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Fundação de Amparo à Pesquisa do Estado de São Paulo


Mechanism that triggers the inflammatory process by Mayaro virus is discovered

A Brazilian team at FAPESP-supported Center for Research on Inflammatory Diseases identified the strategy used by immune cells to combat the pathogen Mayaro virus. The study provides a basis for the development of drugs against this disease, targeting the NLRP3 inflammasome and its role in producing proinflammatory molecules.

Black carbon found in the Amazon River reveals recent forest burnings

International researchers have found that most of the black carbon transported to the Atlantic Ocean is 'young' and likely results from recent forest fires. The study, published in Nature Communications, used radiometric dating and molecular composition analysis to quantify and characterize the black carbon flowing in the Amazon River.

Study measures impact of agriculture on diet of wild mammals

Researchers analyzed stable carbon and nitrogen isotopes in fur samples from 29 species of mammals to measure the impact of agriculture on their diet. The study found that herbivores and omnivores inhabiting forest fragments consumed agricultural resources, while carnivores close to croplands preyed on prey that feed on these resources.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalProceedings of the National Academy of Sciences·DateNov 18, 2019

Protecting native vegetation on rural properties yields Brazil USD 1.5 trillion per year

The study estimates that preserving 270 million hectares of native vegetation yields Brazil USD 1.5 trillion per year in ecosystem services such as crop pollination, pest control, and water security. This research supports the importance of Legal Reserves and Permanent Conservation Areas in maintaining environmental services.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalPerspectives in Ecology and Conservation·DateNov 14, 2019

Listening to music while driving reduces cardiac stress

A study by Brazilian researchers found that listening to instrumental music attenuates cardiac stress while driving, increasing parasympathetic nervous system activity and reducing sympathetic nervous system activation. This can contribute to the creation of cardiovascular preventative measures for situations of acute stress.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalComplementary Therapies in Medicine·DateNov 12, 2019

A novel method for analyzing marine sediments contributes to paleoclimate reconstitution

Researchers developed a novel method using quartz and feldspar grains from the Parnaíba River in Brazil's Northeast region. The analysis reveals significant differences in luminescence between samples from headwaters and lower reaches of the river, reflecting changes in precipitation patterns over the past 30,000 years.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalPaleoceanography and Paleoclimatology·DateNov 6, 2019

Study aims at boosting antitumoral activity of compound extracted from an Amazon plant

Researchers in Brazil have successfully developed a modified strain of Uncaria guianensis, a medicinal plant native to the Amazon Rainforest. By modifying its alkaloid production using 'precursor-directed biosynthesis,' the team was able to create more potent chemicals with enhanced therapeutic effects.

Novel formulation of an injectable drug to treat joint inflammation acts for ten days

Researchers developed an injectable drug formulation using lipid nanoparticles to sustain the effect of naproxen in treating temporomandibular joint inflammation. The study showed significant reduction in inflammation and absence of side effects, making it a potential treatment option for this condition.

Ultrafast particle interactions could help make quantum information devices feasible

Researchers detected energy transfer from excited electrons to the crystal lattice on the femtosecond timescale, enabling the development of materials that retain energy for longer periods. This study contributes to the retardation of decoherence and the creation of quantum information devices such as optical switches.

Acute chikungunya infection studied at the molecular level in Brazilian patients

Brazilian researchers used computational tools to analyze blood cells from patients infected with chikungunya virus, identifying genes associated with the disease and potential biomarkers of predisposition to chronic joint pain. The study suggests that certain gene signatures can be explored as therapeutic targets.

High diversity of harvestmen in Atlantic Rainforest and ancient geological events

The study found that ancient geological events, such as mountain range uplift and river formation, drove the emergence of new species of harvestmen in the southern portion of the Atlantic Rainforest. This discovery challenges the assumption that climate fluctuations are the primary cause of high biodiversity in this biome.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalMolecular Phylogenetics and Evolution·DateAug 22, 2019

Physical activity in adolescence and later life reduces the risk of colorectal adenoma

A study analyzing data from almost 30,000 nurses found that physical activity in adolescence and later life cumulatively reduce the risk of advanced adenomatous polyps, a precursor to colorectal cancer. The study showed that adequate physical activity in both adolescence and adulthood reduces the risk by 39%.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalBritish Journal of Cancer·DateAug 19, 2019

Thyme essential oil in corn starch particles combats Aedes aegypti larvae

Researchers developed a novel, biodegradable larvicide system using thymol from thyme essential oil, which is effective against Aedes aegypti mosquitoes. The system uses microcapsules made of corn starch particles to control the release of larvicide, making it suitable for small water containers and reducing environmental harm.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalIndustrial Crops and Products·DateAug 6, 2019

Biomarkers confirm higher incidence of thyroid cancer among World Trade Center responders

A method developed by Brazilian and US researchers confirms a three-fold increase in thyroid cancer incidence among WTC responders compared to the general population. The four-biomarker panel distinguishes between malignant and benign tumors with no false positive results, enabling early detection and treatment.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalInternational Journal of Environmental Research and Public Health·DateAug 5, 2019

Low muscle mass in arms and legs can heighten the mortality risk in older men and women

A study of individuals over 65 years old found that low appendicular muscle mass significantly increased all-cause mortality risk nearly 63-fold in women and 11.4-fold in men. The researchers used DXA body composition analysis to determine the correlation between body composition factors and mortality risk.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalJournal of Bone and Mineral Research·DateJul 31, 2019

Cannabidiol reduces aggressiveness, study concludes

A Brazilian study found that cannabidiol attenuates social isolation-induced aggression in mice by facilitating the activation of serotonin and CB1 receptors. The researchers used a resident-intruder test model to demonstrate that lower doses of cannabidiol inhibit aggressive behavior, while higher doses have little effect.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry·DateJul 29, 2019