Scientists at the University of Granada have found that only a specific group of cord blood stem cells (CB-SC) maintained in culture are useful for therapeutic purposes. The researchers identified Wharton's jelly stem cells (HWJSC) as the most suitable subgroup, which can develop into several types of tissue and modulate immune responses.
A recent study found immunohistochemistry to be a reliable and accurate method for detecting ALK rearrangement in non-small cell lung cancer. The technique outperformed fluorescence in situ hybridization, which is currently the standard but time-consuming method.
A team of researchers at St. Michael's Hospital has discovered multiple ways kidney tumours can achieve the same result – namely, grow. By examining chromosomal changes, methylation, and gene expression, they identified specific regions where genetic alterations occur in kidney cancer.
A Tel Aviv University researcher is using fruit flies to study the functioning of neurons and potential treatments for Alzheimer's disease. By genetically modifying flies to express a protein linked to human Alzheimer's, she hopes to unlock its function and develop new therapies.
The study found an increase in non-smokers developing lung cancer, particularly women, and a shift towards adenocarcinoma. Researchers attributed this change to improved diagnostic techniques and management of lung cancer.
A recent study published in JAMA found that HIV-infected women with normal cervical cytology and negative oncogenic HPV DNA had a similar risk of cervical precancer and cancer to uninfected women over a 5-year period. The study's findings suggest that current screening guidelines may need to be revised for HIV-infected women.
Researchers at McGill University discovered that heart muscle fibers are arranged in a special 'minimal surface' called the generalized helicoid. This finding offers significant new understanding of heart-wall muscle fiber geometry and could be used to guide tissue repair after heart attacks.
Researchers have found a promising combination of nab-paclitaxel and carboplatin to be effective in treating non-small cell lung cancer (NSCLC) patients who are ineligible for bevacizumab. The treatment resulted in an overall response rate of 41% and stable disease in 39% of patients.
Researchers have developed a computational model called 'cell graphs' that links the structure of human tissue to its corresponding biological function. This new tool uses graph theory and can be used to determine whether a tissue sample is cancerous or not, eliminating differences of opinion between doctors.
A study found that a simple genetic test can predict the aggressiveness of rhabdomyosarcoma tumours in children, allowing for tailored treatment and improved survival rates. The test identified a panel of genes whose altered activity levels could be used to predict patient response to treatment.
Imaging amino acid transporters with PET/CT has significantly altered management plans for 41% of patients with brain tumors, according to research. The imaging modality has improved detection of primary and recurrent high- and low-grade brain tumors, leading to changes in treatment from 'watch and wait' to chemotherapy or vice versa.
A study found that women with invasive epithelial ovarian cancer and a BRCA gene mutation had improved 5-year overall survival, with BRCA2 carriers having the best prognosis. The study analyzed data from 26 observational studies and included 1,213 cases with pathogenic germline mutations in BRCA1 or BRCA2.
A significant number of women with breast cancer are not receiving guideline-recommended adjuvant treatment. The research found that socioeconomic factors such as poverty, insurance status, and education level significantly contribute to this disparity. Women from high-poverty areas were less likely to receive guideline therapy, highli...
Dr. Richard A. McIndoe is leading a $7.5 million National Institute of Diabetes and Digestive and Kidney Diseases grant to support studies on diabetes affecting 8.3% of Americans. The Diabetic Complications Consortium shares data on complications like heart attack, stroke, vision loss, and kidney damage.
The Monell Center has received a $2 million NIH Core grant to enhance technological and research services. The funding will support three Research Cores providing specialized expert services, equipment, and training in chemical senses research techniques.
Researchers at Montana State University have discovered that dog-sized dinosaurs that lived in the Antarctic Circle had bone tissue very similar to those living elsewhere on the planet. This finding may help explain how dinosaurs were able to dominate the Earth for 160 million years.
The American Association for Anatomy's ASCES journal has secured the number one ranking in Education, Scientific Disciplines with its debut impact factor of 2.976. The journal provides an international forum for anatomy education research, attracting contributions from top researchers worldwide.
Scientists at the Allen Institute have identified complex cellular patterns in brain development, suggesting multiple mechanisms beyond Reelin involved in proper neuron migration. The findings have major implications for understanding brain disorders like autism.
Research found that high EGFR expression is a predictor of improved survival in advanced non-small cell lung cancer patients treated with cetuximab and chemotherapy. Patients with high tumor EGFR expression averaged 12 months of overall survival, compared to 9.6 months for those without high expression.
Researchers from Boston University School of Medicine found that traditional Korean medicine SCRT treatment alleviates asthma-like pulmonary inflammation via suppression of specific chemokines or proteins. The study, published online in Annals of Allergy, Asthma & Immunology, suggests a potential mechanism for reduced inflammation.
