A study led by UCL researchers found significant disparities in opioid painkiller access between countries, with some regions reporting rates as low as 0.01 MME per 1,000/day, while others have surpassed the US in opioid sales. The findings highlight the need for global policies to improve palliative care and pain relief provision.
A comprehensive review of 38 interventions performed at embryo transfer found that bed rest post-procedure decreased pregnancy rates by 15%. The use of ultrasound guidance and soft catheters increased pregnancy chances by 26% and 12%, respectively. The study calls for more research into promising interventions to optimize IVF success.
A recent study published in Clinical Epidemiology found that cases of cognitive decline among older adults in the UK have nearly doubled between 2009 and 2018. The researchers observed a significant increase in the number of people reporting memory concerns to their doctors, with 46% developing dementia within three years.
Teenagers involved in arts activities are less likely to engage in antisocial behaviour up to two years later. They also exhibit better self-control scores and view antisocial behaviour negatively.
Researchers have developed a monoclonal antibody called PRN100, which showed safe and encouraging results in treating Creutzfeldt-Jakob disease (CJD) in six patients. While the findings are preliminary and require further studies, they offer new prospects for this rare and fatal disease.
A recent survey of over 3,200 NHS healthcare workers found that most preferred education and support as a solution to boost vaccination uptake. The study suggests that mandatory vaccinations may actually worsen trust and lead to thousands of staff leaving the profession.
Researchers found that four-month treatment is as effective as six months in non-severe TB cases, allowing for savings on screening and training healthcare workers. The study's results led to a change in the World Health Organisation's global guidelines, recommending a shorter treatment course for children with non-severe TB.
A recent study published in JAMA Psychiatry has found that individuals without jobs or stable housing experience worse depression symptoms when treated with therapy or antidepressants. The researchers analyzed data from nine studies involving over 4,800 participants and discovered that unemployed patients had 28% poorer outcomes compar...
Research finds that global warming of 2°C will significantly increase temperature-related mortality rates in England and Wales by 42%, from around 117 deaths per day to 166. The risk further increases beyond 2.5°C, with a potential 75% increase in mortality risk at 3°C.
A new study developed an algorithm estimating a person's risk of developing prostate cancer based on age and two prostate cancer markers. The approach was found to reduce the number of false positives by three quarters compared to a standard PSA test while catching the same proportion of cancers, making screening safer and more accurate.
Researchers at UCL have created a technique called magnetomechanical stimulation that uses microscopic magnetic particles to control touch-sensitive brain glial cells. This allows for precise and remote activation of astrocytes, providing a new tool for understanding their function and potential treatment of neurological disorders.
Researchers discover a genetic mechanism linking ALS and dementia to UNC13A protein corruption, providing hope for new treatments by blocking corrupted instructions. The study found that genetic variants increase the risk of UNC13A mRNA corruption in patients with ALS and FTD.
Researchers adapted cancer models to predict effective drug combinations for treating Covid-19 at different stages of the disease. The study identified existing therapeutics that might be suitable for treating severe cases, and could help lower Covid-19 related deaths.
A team of researchers detected a ring of planetary debris surrounding the white dwarf WD1054–226, suggesting a nearby planet may be present in its habitable zone. The study found that the debris is kept in a precise arrangement by a nearby planet's gravitational influence.
Scientists at University College London have developed a novel cancer therapy using magnetic seeds guided by an MRI scanner to heat and destroy tumours. The therapy, called MINIMA, has the potential to precisely treat hard-to-reach cancers with minimal side effects.
A new study published in Genome Research has identified a group of genes that play a crucial role in building cellular components and may contribute to human longevity. Inhibiting these genes may increase lifespan by reducing their impact on the body later in life.
A UK study found that over a third of care home residents and a quarter of staff in England showed evidence of SARS-CoV-2 infection during the first two waves of the pandemic. The study also revealed that antibodies against the virus became undetectable in half of the population within eight months.
A large-scale review of anti-inflammatory drugs used for autoimmune disorders suggests that current treatments can worsen lipid metabolism, leading to increased cardiovascular disease risk. Researchers propose the development of combination therapies targeting lipid metabolism to reduce immune complications and CVD risk in patients.
Researchers found that male mosquitoes beat their wings up to 500-1,000 times a second, changing frequency to produce 'distortion tones' more audible to the male ear. This change is partly due to their circadian clock and allows males to detect females in swarms.
A large-scale international study found that simple health assessments can identify people with chronic lung conditions like COPD. The screening tools were effective in diverse low- and middle-income settings, highlighting a pressing need for global awareness and early diagnosis.
