A Brazilian study of 2,777 patients hospitalized between January 5 and September 12, 2021 found that vaccination was the sole predictor of mortality in those over 60 with kidney failure. Vaccination also reduced hospitalization risk among non-vaccinated patients with comorbidities.
A new synthetic substance, PECS-101, has been shown to prevent neuropathic pain caused by chemotherapy while improving cancer treatment outcomes. The study, conducted in mice, found that PECS-101 had no adverse effects and did not cause dependence.
A study by Brazilian researchers found that regular fires enhance functional diversity and carbon fixation in savannas. They measured species numbers, attributes, and carbon dynamics in two areas, one with frequent fires and the other without fires for 16 years.
Researchers in Brazil and Portugal create biodegradable plastic film using eutectic solvents and natural pigments extracted from yeast. The process is environmentally sustainable and has potential applications in smart packaging with antioxidant and anti-microbial properties.
Scientists discovered two new targets, EPPIN domains, to block sperm motility, a complex process that allows sperm to reach the egg. The study demonstrates the feasibility of using mice as models for in vivo trials, simplifying preclinical studies and paving the way for novel male contraceptives.
A study tracking 425 patients post-COVID-19 found high prevalence of cognitive deficits, psychiatric impairments, and significant memory decline. Researchers observed no correlation between the severity of the disease or socio-economic factors with psychiatric alterations, suggesting a possible link to delayed inflammatory processes.
The detection of high-frequency gravitational waves would offer insights into the early Universe's phases, inaccessible to electromagnetic wave investigations. Currently, technological challenges limit the sensitivity of proposed projects to six orders of magnitude lower.
A study by the Brazilian High-Risk Cohort Study for Childhood Psychiatric Disorders found an association between child poverty and externalizing disorders in adolescence and early adulthood. Child poverty was particularly harmful to women, increasing their risk of developing mental health problems and affecting educational attainment.
Researchers attribute vaccine effectiveness to mutations shared with previous variants, resulting in relatively small severe cases and deaths among vaccinated patients. The study analyzed over 200,000 genomes and found identical mutations that could serve as targets for future vaccines.
Researchers found nanoparticles from human activities rapidly grow in atmosphere and influence cloud formation, affecting raindrop formation and changing rainfall regime. The study provides new insights into the impact of small aerosols on precipitation and improves climate change studies based on mathematical models.
Researchers found sublingual immunotherapy with house dust mite extract to be effective in reducing signs and symptoms of atopic dermatitis. The treatment, administered over 18 months, resulted in significant improvements in pruritus and lesions, with rare side effects.
The study demonstrated that photodynamic therapy (PDT) using chlorin e-6 can effectively reduce bacterial plaque biofilms containing cariogenic microorganisms, including Streptococcus mutans. The treatment eliminated S. mutans and decreased total microorganisms by up to 3.7 units, with approximately 99% efficacy of antimicrobial activity.
A Brazilian study found that SARS-CoV-2 can persist in patients for over a month before becoming negative on diagnostic tests. Researchers tracked 38 COVID-19 patients and found that the virus remained detectable in three cases for more than 70 days, raising concerns about quarantine periods.
A study found that 31.4% of trauma patients at Hospital das Clínicas in São Paulo, Brazil, tested positive for psychoactive substance use, including alcohol (23%), cocaine (12%), and marijuana (5%). The study contributes to the development of public policies to prevent accidents.
A study by Brazilian researchers found that these large mammals help regulate plant diversity, productivity, and biomass in understory areas. The spatial structure of plant communities is also influenced, with the Jussara palm playing a key role in attracting animals and dispersing seeds.
A study found that preventing mental health problems among schoolchildren, particularly externalizing disorders, could have prevented grade repetition and dropout. The study involved 2,511 families with children aged 6-14 and showed that girls with externalizing disorders were more likely to be held back a grade.
A Brazilian study found a correlation between dealing with COVID-19 and environmental disasters, highlighting the need for improved infrastructure and community resilience. The study also identified a lack of continuity in funding for disaster relief and pandemic response.
A study of 118 conservation units in Brazil found that 60% use unsuitable methods to detect deer presence. Visual analysis of droppings, fur, and footprints is a reliable method for most species, but others require DNA testing or camera traps.
Researchers discovered nine genes in S. mansoni's autophagy pathway inhibited by the primate's immune system, preventing parasite multiplication and contaminating the host. The study suggests a potential novel therapy and vaccine against schistosomiasis.
Researchers found that inhibiting gasdermin D, a protein involved in septic patients' organ lesions, can prevent multiple-organ damage and improve prognosis. Disulfiram, a drug originally indicated for alcohol dependence, was shown to inhibit gasdermin D and reduce tissue injury.
Researchers found that zika virus injections destroyed brain tumors in mice and reduced tumor size in cerebral organoids, with immune cells alerting the system to its existence. This approach opens up prospects for virotherapy treatment of central nervous system tumors.
Researchers found that local gravitational tides modulate the cyclical behavior of organisms, even in the absence of other rhythmic influences. The study questions the validity of free-run experiments and highlights the importance of considering gravitational oscillations in biological research.
Researchers at TU Delft and UNICAMP successfully teleported the quantum state of a single photon to an optomechanical device containing billions of atoms. This achievement paves the way for creating signal repeaters in a future quantum internet, enabling long-distance quantum communication.
Researchers at UNICAMP discovered that total parasite biomass is a better predictor of complications in patients with P. vivax malaria than parasitemia. The study highlights the importance of parasite biomass in the bone marrow and spleen, which play a major role in vivax malaria complications.
