Researchers at the Center for Cell-Based Therapy identified microRNAs involved in pluripotency maintenance and cell differentiation. The study found that these molecules play a crucial role in regulating ESC behavior, with some miRNAs contributing to both pluripotency and differentiation.
Researchers have discovered a new bioluminescence mechanism in railroad worm Phrixothrix hirtus, emitting red light through the size of its luciferase cavity. This discovery has potential for biomedical applications like imaging muscles and blood tissue.
Researchers have isolated four compounds from Mimosa caesalpiniifolia that show effective antifungal activity against Candida species, including drug-resistant strains. The compounds will be tested in the form of ointments to combat candidiasis, a potentially lethal disease.
Brazilian researchers used computational tools to analyze blood cells from patients infected with chikungunya virus, identifying genes associated with the disease and potential biomarkers of predisposition to chronic joint pain. The study suggests that certain gene signatures can be explored as therapeutic targets.
Researchers have identified three species of electric eels, including one that can produce up to 860 volts, the strongest discharge ever recorded. The discovery opens new avenues of research into strong electric discharges in other fish species.
A Brazilian research group, supported by FAPESP, has developed a nanostructured titanium oxide material through electrospinning and atomic layer deposition. The material exhibits high surface area and reacts with UV light to degrade organic matter.
Researchers at São Paulo State University discovered that breaking time-reversal symmetry creates molecules with spin-polarized orbitals, allowing for the encoding of information. This phenomenon could be exploited in quantum computing and spintronics to develop faster, more efficient devices.
A new study has found that systematic eradication of plants contaminated with the cowpea aphid-borne mosaic virus (CABMV) can keep passion fruit orchards producing for at least 25 months. The technique, known as roguing, involves removing weak or diseased plants to prevent the spread of the disease. In experiments conducted in Brazil, ...
The study found that ancient geological events, such as mountain range uplift and river formation, drove the emergence of new species of harvestmen in the southern portion of the Atlantic Rainforest. This discovery challenges the assumption that climate fluctuations are the primary cause of high biodiversity in this biome.
A study analyzing data from almost 30,000 nurses found that physical activity in adolescence and later life cumulatively reduce the risk of advanced adenomatous polyps, a precursor to colorectal cancer. The study showed that adequate physical activity in both adolescence and adulthood reduces the risk by 39%.
Researchers have identified markers capable of predicting mortality in patients with symptoms of yellow fever, potentially helping to prevent severe conditions. The study found that older patients, high neutrophil counts, and high viral loads at hospital admission are significantly associated with mortality.
The study found that elephants change the structure of African tropical forests, increasing aboveground biomass by 26 to 60 tons per hectare. This process contributes to a corresponding increase in carbon storage, making the forests more resilient to climate change.
A clinical trial published in Appetite found that transcranial direct current stimulation (tDCS) can reduce or increase appetite depending on a patient's genetic profile. The study used a current of 2 milliamperes and 17 thirty-minute sessions over a month, with participants monitored for six months.
Researchers developed a novel, biodegradable larvicide system using thymol from thyme essential oil, which is effective against Aedes aegypti mosquitoes. The system uses microcapsules made of corn starch particles to control the release of larvicide, making it suitable for small water containers and reducing environmental harm.
A method developed by Brazilian and US researchers confirms a three-fold increase in thyroid cancer incidence among WTC responders compared to the general population. The four-biomarker panel distinguishes between malignant and benign tumors with no false positive results, enabling early detection and treatment.
A study of individuals over 65 years old found that low appendicular muscle mass significantly increased all-cause mortality risk nearly 63-fold in women and 11.4-fold in men. The researchers used DXA body composition analysis to determine the correlation between body composition factors and mortality risk.
A Brazilian study found that cannabidiol attenuates social isolation-induced aggression in mice by facilitating the activation of serotonin and CB1 receptors. The researchers used a resident-intruder test model to demonstrate that lower doses of cannabidiol inhibit aggressive behavior, while higher doses have little effect.
Adolescents who skip breakfast tend to have higher waist circumference and body mass index, indicating an increased risk of weight gain. The study suggests that skipping breakfast can contribute to unhealthy habits and behaviors, potentially making adolescents more vulnerable to obesity.
Researchers found that ants receiving protein from herbivorous arthropods increase their aggression in environments with scarce food supply. This discovery challenges the idea that only carbohydrates are offered by plants to protectants.
Researchers found that natural compounds isolated from Nectandra leucantha can kill parasites causing these neglected diseases. The neolignans displayed bioactivity against Leishmania and Trypanosoma cruzi parasites, which affect millions of people in Brazil and other developing countries.
Researchers developed a nanotechnology-based compound that delivers an oral vaccine against hepatitis B to the immune system. The nanostructured silica protects the antigen from digestive acidity, enabling it to trigger an immune response. The study's results show promise for a polyvaccine against six diseases.
Brazilian and Italian scientists developed a method to pattern polythiophene, an electrically conductive polymer, to improve its optical and electronic properties. The resulting device is highly selective in emitting and absorbing light, making it suitable for optoelectronic applications.
Researchers at CRID found that infants produce 40% more NETs than adults, leading to more severe organ damage and higher mortality rates in sepsis cases. Breaking down NETs with a drug can improve survival rates for infant patients, highlighting new treatment strategies.
A new breeding method increases genetic selection efficiency, conserving or improving population diversity. It considers variance in gametic diversity and relative predicted transmitting ability, resulting in gains of up to 16% compared to traditional methods.
Researchers have retraced the pathogen's route as it spread from Pará State in North Brazil. Yellow fever virus was detected in dead monkeys and mosquitoes, revealing a 40-year-old strain behind current epidemic.
