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Harvard John A. Paulson School of Engineering and Applied Sciences


Optimizing how cells self-organize

A new computational framework has been developed to optimize cellular self-organization, allowing scientists to understand and control how cells grow and interact. The framework uses machine learning tools to extract rules that guide cell behavior, enabling the creation of artificial organs and potential treatments for cancer.

SourceHarvard John A. Paulson School of Engineering and Applied Sciences·JournalNature Computational Science·TypeComputational simulation/modeling·DateAug 21, 2025

Designing better brain shunts

Bioengineers at Harvard John A. Paulson School of Engineering and Applied Sciences have developed a computational model called BrainFlow that simulates cerebrospinal fluid flow in the presence of shunt implants, providing insight into optimal shunt design and placement for hydrocephalus patients.

SourceHarvard John A. Paulson School of Engineering and Applied Sciences·JournalProceedings of the National Academy of Sciences·TypeComputational simulation/modeling·DateJul 21, 2025

Extraterrestrial habitats: bioplastics for life beyond earth

A team of researchers at Harvard University has demonstrated the growth of green algae inside shelters made from bioplastics in Mars-like conditions. The experiments show a closed-loop system that can sustain itself and grow over time, offering a potential solution for sustainable habitats in space.

SourceHarvard John A. Paulson School of Engineering and Applied Sciences·JournalScience Advances·TypeExperimental study·DateJul 2, 2025

Modeling electric response of materials, a million atoms at a time

Researchers developed a machine learning framework that can predict how materials respond to electric fields up to a million atoms, accelerating simulations beyond quantum mechanical methods. This allows for accurate, large-scale simulations of material responses to various external stimuli.

SourceHarvard John A. Paulson School of Engineering and Applied Sciences·JournalNature Communications·TypeComputational simulation/modeling·DateJun 9, 2025

A router for photons

Harvard researchers have created a photon router that could plug into quantum networks to create robust optical interfaces for noise-sensitive microwave quantum computers. The breakthrough enables control of microwave qubits with optical signals generated many miles away, bridging the energy gap between microwave and optical photons.

SourceHarvard John A. Paulson School of Engineering and Applied Sciences·JournalNature Physics·TypeExperimental study·DateApr 2, 2025

NTT Research and Harvard scientists optimize biohybrid ray development with machine learning

Researchers developed mini biohybrid rays using cardiomyocytes and rubber, demonstrating improved swimming efficiencies approximately two times greater than previous biomimetic designs. The application of machine-learning directed optimization enabled an efficient search for high-performance design configurations.

Encoding many properties in one material via 3D printing

Researchers have developed a 3D printing technique to create liquid crystal elastomers with controllable alignment, leading to new possibilities for shape-morphing materials. By tuning nozzle design, print speed, and temperature, they achieved uniform molecular-scale alignment, translating to prescribed mechanical behavior.

SourceHarvard John A. Paulson School of Engineering and Applied Sciences·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateFeb 5, 2025

Concerning levels of PFAS in fish miles away from large contamination source

A new study by Harvard researchers finds alarmingly high PFAS concentrations in fish tissues even up to 8 km from the military base. The results underscore the urgent need for more comprehensive monitoring of PFAS in aquatic ecosystems, particularly in regions where freshwater fishing is an important food source.

SourceHarvard John A. Paulson School of Engineering and Applied Sciences·JournalEnvironmental Science & Technology·DateOct 16, 2024

Tropical and subtropical industrial fisheries account for about 70% of the methylmercury fished from the ocean

Industrial fishing practices in tropical and subtropical waters release high levels of methylmercury into the ocean. The majority of this mercury is found in large pelagic fish like tuna, which are then consumed by humans. This can lead to developmental delays in children and impaired cardiovascular health in adults.

SourceHarvard John A. Paulson School of Engineering and Applied Sciences·JournalProceedings of the National Academy of Sciences·DateSep 24, 2024

Can you change a chicken into a frog, a fish or a chameleon?

A team of researchers developed a theoretical framework that can reproduce and predict the patterns associated with gastrulation in a chicken embryo. Small changes in cell parameters and behavior can have a dramatic impact on the resulting gastrulation patterns, which are seen in other species such as frogs, fish, and chameleons.