Women who participate in clinical trials are more likely to experience positive emotions and fewer negative emotions than those who do not. The study suggests that recruiters should disclose the potential for regret and other negative feelings when participants opt out, to increase enrollment.
Researchers at Washington University in St. Louis have developed a device that stimulates nerves in the upper arm and forearm to transmit sensory signals to the brain, enabling users to feel hot and cold and the sense of touch through their prosthetic hands. The team plans to test the device on nonhuman primates to determine its effect...
Benjamin Tolchin, a Massachusetts researcher, will receive a $130,000 award to investigate psychogenic non-epileptic seizures (PNES) and develop new treatment approaches. His research aims to identify ways to increase the number of patients who successfully complete therapy and eliminate their PNES.
The RTS,S/AS01 vaccine candidate demonstrates partial protection against clinical malaria in young African children, with efficacy increasing with a booster dose. The vaccine's impact on severe malaria and hospitalizations is also significant, especially in areas of high transmission.
Researchers studying sleep apnea aim to understand the link between breathing patterns and blood pressure control in the brain. The IUPUI study may lead to innovative treatments for hypertension.
The World Health Organization has announced a new statement on the public disclosure of clinical trial results, including timelines for researchers to report their findings. The new statement aims to ensure that all interventional clinical trials are reported and publicly disclosed.
A Northwestern University study found that clinical trials for finasteride, a common hair loss treatment, inadequately reported sexual dysfunction, which may persist. The study analyzed 34 clinical trials and found no adequate information on the severity, frequency, or reversibility of sexual adverse effects.
Researchers created a publicly available website, neuroelectro.org, to collect and standardize data on neuronal function. The site enables the comparison of physiological information across different types of neurons, promoting new methods of analysis.
The DFG is establishing new Clinical Research Units and Research Units to investigate various topics, including pregnancy complications, particle physics, and nanotechnology. The research collaborations will focus on developing systematic design rules for nanoparticle synthesis and improving public transport planning.
Dr. Elizabeth Jaffee receives the AACR-Joseph H. Burchenal Award for her pioneering contributions to immunotherapies for breast and pancreatic cancers, leading to improved treatments and patient outcomes. Her work also focuses on establishing biomarkers of tumor microenvironment reprogramming.
The Pfizer/ACMG Foundation Clinical Genetics Combined Residency for Translational Genomic Scholars Fellowship Award provides clinical research training in biochemical genetics, including lysosomal storage diseases and therapeutics. The award grants $75,000 per year to three recipients selected by the ACMG Foundation.
Amy Kritzer and Ronit Marom received the Genzyme/ACMG Foundation Medical Genetics Training Award in Clinical Biochemical Genetics to advance education, research, and standards of practice in medical genetics. The $75,000 award provides clinical and research training at premier medical centers.
A study found that investigators are more likely to respond to clinical trials if contacted by a point person or navigator. The Point-Person Project built a national network of navigators to find experts in pediatric clinical research.
Researchers at NYU have devised a computer model that explains how the brain classifies visual stimuli into distinct categories. The model, published in Nature Communications, reveals that top-down feedback projections from category-selective neurons to feature-coding neurons are essential for learning correct category boundaries.
Duke Medicine researchers found that only 13.4% of clinical trials reported findings within the required one-year window, with industry-sponsored trials reporting at 17%, while academic/non-NIH-funded trials reported at just 5.7%. The lack of transparency hampers progress and violates obligations to patients.
Columbia University researchers successfully converted human skin cells into hypothalamic neurons, a type that regulates appetite. These neurons provide a patient-specific model for studying the neurophysiology of weight control and testing potential therapies.
The NIH/National Institute of Allergy and Infectious Diseases has launched a clinical trial to test the safety and efficacy of ZMapp, an experimental Ebola treatment. The study will enroll adults and children with known Ebola infection and compare the treatment to standard care.
A study of children with DNA abnormalities on chromosome 16 found a significant delay in processing sound and language, linking the deletion to key biological pathways. The research may lead to future medical treatments for specific subtypes of autism and other neuro disorders.
Researchers found altered patterns and frequencies of electrical activity in dopamine midbrain neurons critical for emotional and cognitive processing. These findings suggest that impaired dopamine neuronal activity contributes to schizophrenia's negative symptoms, such as cognitive deficits and impaired motivation.
A recent study by UT Southwestern Medical Center found that patients with a prior cancer diagnosis have similar clinical outcomes to those without a history of cancer. The researchers studied over 102,000 patients and found that these patients had better overall survival and lung cancer-specific survival rates.
