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Fundação de Amparo à Pesquisa do Estado de São Paulo


Researchers map incidence of malaria in pregnancy in Brazil

A study published in Lancet Regional Health – Americas found that malaria in pregnancy is still a major public health problem in the North of Brazil, with younger women being most at risk. The researchers believe that expansion of healthcare services and inclusion of artemisinin in therapeutic schemes contributed to the decline in cases.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalThe Lancet Regional Health - Americas·DateAug 16, 2022

North Atlantic temperature helps forecast extreme events in Northeast Brazil up to 3 months in advance

A study by Brazilian, Chinese, Australian, and German researchers found that North Atlantic temperature can predict reduced rainfall and intense droughts in the Northeast region of Brazil. The findings suggest a more persistent influence of the North Atlantic than previously thought.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalGeophysical Research Letters·DateJul 21, 2022

Novel compounds discovered in marine sponge can kill drug-resistant bacteria

Brazilian researchers have identified bioactive compounds in a marine sponge that killed antibiotic-resistant bacteria, paving the way to develop new drugs. The substances proved capable of eliminating bacteria such as Escherichia coli and Staphylococcus aureus, which are responsible for many hospital-acquired infections.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalJournal of Natural Products·DateJul 13, 2022

Physical exercise boosts beneficial cardiovascular effects of losartan in men with high blood pressure

Researchers found that aerobic exercise improves autonomic regulation of the heart and contributes to proper functioning of the cardiovascular system. Walking for 45 minutes three times a week increased heart rate variability, a scientifically validated parameter to assess the functioning of the autonomic nervous system.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalClinical and Experimental Hypertension·DateJun 22, 2022

Molecule that combines three distinct technologies against most aggressive type of brain cancer is tested

Researchers have developed a molecule that uses nanotechnology, chemotherapy and a monoclonal antibody to target glioblastoma multiforme, the most aggressive type of brain cancer. The treatment showed promise in isolated cells and animal models, with significant reductions in tumor volume and no increased toxicity.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalInternational Journal of Pharmaceutics·DateJun 14, 2022

Physical activity should be encouraged during pregnancy, even for socially vulnerable women

Research in western Amazonia found that at least 150 minutes of exercise per week correlated with lower birth weight and reduced risk of childhood obesity and diabetes. The study also showed that physical activity during pregnancy may help prevent excessive weight gain, contributing to a reduced birth weight.

Transcranial stimulation lowers blood pressure in patients with resistant hypertension, study shows

A recent study published in Frontiers in Cardiovascular Medicine found that transcranial direct current stimulation (tDCS) can lower blood pressure in patients with resistant hypertension. After a single session or ten sessions, the treatment reduced peripheral and central blood pressure in some patients by up to 15 mmHg.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalFrontiers in Cardiovascular Medicine·DateJun 7, 2022

Study proposes mathematical tool to help understand fractal structure of quark-gluon plasma

A new study proposes a mathematical tool to understand the fractal structure of quark-gluon plasma, which is formed in high-energy collisions. The fractal structure explains some phenomena seen in these collisions, including particle momentum distributions that follow Tsallis statistics.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalThe European Physical Journal Plus·DateJun 6, 2022

Study reveals potential target for treatment of diseases associated with mitochondrial DNA mutations

A study by Brazilian scientists reveals that autophagy can modulate the accumulation of mutant mitochondrial DNA in cells during aging. The researchers found that mice with liver-specific atg7 knockout showed reduced buildup of mutant DNA, suggesting a potential therapeutic target for diseases associated with mitochondrial DNA mutations.

The gut microbiota compound that could become a drug for prevention and treatment of bronchiolitis

Researchers have discovered that short-chain fatty acid acetate from the gut microbiota can minimize the effects of infection by respiratory syncytial virus (RSV) and mitigate its severity. The compound was found to activate antiviral molecules, such as RIG-I, which are effective against RSV, leading to a 88% reduction in viral load.

Light-based therapies achieve good results in rehabilitation of patients with post-COVID complications

Researchers have found that light-based therapies such as photobiomodulation and photodynamics can effectively treat a range of post-COVID complications, including muscle and joint damage. The studies, conducted in Brazil, utilized laser irradiation, negative pressure, and other technologies to improve symptoms and promote healing.

Antioxidant derived from unripe acerola can replace synthetic additive banned in several countries

Researchers at the University of São Paulo developed a natural antioxidant from unripe acerola, replacing banned synthetic additive TBHQ. The antioxidant microparticles were found to be effective in a range of applications, including food products and cosmetics, without affecting color, flavor or odor.

Dwarf planet Ceres was formed in coldest zone of Solar System and thrust into Asteroid Belt

Researchers propose that Ceres was formed outside the Frost Line, where ammonia ice is abundant, and then pulled into the Asteroid Belt by gravitational instability. Computer simulations support this hypothesis, showing that giant planet formation led to a turbulent environment that scattered objects into stable orbits.

Study points to ways of involving visually impaired people in environmental disaster prevention

A Brazilian study found that inclusion of visually impaired individuals is crucial for effective disaster prevention policy. The research highlighted barriers to their participation and proposed solutions such as smartphone apps and education to mitigate vulnerability to environmental hazards.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalInternational Journal of Disaster Risk Science·DateMay 10, 2022

Brazil’s Northeast region probably dried up during Earth’s last minimum axial tilt thousands of years ago

A recent study suggests that tree density in the Cerrado biome has been controlled mainly by the length of the dry season over the past 45,000 years. The research found a link between changes in the dry season and variations in Earth's axial tilt, which may lead to similar trends in the late 21st century.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalQuaternary Science Reviews·DateMay 3, 2022

Combination of weak muscles and abdominal obesity can be an early sign of functional decline in men

A Brazilian study analyzing data from 3,875 elderly men and women found that weak muscles combined with abdominal obesity can indicate an early sign of functional decline. The study suggests that monitoring simple actions such as sitting down, standing up, walking short distances may help identify this condition.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalAmerican Journal of Clinical Nutrition·DateApr 28, 2022

Deforestation of Indigenous lands could prevent Brazil from achieving climate change mitigation targets

Deforestation in Indigenous lands, particularly in Apyterewa Territory, poses a significant threat to Brazil's ability to meet its international climate change mitigation targets. The Brazilian government must take effective action to enforce environmental laws and protect the Amazon region.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalScience·TypeImaging analysis·DateApr 19, 2022