Researchers have developed a new integrated genetic/epigenetic DNA-sequencing protocol called MultiMMR that can identify mismatch repair (MMR) deficiency in a single test. This alternative to complex testing workflows determines causes of MMR deficiency often missed by current clinical tests.
Aged African green monkeys developed severe respiratory distress syndrome (ARDS) with symptoms similar to those in human cases of COVID-19 after SARS-CoV-2 infection. The study suggests these monkeys may be suitable models for studying severe forms of COVID-19.
A study found that sudden deaths outside the hospital in New York City followed the geographic distribution of SARS-CoV-2, suggesting an association between the two. The rate of sudden death in 2019 was also predictive of increased sudden deaths during the pandemic surge.
Research from Purdue University and Oklahoma State University found that households purchasing food for children tend to buy more dairy products, including fluid milk and yogurt. This study provides insights into consumer behavior and can inform product marketing efforts and stakeholder decisions in the dairy industry.
Radiologists question the status quo to spark positive dialog and improve patient care. Featured articles debate the use of physician extenders and incorporation of AI algorithms into daily practice.
A survey of school nutrition staff in the US revealed significant concerns about COVID-19 transmission risks and lack of support from authorities. Respondents described feelings of exhaustion, fear, and stress due to high-risk working conditions.
New research highlights the challenges of providing childhood vaccinations in hard-to-reach populations and the emergence of vaccine hesitancy among wealthy families in low- and middle-income countries. Targeted interventions are needed to reduce inequality gaps and ensure universal coverage.
A longitudinal study of first-year university students found that those enrolled in the University of Vermont's Wellness Environment program had improved mood levels and fewer attention problems compared to non-participants. The study suggests that colleges and universities should track students' emotional health and develop specific p...
A new study published in The American Journal of Pathology reports that neutralizing tumor necrosis factor (TNF) can prevent rejection and tissue injury after cell transplantation, improving graft survival and regenerative medicine outcomes. TNF is identified as a master switch for orchestrating cytokines and inflammatory signals.
A new study in the Journal of Dairy Science found that heifers trained on a phantom before introducing an automated milking system visited the actual system more frequently, increasing milk yield. The training program reduced the need for human assistance during milking and prepared animals well for early lactation.
A new study published in the American Journal of Preventive Medicine highlights the devastating impact of structural racism on the health of foreign-born Blacks and Latinx. Chronic exposure to stressors erodes health, with significant disparities found among these groups compared to US-born individuals.
A study published in the Journal of Dairy Science found that kefir sweetened with demerara sugar or fructose has higher sensory acceptance scores and improves consumer emotions, leading to increased consumption.
A panel of experts developed guidelines for accurate determination of death in mountain rescue situations, taking into account the challenges of remote environments. Definitive signs of death include dependent lividity, rigor mortis, and decapitation, but absence of vital signs is not definitive.
Researchers found that self-collected saliva samples can reliably detect SARS-CoV-2 genetic material at a rate similar to nasopharyngeal and oropharyngeal swabs. The study also showed that saliva samples remained stable for up to 24 hours, providing a cheaper and less invasive option for COVID-19 testing.
Researchers found that individuals changed their behavior in reaction to COVID-19 presence 12 days before government lockdowns, underestimating the true impact of social distancing. Sociodemographic variables, such as education level and minority populations, were significantly associated with delays in social distancing behavior.
A recent study found that only seven percent of high-risk noncardiac surgery patients underwent preoperative screening for biomarkers, leading to increased mortality and complications. Researchers emphasize the need for improved compliance with guidelines and education among physicians.
A new study published in the Journal of the Academy of Nutrition and Dietetics found that exposure to small grocery stores with healthier inventories is associated with significant improvements in childhood obesity. In contrast, increased availability of convenience stores selling predominantly unhealthy foods was linked to a higher li...
A new longitudinal study found that individuals with autism spectrum disorder (ASD) experience significant cognitive gains between ages 12 and 23, with IQ increasing by an average of 7.48 points. Early language regression and greater communication problems at age 12 were associated with greater IQ increases.
A nationwide study investigates child nutrition administrative agencies' responses to meal service provision during school closures. Most jurisdictions provided easily interpretable information, but few offered comprehensive implementation guidance or communication with families.
The NCCU project aims to apply evidence-based findings into real-world applications, addressing health disparities in underserved communities. Community advisory boards and focus groups will be formed to engage communities and support mentoring and networking efforts.
A rapid review found extensive evidence of an association between loneliness and increased risk of mental health problems for children and young people. Loneliness is associated with both depression and anxiety, with some studies suggesting a three-fold increase in depression among lonely youth.
A new multiplex real-time RT-PCR assay has been developed as a simpler, more cost-effective alternative to existing SARS-CoV-2 testing methods. The assay performs comparably to the modified CDC test while allowing for increased patient throughput and reduced reagent consumption.
Researchers identified cytoplasmic localized histone deacetylase 6 (HDAC6) as a promising therapeutic target for OA. The study shows that Tubastatin A administration can postpone development of OA and improve cartilage degradation, suggesting it as a potential treatment.
A new study shows that getting only half a night's sleep hijacks the brain's activity during learning and memory consolidation, leading to increased vulnerability to conditions like anxiety and posttraumatic stress disorder. The research found that even partial sleep deprivation can be worse than no sleep at all.
Researchers found that mid-range levels of an immune marker at birth are associated with the lowest risk for autism spectrum disorder. Babies born with high levels of inflammation had a higher risk of developing ASD.
