A new blood test measures a protein called cardiac myosin binding protein-C (cMyBP-C) to detect heart attacks more quickly. cMyBP-C is released to the bloodstream within just 15 minutes of cardiac damage, rising to significant levels in three hours.
Researchers found that collecting and bleeding horseshoe crabs for biomedical purposes causes short-term changes in their behavior and physiology. The study suggests delaying the blood harvest or improving transportation conditions could help the animals recover and breed again, potentially mitigating population declines.
A diet rich in carbohydrates can lead to detrimental effects on brain health, increasing the risk of dementia and cognitive impairment. Dr. David Perlmutter explains that carbohydrate calories have a more significant impact on human physiology than calorie sources from fat.
Researchers discovered a protein responsible for gas exchanges in zebrafish gills, which may mimic human kidney function. NHE3 protein controls sodium and hydrogen ions, aiding in energy-saving balance and waste removal.
Researchers at UMass Medical School develop a novel model to study the effects of vitamin B12 on gene expression and physiology in C. elegans worms. The study reveals that vitamin B12 regulates development through the methionine/SAM cycle and alleviates toxic buildups of propionic acid, leading to improved fertility.
A study revising rules for deciphering dinosaur color suggests a link between color, physiology, and the origin of flight. Researchers found diverse melanosome shapes and sizes in feathered dinosaurs, paravians, and living mammals and birds.
A University of Arizona researcher has shown that genetic mutations in the titin gene can cause skeletal muscle myopathy, a disease characterized by muscle weakness. The study, published in the Journal of General Physiology, could be an important step in developing treatments for this condition.
Researchers have identified a specific protein involved in mediating the skin's response to UVR and found that the signal transduction cascade resembles a light-activated pathway in the eye. This new insight into the molecular pathway underlying UVR detection could lead to improved sun protection methods.
Researchers at the University of Cincinnati identified serine/threonine protein kinase-29 (STK-29) as a key component linking circadian rhythms and cell division cycles. The study, led by Christian Hong, provided insights that could lead to improved disease treatments and drug delivery.
A study in The Journal of General Physiology reveals how nicotine up-regulates nAChRs through COPI-coated vesicles, playing a major role in nicotine addiction. This finding may also contribute to the decreased susceptibility of smokers to Parkinson's disease.
A new MRI approach called quantitative susceptibility mapping (QSM) has been validated for measuring Multiple Sclerosis (MS) progression. QSM provides a quantitative way to measure myelin content and iron deposition in the brain, which are important factors in MS physiology. The study demonstrated that using the correct model can separ...
A new CU-Boulder study found that toddlers who go to bed later than their melatonin increase have difficulty settling down at night. Toddlers with longer intervals between melatonin release and bedtime take longer to fall asleep and experience increased bedtime resistance.
Researchers discovered that ATP-sensitive potassium channels in skeletal muscle play a crucial role in regulating energy consumption even during mundane activities. By modulating KATP channel activity, new strategies may be developed to combat metabolic disorders such as muscle wasting and obesity.
Researchers found that diabetes drugs have different effects on the hearts of men and women, with metformin improving heart function in women but worsening it in men. The study suggests that sex differences play a role in how patients respond to treatments.
Heterotrimeric G proteins play significant roles in plant development, including fruit and seed size and production, defense against pests and pathogens, and response to abiotic stresses. Research by Sona Pandey and collaborators showed that elevated G protein quantities in Camelina sativa led to increased seed production and size.
Male fruit flies that expect sex but don't receive it experience rapid decreases in fat stores, resistance to starvation, and more stress. Mating partially reverses the negative effects on health and aging. The study provides new insights into how sensory perception and physiological state are integrated in the brain.
John Jelesko, an associate professor of plant pathology and physiology at Virginia Tech, has been recognized as an AAAS Fellow for his distinguished contributions to the field of plant specialized metabolism. His research has led to a better understanding of plant metabolism with significant implications for the pharmaceutical industry.
Researchers observed cyanobacteria assembling carboxysomes, vital cellular machinery for photosynthesis and carbon fixation, from the inside out. The findings illuminate bacterial physiology and may influence nanotechnology development.
A new study in The Journal of General Physiology has shed light on the biophysical processes underlying regulation of circadian rhythms. Researchers found that decreased BK channel activity, particularly a specific variant containing SRKR, contributes to reduced SCN neuron excitability during the day.
New research suggests that childhood exercise can improve leptin sensitivity and reduce fat deposits, potentially staving off some bad effects of maternal obesity. Exercise as early as adolescence has been shown to have a persistent effect on the satiety centers of the brain, even years later.
