The Butantan Institute and MSD will exchange proprietary process information and clinical trial data, accelerating vaccine development. The partnership aims to create a tetravalent vaccine effective against all four dengue virus serotypes.
Researchers propose guidelines for the therapeutic use of melatonin to address potential health risks, citing over 23,000 published studies. The guidelines aim to provide a systematic framework for analyzing melatonin's effects and role in human physiology and pathophysiology.
Researchers found that influenza virus impairs immune response to pneumococcus, especially monocyte activity. The study identified a key cellular mechanism controlling pneumococci proliferation and movement from nose to lungs.
The study found that over half (55.3%) of the 365 victims had consumed alcohol or drugs shortly before their death, with a high prevalence of cocaine and cannabis use. This correlation suggests a significant link between substance use and violent deaths in São Paulo City.
A study found a correlation between oral cancer progression and the abundance of specific proteins in tumor tissue and saliva. The discovery offers a new parameter for predicting disease progression and may help guide treatment choices.
A new study reveals that sambaqui societies living in coastal Atlantic Forest areas between 8,000 and 1,000 years ago consumed a range of plants and had a more diversified economy than previously believed. Analysis of their middens shows evidence of plant cultivation and high consumption of carbohydrates.
Researchers have discovered a way to create artificial magnetic fields using graphene sheets with a twist, enabling the control of electronic properties through electrical fields. This breakthrough has clear technological potential and could lead to new materials with unique properties.
Researchers have developed an ointment to counter the effects of brown recluse spider bites, which can cause skin necrosis and renal failure. The trial has started in Brazil with 240 participants, comparing the effects of the ointment with a placebo.
Brazilian researchers clarify aquatic dune dynamics, contradicting conventional models. Their findings have applications in understanding Martian terrain and optimizing oil flows.
Experimental inhibition of prostaglandin E2 enhanced the ability of mice to combat infectious colitis, resulting in increased migration of defense cells and production of antimicrobial peptides. Inhibiting PGE2 also favored the expression of defensins, considered natural antibiotics, in the colon.
A study in Scientific Reports identifies mechanisms of pesticide resistance in cattle ticks, which contribute to significant economic losses. The study reveals that the ticks' ability to detoxify toxicants, including ivermectin, is a key factor in their resistance.
Research reveals Salmonella species, causing foodborne diseases, are resistant to multiple antibiotic classes. The study identified 39 genes linked to this resistance, shedding light on the epidemiology of salmonellosis in Brazil.
A comprehensive study confirms the existence of a single ancestral population for all Amerindian ethnic groups, contrary to traditional theories linking Africa or Australasia. The study reveals that the Lagoa Santa people were descendants of Clovis culture migrants from North America.
Researchers identified the function of a protein controlling allergic diseases, which can lead to medication development for autoimmune disorders and certain cancers. Increasing this protein blocks CD4+ T lymphocytes responsible for producing cytokines triggering allergic reactions.
Researchers identified luciferin in a non-luminescent Brazilian cave worm larva, sparking interest in its potential biochemical functions. The discovery is the first of its kind in the Neotropics and opens up new avenues for research on the molecule's applications in biotechnology, medicine, and pharmaceuticals.
Researchers identified 35 genes linked to reproduction, milk production, growth, meat quality, and health in Gir cattle. These genes are a key step towards developing novel lines with desired traits for producers and consumers.
A study published in Scientific Reports found Zika virus in dead monkeys in Brazil, indicating a potential sylvatic transmission cycle. The infected animals were more vulnerable to attack by humans, highlighting the need for further research on the role of wild animals in maintaining the urban cycle of Zika.
A study conducted in Brazil found that roasted jackfruit seeds can replace between 50% and 75% of cocoa powder in milk and coffee used to make cappuccino without impairing flavor or aroma. The researchers developed an instant powder containing coffee with milk and chocolate, which can be a potential substitute for traditional cappuccino.
Researchers discovered that chemotherapy drug paclitaxel can also activate a key cellular receptor in the innate immune system, reactivating the patient's immune response to combat tumors. This finding opens up new prospects for cancer treatment strategies, including immunotherapy and adjuvant therapy.
Researchers found that volunteers with dyslexia read faster when using green filters than without, while those without dyslexia showed no difference. The study suggests that the filters may attenuate cortical hyperexcitability in the brain, leading to improved reading performance.
For Syrian refugees in Brazil, food serves as a bridge to their past, recreating memories of Damascus, Homs, and Aleppo. It strengthens their sense of identity as Syrians, providing a connection to their homeland and a sense of belonging in their new life.
Researchers found that exercise stimulates autophagy, a cellular process responsible for removing damaged proteins and toxins from muscles. The study shows that regular physical activity can reduce the buildup of toxic proteins in muscles, leading to improved muscle function and reduced wasting.
Researchers affiliated with São Paulo State University have identified four extremely young asteroid families using a numerical simulation method. The newly discovered families are estimated to be less than 7 million years old and were dated using the backward integration method, which is precise for young families.
A new study reveals that protein galectin-1 has anti-inflammatory properties capable of minimizing damage to kidney cells by hypoxia and reperfusion, common processes in transplants. Galectin-1 may provide an alternative to corticosteroids for ischemia-reperfusion injury.
Researchers found that giant jararacas are more abundant in an urban park with fewer predators than a nearby nature reserve. The study suggests that the lesser presence of predators is the key factor explaining this phenomenon.