A study by Ivy Haskins at GWU Medical Center investigated the effectiveness of volume-based enteral nutrition support regimens compared to hourly rate-based protocols. The results found that VB protocols provide a significantly greater provision of prescribed calories but may not improve clinical outcomes.
A new review highlights techniques to provide optimal dosing recommendations for patients with kidney disease. Mathematical modeling tools can help analyze clinical program level data to inform dosing decisions.
The Alzheimer's Association has awarded nearly $4 million in new grants to support five Phase 1 and 2a clinical trials exploring innovative treatments for Alzheimer's disease. These grants will help bridge the gap in funding for early-phase clinical drug trials, supporting promising projects from academia and industry.
The National Institute of Allergy and Infectious Diseases has awarded contracts to three organizations to conduct early-stage human clinical trials for investigational infectious disease treatments. The trials will test the safety of novel drugs against a range of emerging and re-emerging pathogens, including viruses and bacteria.
A lack of regulation puts clinical physiologists at risk of causing harm to patients. Clinical physiologists must be properly regulated to ensure patient safety.
The University of Texas at Arlington is leading a multi-institution study to determine the optimal amount and nature of clinical experiences required for nursing school graduates to achieve competency upon graduation. The research involves over 1,700 students and partners with six North Texas health care systems.
The Multiple Myeloma Research Foundation has made landmark genomic and clinical data from the CoMMpass Study available to researchers via the MMRF's Researcher Gateway. This data includes patient-level biomarker and clinical data, genomic information, and treatment responses, offering new avenues for research into multiple myeloma.
Pragmatic clinical trials require collaboration between researchers and health care providers. A new guide emphasizes building strong partnerships, defining clinically important questions, and involving stakeholders in study design. Successful trials produce long-term scientific relationships and evidence for improving care.
A phase I trial of AG-120, an oral inhibitor of mutant IDH1, has shown clinical activity in patients with advanced acute myeloid leukaemia (AML) and the IDH1 mutation. The drug reduced 2-HG levels to normal, allowing cells to mature into normal functioning cells.
Rare cancer patients face scarce clinical evidence due to conventional trial methodologies requiring large patient numbers. The European Organisation for Research and Treatment of Cancer recommends alternative study designs and collaborative networking.
UC San Diego has been designated as one of three 'alpha clinics' by the California Institute for Regenerative Medicine to accelerate clinical development of emerging stem cell therapies. The designation will support the establishment of a comprehensive regenerative medicine clinical hub and attract patients, funding agencies, and study...
The University of Hawai`i Cancer Center has received a $3.5 million NCORP grant to improve cancer care and prevention among minority and underserved populations in Hawaii. The grant will fund clinical trials and research aimed at reducing cancer disparities and enhancing patient outcomes.
A recent clinical trial evaluated heterologous prime/boost regimens for preventative HIV vaccination, demonstrating strong anti-HIV immune responses in healthy volunteers. The results suggest that a regime combining NYVAC-B and rAd5-vectored vaccines yields better outcomes compared to other vaccine combinations.
BioMed Central partners with the University of Michigan to launch an open-access journal focused on clinical research surrounding diabetes and endocrine diseases. The new journal aims to promote better care for patients by sharing new knowledge, both research and clinical, on various aspects of endocrine disorders.
Researchers at Lund University have discovered a new learning mechanism in individual nerve cells, which enables the brain to time its reactions and control complex processes like blinking and intelligible speech. This discovery has significant implications for rehabilitation following stroke, autism, ADHD, and language problems.
The VCU Center for Medication Development for Cocaine Use Disorder aims to develop safe and effective treatments for cocaine addiction. The center will conduct preclinical and early clinical trials, and provide educational resources to train the next generation of translational scientists.
The NCI/FDA workshop resulted in the development of two innovative clinical trials, Lung-MAP and ALCHEMIST, which employ a 'Master Protocol' approach to improve patient outcomes. These trials aim to accelerate the development of targeted therapies for lung cancer by integrating multiple sub-studies based on genomic profiles.
The American Gastroenterological Association has released a new clinical decision tool to guide gastroenterologists in assessing and treating patients with Crohn's disease. The tool synthesizes current literature to create a practical algorithm for clinicians, providing a pathway for better quality care.
The Phase I Clinical Trial of nintedanib combined with paclitaxel showed a 50% complete response rate in early HER-2-negative breast cancer patients. The study's results have validated the safety and efficacy of the drug combination, paving the way for a large-scale Phase II Clinical Trial.
The Phase 1-2a clinical trial demonstrated a 92% objective response rate, including complete remissions in eight patients and partial remissions in four patients. Four out of seven evaluable patients with chemotherapy-refractory DLBCL achieved complete remissions, with durations ranging from 9 to 22 months.
