Researchers found that Parkinson's patients exhibit 53% lower step length synergy while crossing obstacles compared to healthy subjects. This impairment affects gait timing and foot positioning, making it difficult for patients to navigate obstacles safely, increasing the risk of falls.
A new technique developed by HUG-CELL reconstructs livers in the laboratory using extracellular matrix and human cells. The method, which can be used to produce other organs as well, shows promise for increasing organ supply and reducing rejection risks for transplant patients.
A study analyzing socioeconomic and environmental indicators for the São Paulo Macrometropolitan Area found environmental inequity and dependency. The analysis detected asymmetries that impair mutual exchange between cities, with some providing essential services like water, food, and power generation while others receive them.
Researchers found that high-fiber compounds reduced the expression of a gene and cytokine receptor involved in viral cell entry and inflammation. The findings suggest that high-fiber diets may help control inflammation caused by COVID-19, which can lead to gastrointestinal symptoms and changes in gut microbiota.
Researchers at UFSCar in Brazil have developed a novel luciferin-luciferase system that produces far red light at 650 nanometers, three times brighter than natural luciferin and luciferase. This system has better thermal stability, cell membrane penetrability, and more lasting continuous bioluminescence.
Researchers discovered the Leishmania parasite's arsenal to affect cellular defense and enhance leishmaniasis, using autophagy to block caspase-11. The findings shed light on a key mechanism involved in other diseases and may lead to novel treatments for leishmaniasis.
A study from Brazil's University of São Paulo used self-assembled molecular monolayers to create biosensors for detecting the gene PCA3, which is specific to prostate cancer cells. The technique can also be used to diagnose infectious diseases like COVID-19, offering a non-invasive alternative to current methods.
Researchers developed a non-invasive methodology using artificial intelligence to analyze crop seed quality. The technique uses light-based technology and machine learning to identify immature or poor-quality seeds, avoiding the need for destructive germination tests and providing more accurate results in less time.
Researchers discovered a novel pathway linking T-lymphocyte extracellular vesicles loaded with microRNAs to increased osteoclast formation and bone erosion. The study suggests that these extracellular vesicles act as inflammatory mediators, inducing differentiation of osteoclasts via inhibition of cyclooxygenase 2.
Researchers found that dynamic stretching can improve kicking accuracy, while intense physical exercises have a negative effect on kick velocity. Consumption of carbohydrate beverages during matches also enables players to maintain adequate kicking performance.
Researchers at the University of São Paulo's Chemistry Institute have successfully controlled enzyme activity using infrared laser irradiation and gold nanoparticles, enhancing lipase biocatalysis by up to 58% compared to nanospheres.
A new class of nanomaterials made from perovskite have improved the efficiency of quantum dots, allowing for brighter displays and more efficient electronics. By analyzing the interactions between bright and dark states, researchers were able to verify energy alignment and make discoveries regarding electron behavior.
A study found that deforestation in the Amazon leads to an increase in antibiotic-resistant soil bacteria, with a larger number of genes and molecular mechanisms detected in deforested areas than in forested ones. The researchers warn that these microorganisms can pose a significant public health risk if they reach humans.
Bacterial mutants struggling to survive due to nutrient scarcity often form clusters to cooperate and share nutrients, rather than competing with wild-type bacteria. This cooperative behavior masks the true frequency of mutations, making it seem like a lower rate of mutant emergence is occurring.
Researchers have confirmed the safety of an anti-inflammatory peptide, TnP, which shows promise in treating chronic inflammatory diseases like multiple sclerosis. The peptide has been tested in zebrafish and shown to be non-toxic, crossing the blood-brain barrier without causing neurological problems.
Researchers successfully targeted Cryptococcus species using reprogrammed CAR T-cells, effectively controlling the growth of fungi. The treatment showed promising results in vitro and in mice, with reduced titan cells indicating a good prognosis for new treatments. This innovative approach could also be applied to other fungal infections.
