A new experimental drug that inhibits AHR has been shown to effectively combat Zika virus replication and prevent microcephaly in mouse fetuses. The study found a significant reduction in viral load and histopathological changes, suggesting a promising antiviral therapy.
Researchers discovered a hybrid fungus, Aspergillus latus, in a hospital environment, which is up to three times more drug-resistant than its parental species and highly dangerous. The study aims to investigate the role of fungi in COVID-19 and improve treatment strategies.
Scientists at São Paulo State University identify 19 Centaurs of interstellar origin with highly inclined orbits, suggesting they formed around other stars and were later captured by the Solar System. This discovery sheds light on the formation of the Solar System and the chemical enrichment of the Sun.
The discovery of the DRIK1 protein has opened up new avenues for developing more drought-resistant plants. By identifying a synthetic molecule that binds to the protein, researchers aim to breed plants with naturally reduced or inhibited activity, reducing losses related to climate change.
Researchers have successfully treated horse melanomas using Amblyomin-X, a protein derived from tick saliva. The treatment resulted in tumor shrinkage and remission in some cases, with no adverse reactions reported. Further analysis of signaling pathways revealed activation of the innate immune system's rapid response.
A Brazilian biotech startup is developing a low-cost, high-performance COVID-19 diagnostic test using only locally sourced inputs. The test uses a cell-free protein synthesis technology to accelerate and optimize protein production processes.
A review article by Brazilian researchers highlights the risks of short periods of inactivity on the cardiovascular system and recommends exercising at home during the pandemic. Exercise can help control blood pressure, reduce inflammation, and improve quality of life, even for high-risk groups.
Researchers at São Paulo State University developed a computational tool tracking COVID-19 growth rates across over 200 countries. The 'COVID-19 accelerometer' plots real-time growth curves to assess the effectiveness of public policies aimed at containing the pandemic.
A recent study found that the international trade in timber, tobacco, cocoa, coffee, and cotton significantly contributes to malaria risk in countries with deforestation hotspots. The research linked over 10% of malaria cases to demand from developed countries for these commodities.
Researchers developed a thermoluminescent material that responds to UV radiation, overcoming current limitations in personal and environmental UV dosimetry. The new material enables accurate detection of UV exposure and has potential applications in various fields.
Researchers at the University of São Paulo's Engineering School have developed a low-cost mechanical ventilator that costs approximately 7% as much as conventional ventilators. The device has already been tested in animals and humans and shows promise in treating patients with acute respiratory syndrome, a severe outcome of COVID-19.
A study used satellite images and machine learning to analyze forest fragment degradation and regeneration in the Atlantic Rainforest. Researchers found that certain tree species indicate forest regeneration, while others mark degraded areas.
Brazilian pulmonologist Dr. Elnara Negri argues that COVID-19 should be treated as a thrombotic disease, citing the use of anti-coagulant drug heparin to improve patient outcomes. She reports a successful treatment protocol with 80 patients, with none dying and four in ICU.
Brazilian researchers found Zika virus can infect multiple regions of the placenta, highlighting the need to collect and store samples properly. Diagnostic tests must consider these regions to ensure accurate results.
A Brazilian startup has developed a novel COVID-19 patient monitoring system that utilizes Internet of Things (IoT) technology to track clinical signs in real-time. The system alerts medical teams to patients with deteriorating conditions, enabling timely hospital referrals and reducing the risk of contagion.
A new study has identified a group of genes with altered expression in autism spectrum disorder, affecting communication among neurons. The discovery could lead to improved diagnosis and treatment by targeting these genes.
Researchers have discovered that patients with breast cancer develop alterations in monocytes, a type of leukocyte, early in the disease course. This finding paves the way for enhanced diagnosis and treatment of breast cancer, potentially allowing for earlier identification of aggressive tumors and personalized immunotherapy strategies.
A study at Harvard Medical School found that administering CoQ10 reverses damage to germinative cells caused by BPA exposure. The antioxidants reduced oxidative stress and cell death rates in worms exposed to BPA, suggesting a potential strategy for reversing BPA-induced fertility issues.
Researchers have developed a zinc-doped manganese chromite crystal with significant technological potential. The material exhibits paramagnetic-to-antiferromagnetic phase transition at 19 kelvin, making it suitable for various applications.
A startup-developed AI system using facial recognition and thermal imaging detects fevers remotely in people near hospital front desks, alerting staff to potential COVID-19 cases. The system has been successfully implemented at Albert Einstein Jewish Hospital in São Paulo, Brazil.
A study by researchers at the University of São Paulo has identified a promising technological alternative to solvents used in batteries. Highly concentrated aqueous electrolytes offer significant advantages over conventional methods, including being nontoxic and cheaper. However, challenges such as hygroscopicity and corrosion need to...
Magnamed will supply 6,500 mechanical ventilators to hospitals in Brazil by August to help meet growing demand during the COVID-19 pandemic. The company partnered with several leading Brazilian and multinational corporations to achieve this goal.
A new diagnostic strategy has been developed by Brazilian researchers to detect biomarkers of early-stage multiple sclerosis. The method uses a nanobiosensor that can accurately identify specific antibodies in cerebrospinal fluid and blood serum, allowing for early diagnosis and treatment.
Researchers have identified two novel viruses in Brazilian patients with suspected dengue, one from the Ambidensovirus genus and the other from Chapparvovirus. The study used metagenomics to analyze blood samples and found an unexpected presence of these viruses in human hosts.
A study found that 54.8% of COVID-19 cases imported to Brazil by March 5 came from Italy, while 24.9% traveled from Italy to São Paulo. The virus spread quickly in Brazil, with the first cases reported in São Paulo City, and sustained community transmission now prevails.
