A study published in Clinical Infectious Diseases demonstrated the pivotal data for T2Candida and T2Dx, detecting Candida species with 91.1% sensitivity and 99.4% specificity in 3-5 hours without blood culture. This technology has the potential to reduce costs, length of stay, and mortality rates associated with Candida infections.
A study of African buffalo found that de-worming drastically improves an animal's chances of surviving bovine tuberculosis. However, this treatment allows infected animals to continue spreading TB within the herd, leading to unexpected negative consequences for the population as a whole.
The Ebola epidemic in West Africa lacks standardized treatment guidelines, with conflicting reports on mortality rates and treatments. Experts propose a range of measures, including the development of guidelines and international cooperation to ensure quality control and transparency.
Researchers have developed a novel treatment approach for persistent viral infections like herpes by blocking the activity of host cell protein LSD1, reducing HSV infection, shedding, and recurrence. This epigenetic therapy shows promise as an antiviral strategy to control shedding and reactivation of latent virus.
A recent study published in Nature Climate Change found that climate change will slow China's efforts to reduce infectious diseases like diarrheal and vector-borne diseases. The researchers predict that changes to the global climate could delay China's progress by up to seven years by 2030.
The Ebola pandemic serves as a stark reminder of the interconnectedness of human, animal, and environmental health. The study emphasizes the urgent need to adopt a One Health approach to detect and prevent infectious diseases, particularly in developing countries.
The article highlights the link between animal health, human health, and the environment in the emergence of infectious diseases. Key findings include the need to build capacity in developing regions and the importance of One Health approach.
QUT researchers have developed a system that can predict dengue fever outbreaks in China by combining internet search metrics with environmental factors. The system achieved a 99.8% success rate in detecting outbreaks within three days, highlighting the potential for early warning systems to reduce the impact of infectious diseases.
This Special Issue examines the evolution of knowledge on infectious diseases, military psychiatry, and surgical pain since World War I. Research highlights the need for new antimicrobial drugs and improved treatments for post-amputation pain, while also discussing the impact of war on healthcare and public health policy.
A new analysis of over 12,000 outbreaks affecting 44 million people worldwide reveals a rising trend in global infectious disease outbreaks, with 65% caused by zoonoses. Despite this increase, the impact of outbreaks is declining on a per capita basis.
Researchers will screen tens of thousands of chemical molecules to identify effective adjuvants for vaccines against infectious diseases. The project aims to develop novel applications for enhancing the immune response against Ebola virus, HIV, and other virus infections.
The NIH has awarded $29 million to expand the Rare Diseases Clinical Research Network, a collaborative effort of physician scientists and patient advocacy groups. This funding will support clinical research and investigation of new treatments for patients with rare diseases, with a focus on improving diagnosis and treatment outcomes.
Researchers found camels to be the primary reservoir of Middle East respiratory syndrome coronavirus (MERS-CoV), shedding the virus in their nasal secretions for up to 35 days. Vaccinating camels may reduce transmission risk to people and other camels.
A meta-analysis of 70 studies found that fludeoxyglucose F18-PET combined with CT is less accurate for diagnosing lung cancer in areas with endemic infectious lung diseases. The pooled sensitivity was 89%, but specificity was lower (61%) compared to non-endemic regions (77%).
The Global Health Innovative Technology Fund (GHIT Fund) has awarded $15.3 million in grants to support the development of promising vaccines and drugs against three insect-borne diseases: malaria, dengue, and Chagas disease. These investments aim to tackle diseases that disproportionately affect the world's poorest populations.
The US National Science Foundation, NIH, and USDA have awarded over $12 million in new research grants to study the ecological and biological mechanisms behind human-induced environmental changes and infectious diseases. Researchers will investigate topics such as landscape structure on disease dynamics and host vaccinations' impact on...
Leading infectious disease experts argue that screening and isolating infected patients may not be effective in preventing MRSA spread. Instead, they recommend a broader approach focusing on reducing all hospital-acquired infections.
The article highlights the importance of recognizing Ebola virus infection and isolating patients in hospitals worldwide. Despite concerns about transmission, experts argue that developed countries' effective hospital infection control practices minimize the risk of further spread.
Researchers have developed a new nasal test that can quickly and accurately diagnose Creutzfeldt-Jakob disease, an incurable neurodegenerative disorder. The test was successfully tested in 97% of patients with the disease and showed 100% specificity for non-patients.
A new paper by UCSB researchers scrutinizes Naegleria fowleri, a heat-loving amoeba causing rare but fatal infections. The study highlights the distinction between sapronotic diseases and conventional infectious diseases.