A study by researchers at the University of Campinas investigated optomechanical coupling, creating a theoretical model that was validated by simulations and comparisons with experimental results. The researchers found that both dispersive and dissipative interactions occur in microcavities, which can contribute to advances in fields s...
A research group from Brazil, Argentina, Chile, and the UK propose six criteria to mitigate the impacts of invasive species. The guidelines include a detailed survey of the situation and recommended responses such as cost-benefit analysis and intervention strategies.
A team of researchers characterized the tools used by bearded capuchin monkeys in Brazil's Serra da Capivara National Park. The study found that different activities created unique use-wear marks on the tools, allowing for identification of their purpose and usage.
A Brazilian study reveals that human activities have caused biodiversity and biomass losses in over 80% of the remaining Atlantic Rainforest fragments. The destruction corresponds to the loss of 70,000 km² of forest, worth $2.3-2.6 billion in carbon credits.
A groundbreaking study aims to create predictive models to monitor and combat epidemics of yellow fever and other mosquito-borne diseases. By analyzing factors such as deforestation, rainfall variations and non-human primate populations, researchers hope to develop models that can predict outbreaks and protect the public.
Researchers found that the black and white tegu lizard's baroreflex mechanism is more efficient at lower temperatures, relying on vascular adjustments rather than heart rate alterations. This discovery provides new insights into the physiology of ectothermic animals and paves the way for further research on novel applications.
A two-year study in Brazil found that fertilizing a grass cover crop with potassium improved cotton fiber quality, leading to higher market value. The technique also reduced production cost by optimizing operational logistics and conserving water.
Researchers found that higher lung ultrasound scores correlated with increased risk of ICU admission, intubation, and death in severe COVID-19 patients. The study used a scoring protocol covering 12 lung regions to predict patient outcomes.
Researchers developed a template-free technique to fabricate flexible cilia mimicking biological functions, with applications in transporting substances into cells or directing fluids. The cilia's motion can be controlled by a magnet, and their length can be varied from 10 to 100 microns.
A study published in PLOS ONE analyzed dream reports from 67 subjects produced during the pandemic, finding a higher prevalence of negative emotions and terms related to cleanliness and contamination. The researchers used natural language processing tools and mathematics to extract semantics, highlighting the continuity between dreams ...
Researchers developed a 10-minute COVID-19 diagnostic test using nanoparticles that can detect IgG antibodies and is priced at about 1/5 of similar devices on the market. The test costs around $5.50, or 30 Brazilian Reais, once approved by ANVISA.
A study published in Frontiers in Immunology found that Brazilians of African descent are less likely to find a donor in the National Register of Voluntary Bone Marrow Donors, with an up to 60% reduction in chances. The lack of representation and genetic diversity makes it harder for individuals with African ancestry to find compatible...
BIOinFOOD's new test uses genetically modified brewer's yeast to detect SARS-CoV-2 presence in saliva, promising high sensitivity and speed. The test is expected to be available by mid-2021 and may use red light for easy identification.
Researchers found that melatonin synthesized in the lungs acts as a barrier against SARS-CoV-2, preventing expression of genes that encode proteins in cells serving as viral entry points. The hormone also inhibits immune response to allow virus to remain in respiratory tract for a few days.
A Brazilian study found that children born to obese mothers are more prone to developing metabolic disease due to a lack of the Mfn2 protein in their mother's eggs. This protein regulates mitochondrial function and energy production, leading to abnormal mitochondria shape and dysfunction.
Researchers found that scorpion venom triggers a systemic neuroimmune reaction leading to pulmonary edema and cardiac alterations. Administration of corticosteroids, such as dexamethasone, can quickly inhibit the inflammatory process and prevent death in mice.
Brazilian researchers estimate a 35% reduction in physical activity and a 28% increase in sedentary behavior during the initial months of pandemic confinement. This could result in an annual increase of over 11 million new cases of type 2 diabetes and more than 1.7 million deaths.
