A new chemical compound named '1938' has been identified that can stimulate nerve regeneration after injury and protect cardiac tissue from damage. The compound activates the PI3K signalling pathway and has shown increased neuron growth in nerve cells and improved recovery in animal models.
A recent study has revealed how genetic and environmental factors interact to cause cleft lip or palate in a developing fetus. The research found that mutations in the e-cadherin gene combined with exposure to inflammatory risk factors during pregnancy can lead to cleft lip, which affects one in 700 live births.
A new international clinical trial is evaluating new antibiotic combinations for newborn babies with sepsis, which affects up to 3 million babies globally. The NeoSep1 trial will assess the safety and efficacy of three new antibiotic treatments against existing standard regimens.
Researchers at UCL have uncovered the molecular basis of a woman's rare genetic mutation that allows her to live pain-free and heal rapidly. The study found that the mutation in the FAAH-OUT gene turns down FAAH gene expression, affecting other molecular pathways linked to wound healing and mood.
Victims of sexual assault are often blamed for not fighting back, but neuroscientific research suggests this may be due to involuntary immobility. Thirty per cent of women experience sexual assault or rape in their lifetime, and 70% report being 'frozen' during the ordeal.
A new study predicts that climate change will expose species to potentially dangerous temperatures, leading to an abrupt loss of habitat. The research found that up to 30% of species will be at risk of experiencing unfamiliarly hot temperatures across at least 30% of their geographic range in a single decade.
A study found that UK schools affiliated with Accelerated Christian Education (ACE) use curriculum materials denying human-caused climate change and presenting evolution as a conspiracy theory. This raises concerns about the quality of science education in these schools.
A new study led by UCL researchers finds that a particular gene affecting nose shape is inherited from Neanderthals and may have been influenced by natural selection. The study used data from over 6,000 volunteers and identified 33 genome regions associated with face shape.
A new study by UCL researchers hints at the possibility of detecting conditions such as coeliac disease and Parkinson's disease in principle up to 10 years before diagnosis. The review of existing evidence indicates a 'diagnostic window' – the point at which diagnosis may be possible for some patients.
A new study recommends using more positive and empathetic language to communicate fertility awareness, targeting both men and women. The review suggests five key changes to promote fertility awareness in a supportive way, including avoiding blame and stigma, emphasizing the choice of parenthood, and promoting healthy habits.
Researchers at UCL have identified proteins in the blood associated with an increased risk of developing heart diseases, including heart failure. The findings could lead to more refined cancer treatments that minimize cardiotoxicity and improve survival rates.
A deep learning AI model has been developed to screen for retinopathy of prematurity (ROP) in infants at risk of blindness. The tool was trained on images of newborns and found to be as effective as senior paediatric ophthalmologists in discriminating normal retinal images from those with ROP that could lead to blindness.
Researchers discovered two massive touching stars that will eventually become black holes and collide, generating waves in space-time. The stars are currently feeding each other every three days before the smaller star collapses into a black hole in 700,000 years.
A new genetic therapy, BIIB080, has been shown to safely lower levels of the harmful tau protein in patients with Alzheimer's disease. The trial found a greater than 50% reduction in tau protein concentrations after 24 weeks in treatment groups.
Researchers have sequenced the genomes of two hornet species, revealing clues to their invasive success. The study found rapid genome evolution and genes related to communication and smell, which may help explain why hornets are successful as invasive species across the globe.
Researchers found that people whose depression symptoms improved after psychological treatment had a lower risk of developing cardiovascular disease over three years. The association was strongest in younger adults and suggested that accessing psychological therapy could have long-term physical health benefits.
A new study found that people with long Covid smell loss have reduced brain activity and impaired communication between key smell-processing regions. This suggests a possible link between smell loss and brain changes, which may be reversible through olfactory training.
A study published in Brain found that disconnecting nerve pathways in the brain can lead to improved seizure freedom in patients with frontal lobe epilepsy. The research, involving 47 patients, revealed that cutting these connections resulted in 88% of patients being seizure-free after three years.
A new study published in The European Heart Journal – Digital Health found that smart watch data can predict a higher risk of developing heart failure and irregular heart rhythms. Researchers used machine learning to analyze ECG recordings from wearable devices and identified extra beats as indicators of increased cardiovascular risk.
A new study led by UCL researchers found evidence of ancient empires' impact on migration in Africa, revealing genetic traces from across the continent. The study used DNA data from over 1,300 individuals from 150 ethnic groups, identifying migrations linked to empires like Kanem-Bornu and Aksum.
A new report reveals that children born into the poorest fifth of families in the UK are 12 times more likely to experience poor health and educational outcomes by age 17. This clustering of adverse outcomes is linked to early childhood disadvantage, with modest reductions seen when lifting families out of poverty.
Researchers found giant gas giants orbiting low-mass stars, challenging the widely accepted planet formation model. The study used NASA's TESS satellite data and identified 15 potential giant planets, with five confirmed as actual planets.
Researchers have developed a new technique that combines real-time images with short-wave infrared light to differentiate between cancerous tumours and healthy tissue. This innovation has the potential to improve treatment outcomes for neuroblastoma patients by allowing surgeons to remove cancerous cells more precisely.
A study found that preterm infants do not habituate to repeated pain, unlike full-term infants. This lack of adaptation may affect their brain development and increase vulnerability to pain. The researchers' findings suggest that the ability to adapt to pain might develop during the third trimester of pregnancy.