Researchers found that slowness of gait alone can predict loss of capacity to perform basic and instrumental activities of daily living (BADL and IADL) in older adults. The study analyzed data from over 3,000 people aged 60 and over, concluding that measuring gait speed is sufficient for efficient prediction of functional disability.
A study by researchers at the University of São Paulo developed a model that can predict the likelihood of politicians being convicted of corruption based on their voting histories. The model achieved 90% accuracy in identifying corrupt deputies.
A study of over 4,000 Brazilian crowdfunding campaigns found that cities with higher income inequality led to successful campaigns, while diverse rewards and lower fundraising targets improved outcomes. Researchers also developed an algorithm to predict campaign success using artificial intelligence.
Children with congenital zika syndrome exhibit different neurological development profiles, with varying abilities to respond to stimuli. Larger head circumference is associated with higher cognitive and motor scores, according to the study published in PLOS ONE.
A bile acid derivative, TUDCA, reduced food intake and increased energy expenditure in mice with an Alzheimer's-like disorder. The treatment improved quality of life by mitigating metabolic abnormalities associated with the disease.
Researchers developed a novel computer simulation method that can analyze key proteins in the reproductive cycle of SARS-CoV-2, promising to accelerate the search for bioactive compounds against COVID-19. The method estimates a reduction in research time from two to three years to under a year.
Researchers from Brazil and international collaborators demonstrate the conversion of low-cost waste biomass into bioplastic, electronic devices, and other high-value materials. The study highlights the potential of this approach to address global waste management challenges and promote a circular economy.
A recent study by Brazilian, Argentine, and US researchers has revealed 28 new species within the Aurelia genus of jellyfish. The identification was made possible through combining morphological data with four molecular markers derived from both mitochondrial and nuclear DNA.
A study from the University of São Paulo found that people infected with Chikungunya may develop partial immunity to Mayaro virus. The researchers observed a significant reduction in disease severity and viral load, suggesting cross-protection through neutralizing antibodies and immune memory.
A conservation incentive mechanism has stimulated creation of protected Atlantic Rainforest areas, mainly APAs with few restrictions. However, its impact is limited by the number of units created and differing responses from states and municipalities.
Researchers in Brazil and Belgium developed a stable, immune-resistant molecule from rattlesnake venom using PEGylation. The resulting drug candidate modulates blood clotting and has potential for anti-coagulant and wound dressing applications.
The study, published in Scientific Reports, used eDNA sequencing to investigate fish diversity in the Amazon River basin. Researchers found that only 26% of species identified with precision at the species level could be linked to traditional catch data.
A new species of green microalgae was identified in a reservoir in northwest São Paulo, Brazil, and reclassified into the genus Nephrocytium. The discovery was made through phylogenetic analysis and molecular sequencing, confirming that the microalga is distinct from other known species.
Researchers have identified metabolic signatures in blood plasma that can predict a patient's response to chemotherapy and prognosis. This discovery enables physicians to personalize treatment and enhance its efficiency, leading to improved outcomes for patients with gynecologic tumors.
A study conducted at the University of São Paulo analyzed how dogs living inside the home exchange looks with their owners to obtain food or other desired objects. The researchers found that 95.7% of those living inside the home used gaze alternation at least once, while those living outside communicated less intensely.
A study analyzing data from 109 COVID-19 patients found that obesity is the key factor associated with endothelial dysfunction, a condition increasing heart attack and stroke risk. The results suggest an 17% higher cardiovascular risk for obese patients compared to those of normal weight.
Researchers identified clusters of asphyxia-associated neonatal mortality in cities with low per capita GDP, highlighting the need for targeted healthcare interventions. The study's methodology can help policymakers plan strategies to reduce avoidable newborn deaths.
Researchers identified bacteria and yeast on photovoltaic panels in Brazil, similar to those found in Spain, the US, Arctic, and Antarctic. The microorganisms have adapted to sunlight, temperature fluctuations, and water scarcity, making them suitable for biotech applications.
An updated vaccination strategy is credited with averting an outbreak of urban yellow fever in São Paulo State, according to research published in Scientific Reports. The study found that the virus spread rapidly, reaching cities never affected before, and that a high number of cases were reported in areas with low vaccination coverage.
A study at the University of São Paulo found that Torquetenovirus (TTV) titer is higher in people infected by SARS-CoV-2, suggesting it could be a biomarker for COVID-19 severity. TTV load correlates with disease progression and outcome, and its measurement may support diagnosis.
A study found that cardiopulmonary exercise testing is highly applicable for early detection of respiratory disorders in obese individuals. The test assesses physiological responses to exercise and identifies potential issues before symptoms appear.
A Brazilian study expands amphibians' known reproductive modes to 74, creating a new classification. The research analyzed 2,171 species of amphibians, including anurans with 71 reproductive modes, some laying eggs in aquatic environments while others develop directly.
A clinical trial of 465 patients found that administering heparin in therapeutic doses reduced mortality from COVID-19 by 78%, with benefits only observed when administered between seven and 14 days after symptom onset. The study suggests that timing is crucial for treatment efficacy.
Researchers used machine learning and genomics to identify molecular markers of resistance to sugarcane yellow leaf disease in over 97 sugarcane genotypes. The study found that energy cane varieties with higher fiber content are more resistant to the disease, paving the way for commercial launches.
A Brazilian study reveals that forest fires and wildfires modify the freezing process of cloud droplets, altering natural cloud functioning and potentially impacting precipitation. The research used a large dataset to show that aerosols emitted by fires can affect cloud formation in southern Amazonia during the rainy season.
Chromobacterium violaceum uses zinc ion transporter ZnuABC to overcome host constraints on metal availability, increasing its virulence. The discovery offers a route for novel therapies against bacterial infections.