Researchers discovered significant variations in enzyme expression between adults and children, impacting drug treatment effectiveness. Enzyme levels change dramatically during early life stages, affecting individual susceptibility to drug reactions.
Scientists discovered that mice lacking the DNA repair enzyme NEIL1 develop severe obesity and metabolic syndrome, with enlarged livers and insulin resistance. The study suggests an important role for NEIL1 in preventing metabolic disorders.
A new study found that the food additive dihydrocoumarin inhibits the activity of Sir2p and SIRT1 enzymes in yeast, which are forms of sirtuin also found in humans. This inhibition increases cell toxicity and decreases lifespan by up to 30%.
A new biochip tool called MetaChip can analyze drug candidates for toxicity and eliminate harmful ones before they advance to pre-clinical stages. The technology mimics the effects of metabolism in the human liver, enabling early detection of toxic compounds that could be difficult to predict or find with current testing methods.
Researchers found elevated tungsten and cobalt levels in Fallon's air, differing from nearby towns. The findings suggest a possible environmental cause for childhood leukemia cases in the area, prompting further research to examine the relationship between these metals and cancer development.
Research shows lead may cause additional long-term health problems, disrupting immune cells that fight off pathogens. An estimated 434,000 US children under age 5 have elevated lead levels in their blood.
Researchers at Queen's University have developed a new eye movement test to identify children with Fetal Alcohol Spectrum Disorder (FASD), which affects approximately one percent of Canadian children. The test can cut across cultural barriers and provide objectivity in identifying the disorder, allowing for improved treatment.
Researchers at Rice University have developed a method to reduce the toxicity of water-soluble carbon nanotubes through surface modifications. The study found that even minor changes can dramatically decrease cytotoxicity, making these nanoparticles more suitable for medical diagnostics and imaging.
Despite exposure to environmental chemicals, breast-feeding remains a healthy option for infants. Research suggests few adverse effects have been documented, and none have been clinically or epidemiologically demonstrated.
Jaap Sinninghe Damsté is awarded the Treibs medal for his research into marine sediments and the discovery of anammox bacteria, which has major consequences for the nitrogen cycle. He uses organic molecules to reconstruct life and climate in previous epochs.
The company will use the investment to accelerate its drug development program for neuropathic pain, a prevalent condition affecting an estimated 45% of diabetics and 75% of those over 70. With a significant worldwide market valued at US$3 billion, Spinifex aims to deliver a novel solution to this unmet medical need.
A study of 2,593 cases found that school pesticide exposure led to acute illnesses in children (7.4 cases per million) and adults (27.3 cases per million). The majority of illnesses were associated with insecticides, with integrated pest management programs recommended to prevent such exposures.
A recent study by the University of Florida found that fentanyl patch abuse led to the death of 115 people in Florida last year. The abuse often involves removing the full dose from the patch and taking it all at once, either through injection, ingestion, or smoking.
Researchers at Virginia Tech will use 'in situ click chemistry' to design a novel, species-specific insecticide for Anopheles gambiae mosquitoes, reducing toxicity and ensuring safety for humans and animals. The project aims to provide an effective solution for malaria control in communities worldwide.
Research reveals that an individual's genetic makeup determines how arsenic is metabolized, affecting disease risk. The study found a specific gene variant associated with altered urinary arsenic metabolites in children, but not adults.
Tercica has presented human and animal safety data showing no immunotoxic effects with long-term rhIGF-1 treatment. The data also demonstrate a reduction in the incidence of some endocrine cancers in animals, providing further evidence supporting the long-term safety of rhIGF-1 therapy.
The University of Arizona has received a $14 million grant to focus on two major types of contaminants: arsenic and halogenated organic solvents like TCE. The research projects will improve hazardous waste management in Arizona and the Southwest, and can serve as a model for arid and semi-arid regions worldwide.
A recent study found that homemade gene expression technology is less reliable than commercial microarray platforms. The research, led by OHSU scientist Peter Spencer, used standardized protocols to compare lab-built and commercially produced microarrays, showing improved reproducibility with commercial platforms.
The Tri-Institutional Stem Cell Initiative aims to decipher molecular codes responsible for human cellular diversity and design cell-based therapies. This collaboration will bring together researchers from Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, and The Rockefeller University to explore stem cell biology.
A concentrated form of Vitamin E called tocotrienol rich fraction (TRF) from rice bran oil may effectively reduce total cholesterol levels by up to 42% and LDL or 'bad' cholesterol levels by 62%. Researchers found that a minimum dose of TRF of 8 IU kg/day provided the maximum antioxidants and lowered cholesterol.