A study by São Paulo State University reveals that large fruit-eating mammals like peccaries and tapirs increase soil nitrogen levels, making areas more fertile for plants. This boosts plant growth, supporting the ecosystem, particularly in tropical forests.
Analysis of upward flashes suggests a possible explanation for the formation of luminous structures after electrical discharges split in the atmosphere. The study found that a low-luminosity discharge with a structure resembling a paintbrush may change direction, split in two, and define the path of the lightning flash.
Researchers associate the enzyme LMWPTP with chemotherapy resistance, metastasis, and autoimmune diseases. Inhibiting this protein phosphatase could lead to novel monitoring and treatment opportunities for cancer and other diseases.
Researchers have deciphered the structure of a protein found in parasites that cause elephantiasis and cutaneous leishmaniasis, enabling the search for more potent molecules capable of directly destroying pathogens. The study aims to reduce or avoid adverse side effects of current treatments.
A novel method identifies areas most suitable for the conservation of the endangered black lion tamarin, considering both climate and landscape factors. The study used modeling to pinpoint areas with suitable forest cover and climate, indicating a need for targeted strategies in forest restoration to connect fragmented habitats.
Researchers found that acute intervention in epigenetic mechanisms produces antidepressant-like effects more rapidly than conventional drugs. The study used epigenetic modulators to 'erase' the damage done by stress to neuroplasticity, showing a potential faster route to treating depression.
Researchers developed a novel spectroelectrochemical cell to study electrolyte behavior, improve fuel cell performance, and analyze catalyst efficiency. The device can perform in situ infrared spectroscopy, Raman spectroscopy, and X-ray absorption/diffraction analysis.
A Brazilian researcher conducted an experimental study of electron-plasma interactions, simulating plasma conditions in a vacuum using short electromagnetic waves. The study found that electrons transfer energy to the wave and then receive energy from it, with non-linear effects occurring at high electric current values.
Researchers have discovered that scorpion venom molecule VmCT1 is effective against all three stages of the parasite that causes Chagas disease. Novel analogs with arginine substitutions displayed enhanced biological activity and better selectivity, offering new prospects for treatment.
A recent study by Brazilian researcher Emmanuel Albuquerque de Souza shows that maresin and resolvin produced from omega-3 fatty acids can stimulate periodontal ligament stem cells even in the presence of inflammation. This finding has significant implications for regenerative therapy in treating periodontal disease.
Researchers at UNICAMP conducted over 120 experiments to model Mars' long, slow-moving barchan dunes. They identified five basic types of interaction between the dunes, including chasing and merging mechanisms.
Researchers found a drug used to treat pulmonary hypertension significantly reduced tumor cell migration and invasion, and showed promise in slowing breast cancer progression. The study aims to conduct clinical trials with patients undergoing chemotherapy to further investigate the treatment's effectiveness.
Researchers developed a wearable device called Biomechanics Sensor Node that captures user data and controls virtual environments. The system stimulates sensory systems, especially sight and hearing, to intensify central nervous system information input and output.
Researchers at São Paulo State University developed a biodegradable film for food packaging made from bacterial cellulose scraps and hydroxypropyl methylcellulose. The product outperforms traditional films, with improved mechanical strength and reduced water vapor permeability.
Researchers found that some caterpillars have bodies covered with molecules identical to those of the plants they inhabit, making them 'invisible' to ants. Others produce a caloric reward for ants to coexist, demonstrating a form of chemical mimicry and potential adaptive advantage.
The study found that black people and women were the most affected by the pandemic, with three informal workers losing jobs for every one formal worker terminated. The emergency aid program had a limited impact, mainly benefiting large employers and those on minimum wage, but failed to cover small and medium enterprises.
The FAPESP COVID-19 Research Webinars will address manufacturing and distribution logistics of the COVID-19 vaccine portfolio. The event features expert speakers from leading institutions, including Tiago Rocca, Margareth Dalcolmo, and Prashant Yadav.