A study published in the Journal of the National Cancer Institute found that breast cancers discovered between screening mammograms tend to be more aggressive and have a poorer prognosis. The research compared data from women with interval cancers (detected between mammograms) to those detected during routine screening.
A recent study found that nearly 40% of virological breakthroughs in patients receiving nucleoside analogs for chronic hepatitis B were not related to antiviral drug resistance. Non-adherence to medication was identified as a common cause of reemergence.
Bjorn R. Olsen, Richard Drake, and Gary C. Schoenwolf received the highest awards from the American Association of Anatomists for their outstanding contributions to anatomical sciences, with Olsen receiving the Scientific Achievement Award, Drake the Distinguished Educator Award, and Schoenwolf the Exemplary Service Award.
Researchers from University of Granada successfully created the first bioartificial organ in Spain by replacing pig corneal cells with human stem cells. The new organ maintains the basic structure of the cornea while replacing its cellular components.
The ASGE has established guidelines for the use of real-time endoscopic assessment in managing diminutive colorectal polyps. The recommendations aim to minimize risk and delay while improving cost effectiveness of colonoscopy. Diminutive polyps are common, but pathological assessment can be costly and delay patient information.
A research team used 100-year-old specimens from California Academy of Sciences to estimate when avian pox hit Galapagos. The study found that humans likely played a role in spreading the disease, highlighting the need for policies to prevent further spread.
Researchers are working to identify factors that cause neural implants to fail, which can occur within six to eight weeks. A team led by the University of Houston is using advanced software and imaging techniques to analyze brain cell responses to implants, aiming to improve prosthetic limbs for amputees.
Patients with abnormal liver function who receive statin treatment show improved liver function and reduced risk of cardiovascular events. Long-term statin treatment is a safe and promising strategy for patients with non-alcoholic fatty liver disease (NAFLD).
A study analyzing European Prospective Investigation into Cancer and Nutrition data found that current hormone therapy use increases the risk of ovarian cancer by 29%. The risk did not differ by type or duration of hormone therapy, suggesting a potential long-term hazard.
A study analyzing data from the Women's Health Initiative found that statin use did not lower the risk of colorectal cancer among postmenopausal women. Researchers identified no association between statin use and reduced risk for colorectal cancer, tumor location, stage, grade or histology.
Researchers can now study the mouse brain in unprecedented detail, thanks to a new atlas that provides a 3D reference point for genetics, toxicology, and drug discovery. The atlas features images with resolutions up to 21 microns, eliminating variability issues associated with conventional histology.
Research finds pentoxifylline improves NASH, reducing fat and inflammation; vitamin E also shows promise in improving liver histology independently of insulin resistance. Studies suggest new treatment options for overweight individuals with liver disease.
A study published in The Journal of the National Cancer Institute found that alcohol consumption is more strongly related to the risk of lobular carcinoma than ductal carcinoma, and more strongly related to hormone-receptor-positive breast cancer than hormone-receptor-negative breast cancer.
A double-blind, randomized placebo-controlled trial found that high doses of ursodeoxycholic acid failed to improve overall liver histology in patients with nonalcoholic steatohepatitis. Only lobular inflammation showed significant improvement in certain subgroups.
The International Society for Heart and Lung Transplantation has developed a standardized nomenclature for cardiac allograft vasculopathy, which will benefit heart transplant patients. The new classification system defines four levels of CAV severity, allowing for more accurate treatment options and improved patient outcomes.
A nationwide study published in the World Journal of Gastroenterology found that diarrhea is a relatively uncommon but insidious condition underlying various illnesses in neonates. The study highlights the importance of recognizing rare chronic cases and advocating specific guidelines for managing diarrheal disorders in neonates.
Researchers at Catholic University of Rome have developed a promising new therapy against systemic sclerosis (scleroderma), an autoimmune disease characterized by skin hardening and organ dysfunction. The treatment targets the immune system's B-cells, reducing side effects associated with traditional immunosuppressive therapies.
Researchers found that p53 is activated during the formation of spermatozoa and ova, controlling the creation of gametes to prevent mutations. This discovery suggests a new role for the tumour suppressor gene in evolution, potentially leading to new approaches in cancer research.
A new diagnostic scan using 124I-girentuximab with PET/CT imaging can distinguish between aggressive and less aggressive kidney masses, helping to avoid unnecessary surgeries. The test has a sensitivity and specificity of 86% and 87%, respectively, making it a promising tool for personalized treatment strategies.
