Jayne S. Weiss, MD, has been awarded the 2020 Castroviejo Award for her outstanding work on corneal dystrophies, particularly Schnyder corneal dystrophy. Her research focuses on genetic mapping and pathophysiology of corneal diseases, making significant contributions to the field.
Researchers at LSU Health New Orleans found that asthma status reversed the relationship between neighborhood disadvantage and obesity in African American adolescent females. The study analyzed data from 129 participants and found that those with asthma were less likely to be obese compared to those without asthma.
A new study found that partial replacement, or hemiarthroplasty, is a viable alternative to total hip arthroplasty for treating displaced femoral neck fractures in patients over age 50. The study reported similar rates of outcome measures between the two techniques, with no significant difference in the incidence of secondary procedures.
Researchers at LSU Health found that metformin can delay mammary gland development, enhance tumor growth and metastasis, and decrease AMPK activation. The study suggests metformin's therapeutic value in treating breast cancer in patients with low Nischarin expression levels.
Researchers found that continuous communication, strategic partnerships, education, and integrated systems are crucial for effective disaster response. Community-based organizations and public health agencies must work together before a disaster strikes to build resilience in disaster-prone areas.
LSU Health New Orleans has been awarded a $13.6 million grant to expand its clinical trials network, providing cancer care and access to over 50% of newly diagnosed patients in the region. The new network will also increase minority patient participation in clinical trials.
A multidisciplinary team at LSU Health is using two new research techniques to study the link between obesity and breast cancer. They will observe breast tumor development in real-time using a biomimetic tissue-engineered 3D culture system, and analyze the extracellular matrix of breast cancer tumors using decellularization technique.
A new study by LSU Health New Orleans researchers reveals that mothers' pre-pregnancy weight status impacts the composition of their breast milk, affecting infant growth. Infants born to overweight or obese mothers exhibit less responsive growth to breast milk.
Researchers at LSU Health Sciences Center have identified a potential target for treating Chlamydia, a common STD that can cause severe outcomes if left untreated. The study found that small molecules produced by the gut microbiome can kill Chlamydia bacteria by forcing it to produce ammonia.
Researchers found a compound named 5'-iodotubercidin (5'-IT) that suppresses neuroblastoma cell growth and identified a potential new therapeutic approach. The study, led by Dr. Michael Lan, discovered a DNA-binding protein called INSM1 that is overproduced in neuroblastoma tumors.
A recent LSU Health study reports high levels of trauma and post-traumatic stress disorder (PTSD) symptoms among women exposed to the 2010 Deepwater Horizon oil spill. The research found that nearly half of these women did not receive mental health treatment in the past year, underscoring the need for better access to care.
Pembrolizumab, a new immunotherapy drug, shows lasting tumor control and improved overall survival in advanced Merkel cell carcinoma patients. The study reports generally manageable side effects and supports the use of immunotherapy as an effective treatment option for this aggressive form of skin cancer.
A 58-year-old female patient with advanced Alzheimer's disease showed significant improvement in brain metabolism and symptoms after undergoing hyperbaric oxygen therapy. The patient reported increased energy, mood, and cognitive function, and experienced reduced anxiety and disorientation.
A new study led by Dr. Suresh Alahari found that the protein Nischarin regulates cell attachment and alters exosome properties, reducing breast cancer cell motility and adhesion. The research team's findings suggest that Nischarin-expressing exosomes may serve as an effective treatment for cancer.
Research suggests that a novel protein called Nischarin may be a promising therapeutic target for obesity and diabetes. Studies found that Nischarin expression is suppressed in fat tissue of obese humans and that its disruption leads to insulin resistance in female mice, but not male mice.
A new antibiotic, zoliflodacin, has shown promising results in treating uncomplicated gonorrhea infections with a single oral dose. The study found a cure rate of 96% for participants treated with zoliflodacin, compared to 100% for those treated with ceftriaxone.