A new consensus statement calls for routine radiological screening of contact children in suspected child physical abuse cases to prevent further harm. Siblings are at risk of experiencing physical abuse, with a strong association between index and contact children.
A new non-invasive diagnostic technique using smartphone photographs of the eye and face has been successfully developed to detect anaemia in children. The study, published in PLOS ONE, used images from 43 children under four to predict blood haemoglobin concentration with high accuracy.
Researchers found that loneliness is a major risk for mental health problems during pregnancy and after birth, with stigma, self-isolation, and emotional disconnection contributing factors.
Researchers from UCL Cancer Institute found that head injuries may contribute to the development of gliomas, a type of aggressive brain tumour. Studies in mice and human populations suggest that genetic mutations acting with inflammation can change cell behavior, increasing cancer risk.
A new study by UCL and King's College London researchers found that vaporized cannabis has the same short-term effects on adolescents (16-17 years old) as on adults (26-29 years old), regardless of CBD levels. The study also showed that CBD does not reduce the psychoactive effects of THC in cannabis.
Researchers at UCL discovered a new type of ice, medium-density amorphous ice (MDA), which has the same density as liquid water and exhibits properties similar to solid water. This finding may challenge existing models of water and raise questions about its anomalies.
Researchers found that allocating emissions based on ticket prices rather than travel class provides a more accurate representation of individual contributions. This approach encourages people from all budgets to seek alternative modes of transport and increases estimates of corporate emissions.
A new personalized treatment for bile duct cancer has shown remarkable results, with patients surviving for up to two years when treated with the drug futibatinib. The Phase II clinical trial found that the drug was more effective at reducing tumor size and producing modest side effects compared to chemotherapy.
A new study led by UCL researchers found small causal effects of childhood maltreatment on internalising and externalising disorders, including depression, anxiety, and psychosis. The study analysed 34 quasi-experimental studies involving over 54,000 people and suggests that preventing eight cases of child maltreatment could prevent on...
Researchers developed a framework to address women's reproductive needs holistically, combining family planning, contraception, and preconception care. The model suggests teaching children about reproductive health in school and using social media campaigns to raise awareness of reproductive preferences.
A new study has mapped the parts of the brain that support fluid intelligence, a key feature of human cognition. The research found that patients with damage to the right frontal regions performed poorly in tasks requiring problem-solving and reasoning.
A recent study published in Nature Communications found that people's sleep duration follows three distinct phases across the lifespan. The study, which analyzed data from 730,187 participants, reveals a decline in sleep duration during mid-adulthood until age 33, followed by a plateau until early 50s.
A recent study by University College London reveals that the COVID-19 pandemic has exacerbated mental health issues and food insecurity among individuals living with obesity. Nearly half of participants reported worsening mental health, while nearly a third experienced severe depression. Food insecurity also increased significantly, wi...
A new study suggests that UK woodlands could store nearly twice as much carbon as previously thought, based on a 3D scanning technique and analysis of 815 trees in Wytham Woods. This underestimation has serious implications for climate mitigation, forest protection, and restoration targets.
A new study found that wild chimpanzees in Tanzania's savanna-mosaic habitat spent as much time in the trees as those in dense forests. The researchers suggest that bipedalism may have evolved to move around trees, contradicting traditional theories that link open habitats to upright walking.
Researchers analyzed data from 5,086 children, finding that health issues were more common among those who tested positive for Covid-19. Symptoms experienced by children and young people with long Covid changed over the course of a year, with some symptoms declining while new ones emerged.
A new study found that early-life experiences can alter gene expression in fruit flies, leading to improved health and extended lifespan. The researchers discovered that changes in chromatin packaging persisted across the lifespan, counteracting normal aging processes.
A gold coin long dismissed as a forgery appears to be authentic and depicts Emperor Sponsian, who ruled Roman Dacia during civil wars. The study used scientific analysis to confirm the coin's authenticity, shedding light on Sponsian's history.
Researchers have developed mini eyes, or organoids, from stem cells donated by patients with Usher syndrome. These mini eyes allow scientists to study light-sensing cells and understand the development of blindness in the disease.
A new AI tool helps governments decide whether to bail out a bank by predicting if the intervention will save money for taxpayers. The algorithm assesses financial implications and suggests optimal bailout strategies.
A new study has shown that total ankle replacement and ankle fusion surgeries equally improve quality of life for patients with advanced ankle osteoarthritis. However, a fixed bearing joint replacement showed significant improvement over ankle fusion in clinical scores.
Research by UCL found gig workers are more likely to experience road collisions due to factors like company oversight, payment structures, and rider incentives. The study also highlights the need for better protection and safety measures in the gig economy.
A new study by UCL researchers found that tailoring whole genome sequencing analysis to individual patients can double the diagnostic rates of rare diseases. The personalised approach increased the diagnostic rate from 16.7% to 31.4%, detecting potential disease-causing variants in a further 3.9% of patients.
A new study published in Science found that a highly magnetised dead star, known as a magnetar, is likely to have a solid surface with no atmosphere. The research team used data from the NASA satellite IXPE to observe the polarisation of X-ray light emitted by the star, which revealed a signature consistent with a solid crust.
Researchers have developed a new gene therapy that selectively targets overactive brain cells, reducing excitability and suppressing seizures in mice. The treatment shows promise for treating neurological disorders such as epilepsy, Parkinson's disease, schizophrenia, and pain disorders.
A new study by UCL researchers found that problem drinking is associated with a higher risk of suicide and self-harm, particularly among those with 'probable dependence'. The study also identified signs of alcohol negatively impacting people's lives as risk factors.