A new study published in Experimental Physiology found that women exhibit greater shortness of breath when exercising compared to men. The study suggests that this disparity is caused by a stronger electrical activation of the respiratory muscles, specifically the diaphragm, needed to compensate for smaller lungs and airways.
Researchers at Penn Medicine have identified a molecule, HDAC3, that plays a starring role in maintaining proper intestinal integrity and function in the presence of friendly bacteria. The study found that HDAC3 regulates the relationship between commensal bacteria and mammalian intestine physiology.
Researchers have identified a key channel crucial for hearing, contradicting the long-held theory that TMC proteins are the transduction channel. The new findings suggest that the actual channel may be a distinct membrane protein expressed alongside other key molecules.
A recent study published in Experimental Physiology has found that exercise during pregnancy significantly alters the vascular smooth muscle of offspring into adulthood. This research suggests that maternal exercise may have long-lasting implications for cardiovascular disease susceptibility in children born to exercise-trained mothers.
Researchers have uncovered tiny changes in plants' physiology that enable advanced photosynthesis, allowing for increased growth rate and water efficiency. This knowledge could be used to breed faster-growing, drought-resistant crops like rice.
A study published in the journal Physiology & Behavior found that cats from multi-cat households do not exhibit higher stress levels than those from single-cat households. The researchers discovered that a cat's personality, as classified by its owner, plays a significant role in determining its stress response to stroking.
Five Human Frontier Science Program (HFSP) grantees were awarded Nobel Prizes in Physiology or Medicine and Chemistry for their groundbreaking work. This achievement underscores the value of supporting innovative research projects and fosters collaboration among scientists.
Dr. Südhof's pioneering work on synaptic transmission has led to a better understanding of brain function under normal and pathologic conditions, such as Alzheimer's disease. He was recognized for his discoveries of key information about cellular transport systems, alongside Dr. James E. Rothman and Randy W. Schekman.
A study published in Experimental Physiology found that paracetamol can improve exercise endurance in the heat by reducing body temperature. This improvement allows individuals to exercise for longer periods without overheating. The researchers hope to investigate the specific mechanisms by which paracetamol achieves this effect.
Researchers uncover a surprisingly long-lasting opioid mechanism for chronic pain control, which also leads to physical and physiological dependence. The study suggests that stress may be a key factor in relapse in chronic pain patients and raises questions about the long-term consequences of this mechanism.
Dr. R. Clinton Webb, a leading expert in hypertension research, is honored with the American Heart Association Council on High Blood Pressure Research's Lifetime Achievement Award. He is recognized for his groundbreaking contributions to the field of hypertension and his dedication to mentoring and service.
The Entomological Society of America recognized Elina Lastro Niño, Kumaran Nagalingam, Lisa Overall, and Paul Michael Bardunias with various awards for their research and contributions to the field of entomology. The winners were announced at the 2013 ESA meeting.
Researchers have discovered a compound that successfully blocks smooth muscle growth and promotes repair of the injured endothelium in stented arteries. This innovation has the potential to eliminate blood clots forming inside stents, reducing the risk of complications.
Researchers at MIT have elucidated a 37th type of chemical reaction, crucial for understanding climate-affecting aerosols and human physiology. The reaction involves the decomposition of complex organic molecules and has significant implications for combustion reactions in engines.
A new technique developed by University of Iowa physiologist Gary Pierce uses the finger's pulse to measure aortic stiffness, a common risk factor for heart disease. The method, which is non-invasive and easily obtainable during routine exams, can provide useful diagnostic information for middle-aged and older patients.
A Kansas State University study shows that the Clean Air Act has helped forest systems recover from decades of sulfur pollution and acid rain. The research found a clear shift in tree growth and physiology since the Clean Air Act was passed in 1970, with significant improvements seen after 1982.
A new bioinformatics software tool, DrGaP, has been developed to identify genetic mutations responsible for cancers. The tool combines statistical methods and bioinformatics tools to distinguish between driver mutations and passenger mutations, leading to a more complete identification of altered genes and signaling pathways in cancer.
Researchers discovered a new aspect of the gene-splicing process that produces messenger RNA, controlled by the rare small RNA U6atac. This mechanism regulates hundreds of genes involved in cell growth, cell-cycle control, and global physiology.
Researchers at LA BioMed discovered a link between maternal nicotine exposure during pregnancy and asthma in the third generation. The study found that even though the third generation was not directly exposed to nicotine or smoking, they were still more likely to develop asthma due to epigenetic modifications caused by maternal smoking.
Researchers at Scripps Research Institute have discovered a new type of chemical modification that affects proteins involved in glucose metabolism, potentially playing a role in cancer and diabetes. The modification acts as a regulator of cellular processes, including the production of glucose.