A study conducted in northwestern São Paulo found that nearly a third of the population under 40 lacked immunity against measles, with only 1% over 50 showing similar results. Vaccination remains essential in preventing transmission and controlling outbreaks.
The study found that extreme rainfall days have increased significantly in metropolitan São Paulo, with a four-fold rise over the past seven decades. The researchers also observed an increase in consecutive dry days, suggesting that heavy rainfall events are becoming more concentrated in shorter periods.
Researchers at the Butantan Institute and Boston Children's Hospital have developed a novel pneumonia vaccine capable of providing protection against all serotypes of Streptococcus pneumoniae. The vaccine is less expensive and more effective than current vaccines, with an estimated price of $2 per dose.
Researchers identified 497 genes expressed in resistant mice and 22 genes in susceptible mice, showing the development of disease depends on host genetics. The study aims to develop biomarkers for diagnosis and treatment of leishmaniasis.
A study by Brazilian researchers suggests the Solar System took shape in its current form between 10-60 million years after its formation. The model, supported by São Paulo Research Foundation - FAPESP, reveals a chaotic phase that placed objects in their current orbits within the first 100 million years.
Researchers found that smaller forest fragments result in fewer species and interactions between plants and seed-dispersing birds. This leads to a loss of ecological functions, including constant forest regeneration, with larger bird species playing a crucial role in dispersing large seeds.
Researchers tested zika virus as a therapy for dogs with spontaneous brain tumors, achieving tumor reduction and longer survival. The treatment was well-tolerated and safe, with no adverse side effects.
Researchers developed a computer program analyzing molecules in blood plasma to identify individuals at risk of becoming overweight and developing obesity-related diseases. The test is 90% accurate in detecting whether the subject will gain weight without intervention, also predicting diabetes and other health risks.
Researchers found that destroying 25% of a one-hectare Atlantic rainforest fragment can raise the local temperature by 1°C. Clear-cutting the entire fragment would increase temperatures by up to 4°C, threatening the biome's carbon balance.
Researchers at the University of São Paulo, Adolfo Lutz Institute, and Oxford University have published the complete genome sequence of SARS-CoV-2 in Brazil. The study reveals differences between the genomes of viruses isolated from two Brazilian patients, suggesting internal transmission is occurring in European countries.
Researchers in Brazil identified a gene expression profile associated with cachexia, a potentially fatal syndrome characterized by severe weight loss and muscle wasting. The study found that pancreatic, esophageal, colorectal, stomach, and head-and-neck cancers are most frequently linked to cachexia.
A Brazilian research group uses VideometerLab, a multispectral imaging instrument, to analyze pupae and detect dead or empty insects. The device provides precise data on sample quality, improving the efficiency of biological control.
A study found that prenatal hypoxia may contribute to schizophrenia by altering the functioning of astrocytes and mitochondria. Researchers investigated the effects of hypoxia on rat astrocytes and observed changes in mitochondrial calcium balance, which can lead to cell death.
Brazilian researchers found a correlation between salivary uric acid levels and body fat percentages in teenagers, suggesting a reliable biomarker for early detection of chronic diseases. The study identified the level of uric acid in saliva as a good predictor of body fat percentage.
Researchers have developed a novel formulation that reduces the toxicity of crotoxin, a toxin from rattlesnake venom, and enhances its analgesic effect. In an animal model of neuropathic pain, the formulation demonstrated promising results, with longer-lasting analgesic effects compared to traditional treatments.
A novel simplified biotechnological route has been developed to convert sugarcane bagasse and wheat straw into fine chemicals. The new process uses a cascade of three catalytic enzymes to release ferulic acid from lignocellulosic biomass and convert it directly into coniferol, resulting in high conversion yields.
Researchers used high-resolution microcomputed tomography to study the anatomy of three known specimens of T. marauna, a Neotropical electric fish species. The study revealed characteristics of the fish's bones without requiring dissection, providing new insights into this rare species.
Researchers from Brazil, the UK, and Italy developed a novel palladium compound that acts selectively and powerfully against ovarian tumor cells without affecting healthy tissues. The compound has shown twice the potency of cisplatin against resistant tumor cells.
Researchers propose combining fever resistance with temporary tolerance promoted by controlled hypothermia for studying and treating severe conditions like sepsis. This innovative concept aims to understand human physiology's integrated defense strategies against infection.
Brazilian scientists led by Rodrigo Ramos Catharino found that Zika virus inhibits tumor cell proliferation in prostate cancer cells, even when inactivated. The study, supported by FAPESP, used a human prostate adenocarcinoma cell line and identified markers of metabolic changes caused by the virus.
Researchers found that smoked cannabis use impaired executive functions and increased the likelihood of relapse among cocaine addicts. The study suggests that harm reduction strategies using cannabis may not be effective in treating cocaine addiction.
Researchers identified secondary and tertiary fission clusters in young asteroid families formed by collision. The discovery challenges the long-held view that fission clusters and collisional families are distinct.
A team of Brazilian researchers has developed a technique to create functional mini-livers using human blood cells and 3D bioprinting. The innovation allows for the production of hepatic tissue in the laboratory in just 90 days, and may become an alternative to organ transplantation in the future.
Researchers have identified a genetic signature associated with the degree of pathological angiogenesis in breast cancer tumors. The study combined gene expression profiles from public databases with analysis of retinopathy models to uncover key genes involved in pathological angiogenesis, providing a new tool for breast cancer treatment.
Researchers found that the sympathetic nervous system can limit the generation of effector responses by inhibiting the action of cells attacking an antigen. This discovery opens up opportunities for novel therapies in autoimmune diseases like multiple sclerosis.