Researchers analyzed clinical samples from suspected Lassa fever cases in Sierra Leone and found nearly 9% tested positive for Ebola virus. The study demonstrates that Ebola has been circulating in the region since at least 2006.
Endemic infectious diseases continue to affect millions of individuals in the US, with racial and ethnic minorities disproportionately affected. Emerging vector-borne and zoonotic disease infections are threatening new areas and populations.
Boston Medical Center (BMC) has been awarded a five-year $861,000 grant to train Ugandans in basic research on tuberculosis and emerging infectious diseases. The program will provide rigorous training in basic research approaches and enable Uganda's Makerere University to build capacity for conducting basic sciences research.
Researchers found that even uninfected cells can trigger immune defenses against TB by transferring immune-stimulating proteins from infected dendritic cells. This discovery could lead to more effective vaccines, including the BCG vaccine for TB, which works on a similar principle.
Researchers found three diseases have failed to receive official recognition and funding, impacting human and animal health in developing nations. A multidisciplinary One Health approach could improve human and animal health and control these diseases.
Researchers found that most genes from soil bacteria are not poised to contribute to antibiotic resistance in infectious bacteria. The study suggests that sharing of these genes between species is rare, and gene sharing may be driven by exposure to new antibiotics.
The Society for Healthcare Epidemiology of America has released new guidelines prioritizing strategies to reduce the prevalence of Clostridium difficile in healthcare settings. These recommendations emphasize a multidisciplinary approach, including antimicrobial use stewardship, contact precautions, and hand hygiene protocols.
A team of researchers led by David Hughes is studying the role of group size, complexity, and connectedness in driving infectious disease transmission. By analyzing ant colonies, they aim to develop strategies to reduce the spread of diseases, including those affecting humans in schools, hospitals, and farms.
International research group recognizes UTMB professors Frederick A. Murphy and Thomas G. Ksiazek for their groundbreaking work on filoviruses, including Ebola and Marburg viruses. The award acknowledges their decades-long efforts to develop vaccines and treatments for these deadly diseases.
A recent NIH study found that a rare genetic disorder, CDG-IIb, can confer resistance to severe or recurrent viral infections like HIV and influenza. The researchers discovered that these viruses replicate less efficiently in cells with the disease, creating fewer and less infectious viruses.
Scientists at the University of Washington are developing new methods to rapidly identify and treat emerging infectious diseases. The researchers aim to create a flexible arsenal against multiple pathogens, using machine-learning computer modeling and genomic analysis to discover ways to measure disease severity.
Researchers found that heparin interactions with the terminal domains of murine prion protein stabilize the protein, preventing aggregation. This stabilization prevents prion conversion and disease. Heparin may establish groundwork for therapeutic use against prion diseases.
Researchers use shrink wrap to boost signal of fluorescent markers in biosensing, enabling detection of infectious diseases with lower limits of detection. The technique could lead to a low-cost, highly sensitive diagnostic device using common, everyday materials.
Clemson University scientist Lesly Temesvari receives a $147,157 NIH grant to study the stress response in Entamoeba histolytica and potentially develop new therapeutic targets. The research aims to interrupt the parasite's survival mechanisms, which could lead to the discovery of new treatments for the disease.
Researchers have discovered an infectious form of the cat parasite Toxoplasma gondii in western Arctic Belugas, raising public health concerns. The discovery also highlights the impact of climate change on pathogen circulation, allowing previously isolated parasites to spread to new hosts.
Researchers found that internet-based surveillance can detect infectious diseases like Dengue Fever and Influenza up to two weeks earlier than traditional methods. This early detection enables timely public health responses, potentially reducing the spread of epidemics.
Researchers found that young natural killer cells play a key role in preventing infectious mononucleosis caused by Epstein-Barr Virus. A potential vaccination is being explored to protect against EBV infection and reduce the risk of developing Hodgkin lymphoma.
The National Institute of Allergy and Infectious Diseases (NIAID) has named leadership groups and clinical trials units to lead the restructuring of HIV/AIDS clinical trials networks. The new structure aims to increase collaboration, expand research scope to include co-infections, and create transparent mechanisms for idea solicitation.
A new guideline recommends most immunocompromised patients receive annual influenza shots, while those with cancer or undergoing chemotherapy should not. The guideline aims to provide 'one-stop shopping' for clinicians caring for immunocompromised patients.
The University of Pittsburgh's Project Tycho has digitized all weekly surveillance reports for reportable diseases in the US since 1888, revealing patterns and insights into vaccine effectiveness. The database contains data on eight vaccine-preventable diseases, showing a resurgence of some diseases despite vaccination efforts.