Climate change is affecting infectious diseases worldwide, causing human health and biodiversity conservation impacts. The study proposes modeling disease systems to predict and mitigate the spread of lethal diseases.
A recent study published in The Journal of Physiology found that high doses of the antioxidant compound resveratrol, commonly found in red wine and supplements, can block cardiovascular benefits of exercise in older men. This counterintuitive result highlights the complex relationship between antioxidants and exercise.
Researchers have found that a drug already approved to treat multiple sclerosis may also slow and potentially reverse cardiac hypertrophy, a disorder that often leads to heart failure. By mimicking certain lipids in the body, FTY-720 significantly reduces heart mass and improves overall cardiac function.
A study reveals that the acetylcholine-activated inward-rectifying potassium current (IKACh) plays a critical role in regulating cardiac pacemaker activity and heart rate. The research found that mice lacking IKACh displayed a moderate increase in resting heart rate and delayed recovery after stress or exercise.
Researchers analyzed the membrane components of V. cholera that enable it to withstand increases in osmotic pressure, revealing comparable gating and conductive properties with E. coli channels. The study found that V. cholerae was more sensitive to abrupt decreases in osmolarity than E. coli.
Researchers found a conserved phospholipid enzyme, PIKfyve, crucial for insulin signaling in muscle cells, leading to glucose intolerance and insulin resistance. The study's mouse model exhibits metabolic defects similar to human prediabetes, offering new insights into treating these conditions.
Research at the University of Alberta found that rats with low birth weights are more susceptible to age-related vision loss. The team's findings suggest a potential link between low birth weights and complex diseases like age-related eye disorders.
A study reveals why Puerto Rican lizards don't rapidly extend their dewlaps like Jamaican cousins, instead using alternative strategies to enhance detection of displays. The research shows the island's species lacks physiology for rapid movement, relying on tailoring speed and duration of displays to match forest conditions.
A University of Oregon study found that 17% of female students alter their menstrual cycle for convenience or personal preference. Women who prefer a monthly cycle are less likely to modify their bleeding schedule, suggesting healthcare providers can educate them on suitable options.
A new study published in Psychological Science found that people who gain weight are more likely to exhibit impulsive behavior but also report increased deliberation. This surprising finding suggests an intimate relationship between a person's physiology and psychology.
A new study published in The Journal of Physiology found that hormone replacement therapy (HRT) significantly improves muscle function down to the muscle fibre level in postmenopausal women. HRT has been shown to reduce age-related decline in muscle mass and strength, particularly at cellular and molecular levels.
Researchers develop new methods to visualize calcium signals in entire astrocytes, revealing their role in modulating synaptic activity and regulating local blood flow. These findings pave the way for future exploration of astrocytic physiology.
Researchers discovered BB FCF as a selective inhibitor of Panx1, a protein involved in inflammation and cell death. The study suggests that BB FCF could aid in the development of pharmacological tools to inhibit Panx1, potentially treating conditions such as Crohn's disease and AIDS.
Dr. Lawrence Witmer's Visible Interactive Dinosaur (VID) project aims to digitally recreate the tissues stripped away by time, creating the most realistic dinosaur renderings. The project has dual purpose of helping paleontologists and educating the public about physiology and anatomy.
Physiology's enduring relevancy is highlighted through Dr. Joyner's research on complex bodily functions like blood pressure and blood flow during exercise. The redundancy in human systems complicates genetic explanations for diseases, leading to a comeback of multi-directional thinking in physiology
Researchers tracked 20 mountain lions over six years, finding that habitat fragmentation affects pumas' physiology, behavior, and ecology. The study helps identify corridors where pumas travel between high-quality habitats, aiding conservation efforts in human-dominated landscapes.
Researchers at UMMS found that small amounts of junk foods can trigger significant changes in gene expression and physiology, potentially impacting human health. The study used C. elegans as a model organism and identified a genetic regulatory network facilitating rapid responses to internal and external cues.
The Scandinavian Plant Physiology Society (SPPS) has renewed its partnership with Wiley over sixty years ago. The journal Physiologia Plantarum, an international thought leader in plant physiology, benefits from the collaboration. With a global focus and members from various countries, SPPS promotes experimental plant biology research.
Researchers monitored sleeping adolescents' brain waves, finding that synaptic density in the cerebral cortex peaks at age 8 and declines until adulthood. EEG sleep analysis identifies crucial aspects of adolescent brain maturation.
A new study investigates the role of protein kinase C (PKC) in airway smooth muscle contraction, revealing its potential as a therapeutic target for treating asthma and chronic obstructive pulmonary disease (COPD). The research suggests that PKC activation could contribute to airway hyperresponsiveness and exacerbate lung diseases.