launched to raise awareness of five critical animal infectious diseases affecting animal and public health. The series explores disease surveillance, prevention, and control through scientific insights and global collaborations.
A new study found that women with the most common autoimmune diseases die from cardiovascular disease more frequently than men. This highlights the need for improved CVD risk management in these patients.
A hospital-based outbreak detection system has been shown to prevent infections, save lives and cut costs. The Enhanced Detection System for Healthcare-Associated Transmission (EDS-HAT) uses genomic sequencing to analyze infectious disease samples from patients, identifying near-identical strains that flag potential outbreaks.
BEACON leverages AI, LLMs, and expert networks to rapidly collect, analyze, and disseminate information on emerging infectious diseases. The platform provides near real-time reports of sentinel cases, clusters, and outbreaks.
A Lehigh University researcher is developing a new platform to enhance flu forecasting through a human judgment temporal forecast system, which aims to improve evidence-based public health decision making. The system will collect unbiased opinions and forecasts from public health experts and the general public.
A massive analysis of over 300 million hospitalizations records in eight countries found that flooding increases the risk of serious diseases like cardiovascular, respiratory, and infectious diseases. The study highlights the need for better preparedness and response to mitigate health impacts of floods.
A recent study warns that climate change is creating new pathways for the spread of infectious diseases like brucellosis and E. coli in the Arctic, due to melting permafrost and increased human activity. The thawing of soil frozen for thousands of years could unlock dormant microbes with pandemic potential.
A recent study examines the correlation between different transmission-risk metrics and environmental factors in indoor spaces. The research found conflicting outcomes among five metric types, emphasizing the need to consider facility type and disease nature when evaluating non-pharmaceutical interventions.
A groundbreaking study published in eBioMedicine has shown that a new mRNA vaccine is effective in boosting immunity against tuberculosis. The vaccine demonstrated potent immune responses in infected mice and improved long-term protection when combined with the BCG vaccine.
A new study by Wits University and NICD shows that conditional cash transfers and TB counselling improve treatment success rates and reduce loss to follow-up in South Africa. The intervention resulted in halving unsuccessful TB outcomes compared to standard care, bringing the country closer to its 90-90-90 TB targets.
A new study suggests that COVID-19 likely emerged from the natural fusion of two rare infectious diseases, glanders and Sennetsu fever, with some common human diseases. DNA methylation patterns at 865,859 CpG sites in blood samples from early COVID-19 patients revealed strong genetic link evidence supporting this theory.
NUS Medicine has launched a new centre to bolster global pandemic preparedness and response to infectious disease emergencies. The Centre for Infectious Disease Emergency Response (CIDER) will serve as an education and operational hub for public health professionals, researchers, and policymakers.
Researchers uncovered eight rare diseases that carry significantly increased risks for COVID-19-related mortality in fully vaccinated individuals. These conditions, including infertility disorders and kidney diseases, pose a nearly fivefold greater risk of death from COVID-19 than the general population.
Researchers have developed new models to explore the role of a membrane anchor on the folding and aggregation of PrP. Anchoring stabilizes folding and inhibits aggregation, with clumping induced by pre-formed aggregates, suggesting a potential mechanism for infectious prion diseases.
The rollout of doxycycline as a prevention strategy for sexually transmitted infections (STIs) has shown promise in reducing syphilis and chlamydia rates, but its effectiveness on gonorrhea is limited. Close monitoring for antimicrobial resistance is necessary to ensure the long-term efficacy of doxy PEP.
The NIH and its partners remain focused on monitoring the H5N1 virus, which has caused sporadic infections among wild birds and poultry farms. Researchers highlight four keys to controlling the current outbreak: timely collaborations, disease surveillance, medical countermeasures, and precautions to prevent exposure.
EBViously aims to prevent infectious mononucleosis and secondary diseases such as ME/CFS, while also protecting against certain types of cancer. The company's innovative vaccine candidate uses virus-like particles derived from EBV to trigger a targeted immune response.