A new editorial and free resource clarify corneal dystrophy diagnoses based on corrected medical literature, with the International Committee for Classification of Corneal Dystrophies providing an updated standard classification. The IC3D nomenclature has become internationally accepted.
Research by LSU Health New Orleans found that early team-based exposure to multiple health disciplines in pipeline programs reduces traditional role and leadership stereotypes. This leads to improved collaboration and better patient outcomes, as seen in the study's statistically significant positive changes in IPE perceptions.
The project aims to increase access to certified sexual assault nurse examiners (SANE) for people who have been sexually assaulted in 12 southeast Louisiana parishes. The grant will train 140 nurses, with a minimum of 75 SANE-certified nurses.
A Phase III clinical trial is enrolling men with metastatic Stage 4 prostate cancer to compare standard systemic therapy with or without surgery or radiation therapy. The goal is to delay disease progression and improve survival.
Researchers aim to address muscle power deficits in children with cerebral palsy, using a combined impairment and task-specific approach. The study will investigate the effects of PT3 on functional walking capacity, muscle performance, and architecture.
A study by LSU Health finds that Louisiana Medicaid patients have limited access to outpatient orthopaedic care, with only about 10% of the orthopaedic workforce in the state available. The limited access can cause delays in care and lead to poorer outcomes.
Researchers have developed a novel statistical method called AA9int to evaluate gene-to-gene interactions associated with cancer and other complex diseases. This approach identifies combinations of genetic variants for predicting cancer risk and prognosis, increasing our understanding of the biological mechanisms of cancer development.
A study published in Frontiers in Public Health found that Grenadian female adolescents adhering to a traditional diet rich in healthy foods have lower rates of obesity than those consuming a more westernized diet. The researchers identified a generational effect, where the prevalence of obesity increases with future generations.
Research led by LSU Health found that hypoxia decreases Protein S, a natural anticoagulant, increasing the risk of potentially life-threatening blood clots. The study identified the gene regulatory mechanism controlling PS production in response to oxygen levels.
Research by LSU Health New Orleans School of Public Health found that flushing water lines may not be effective in reducing lead levels, potentially increasing exposure to children. The study suggests that certified water filters and more proactive interventions may be needed to protect children from lead in drinking water.
Researchers at Louisiana State University Health Sciences Center have identified miR-27b, a microRNA, as a potential therapeutic target for breast cancer treatment. The study found that suppressing miR-27b enhances the expression of PDHX, a protein involved in cell metabolism, which helps suppress tumor progression.
Researchers investigating genetic and environmental factors contributing to aggressive prostate cancer in African-American men, a population with a 15% lifetime risk compared to 10% for white men.
A collaborative effort to build capacity in addressing post-disaster behavioral health issues successfully expanded local mental health infrastructure by hiring new staff and training providers on evidence-based models. The Resilient Baton Rouge program achieved multiple objectives, including planning and coordinating service delivery ...
A new study from LSU Health Sciences Center found that opioids significantly increase the risk of fracture nonunion following acute and chronic administration. The researchers also suggest that certain medications, including Schedule II opioids and prescription NSAIDs, create a greater nonunion risk than non-opioid analgesics.
The American Cancer Society recommends earlier colorectal cancer screening for average-risk adults beginning at age 45, based on research showing an increased incidence of CRC in younger adults. Colorectal cancer incidence has declined steadily over the past two decades in people 55 and older due to screening.
The Louisiana Tumor Registry has been awarded a one-year, $1.8 million contract to continue its work as a SEER Program-designated cancer registry. The award includes options for an additional nine years of funding, making it one of 16 competitively awarded SEER registries in the US.
A recent study found that obesity contributes to poorer outcomes in non-white patients who have hemorrhagic strokes, with African-Americans being particularly vulnerable. The research highlights the need for targeted interventions to address nutritional needs and reduce the burden of obesity on recovery following stroke.