Tau Flow's computational fluid dynamics (CFD) technology creates virtual prototypes of processes or environments, reducing time and money spent on trial and error methods. The company has successfully implemented its solution in various industries, including Formula 1, cosmetics, and mining.
Researchers analyzed Tipuana tree rings and bark to measure environmental pollution levels, finding reduced levels of cadmium, copper, nickel, and lead over the past three decades. The study suggests a correlation with declining gasoline emissions in Brazil.
A Brazilian study found that climate change could lead to the extinction of up to 10% of frog and toad species endemic to Brazil's Atlantic Rainforest biome within the next 50 years. The researchers used spatial distribution data and ecological niche models to predict which areas would be favorable for each species.
Researchers at the University of São Paulo's Physics Institute have successfully entangled six light waves using an optical parametric oscillator. This achievement could lead to faster processing speeds and improve the feasibility of quantum computing by enabling the creation of systems with multiple entangled components.
The Brazilian stingless bee, Tetragonisca angustula, uses a unique defense strategy by positioning its hovering guards in an organized manner at the nest entrance. This allows for rapid detection and interception of intruders, improving nest vigilance.
A patent mining method developed by Brazilian scientists uses big data tools to identify technological routes, trends, and partnerships in various knowledge areas. The method has been validated in an analysis of studies on hemophilia, revealing a promising molecule called XTEN that can extend the half-life of recombinant factor VIII.
Researchers found that a single dose of cannabidiol eliminated symptoms of depression in rats and maintained benefits for up to seven days. The study's findings suggest that cannabidiol rapidly triggers neuroplastic mechanisms to repair damaged neuronal circuitry, providing new hope for treating broad-spectrum depression.
Researchers developed a new device combining low-intensity laser light and therapeutic ultrasound, reducing fibromyalgia pain by 73.37%. The treatment showed better analgesic and anti-inflammatory effects when applied to the palms instead of tender points.
A new phase has been proposed in the relationship between figs and wasps, revealing a sixth developmental cycle where insects other than wasps can insert their eggs into figs. This finding highlights the complex mutualism between figs and wasps, which have evolved over 65 million years.
A new study reveals that Amazonian wetlands are home to an astonishing 3,615 tree species, exceeding expectations by three times. This comprehensive list of tree species was compiled from forest inventories and botanical collections, providing valuable insights into the region's biodiversity.
Researchers discovered that a weaker immune response activation triggers the replacement of one dengue virus lineage by another, despite lower multiplication rates. This finding has significant implications for vaccine development and understanding viral interactions with the human population.
Researchers detected higher levels of chemical substances in Africanized honeybee brains than in gentler strains, triggering irascible behavior. The compounds also regulate food intake and digestion in flies and mice, illustrating molecular mechanisms underlying different species' behavior evolution.
A novel laboratory-synthesized molecule based on natural compounds found in marine gliding bacteria is capable of killing even the strain that resists conventional antimalarials. In tests, it displays low toxicity and high selectivity, acting only on the parasite and not on other cells of the host organism.
Researchers in Brazil create transgenic male mosquitoes with defective sperm to reduce Aedes aegypti population. The goal is to integrate this strategy with education, vaccines, larvicides, and insecticides to control arbovirosis diseases.
A low-protein diet during pregnancy and lactation may increase the risk of prostate cancer in offspring, according to a study with rats. The study found that females fed a low-protein diet had offspring with preneoplastic alterations capable of interfering with glandular function.
Brazilian researchers have identified a key gene, ScGAI, that accelerates sugarcane growth by regulating developmental hormones such as ethylene and gibberellins. Silencing the gene in transgenic sugarcane lines resulted in increased culm volume and rapid internode elongation.
A Brazilian research team used CRISPR/Cas9 to investigate the Aire gene, which plays a crucial role in controlling aggressive autoimmunity. The study found that Aire-mutant mTECs were worse at adhering to thymocytes and losing their original function.
Researchers describe how Oropouche virus replicates in human cells by hijacking the Golgi complex, a process that could lead to novel targets for preventing infection. The study provides new insights into the replication mechanisms of emerging viruses.
Researchers have synthesized a new 2D material called hematene from iron ore, which exhibits enhanced photocatalytic properties. Hematene's ability to split water into hydrogen and oxygen makes it an efficient candidate for generating electricity.
A new study analyzed speleothems in Brazilian caves to reconstruct rainfall distribution during the Middle Ages. The research found that southwestern Brazil was wetter than now, while the Northeast region was drier. This analysis provides insights into the climate changes that occurred during the Little Ice Age.
A study in São Paulo City found that falling temperatures correlate with rising numbers of deaths from stroke, particularly among over-65s. Lower temperatures are a risk factor for hemorrhagic stroke, especially among women.
A study has identified 600 novel long noncoding RNA molecules that regulate the effects of androgens and androgen receptors on gene expression in prostate tumors. These lncRNAs are powerful regulators of gene expression and interact with and magnify the effect of regulatory proteins, suggesting a new target for treatment.
Treevia's SmartForest system uses wearable devices and electronic sensors to monitor tree growth, quality, and health in real-time. This allows for more efficient and data-driven forest management decisions.
Researchers found that PI3Kγ expression increases during T. cruzi infection, essential for avoiding excessive inflammation and controlling heart parasitemia. The enzyme's absence in macrophages impairs their ability to kill parasites and control inflammation.
Researchers found that sodium nitroprusside prevented behavioral alterations associated with schizophrenia in rats, suggesting a potential preventive treatment for young people at risk. The study used an animal model that mimics the condition in children and adolescents considered at risk for development of the disease in adulthood.