Researchers found that a faster rate of binding does not always translate to greater potency, as the study's lead author David Heppner explained. The team proposed a two-step design process balancing inactivation efficiency rates with target selectivity and other parameters to identify promising compounds.
Researchers created a glycan-binding protein that can analyze and treat diseases via sugar patterns found on the surface of cells. The tool, named sCore2, was developed by retraining an enzyme to bind to specific sugars, providing a new way to study glycans and their role in disease.
Researchers from University at Buffalo and University of Colorado Boulder have developed novel equations to characterize two-dimensional wave patterns, including the 'matrix tide' observed in China's Qiantang River. These equations use numerical simulations to model complex wave patterns that were previously difficult to solve.
Researchers highlight the potential of solvent-based recycling and AI-assisted sorting to recycle complex plastics. However, the study emphasizes that replacing fossil-based plastics with biobased alternatives poses significant challenges, requiring comprehensive approaches and life cycle assessments.
A new breast scan system combines photoacoustic and ultrasound imaging to produce clear 3D images of common breast cancer subtypes. The system, called OneTouch-PAT, takes less than a minute to complete and excels at detecting suspicious lesions in women with dense breast tissue.
Scientists have discovered that repeat RNAs aggregate inside droplets but can be disassembled with an engineered piece of RNA. The study sheds new light on how these clusters form within biomolecular condensates and presents a potential therapeutic application.
Researchers identified nearly 500 switch-like genes, which express at high or low levels, and linked them to various ailments like vaginal atrophy and COVID-19. The study suggests that hormones and genetic variation drive this 'switch-like' behavior.
A University at Buffalo-led study proposes using AI-powered handwriting analysis to identify spelling issues, poor letter formation, and other indicators of dyslexia and dysgraphia. The work aims to augment current screening tools and provide an early detection tool for these neurodevelopmental disorders.
A University at Buffalo study found that historically redlined neighborhoods have a disproportionate impact on breast cancer factors and survival, with lower socioeconomic status and exposure to pollution contributing to the increased risk. The research suggests that addressing environmental disparities in these communities is crucial ...
Researchers discovered two proteins, GSK3ß and ERK1, that regulate the movement of a toxic huntingtin protein in neurons. Inhibiting GSK3ß led to reduced axonal blockages and neuronal cell death, while inhibiting ERK1 had the opposite effect, increasing transport problems and cell death.
A new clinical artificial intelligence tool, SCAI, developed by University at Buffalo researchers has demonstrated remarkable accuracy on all three parts of the USMLE exams. Achieving higher scores than most physicians and all other AI tools, SCAI has the potential to become a critical partner for physicians.
A new vaccine platform developed at the University at Buffalo has demonstrated complete protection in mice against a deadly variant of bird flu. The vaccine, which combines key proteins hemagglutinin and neuraminidase, shows promise as a versatile and easy-to-produce vaccine that could be effective against evolving bird flu strains.
A recent study published in the Journal of Sex Research found that psychedelic experiences can enhance participants' perceptions of their relationship quality, attraction to their current partner, and sexual activities. Additionally, approximately 10% of participants reported influences on their gender identity and expression.
A University at Buffalo study found that pregnant women who ate chili once per month had a 3.5% risk of developing gestational diabetes, compared to 7.4% for those who never ate chili. The researchers attribute the benefits to capsaicin and phenolic compounds in chili.
A new study from the University at Buffalo measures neonatal intensive care unit (NICU) admissions and satellite-based air pollution data, finding that newborns exposed in the last month of pregnancy to higher levels of NO2 have a 30-35% higher risk of NICU admission and an 11-22% increased risk associated with PM2.5.
A study found nine cases of vision problems in patients taking GLP-1 medications, with seven experiencing nonarteritic anterior ischemic optic neuropathy (NAION). Neuro-ophthalmologists warn of potential risks due to the increasing demand for these drugs, which can cause blood sugar fluctuations.
A University at Buffalo-led team has identified a strain of bacteria that can break down and transform at least three types of PFAS, as well as some of the toxic byproducts of the bond-breaking process. The bacteria, Labrys portucalensis F11, metabolized over 90% of perfluorooctane sulfonic acid (PFOS) after a 100-day exposure period.
Researchers have identified 11 genes affected by PFAS exposure, which could serve as markers to detect neurotoxicity. The study found distinct molecular structures within each type of PFAS drive changes in gene expression, highlighting the need for individual investigation.
Researchers at University at Buffalo have developed a plasma-electrochemical reactor that produces ammonia from nitrogen in the air and water, with no carbon footprint. The process uses renewable electricity and can be scaled up to meet industrial demands.
Researchers propose that small black holes born in the early universe could have left behind hollow planetoids and microscopic tunnels, potentially detectable with telescopes or by monitoring old materials. The study suggests a low probability of primordial black hole passage but emphasizes the potential for discovery.
A new study published in the New England Journal of Medicine found that blocking the artery supplying the brain covering reduced re-operations for chronic subdural hematomas by threefold. The EMBOLISE trial followed 400 participants and showed a significant reduction in recurrence rates with a simple, minimally invasive procedure.
Researchers at the University at Buffalo have identified the binding site of low-dose ketamine, revealing how it alleviates major depression symptoms within hours. The study also identifies how depression originates in the brain and may lead to further research on using ketamine-like drugs for other brain disorders.
Researchers have discovered a gene called NANOG that can improve nerve regrowth and re-establish innervation in damaged muscles after traumatic nerve injuries. This discovery has significant potential to help mitigate long-term disability for people with debilitating nerve injuries.
Researchers argue that current cannabis policies are driven by politics, not science, and call for a shift towards harm reduction and health promotion. The field should use the social ecological model as a framework for developing comprehensive policies.