Researchers developed a recombinant fusion protein that can be orally administered, increasing white blood cell count for three days. This breakthrough uses transferrin to bind to intestinal cells and transport the protein to the bloodstream.
Barron and Monteiro-Riviere's project explores fullerene interactions with skin cells, aiming to develop new nano-biohybrid materials. The researchers will investigate physiochemical properties of fullerenes to predict uptake and activity.
A recent study by Leonidas Koniaris and colleagues found that lethal injection methods in the US are often inadequate, leading to unnecessary suffering. The study analysed data from executions in Texas and Virginia, as well as autopsy toxicology reports, revealing low concentrations of thiopental in the blood of executed inmates.
Scientists have discovered that elevated estrogen levels can reduce the severity of asthma by preventing abnormal airway constriction. Selective estrogen receptor modifiers (SERMs) also showed similar effects, suggesting a new molecular target for asthma therapy.
Researchers at Queen's University discovered that a combination of gabapentin and morphine provides better pain relief for patients with diabetic neuropathy and postherpetic neuralgia, while also minimizing side effects. The study used a clinical trial to compare the treatment to individual medications and a placebo.
The National Centre for Text Mining provides a groundbreaking service for the academic community, utilizing natural language processing and data mining to uncover hidden patterns and associations. This innovative approach has already shown promise in fields like drug discovery and predictive toxicology.
Scientists have detected high levels of silver contamination in North Pacific waters, linked to atmospheric emissions from Asia. The findings suggest that silver could be used as a tracer element for tracking the fate of industrial emissions, with implications for understanding pollution patterns.
Dr. Moore's distinguished career has led to evidence-based frameworks for clinical dentistry, with notable contributions in pediatric sedation guidelines and diabetes research. His work has provided a foundation for optimal pain control and minimal adverse effects in clinical analgesics and anesthetics.
The William C. Rose Award lecture will focus on the importance of cytochrome P450s in drug development, endocrinology, and toxicology. Dr. Guengerich's recent work includes kinetic analysis and methods to define substrates and products of orphan P450s.
Researchers have identified networks of genes that respond to alcohol in the brain, which may play a role in determining genetic differences in behavioral responses to alcohol. The study found that certain genes were regulated differently in two mouse strains, leading to distinct behavioral responses to alcohol.
Microbial contamination of food is a significant problem worldwide, causing millions of deaths and illnesses. Experts recommend new approaches to food control, including centralized policies and increased surveillance, to ensure safe food production and trade.
The report lists 58 substances as 'known human carcinogens' due to evidence from human studies, including HBV, HCV, and HPV. Eleven new substances have been added to the list of 'reasonably anticipated human carcinogens', including naphthalene, MeIQx, and lead.
A scientist at the Marine Biological Laboratory has published a study showing that a combination of pollutants bromoform, chloroform, and tetrachloroethylene can alter nerve cell growth in clam embryos. The study found increased production of an enzyme involved in neural development, which may be linked to neurological disorders such a...
Researchers have developed a new treatment that significantly reduces morphine use after hysterectomies, leading to improved lung function and more consistent pain relief. The treatment combines two non-opioid drugs, gabapentin and rofecoxib, which work together to alleviate movement-related pain and promote better breathing.
The Life Sciences Research Office has established scientific criteria to assess the impact of non-tobacco additives on cigarette smokers. The criteria focus on identifying potential risks and determining safe levels of additives, while considering inhalation testing within a smoke matrix.
UCR researchers Ludwig Bartels and team advance nanoscale electronics development by controlling chemical reactions one molecule at a time. They use an STM to guide individual molecules through step-by-step reactions, enabling fine-tuning of reactivity and optimizing atomic-scale construction of complex molecules.
The NIEHS is developing a new RNAi library to better understand the effects of environmental toxins on human health. This technology will help researchers identify specific genes responsible for adverse responses to chemicals, ultimately aiding in the development of new disease prevention strategies.
Researchers are exploring the use of genetically endowed worms to replace rodent studies in toxicology testing, potentially saving millions of dollars. The C. elegans worm has a unique biology that makes it an ideal model for testing chemicals, with its short lifespan and transparent body allowing for direct monitoring of internal organs.
A team of researchers from MIT has identified three new carcinogens found in cigarette smoke as risk factors for bladder cancer in nonsmokers. The study, led by Professor Steven R. Tannenbaum, aimed to identify sources of exposure for non-smokers and highlights the importance of preventing cancer rather than treating it.