Researchers have detected ranavirus infection in wild bullfrog tadpoles in Brazil's Atlantic Rainforest, linked to declining amphibian populations worldwide. The virus may have spread from frog farms, highlighting the dual threat of invasive species and pathogens.
Researchers at CBPF and UFABC used quantum correlations to reverse thermodynamic arrow of time, allowing heat to flow from cold to hot without external energy. The experiment demonstrates a generalized form of the second law of thermodynamics, highlighting the role of quantum correlations in thermal transfer.
Researchers have developed a genetically modified virus that kills cancer cells and makes them sensitive to chemotherapy drugs, halting tumor progression in mice. The combination of p53 gene therapy and cabazitaxel resulted in full control of tumor growth, with an additive or synergistic effect.
Phelcom's Eyer uses a portable optical device connected to a smartphone to capture images of the retina for remote diagnosis. The app sends images over the internet to Eyer Cloud, which stores and manages patient files. With an accuracy rate of around 80%, the system has the potential to examine 50,000 patients next year.
Brazilian and German scientists have discovered genes linked to sex differentiation in the giant Amazon fish, enabling early sexing and paving the way for genetic improvement. The research, supported by FAPESP, has significant implications for the Brazilian aquaculture industry and the conservation of this iconic species.
The study found that climate change could lead to a decline in ectomycorrhizal tree species by up to 10% if CO2 emissions continue unabated until 2070. This decline may have significant implications for forest ecosystems and growth.
The study identifies Bulbostylis paradoxa as a plant that rapidly regrows and flowers in the Brazilian savanna after a fire. This rapid response is a significant advantage for the plant, enabling it to flower, fructify, and disperse seeds before competitors arrive.
The study used CT scans and 3D imaging to analyze cranium fossils of two extinct species, identifying adaptations and relationships with extant platyrrhine species. The results showed that C. bambuiorum is closely related to Ateles, Brachyteles, and Lagothrix, contradicting its initial classification.
Researchers discovered a modified enzyme produced by fungus Trichoderma harzianum that increases glucose release from biomass for fermentation. The modified protein proved 300% more efficient than the wild-type enzyme in terms of glucose release, making it suitable for industrial application.
A study by Brazilian scientists shows that moderate strength and weight training can reduce liver fat and improve blood sugar control in obese and diabetic individuals. The exercise protocol reduced local fat in the liver and improved cellular insulin signaling, even before significant weight loss occurred.
Recent research on sickle cell disease highlights major progress in diagnosis and treatment, but warns that more screening of newborns is needed, particularly in sub-Saharan Africa. The study emphasizes the importance of investing in health policies to address the growing number of cases.
A Brazilian-US research team has sequenced the mitochondrial genome of the tube anemone Isarachnanthus nocturnus, revealing a massive 80,923 base pairs. The discovery challenges current classifications and sheds light on the evolution of cnidarians.
A study found that brain activity related to auditory perception parallels heart rate, suggesting that stress-induced changes in heart rate may impair auditory perception. Researchers suggest that vagus nerve activation by electrical stimulation could improve auditory perception and treat attention and communication disorders.
A study reveals that freshwater stingray toxins vary among individuals of the same species, with young female venom causing more pain than adult male venom. Adult rays' venom is more effective at producing tissue necrosis, a deadly effect for small fish and crustaceans.
Research reveals that urban pollution from Manaus significantly impacts cloud production and rainfall in the Amazon, with far-reaching consequences for regional and global climate patterns. The study found an average increase of 200% in secondary organic aerosols, leading to a 400% boost in aerosol formation.
Researchers found that a nonlethal dose of insecticide curtailed the lives of bees by up to 50% and altered the behavior of worker bees when combined with a fungicide, potentially jeopardizing colony survival. The study suggests that the impact of pesticides on bees could be worse than previously thought.
Scientists investigated satellite data collections for burned areas in the Cerrado biome, improving Brazil's space research output. The study refined data to provide more precise information on burned areas, including emissions and land use patterns.
A study reveals that substituting diesel with liquefied natural gas (LNG) in São Paulo can reduce fuel costs by up to 40% and greenhouse gas emissions by 5.2%. LNG is found to be a more environmentally friendly option, with lower emissions of CO2-eq, CH4, and N2O.
Researchers found that high levels of PM10 reduced average tree growth by up to 37% and varied interannually with pollution levels during driest months. Trees exposed to higher levels of pollution grew less in trunk diameter development throughout their lives.
Researchers found that overweight adolescents have similar increased risks of developing heart disorders as obese teenagers. Cardiovascular fitness tests with boys and girls aged 10-17 showed no significant difference in heart rate variability between the two groups.
A study conducted in Brazil found that intensive silviculture using herbicide spraying and substantial fertilizer application promotes tropical forest regeneration and biomass gain, exceeding traditional manual weeding methods. Researchers aimed to maximize woody biomass accumulation for carbon sequestration and financial viability.
A study suggests that low plasma levels of PDIA1, an enzyme involved in protein disulfide isomerization, are associated with a higher risk of thrombosis. Researchers found no correlation between PDIA1 levels and well-known risk factors for cardiovascular disease.
Researchers used cognitive dysfunction tests and analysis of drug use patterns to identify patients at high risk of relapse after treatment. The study suggests that a revised classification system may be needed to better predict vulnerability to relapse.
Brazilian researchers developed a software program called Polyploid Gene Assembler (PGA) to map specific portions of plant DNA, saving at least two orders of magnitude compared to mapping the whole genome. The technique uses publicly available data from related grasses to locate genes of interest for plant breeders.
A new study estimates that lifestyle risk factors, such as smoking and unhealthy diet, account for 114,497 annual cancer cases in Brazil, representing 27% of all cancer cases. Eliminating these risk factors could halve the number of certain types of cancer cases, according to Brazilian researchers.