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Fundação de Amparo à Pesquisa do Estado de São Paulo


Change in vaccination strategy averted outbreak of urban yellow fever in São Paulo State, scientists say

An updated vaccination strategy is credited with averting an outbreak of urban yellow fever in São Paulo State, according to research published in Scientific Reports. The study found that the virus spread rapidly, reaching cities never affected before, and that a high number of cases were reported in areas with low vaccination coverage.

Heparin dose capable of preventing COVID-19 deaths is four times higher than the dose recommended by WHO

A clinical trial of 465 patients found that administering heparin in therapeutic doses reduced mortality from COVID-19 by 78%, with benefits only observed when administered between seven and 14 days after symptom onset. The study suggests that timing is crucial for treatment efficacy.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·TypeRandomized controlled/clinical trial·DateOct 29, 2021

Artificial intelligence accelerates search for markers of resistance to sugarcane yellow leaf disease

Researchers used machine learning and genomics to identify molecular markers of resistance to sugarcane yellow leaf disease in over 97 sugarcane genotypes. The study found that energy cane varieties with higher fiber content are more resistant to the disease, paving the way for commercial launches.

Scientists discover how forest fires influence rain cloud formation in the Amazon

A Brazilian study reveals that forest fires and wildfires modify the freezing process of cloud droplets, altering natural cloud functioning and potentially impacting precipitation. The research used a large dataset to show that aerosols emitted by fires can affect cloud formation in southern Amazonia during the rainy season.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalNature Communications·TypeData/statistical analysis·DateOct 27, 2021

Aquatic fungus has already wiped amphibians off the map and now threatens survival of terrestrial frogs

A study in the Atlantic Rainforest detected high mortality rates among tiny frogs known as pumpkin toadlets infected with the chytrid fungus. The infection causes a physiological imbalance leading to death from a heart attack. Climate change and drought may exacerbate the threat to terrestrial amphibians.

Climate change caused the devastating floods in part of Brazilian´s Southeast region, study says

A study found that climate change increased the probability of heavy rainfall by 70% in Brazil's Minas Gerais state, leading to severe flooding, deaths, and massive damage. The extreme event caused over 90,000 people to be temporarily homeless and resulted in significant economic losses.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalClimate Resilience and Sustainability·DateOct 19, 2021

Children repeatedly exposed to malaria from birth are more likely to be anemic by the age of two

A Brazilian study found that children exposed to malaria from birth are more likely to develop anemia by age two. The researchers, led by Dr. Marly Augusto Cardoso, followed 1,539 children and discovered that 12.6% were anemic, with a higher prevalence in rural areas not covered by the study.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalPLOS Neglected Tropical Diseases·DateOct 13, 2021

Study reveals how saline solution can inhibit replication of SARS-CoV-2

Researchers at the University of São Paulo found that a hypertonic saline solution can inhibit SARS-CoV-2 replication by up to 88% in human epithelial lung cells. The study suggests that the use of such a solution could contribute to the development of novel prophylactic interventions or treatments for COVID-19.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalACS Pharmacology & Translational Science·DateSep 21, 2021

Researchers identify a novel cell type that makes survivors of sepsis more susceptible to infections

Studies on mice and septic patients show that a specific B lymphocyte subpopulation produces large amounts of CD39, leading to increased adenosine levels and reduced macrophage activity. This results in heightened susceptibility to opportunistic infections, with survivors experiencing a sevenfold higher risk of severe infections.

Older people with abdominal fat and weak muscles are more likely to develop mobility problems

A Brazilian-UK study found that older individuals with both abdominal fat and muscle weakness experience a significant loss of gait speed over eight years. This decline can lead to difficulty walking and increased risk of falls, impacting independence. Researchers urge health workers to measure abdominal fat and muscle strength to pred...

Pregnant women with COVID-19 face higher risk of pre-eclampsia, study shows

A review of scientific literature found pregnant women infected by SARS-CoV-2 have a higher risk of developing pre-eclampsia due to reduced ACE2 availability. ACE2 plays a crucial role in placental development, blood pressure control, and fetal development, making its impairment more susceptible to serious complications.

First genetic sequencing of Brazilian pit viper is completed

Researchers completed the first genetic sequencing of a Brazilian snake's genome, revealing that most toxin genes likely arose from existing functions in ancestral species. The study identified markers for comparing toxin genes with non-toxic 'ancestral' genes, shedding light on the evolution of venom production.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalProceedings of the National Academy of Sciences·DateAug 16, 2021

Combination of muscle strengthening and aerobic exercises can reduce cancer mortality

A systematic review of epidemiological studies found that muscle strengthening exercises associated with aerobic activities can significantly reduce cancer mortality. The analysis suggested that strength training twice a week can protect against cancer, with the benefit being even greater when combined with aerobic activities.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalInternational Journal of Behavioral Nutrition and Physical Activity·TypeMeta-analysis·DateAug 9, 2021