Monash researchers have discovered a unique set of 'super' receptors on immune cells capable of killing HIV across genetically diverse populations. These killer CD4+ T cells can recognize HIV fragments in people with different HLA molecules, a feature that may help control the spread of the disease.
Researchers at Monash University have developed a hand-made super-microscope capable of seeing the building blocks of bacterial cell walls. This discovery has shed light on how bacteria evade the immune system, providing key knowledge to disarm superbug resistance.
Researchers have developed a new class of biosensors that can study biomembrane interactions and reveal how cells respond to disease molecules. This technology has significant implications for designing more effective anti-infective drugs and novel cancer treatments.
A Monash University study has identified a lethal fungus that destroys the immune cell responsible for killing it by depleting its source of nutrients. The research found that Candida albicans competes with macrophages for glucose, leading to their death.
Researchers have developed a way to detect gravitational waves from faint black hole mergers, allowing them to study populations of black holes at vast distances. The new method is estimated to be one thousand times more sensitive than previous techniques, and will enable the detection of thousands of previously hidden black holes.
Gonorrhoea superbugs have developed resistance to all known antibiotics, targeting human immune cells called macrophages. Monash researchers discovered the mechanism of evasion, which could lead to new strategies for combating gonorrhea infection.
A series of papers warns that low back pain is a major health burden globally, with over 540 million people affected. The condition is poorly understood and being mismanaged medically, leading to unnecessary harm and costly treatments.
The World Mosquito Program launches a self-sustaining program in La Paz, Mexico, using Wolbachia mosquitoes to provide long-lasting protection against dengue, Zika, and chikungunya viruses. The initiative aims to strengthen community resilience against emerging health threats.
A research team has discovered a critical moment when DNA escapes from the mitochondria during cell death, potentially triggering autoimmune diseases. This 'Great Escape' moment may one day prove crucial for understanding inflammatory and autoimmune conditions.
Researchers at Monash University have identified a molecular switch in the brain that regulates fat storage after dieting. This switch, called carnitine acetyltransferase (Crat), instructs the body to replace lost weight through increased fat storage.
Scientists have discovered a novel method for filtering salt and metal ions from seawater using MOFs, which has significant potential for the water and mining industries. The technology could reduce energy consumption by up to 2-3 times compared to current methods.
Researchers at Monash University have identified a novel molecular 'blueprint' that enables the immune system to fight disease by 'remembering' past infections. This discovery potentially opens new avenues for improving vaccines and therapies, including those targeting cancer and autoimmune diseases.
A series of studies by Monash University researcher Jose Polo have unveiled new evidence in the decade-long mystery of cell reprogramming. The researchers found that the route to pluripotency depended on the original cell type, with different cell types requiring different approaches. This breakthrough has important implications for re...
Researchers found signals in a tiny worm that control the mechanism of severed nerves self-healing. The discovery enables genetic control over this process, raising hopes for treating nerve injuries in humans. The study used laser beams to sever neurons and observed how they regenerated, finding full function restored within 48 hours.
Researchers at Monash University have created the first high-resolution structure of the Type II secretion system in Pseudomonas aeruginosa, a critical component in the bacteria's ability to secrete toxins. This breakthrough could lead to the development of new drugs targeting this nanomachine to reduce virulence and combat infection.
Monash University researchers identified PRMT1 as an enzyme essential for the immune system's ability to produce antibodies and clear infections. The discovery opens up new avenues for treating cancer and autoimmune diseases by targeting this enzyme.
Researchers at Monash University have discovered the presence of regulatory T cells in the retina, a potential target for treating retinopathy of prematurity. The study's findings suggest that boosting these cells may repair damaged blood vessels in the retina, reducing ROP risk.
A landmark trial found that older stored red blood cells are safe and associated with fewer side effects, including transfusion reactions. The study, published in the New England Journal of Medicine, challenged common practice of allocating the oldest available compatible blood.
A research team has identified a methanotroph strain that can consume both methane and hydrogen gases, improving its growth and survival in various conditions. This finding has significant implications for greenhouse gas mitigation, as industrial companies can use these bacteria to convert harmful gases into useful products.
Researchers at Monash University identified a crucial part of PTPN2's role in early T-cell development, which can contribute to the development of autoimmune disease. Decreased levels of this enzyme lead to pro-inflammatory T-cells that damage body tissues.
Researchers at Monash University have discovered a brain mechanism that controls the conversion of white fat into brown fat after eating, which could lead to new obesity treatments. The 'switch' is turned off during fasting and on during feeding, promoting weight gain when the switch remains active.
A team of researchers from Monash University has identified the Nkx2.5 gene as a key regulator of wing development in emus. This discovery sheds light on the genetic basis of limb reduction and may have implications for human limb development, particularly in individuals born with limb abnormalities.
Monash University researchers have identified a key part of the process by which a common clinical antibiotic is formed, paving the way for novel compounds to tackle bacterial resistance. By understanding this process, scientists can manipulate it to create modified compounds that could help combat superbugs.
The discovery of Nataliyamalikite reveals insights into metals extraction and geological processes. The new mineral's crystal structure was determined using advanced microscopy techniques, shedding light on its properties.
A new therapy developed through stem cell technology has shown promise in treating chronic asthma by reducing inflammation and reversing airway remodeling. The study, led by Monash University scientists, found that induced pluripotent stem cells could effectively treat fibrosis and lung dysfunction associated with asthma.