A new study finds that the gene for starch-digesting saliva may have first duplicated more than 800,000 years ago, seeding genetic variation that shapes modern diet. This early duplication set the stage for significant variation in the amylase region, allowing humans to adapt to shifting diets with increasing starch consumption.
A small clinical trial found that low-dose lithium aspartate is ineffective for long COVID symptoms, but a dose-finding study suggests higher doses may be effective in reducing fatigue and brain fog. Researchers are calling for further studies to explore the potential of lithium aspartate at higher dosages.
Researchers found that individual PFAS have relatively low cytotoxicity and neurotoxicity levels, but the chemicals act together to make mixtures toxic. PFOA and PFOS were found to be major contributors to mixture toxicity.
A new study has identified the genetic elements responsible for transforming classical Klebsiella pneumoniae into a devastating, drug-resistant killer. Researchers found that the plasmid pVir is the primary determinant of hypervirulence in this bacterium.
A University at Buffalo psychiatrist has been awarded $3 million to focus on the mental health of children with cystic fibrosis. The study will evaluate national prevalence of mental health concerns in children under 12, identify best screening methods and characterize issues seen in treated children. Early identification and addressin...
Researchers found that humorous comic strip cartoons increased likelihood of agreeing to take a quiz on personal risk for colon cancer. Exposing people to funny content reduced information avoidance, making them more likely to choose to watch a video about colorectal cancer prevention.
The Eat Local WNY initiative, funded by the US Department of Agriculture, aims to create a thriving community through investment in local food, businesses, and people. The project encourages shoppers to purchase at least 10% of their food from local producers, promoting fair wages for farmers, better stewardship of farmlands, and fresh...
Researchers found a significant association between air pollutant exposure and emergency room visits for mental disorders in communities that were once denied mortgages due to race. Elevated levels of fine particulate matter and nitrogen dioxide in these neighborhoods increased ER visits by 1.04% and 0.44%, respectively.
Researchers at the University of Buffalo have successfully fabricated the world's highest-performing high-temperature superconducting (HTS) wire segment, achieving critical current density and pinning force values previously unseen. The breakthrough could significantly improve the price-performance metric for commercial coated conducto...
A study published by University at Buffalo researchers found that telemedicine referrals led to increased patient retention in treatment, with 65.1% of telemedicine patients still in care at the 30-day mark versus 22.2% of those referred from an emergency department visit. This suggests that telemedicine can remove barriers to care and...
A study found that large language models (LLMs) like ChatGPT underperform state-of-the-art detectors but can explain their analysis in plain language. LLMs' semantic knowledge makes them well-suited for detecting deepfakes, providing a common sense understanding of reality.
A University at Buffalo-led research team has found that the same genes whose mutations gave rise to a low functioning male gorilla reproductive system may also be responsible for human male infertility. Researchers identified 109 reproductive-related gorilla genes that are often mutated when present in infertile men.
A University at Buffalo researcher found that Truth Social was as effective as Twitter in driving news attention for Donald Trump, despite its smaller user base. However, journalists embedded Trump's posts less frequently on Truth Social than on Twitter.
Researchers developed an algorithm that uses stochastic differential equations to identify key data points in noisy data, improving early warning signal accuracy. The approach can be applied to various domains, including ecology and mental health, and has been validated through simulations.
The study charts the family history of Arabica through Earth's heating and cooling periods over the last millennia. The research found that Arabica developed over 600,000 years ago in Ethiopia via natural mating between two other coffee species.
A study by University at Buffalo researchers found that 90.3% of participants receiving telemedicine treatment were cured of HCV, compared to 39.4% in the control group. The researchers also found significant improvements in health and well-being after HCV treatment.
Researchers have successfully transferred electron spin to photons, enabling rapid communication over long distances. This breakthrough could revolutionize optical telecommunications and pave the way for ultrafast communication between Earth and Mars.
Researchers at the University of Buffalo have discovered that fusion proteins hijack gene regulatory complexes through their unfolded domains, causing cancer. The study found that these disordered domains interact with high specificity and form liquid-like droplets, enabling cancerous genes to be activated.
Researchers at University at Buffalo propose a new approach to developing cancer drugs by determining the optimal placement of molecular linkers earlier in the process, reducing trial and error and increasing potency, according to a study published in Communications Chemistry.
Researchers developed a new recombinant flu vaccine called Hexaplex, which provided superior protection against H1N1 and H3N2 viruses in animal models. The vaccine's combination of six proteins from different groups resulted in strong antibody production and T-cell activation, offering broader immunity.
A new study published in JAMA Cardiology found that taking 3,600 steps per day is associated with a 26% lower risk of developing heart failure. The study also found that accumulating more light and moderate intensity daily activities can help prevent heart failure.
Researchers found that memory cells become more stable over time, improving ability to distinguish between similar experiences. This process could lead to new treatments for memory disorders like Alzheimer's disease.
Researchers at UB have developed a new deepfake detection algorithm that reduces biases in facial recognition, with one method classifying videos based on demographics and the other relying on features not visible to the human eye. The algorithms improved fairness metrics and reduced disparities in accuracy across races and genders.
Researchers use quantum chemical calculations to understand sodium's transformation into an insulator at high pressures. The study confirms theoretical predictions made by Neil Ashcroft and connects it with chemical concepts of bonding.
Researchers will compare two healthcare delivery models focusing on early detection and control of postpartum hypertension and social/mental health factors. The study aims to improve birth outcomes for women and children in underserved communities through a patient-centered approach.
Researchers have identified the genetic defect causing infantile cystinosis, a rare disease that shortens lifespan, and developed a protocol to differentiate stem cells into healthy kidney cells. The study suggests using CRISPR genome editing to repair the defective gene and potentially cure the disease.