A brief five-week pilot intervention improved preschoolers' behavioral regulation and liking of fruits and vegetables. The study found significant gains in these skills among children who received the intervention, compared to those who did not.
A new study published in the American Journal of Preventive Medicine found that nearly 17% of patients who have recovered from COVID-19 can still test positive for the virus. Patients with persistent respiratory symptoms, such as sore throat and rhinitis, were more likely to test positive.
A rapid and affordable molecular assay using high-resolution melting technology accurately identifies antimicrobial resistant determinants in Neisseria gonorrhoeae, enabling real-time surveillance to control the spread of drug-resistant gonorrhea.
The study found that removing dairy cows from US agriculture would decrease nutrient supplies, particularly calcium and vitamins, while having a minimal effect on greenhouse gas emissions. However, this reduction in essential nutrients could pose challenges for feeding the human population.
The symposium highlighted the importance of resources and education to improve the quality and safety of milk in developing countries. Implementing technology training packages and workshops led to improved productivity, quality, and safety of milk production.
Researchers found that astrocytes play a critical role in forming synapses in response to cocaine exposure, which can contribute to addiction. Blocking these synapses may help prevent relapse, suggesting a new therapeutic target for substance use disorder.
A new study found that women in states with less restrictive reproductive rights policies are less likely to give birth to low-birth weight babies. Specifically, US-born Black women have a 7% lower risk of low-birth weight compared to those in more restrictive states.
A new study assesses nutrition-related features on leading US grocery store websites, finding that 85% of packaged foods have available nutrition facts panels and ingredient statements. However, key information is not always easily accessible or legible, particularly for mandatory labeling on product packaging.
The percentage of children and adults consuming high amounts of sugary beverages decreased significantly between 2003 and 2016. Notably, certain subgroups, including older adults and non-Mexican Hispanic adults, showed little to no improvement in their consumption habits.
Researchers found that abnormal amyloid deposits were present in fewer older adults with major depression compared to non-depressed control subjects. However, the study suggests that depression is still a risk factor for cognitive decline, but through a mechanism other than amyloid deposition.
A new study published in Mayo Clinic Proceedings finds that EPA and DHA supplementation reduces multiple types of cardiovascular risk, including coronary heart disease events and fatal heart attacks. The research concludes that increasing omega-3 intake through supplements or diet can contribute to cardioprotection.
A study of 607 women with severe migraines found 20% avoid pregnancy due to perceived risks, despite evidence that migraine improves in up to 75% during pregnancy. Women with menstrual-related attacks are more likely to delay family planning.
A study published in the American Journal of Preventive Medicine found that weaker gun laws in neighboring states are associated with increased gun deaths in adjoining states. The researchers analyzed 578,022 firearm deaths over a 17-year period and found that stronger state gun policies were linked to decreased firearm deaths.
Researchers found that levodopa stabilized and improved vision in patients with advanced age-related macular degeneration (AMD), reducing the number of treatments necessary. The drug's ability to target the GPR143 receptor led to a decrease in retinal fluid and an improvement in visual acuity.
A study identified three key factors that predict the first occurrence of nonsuicidal self-harm in adolescent girls: low conscientiousness, high avoidance, and parental substance abuse history. These psychological vulnerabilities were found to distinguish girls who initiated self-harm from those who did not.
A recent study by a team of researchers from the University of Bologna has shed light on the Minoan system of fractions, revealing that the lowest fraction is 1/60. The results have significant implications for understanding the Linear B script and its use in measuring units of measurement.
Researchers developed a machine learning approach to examine placentas, decreasing healthcare costs and allowing more women to be informed of their health risks. The algorithm can identify diseased blood vessels indicating preeclampsia risk with high accuracy.
A new study reveals a significant increase in premature deaths from alcoholic liver disease, particularly among younger women. The gap between men and women's mortality rates has narrowed over the past two decades, with women dying on average two to three years earlier than men.
A new study suggests that a COVID-19 vaccine needs to be at least 80% effective to achieve a complete 'return to normal' and prevent an epidemic. Social vulnerability is also linked to increased COVID-19 infection, with specific factors varying among regions and counties.
Research reveals that crossbreeding Holstein cows with Viking Red and Montbéliarde breeds can significantly improve fertility while maintaining milk production. The study, published in the Journal of Dairy Science, found that crossbred cows had better overall well-being, reduced costs of insemination, and longer herd life compared to p...
Researchers found autistic nerve cells differ in structure and gene expression from typical individuals as early as 9 days into development. The study used induced pluripotent stem cells to model brain development and provides new insights into the origins of autism.
Researchers discovered increased levels of neuroprotein sortilin in pancreatic cancer cells, suggesting it as a potential therapeutic target. Sortilin's expression was found higher in female patients and contributed to invasive properties of pancreatic cancer cells.
A new study found that ideal cardiovascular health is associated with lower odds for developing ocular diseases, particularly diabetic retinopathy. Practicing healthy lifestyles such as regular physical activity, healthy diet, and maintaining normal weight may also contribute to good eye health.
A new study published in The American Journal of Medicine estimates that one out of every 100 American children will die from firearms if current death rates continue, while one out of every 70 will die from drug overdoses. The study aims to educate the public and policymakers about the impact of firearm and overdose deaths.
A study published in the Journal of Dairy Science found that sensory characteristics, such as flavor and heat treatment, and habit are key drivers for long-term milk consumption among children. Increasing milk availability in schools and making it more appealing to children can encourage healthy lifelong consumption.