Researchers at Monash University have developed a therapeutic approach that promotes muscle mass growth by inhibiting three proteins responsible for muscle wasting. The approach, combining molecules to target activin A, activin B, and myostatin, resulted in a 150% increase in skeletal muscle mass in preclinical models.
Researchers have developed a new drug delivery strategy to block pain within nerve cells, offering a major breakthrough in treating chronic pain. The target protein, NK1 receptor, is controlled once it enters the cell, allowing for more effective pain suppression.
A recent study reveals a 400% surge in premature and potentially preventable deaths of Australian nursing home residents over the past decade. Falls and choking were responsible for most unintentional deaths, with a smaller number attributed to clinical care complications or intentional acts such as suicide and assault.
Researchers found chemokines can activate chemokine receptors in different ways, leading to varying responses and chronic inflammation. This discovery may lead to the development of anti-inflammatory drugs targeting specific molecules.
Researchers at Monash University have identified a new concept called 'orphan memory,' which challenges current understanding of gravitational waves. They found that high-frequency waves leave behind a signature that LIGO can detect.
Researchers have identified a key process that contributes to chromosomal abnormalities and miscarriages in older women, offering new hope for improving fertility treatments. The discovery focuses on the regulation of securin levels in egg development, which can help prevent chromosomal abnormalities.
A global health threat, superbugs are bacteria resistant to commonly used antibiotics. Monash University researchers identified the first important clues on how to counter superbug strategies, using electron microscopes and comparing data from antibiotic-resistant Staphylococcus aureus samples with non-resistant strains.
A world-first study found that pregnant rays are traumatized by capture, impacting their reproductive potential and offspring health. The study, led by Leonardo Guida, examined the southern fiddler ray and found that trawl capture can affect fetal development, leading to smaller, lighter offspring with compromised immune systems.
An international study has identified a new therapeutic target for Hepatitis C Virus by hijacking host cell communication systems. The approach may have broader application to other infectious diseases.
Cytomegalovirus has evolved to hide from the immune system by presenting decoy markers, tricking NK cells into thinking infected cells are healthy. The immune system responds by evolving new mechanisms to detect and kill the virus, including a molecule called NK1.1.
An international study led by Monash scientists found that Antarctica and the Southern Ocean's biodiversity management is lagging behind the global average in some areas, but exceling in others. The study's findings have significant implications for conservation efforts globally.
A diet high in short-chain fatty acids produced by gut bacteria has been found to protect against the onset of type 1 diabetes. The study, published in Nature Immunology, suggests that this special diet can improve immune tolerance and reduce inflammation.
A new, inhaled form of oxytocin has shown promising results in preventing postpartum haemorrhage (PPH), a leading cause of maternal deaths worldwide. The inhalable medication could potentially be accessible to mothers sooner, thanks to a streamlined registration pathway.
Researchers have identified a powerful new pathway for enhanced blood cancer therapies by combining epigenetic drugs with immune-based treatments. This approach has shown promising results in inducing cancer cell death and overcoming resistance.
Researchers from Monash University and Cardiff University have made a breakthrough understanding how HIV evades the immune system by mutating key molecules, which will help design better therapies and vaccines. The study provides new insights into HIV's ability to evade the immune system.
A long-term study found gastric band surgery improved patients' chances of diabetes remission, reduced medication needs and enhanced quality of life. The study also showed significant weight loss and low adverse events.
Researchers have discovered a worm gene that triggers feelings of fullness and the need to sleep after eating, opening up potential for an obesity drug. The ETS-5 gene controls signals from the brain to the intestines, influencing food intake and activity.
Australian researchers investigated how certain medications impact MAIT cell function, finding some prevent detection of infections while others activate the immune system. This discovery may lead to better understanding and control of immune reactions to drugs, as well as new therapies that manipulate MAIT cell behavior.
Monash University has been awarded a USD 9.7 million grant to lead a five-year research project on transforming water infrastructure and sanitation practices in urban slums globally. The project aims to improve human health and well-being in informal settlements, with potential applications for new water management policies worldwide.
A landmark study reveals that men with a family history of prostate cancer and the BRCA2 gene fault have a more aggressive form of prostate cancer. The study shows that these cancers are genetically similar to advanced cancers, explaining why BRCA2 patients have poor outcomes.
Scientists have discovered how the human immune system targets Mycobacterium tuberculosis, the bacteria that causes TB. The study provides key insight into how the immune system can recognize TB-infected cells, which could lead to the development of new diagnostic tools and novel immunotherapies.
A new study published in Nature Communications presents evidence suggesting that a low-mass supernova played a crucial role in the formation of our solar system. The research team analyzed short-lived radioactive nuclei found in meteorites and discovered unique 'fingerprints' that point to a low-mass supernova as the trigger.
Monash University scientists have uncovered evidence of how baleen whales evolved from biting prey with teeth to filtering using baleen. The discovery sheds light on the complex evolutionary change that led to the rise of filter-feeding in these massive creatures.
Scientists at Monash University have discovered a new mechanism by which algae in sand survive under conditions of constant mixing. They found that these organisms ferment, producing hydrogen and other compounds like oleate, a component of olive oil. This breakthrough has significant implications for the biofuels industry.
A new study found nearly five deaths per 1000 employed Australian health care professionals were caused by drugs from 2003-2013. The majority of these deaths involved females in their mid-40s with a mental health condition and the intent to self-harm.