A recent study published in Clinical Infectious Diseases found that adherence to national medical guidelines for using antiviral medications in young children with influenza is limited. Almost half of hospitalized children did not receive antiviral therapy, highlighting the need for improved clinical testing and treatment.
Researchers developed an optimized approach to pooled testing, reducing testing costs and time while maintaining accuracy. The study provides a new software package to aid health departments in implementing these protocols, enabling efficient detection and monitoring of infectious diseases.
Researchers at USF Health have created the first ever peer-reviewed guide to audio podcasts dedicated to infectious diseases. The study highlights 38 popular infectious disease-oriented audio podcasts, including a new USF Health series called Contagion: An Infectious Diseases Podcast.
A 30-year study reveals changes in incidence and mortality rates of 15 common neonatal infectious diseases across LMICs, identifying key trends and areas for targeted public health interventions. Higher socio-demographic index and universal health coverage are generally associated with reduced disease burden.
Researchers developed a new experimental infection model using Drosophila flies to test drugs for infectious diseases, reducing the use of vertebrate animals. The model assesses innate immunity against infections by Candida albicans and allows for the design of new therapeutic approaches targeting uncontrolled immune responses.
The partnership aims to co-develop innovative technologies for enhanced health and economic outcomes. Key findings include the need for collaborative research to counter emerging challenges presented by tropical ID, and inform pandemic preparedness strategies.
A new study found that older macaques with smaller social networks suffer less from infectious disease. The research suggests a powerful reason for reduced social connections in aging animals, including humans.
Researchers found Itaconate stimulates immune cells to produce anti-viral proteins called interferons by blocking an enzyme called SDH, offering a potential therapy for autoimmune and infectious diseases.
A new methodology has been introduced that significantly enhances the accuracy of epidemiological estimates for infectious diseases like COVID-19. The approach adopts a history-dependent framework, eliminating biases in traditional models and allowing for more precise predictions of disease spread.
Researchers at Texas Biomedical Research Institute developed a human cell culture model of alveolar macrophages, which helped make a key finding about the role of tumor necrosis factor (TNF) in tuberculosis (TB). The study found that TNF is critical to protect against TB but not other infectious diseases.
Organoids are miniature organs that capture specific organ structures and functions. They have been shown to shed light on genetic cell fates in various diseases, including infectious diseases, metabolic disorders, and malignancies.
Researchers at Cranfield University have developed an innovative method for identifying biomarkers in wastewater using origami-paper sensors, enabling early detection of infectious diseases. The new test device is portable, fast, and cost-effective, making it a game-changer for public health measures.
The NIH has established a pandemic preparedness research network, ReVAMPP, to focus on high-priority pathogens with the potential to cause deadly diseases. The network will study viruses from families that have caused human disease for millennia and aim to develop safe and effective medical countermeasures.
A study analyzing 5.5 million EU/EEA infectious disease cases over 10 years found significant sex differences in notified male versus female cases for several diseases. The proportion of males ranged from 40-45% for pertussis and Shiga toxin-producing Escherichia coli infections to 75-80% for HIV/AIDS.
A study published in PLOS Water found associations between weather, geographic location, and urban/rural settings with waterborne infectious disease hospitalizations. Hospitalization rates were higher for enteric and biofilm-forming bacterial pathogens in areas using groundwater, while precipitation increased parasitic infections.
A new method called FAIRY uses a dye to rapidly determine whether a virus is infectious or non-infectious. The assay has been evaluated against various viruses and confirmed its potential for screening disinfectants and antivirals.
Researchers have developed nanovesicles derived from activated neutrophils, which effectively combat deep tissue pathogens and promote rapid debridement, collagen deposition, and healing. This innovation has the potential to revolutionize the management of complex infectious wounds and boost treatment efficacy.
Researchers tested hundreds of milk products from dozens of states and found no infectious H5N1 virus, but detected viral genetic material in 20% of samples.