The VCU Massey Cancer Center has been awarded a $4.4 million grant to establish a statewide cancer clinical trials network in Virginia, focusing on minority access and addressing cancer disparities. The network will provide cancer patients with opportunities to participate in clinical trials in their local communities.
A phase I clinical trial for MicroVAX's cancer vaccine has begun in Singapore, assessing safety and immune response against breast, prostate, colon, ovary, and lung cancers. The vaccine targets a common protein on many types of cancer.
The LSU Health Sciences Center New Orleans has received a $5.6 million NCI grant to build a regional cancer clinical trials network, focusing on minority and underserved patients who die at higher rates from cancer. The program aims to provide access to state-of-the-art treatments and create jobs in the biomedical workforce.
Researchers investigated how neurons in the inferior colliculus respond to paired sounds producing precedence-effect illusions. After local GABA application, responses to lagging stimuli were suppressed, providing a potential new approach for improving speech perception in patients with hearing aids under background noise.
Researchers at CWRU aim to boost cancer trial participation by educating oncology nurses. The $1.6 million NCI grant-funded program will test a web-based educational tool, Oncology Nurse IMPACT, to address barriers and increase discussions about clinical trials between nurses and patients.
Researchers aim to improve stroke therapies by studying brain networks linked to movement, particularly hand and arm control. They will use techniques like fMRI and transcranial magnetic stimulation to map brain activity and stimulate specific regions.
Huntsman Cancer Institute will become a key partner in the National Clinical Trials Network, providing access to clinical trials for patients across the Intermountain West region. The institute's unique research assets, including the Utah Population Database and Center for Quantitative Imaging Excellence, will enable multi-institutiona...
A recent study found that nearly 30% of completed clinical trials in the US remained unpublished after four years, threatening the validity of medical research literature. The lack of transparency was particularly pronounced among industry-funded studies and those with smaller sample sizes.
The article highlights female underrepresentation in academic medicine, citing a 53% proportion of women entering medical school. The lack of women in clinical academia is linked to implicit bias, affecting research agendas and future clinical practice.
Researchers found that some brain cells in the amygdala respond to judgments based on a viewer's subjective opinions rather than true emotion expressed. This discovery may provide insight into anxiety and unprovoked fear.
The foundation has committed nearly $49 million to support the careers of 77 physician-scientists across the US since 2000. The Clinical Investigator Award program aims to address the shortage of physicians capable of translating scientific discovery into new cancer breakthroughs.
Researchers at Chalmers University of Technology have developed a new technology that uses microwaves to quickly and accurately diagnose stroke patients. The system, called Strokefinder, has been shown to differentiate between bleeding strokes and clot-induced strokes with great certainty in clinical studies.
Vectra DA data demonstrates clinical utility in assessing risk of future joint damage, with high scores associated with radiographic progression. The test may help identify patients at higher or lower risks for radiographic progression while receiving antirheumatic therapy.
The European Society of Cardiology emphasizes the importance of patient-reported outcomes (PROs) in cardiovascular clinical trials. PROs provide valuable information on aspects of life beyond survival, influencing health technology assessments and reimbursement decisions.
A new study suggests revising the definition of kidney disease progression used in clinical trials could shorten trial length and encourage more trials. This revised definition, based on a decline in estimated kidney function, carries higher risks for end-stage renal disease and mortality but is common enough to facilitate testing.
Researchers at Mount Sinai Hospital have re-examined multiple sclerosis (MS) clinical course descriptions to provide a framework for both clinical research and ongoing clinical care. The proposed 2013 revisions include improved clinical descriptive terminology, MRI imaging, and analysis of fluid biomarkers.
Cancer research calls on institutions to increase Hispanic patient enrollment, highlighting health disparities and underrepresentation in clinical trials. The study emphasizes the need for adequate representation to ensure effective treatment and reduce disparities.
A study finds that clinical trial outcome data is often missing or inconsistent in global databases, making it challenging to access unbiased results. The investigators propose strategies to improve reporting, including simpler trial registration and uniform posting of results on registries.
The University of Chicago Medicine Comprehensive Cancer Center has been awarded a five-year, $3.9-million grant to serve as a Lead Academic Participating Site for the National Clinical Trials Network. The new network aims to improve cancer clinical trials' speed and efficiency.
Beaumont Children's Hospital has been awarded a $20,000 grant from CureSearch to support therapeutic clinical trials for children with cancer. The hospital believes that clinical trials are essential in helping children with cancer, and this funding will enable them to open additional studies and reach more patients.