A study published in the Journal of Thoracic Oncology found that high expression of CD24 is a negative independent prognostic factor for progression-free and cancer-specific survival in NSCLC. CD24-high expression was also associated with adenocarcinoma histology, higher risk of disease progression, and cancer-related death.
Joseph W. Sanger, T. Vidhya Persaud, and Richard B. Marchase received the highest honors from the American Association for Anatomy for their unique contributions to anatomical sciences. The awards recognize exceptional service and meritorious achievements in education, research, and scientific advancements.
A phase II study found GS-9450 significantly reduces levels of alanine and aspartate aminotransferases in patients with non-alcoholic steatohepatitis. The treatment also showed promising results in terms of tolerability profile, suggesting its potential as a new treatment option for NASH.
A German study found that high dose UDCA was not superior to placebo in treating NASH, but showed promise in a subgroup of mildly overweight male patients. This result is significant as the incidence of NASH is increasing with rising obesity levels.
A study found that Wilson disease patients' liver histology progression does not correlate with clinical parameters or treatment type. Researchers recommend considering liver biopsy with hepatic copper quantification every 3 years due to the inability of clinical tools to detect fibrosis progression despite treatment.
A new fossil turtle species, Cerrejonemys wayuunaiki, was found in the Cerrejon coal mine in Colombia, dating back to 60 million years ago. The thick shell may have protected it from predators like the Titanoboa, a snake thought to be the world's biggest.
Researchers at Washington University in St. Louis have developed gold nanocages that selectively accumulate in tumors and convert laser light to heat, killing malignant cells. The treatment avoids warm surrounding tissue, making it a promising approach for cancer therapy.
A study of nearly 800 patients with non-small cell lung cancer identified genetic characteristics associated with increased recurrence-free survival, differing between men and women based on age.
Researchers confirm accuracy of transient elastography for diagnosing nonalcoholic fatty liver disease (NAFLD) and excluding advanced fibrosis. The study found TE to be superior to other non-invasive tests in detecting advanced fibrosis, with the potential to spare two-thirds of NAFLD patients from liver biopsies.
Phase II study results of ASA404 showed improved overall survival in patients with squamous and non-squamous NSCLC compared to chemotherapy alone. The drug's unique mechanism of action inhibits tumor blood flow, providing a potential new treatment option for limited options.
Scientists have discovered a possible way to identify malignant breast tumors without invasive biopsies, using an agent called 64Cu-TP3805 that targets a specific biomarker called VPAC1. This method has the potential to significantly contribute to breast cancer management.
A team of researchers at the University of Houston has created a process to grow real human bone in tissue culture, allowing them to investigate how bones form and grow. The technology has potential applications in preventing bone loss in astronauts and patients with spinal cord injuries.
A study published in World Journal of Gastroenterology found that green tea extract inhibited proliferation, reduced collagen content, and downregulated collagen type 1 expression in liver fibrosis models.
Researchers from the University of Granada and University of León found that human mononuclear cells isolated from umbilical cord blood exerted a deleterious effect on rats with liver cirrhosis, inducing hepatorenal syndrome instead of improving health. The study highlights the need for further research in hepatic regenerative medicine.
A Phase II dose-finding study found that green tea extract improved histology and trended towards a reduction in biomarkers associated with cancer development in patients with oral leukoplakia. The extract was well-tolerated, with minimal side effects.
A new study suggests that green tea extract can reduce the risk of oral cancer, with patients who presented with mild to moderate dysplasia having a longer time to develop oral cancer if they took green tea extract. However, more research is needed to confirm its long-term prevention effects.
The PROSPECT trial reveals that most unexpected heart attacks are caused by large plaque burdens and small lumen areas, not mild lesions. Characterization of plaque composition using virtual histology improves the ability to predict future adverse events.
UT Southwestern Medical Center researchers have received a $2 million grant to study lung cancer in nonsmokers. They will use a coordinated approach to discover biomarkers and develop a test to detect early-stage lung cancer.
A new x-ray imaging technique, diffraction-enhanced imaging (DEI), has been developed to visualize individual amyloid beta plaques in the brain. The study successfully images these tiny structures in a mouse model of Alzheimer's disease, providing promising clues for early diagnosis and treatment.
A comprehensive investigation into sea urchins' axial complex has shown that various internal organs are structurally linked. The study uses high-resolution imaging to analyze specimens from multiple orders, providing a re-evaluation of published studies spanning two centuries.
Two new studies present promising findings for hepatitis treatments, including a switch to Tenofovir Disoproxil Fumarate (TDF) for patients with persistent viral replication. The study also explores the long-term effects of Interferon Based Therapy on Hepatic Histology in Patients with Chronic Hepatitis C Virus, showing improved histol...