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Monash University


Bacteria's secret weapon revealed

Researchers at Monash University have discovered a previously unknown way bacteria evade immune responses, targeting mitochondria for disarming. The study suggests potential new ways to combat resistant bacterial infections and could lead to new therapeutic possibilities.

SourceMonash University·JournalNature Microbiology·DateAug 17, 2020

How to repair your gut

A strong cellular lining is essential for a healthy gut, and damage to it can cause painful symptoms. Monash University researchers have identified a key biomolecule, Neuregulin-1, that accelerates the repair of damaged tissue by prompting stem cells to regenerate.

SourceMonash University·JournalCell Stem Cell·DateJul 20, 2020

Superbug impact on the gut

The study found that C. difficile massively activates a human enzyme called plasminogen to destroy gut tissue and spread infection. Researchers developed an antibody that prevents plasminogen activation, stalling infection progress and tissue damage.

SourceMonash University·JournalGASTROENTEROLOGY·DateJun 25, 2020

T cell immunity in the elderly

Researchers found that T cells increase their metabolism to survive, contradicting previous assumptions about immune function. The study suggests that targeted interventions like vaccines or immunotherapies could boost T cell immunity in the elderly.

SourceMonash University·JournalNature Communications·DateJun 5, 2020

Australian researchers set record for carbon dioxide capture

Researchers from Monash University and CSIRO have developed a magnetized Metal Organic Frameworks (MOFs) nanocomposite that captures carbon dioxide with remarkable speed and low energy cost. This technology is 45% more efficient than commercially deployed materials, making it a promising solution for emissions reduction and renewable e...

SourceMonash University·JournalCell Reports Physical Science·DateJun 3, 2020

Astronomers capture a pulsar 'powering up'

Researchers observed an accreting neutron star entering an outburst phase, studying its structure and material movement. The observation revealed a 12-day process, contradicting previous theories of two- to three-day timescales.

SourceMonash University·JournalMonthly Notices of the Royal Astronomical Society·DateJun 2, 2020

Leap forward in the discovery and development of new antibiotics

Researchers at Monash University have made a significant breakthrough in the development of new glycopeptide antibiotics, which could provide a vital advantage in the fight against resistant bacteria. By combining natural enzymes with synthetic chemistry, scientists can now explore new antibiotics that have never been made before.

SourceMonash University·JournalAngewandte Chemie International Edition·DateMay 11, 2020

Study redefines exi'STING' dogma of inflammatory mechanism

Researchers at Monash University have discovered the mechanism behind one of two signalling arms involved in the cGAS-STING pathway. The findings reveal that a closely related TBK1 homologue, IKK-epsilon, plays a crucial role in cytokine production, leading to new understanding of autoimmune diseases and cancer treatment.

SourceMonash University·JournalCell Reports·DateApr 7, 2020

World's first ultrasound biosensor created in Australia

Researchers in Australia have developed a new ultrasound biosensor that can be used to track disease states in real-time, using cheap and portable technology. The sensor uses nanoparticles that alter their stiffness in response to pH changes, allowing for accurate monitoring of biomarkers such as tumor shrinkage and organ response.

SourceMonash University·JournalACS Sensors·DateMar 23, 2020

Cracking the code for hookworm infestation

Researchers at Monash University have discovered a key mechanism that enables hookworms to evade the human immune system. By understanding how these parasites destroy neutrophil extracellular traps, scientists may be able to develop vaccines to boost immunity and prevent reinfection.

SourceMonash University·JournalCell Host & Microbe·DateFeb 12, 2020

Discovery takes pressure off blood measurements

Researchers at Monash University developed a wearable device using continuous wave radar and photoplethysmogram sensors to calculate continuous blood pressure measurements. The device achieved high accuracy rates, with 93% success during sedentary tasks and 83% during exercises.

SourceMonash University·JournalScientific Reports·DateJan 31, 2020

Bacterial link in celiac disease

Scientists have discovered a molecular foundation for bacterial exposure as a potential environmental factor in coeliac disease development. Receptors from immune T cells can recognize protein fragments from certain bacteria that mimic gluten, leading to aberrant recognition and health problems.

SourceMonash University·JournalNature Structural & Molecular Biology·DateJan 8, 2020

Study points to new weapon in fight against lethal fungi

Researchers have gained insights into how nanoparticles can be used to identify invasive microbes and deliver targeted treatments, potentially preventing deadly diseases contracted on medical equipment. The study, conducted by Monash University researchers, found that nanoparticles bound to fungal cells but were non-toxic to them.

SourceMonash University·JournalACS Applied Materials & Interfaces·DateNov 9, 2019

Talking receptors may affect relaxin at work

Researchers at Monash University have discovered that receptors can communicate and interact, affecting the therapeutic actions of relaxin. This finding has implications for clinical trials involving relaxin and other drugs acting on these receptors.

SourceMonash University·JournalJournal of the American Society of Nephrology·DateSep 11, 2019