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Fundação de Amparo à Pesquisa do Estado de São Paulo


Extrasolar asteroid has been orbiting the sun for 4.5 billion years

A Brazilian scientist and her co-author found that an extrasolar asteroid has stably occupied a stable path corresponding to Jupiter's orbit for at least 4.5 billion years. The asteroid is believed to have originated from outside the Solar System, likely captured by Jupiter's powerful gravitational field.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalMonthly Notices of the Royal Astronomical Society·DateMay 21, 2018

International consortium wants to sequence the DNA of 1.5 million species

The Earth BioGenome Project aims to sequence genomes of every eukaryotic species on Earth, filling the huge knowledge gap in biodiversity research. With a cost estimate of approximately US$4.7 billion, the project will lay the scientific foundation for a new bioeconomy and bring innovative solutions to global problems.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalProceedings of the National Academy of Sciences·DateMay 17, 2018

Mechanism underlying malformation associated with severe epilepsy is revealed

Researchers identified dysregulation of the gene NEUROG2 as a key factor in the development of focal cortical dysplasia, a common cause of drug-resistant epilepsy. The study found that overexpression of NEUROG2 was linked to reduced expression of microRNA hsa-miR-34a, leading to nerve cell differentiation failure.

Key enzyme for production of second-generation ethanol discovered in Brazilian Amazon

Researchers from Brazil's National Energy & Materials Research Center (CNPEM) have discovered a key enzyme that can boost the efficiency of sugarcane bagasse saccharification, a crucial step in producing second-generation ethanol. The enzyme, produced by microorganisms living in Lake Poraquê in the Amazon, shows high glucose tolerance ...

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalBiochimica et Biophysica Acta (BBA) - Proteins and Proteomics·DateMay 15, 2018

Research shows how genetics can contribute for advances in 2G ethanol production

Researchers have identified key genes involved in enzymatic degradation of sugarcane biomass by three fungal species. The study, supported by FAPESP, provides insights into the genetic mechanisms controlling enzyme secretion and expression, paving the way for more efficient biomass breakdown and production of biofuels.

An index measures similarity between cancer cells and pluripotent stem cells

Researchers developed an index measuring similarity between cancer cells and pluripotent stem cells to predict tumor aggressiveness, treatment resistance, and clinical outcome. The index may help identify novel therapeutic targets against cancer by pinpointing the point at which tumor cells acquire stem cell-like characteristics.

Mechanical harvesting of papayas might be a reality with computational technique

Brazilian researchers design a non-invasive system that identifies different stages of fruit ripening with an accuracy rate of 95%. The system uses algorithms and digital imaging to analyze the biochemical stage of fruit maturation, providing essential information for precise papaya harvesting.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalComputers and Electronics in Agriculture·DateMar 7, 2018

Study in six countries identifies groups that are vulnerable to severe mental illness

A study of six countries found that young men, ethnic minorities, and people living in socioeconomically disadvantaged areas are more likely to experience first-episode psychosis. The study also showed that environmental factors play a crucial role in the variation of incidence rates across urban and rural areas.

Yellow fever virus is detected in urine and semen almost a month after infection

Researchers detected yellow fever virus in urine and semen samples from a patient who survived the disease almost a month after infection. The discovery suggests the virus may be contagious for a period longer than previously thought, potentially allowing asymptomatic individuals to transmit the disease.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalEmerging Infectious Diseases·DateMar 1, 2018

Genetic factors that make babies susceptible to complications from Zika are identified

Researchers found that genes in neural progenitor cells of affected babies were more active or less active in key signaling pathways, contributing to the development of congenital Zika syndrome. The study used twins and induced pluripotent stem cell technology to replicate the virus's effects in vitro.

Research paves the way for the development of vaccines for emerging viruses

Scientists from Brazil and Senegal discovered the gene responsible for the mild effects of West Nile lineage 8, which could be used to develop a vaccine against more virulent lineages. The researchers found that the substitution P122S induces mutations linked to low replication rates, making it an ideal candidate for a vaccine.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalPLOS Neglected Tropical Diseases·DateJan 30, 2018