The updated HIV care guidelines recommend focusing on preventive care, including screening for high cholesterol, diabetes, and osteoporosis. Primary care physicians should also be familiar with HIV care recommendations to provide comprehensive care to patients with HIV infection.
The Infectious Diseases Society of America has launched a new open access journal, Open Forum Infectious Diseases, which will publish clinical, translational, and basic research findings in infectious diseases. The journal will be fully peer-reviewed and accessible online at no cost.
The National Institute of Allergy and Infectious Diseases is sponsoring a Phase I clinical trial for an investigational genital herpes vaccine candidate, called HSV529. The trial aims to test the safety and immune response of the vaccine in adults aged 18-40 with previous HSV-2 or HSV-1 infections.
The Infectious Diseases Society of America recommends investing in new diagnostic tests that can identify the bug causing an infection faster and provide results more accurately. These tests would help protect antibiotics and ensure patients receive the best treatment for various infectious diseases.
College of Veterinary Medicine researcher Yunjeong Kim is working on a novel approach to combat feline coronavirus and calicivirus infections, which cause life-threatening illnesses in cats. She has identified a promising compound that targets the virus protease, essential for successful replication.
Researchers have discovered that meclizine inhibits mitochondrial respiration, leading to reduced cellular oxygen consumption. This finding opens up new applications for the drug in treating diseases such as heart attack, stroke, and neurological disorders.
A new study found that only 4% of new drugs and vaccines approved between 2000-2011 were for neglected diseases, highlighting a 'fatal imbalance' in R&D efforts. Researchers highlight the need to develop and deliver groundbreaking treatments for poor patients.
A recent study by researchers at the University of Liverpool found that incorporating uncertainties into infectious disease models can significantly improve their effectiveness. The study analyzed previous outbreaks in the UK and found that many models provided only cursory reference to uncertainties, yet still informed policy decisions.
Research finds that maternal smoking impairs infant immunity, leading to a broad range of respiratory and non-respiratory infections. Infants born to smokers are 50% more likely to be hospitalized or die from infectious diseases compared to those born to non-smokers.
Cesar Arias has received the Oswald Avery Award for Early Achievement from the Infectious Diseases Society of America (IDSA) for his groundbreaking work on superbugs and antibiotic resistance. His research aims to combat the growing threat of antibiotic-resistant bacteria and has been recognized globally.
Hospitalized HIV patients are more likely to experience medication errors when cared for by hospital providers unfamiliar with HIV therapy complexities. Involing an infectious diseases specialist can significantly reduce these errors, correcting them in 68% of cases versus 32% without
Firdausi Qadri, a renowned Bangladeshi immunologist, has been awarded the prestigious C.N.R. Rao Prize for her groundbreaking research on enteric diseases and innovative mass immunization strategies. Her work aims to develop new approaches to combat common infectious diseases in developing countries.
Hospitalized patients with severe infections like meningitis and C. diff. experience improved outcomes and shorter hospital stays when treated by infectious diseases specialists. ID consultation reduces readmission rates, ICU days, and total Medicare costs.
The NIH has awarded nine new contracts to strengthen the scope of its Vaccine and Treatment Evaluation Units, increasing funding from eight to nine institutions. The VTEUs will expand their ability to conduct research in domestic and international locations, including resource-poor settings.
The National Institute of Allergy and Infectious Diseases has renewed a 10-year contract with the University of Maryland School of Medicine's Center for Vaccine Development, providing up to $135 million in annual funding. The center will conduct basic research, clinical studies, and vaccine development to combat existing and emerging i...
Duke Medicine has been named a Vaccine and Treatment Evaluation Unit (VTEU) to evaluate vaccines, treatments, and diagnostics. The VTEU will focus on vaccine development for diseases other than HIV, with potential annual funding of up to $135 million.
Scientists from the University of Chicago have developed a unique genetic map that identifies associations between single-gene diseases and complex diseases. The study analyzed over 120 million patient records and found statistically significant correlations between 2,909 disease pairs, including previously unknown comorbidities such a...
The National Institute of Allergy and Infectious Diseases has awarded contracts to nine institutions, including Group Health Research Institute, to expand vaccine and treatment evaluation units. These centers will conduct clinical trials for promising candidate vaccines and therapies, aiming to protect the public from infectious diseases.
The Johns Hopkins Berman Institute of Bioethics has been selected to establish a Center of Excellence to study the ethical, legal, and social implications of genomic research in infectious disease. The center will explore public health genomics in two case studies: pandemic influenza and Hepatitis C.
A UK study finds that only 3.9% of total infectious disease research funding was allocated to antimicrobial resistance, highlighting the need for increased investment in this area. The study calls for strong leadership and sustained targeted spending to combat the growing threat of drug-resistant infections.