Dartmouth Medical School emphasizes ongoing feedback and mentoring in its educational research environment. The school attributes its success to a supportive faculty culture and rigorous evaluation processes.
Professor Ken Donaldson proposes the creation of a new discipline, nanotoxicology, to study the potential harmful effects of nanoparticles. The importance of nanotechnology is debated, but its adverse impacts need to be studied to ensure sustainable development.
Researchers from Lawrence Livermore National Laboratory are presenting their work on using accelerator mass spectrometry (AMS) to detect carcinogens, study biomarkers for atherosclerosis, and develop novel drug delivery devices. AMS applications in biological research and soot production chemistry modeling will also be highlighted.
Researchers have discovered a crucial link between zinc and retinitis pigmentosa, a degenerative eye disease that leads to blindness. The study suggests that trace metals like zinc play a critical role in protein function, with implications for treating other neurodegenerative diseases.
The Indiana University research team aims to reduce tissue damage from shock wave lithotripsy, a common treatment for kidney stones. They're developing protocols and mathematical models to make the procedure safer and more effective.
Research found that injured methamphetamine users stayed in hospitals longer and incurred higher costs, compared to those who tested negative. The study, which analyzed records of 212 patients, showed that positive test results were linked to increased hospital admissions, stays, and charges.
A study by University of Toronto researchers found high levels of mercury in sport-fish eaters' blood, particularly among Asian-Canadians. The findings emphasize the need for ongoing surveillance and education to minimize health risks from contaminated fish consumption.
Dr. Rice received a two-year, $200,000 grant to study chromatin changes contributing to sporadic breast cancers, focusing on epigenetic gene regulation. The GM Cancer Research Scholars Program supports young scientists in cancer research projects.
Researchers found three to four times more antibodies in Alzheimer's patients than healthy individuals, indicating a possible autoimmunity component to the disease. This discovery may lead to an early diagnostic test and more targeted treatments.
A study found that 28% of Central Valley sediment samples are toxic to amphipods and midge larvae due to pyrethroids. The pesticides were present in 68% of these sediments, posing a risk to freshwater organisms.
A recent study led by University of Rochester Medical Center professor Günter Oberdörster investigates the link between nanotechnology and human health. The research suggests that nano-sized particles may accumulate in the body and cause harmful inflammation, potentially leading to brain damage or central nervous system disorders.
A study found that exposure to terbutaline and chlorpyrifos in early development can lead to brain damage and increased susceptibility to pesticide injury. The combination of the two chemicals caused significant loss of brain cells and nerve cell projections, particularly in regions critical for learning and memory.
Researchers found 53 smoking-induced genetic alterations in mice exposed to tobacco smoke, with CYP1B1 enzyme overexpression linked to estradiol activation. This finding may help understand why female smokers are more susceptible to lung cancer than male smokers.
A study by Miriam Jacobs and colleagues has found significant increases in flame retardant levels in cod liver oil supplements over the past four years. This is a growing concern due to the potential for these chemicals to contaminate the environment and human health, particularly through consumption of contaminated fish oils.
Dr. Kenneth Olden has received the Society of Toxicology's Public Communications Award for his efforts to bridge the gap between researchers, policymakers, and the public through open access journals and regional town meetings.
The International Association for Dental, Oral, and Craniofacial Research has awarded Dr. Haas the 2004 Pharmacology/Therapeutics/Toxicology Award for his extensive work on anxiolytic agents in dentistry. Dr. Haas has also made significant contributions to the field through his presentations and leadership roles.
Researchers found that short-term stress combined with exposure to low-dose chemicals causes widespread cellular damage in the brain and liver of rats. The combination also promotes cell death, damages specific brain regions, and increases reactive oxygen species, which can lead to further damage.
A $4 million grant aims to conserve Papua New Guinea's rainforest by discovering medicinal plants. The project seeks compounds active against tuberculosis, HIV, malaria, and cancer, with the goal of providing economic development and biodiversity conservation.
Researchers are testing a gene therapy approach called tumor immunization, which involves delivering the IL12 gene to cancer cells to trigger an immune response. The method has shown promise in laboratory and animal studies, with up to 20% of animals experiencing complete tumor eradication.
Researchers at DMS have found that removing RIP140 allows retinoids to effectively differentiate cancer cells, slowing tumor growth and increasing the efficacy of cancer treatment. This breakthrough sheds light on the potential benefits of retinoid-based therapies for various types of cancer.
Researchers have identified a molecular understanding of the abnormal proteins causing retinitis pigmentosa, a degenerative eye disease. They will now focus on designing effective drugs to delay disease progression by stabilizing the mutated rhodopsin protein.