Researchers identified new genetic mutations in cancer cells that promote survival and resistance to treatment. The study found that no two cancers were genetically identical, even among those with similar characteristics.
Researchers developed a cream combining antioxidants, moisturizers and free radical scavengers to treat ACD. The treatment relieved itch, reduced swelling and protected peripheral nerves without corticosteroid side effects.
Researchers found that nearly two-thirds of low-income participants had never visited a farmers market, highlighting a need for increased awareness. A novel internet-based social marketing strategy, Healthy Roots for You, was tested to increase awareness and encourage future use among low-income residents.
A LSU Health New Orleans study found that DHA in fish oil 'preconditions' photoreceptor and RPE cells to survive future insults, reducing the risk of retinal degeneration. The researchers also discovered that daily omega-3 supplementation may provide an opportunity for halting debilitating eye diseases.
A study on an unusual snapping turtle with one lung found shared characteristics with humans born with one lung who survive beyond infancy. The researchers used digital 3D anatomical models to compare the architecture of the branching patterns inside the lungs and position of the lungs relative to the shell.
Researchers at LSU Health will test the effectiveness of physical exercise to improve blood sugar regulation in HIV/AIDS patients who also consume alcohol. The studies aim to decrease the burden of disease in this vulnerable population and guide larger scale interventions to reduce metabolic disorders.
A pilot case control study found improvements in TBI, PPCS, and PTSD symptoms, brain blood flow, depression, anxiety, and quality of life after HBOT. Significant reductions in suicidal ideation and anxiety were also observed.
Researchers aim to reduce comorbid illness in people living with HIV by developing personalized prebiotic and probiotic therapies, targeting gut bacteria balance. The study seeks to attenuate metabolic health issues associated with harmful alcohol use and heart disease.
LSU Health New Orleans' Precision Medicine team will participate in the National Institutes of Health's All of Us Research Program, aiming to gather information from 1 million or more participants. The program seeks to design individualized approaches to disease prevention and treatment using diverse data sets.
Researchers will investigate how individual differences in stress response affect escalation of alcohol drinking after traumatic stress, with potential treatments for vulnerable populations. The study aims to identify neurobiological targets for treating alcohol abuse in PTSD patients.
The partnership aims to address health disparities by conducting research on patient-derived cancers and training students in cancer health disparities-based precision medicine. This collaboration seeks to bridge the gap in understanding how to plan cancer prevention and care for underserved populations.
Researchers at LSU Health Sciences Center have discovered a new class of molecules called elovanoids that synchronize cell-to-cell communication and reduce inflammation in the brain. These novel molecules, made from omega-3 fatty acids, protect neuronal cells and promote their survival.
The National Institute of General Medical Sciences awards LSU Health a $1.4 million grant to prepare individuals from underrepresented backgrounds for PhDs in biomedical sciences. The program aims to enhance the diversity of the biomedical research workforce and provide hands-on exposure to medical research.
The LSU Health New Orleans Cardiovascular Center of Excellence will receive funding to study the effectiveness of MSI-1436, a novel drug that stimulates heart muscle regeneration. The drug has shown promising results in small animal models and Phase 1 clinical trials for obesity and type-2 diabetes.
A study published in Nature Research's Scientific Reports reveals that the novel protein SATB2 can cause normal cells to become malignant, grow and spread like cancer stem cells. Silencing SATB2 suppresses cell growth and cancer stem cell characteristics, suggesting a potential new target for therapy.
Researchers at LSU Health New Orleans have discovered the potential of a protein called Nischarin to treat or prevent metabolic diseases such as obesity and diabetes. The findings showed that Nischarin interacts with and controls the activity of a gene called AMPK, leading to improved glucose and insulin tolerance.
The LSU Health New Orleans will investigate the effectiveness of the Adenowire in reversing coronary vasoconstriction and preventing no-reflow phenomenon. The technology has the potential to improve outcomes for millions of people worldwide affected by cardiovascular disease.