A global trial led by UCL found that a dolutegravir-based regimen reduced treatment failure among young people aged three to 18 by around 40% compared to standard treatments. The study also showed better growth and lipid profiles in children receiving dolutegravir, making it an effective option for treating HIV in children.
The SARS-CoV-2 Alpha variant adapted to avoid triggering the innate immune response by increasing expression of antagonism proteins, which disable the body's first line of defense. This allows the virus to replicate under the radar in early stages of infection, significantly increasing its chances of infecting a person.
Sauropod dinosaurs were restricted to warmer, drier habitats than other dinosaur types, which could thrive in Earth's polar regions. The researchers found that sauropods' range was more limited during colder periods, suggesting a unique physiology closer to being 'cold-blooded'.
Researchers identified 'pre-resistance' signs in bacteria, predicting future resistance to antibiotics. This discovery allows doctors to select the best treatments for bacterial infections and paves the way for personalized genomic therapy.
Researchers at University College London discovered that embryonic cells can navigate towards harder regions using chemical and mechanical signals, guiding the formation of facial features. This breakthrough could help prevent birth defects and infant mortality by improving understanding of cell migration mechanisms.
A new study by UCL researchers found that people's motivation to seek information falls into three categories: expected utility, emotional impact, and frequency of thought. Those who prioritize these factors tend to seek information more, with better mental health reported by those seeking info on frequently thought-about topics.
Researchers at University College London have successfully grown mini-stomach organoids, which could help study how SARS-CoV-2 affects the stomach. The study found that the virus replicates more noticeably in child and late fetal cells, leading to the death of delta cells that produce a hormone called somatostatin.
Researchers found that three minutes of morning exposure to 670nm deep red light improved color contrast vision by 17% and the effects lasted for at least a week. The study built on previous findings that daily longwave deep red light exposure boosts energy-producing mitochondria cells in the retina.
A new study suggests that unborn babies could contract Covid-19 if their gut is exposed to the SARS-CoV-2 virus. However, researchers say that this risk is extremely limited due to the placenta's protective shield. Vaccination against Covid-19 during pregnancy is still recommended as a way to protect the unborn baby.
A new UCL-led study found that people who survived childhood cancer have a higher risk of cardiovascular disease, infections, and disorders of the immune system by age 45. The study also suggests that cancer survivors treated with chemotherapy and radiotherapy face greater long-term health effects.
Researchers have discovered a new target for COVID-19 vaccines that could complement existing vaccines by inducing an immune response against 'replication proteins', essential for the viral cycle. The approach may lead to the creation of a pan-coronaviruses vaccine protecting against SARS-CoV-2 and other coronaviruses.
A new study found that human-caused bird extinctions lead to the loss of ecological roles, including pollination and seed dispersal. Introduced alien species do not fill these gaps, highlighting the disproportionate impact of human actions on biodiversity.
Researchers used a new X-ray technique to capture detailed images of lung vessels affected by COVID-19. The study revealed that severe infection causes 'shunting' of blood between oxygenated and nutrient-rich systems, leading to reduced oxygenation.
A therapeutic antibody has been shown to unblock and normalise blood vessels inside cancerous tumours, enabling the more effective delivery of targeted cancer treatments. The findings also suggest that inhibiting LRG1 protein production can enhance the effectiveness of immunotherapies, including checkpoint inhibitors and CAR T-cell the...
Researchers found that honeybee colonies modify their social interactions and movement patterns in response to parasite infestations, increasing social distance between young and old bees. This adaptation helps reduce the spread of diseases while maintaining beneficial social behaviors.
Researchers have recorded the sharpest images of living bacteria, revealing a complex architecture that makes them harder to kill by antibiotics. The study found that bacteria with protective outer layers may have stronger and weaker spots on their surface.
A UCL-led research team has identified an anti-viral gene that increases the risk of both Alzheimer's disease and severe Covid-19. The study found that a specific variant of the OAS1 gene amplifies inflammation in the brain, highlighting the importance of the immune system in both conditions.
Researchers at University College London discovered that worm mothers secrete a milk-like fluid to support their offspring's growth. This unique selfless act helps explain mysteries about the biology of ageing in nematode worms, which could have far-reaching implications for understanding human ageing.
A new study co-led by UCL researchers found that people with higher pre-pandemic levels of depression or anxiety were more severely affected by job and healthcare disruptions during the pandemic. Those with severe symptoms experienced a much greater likelihood of disruptions to jobs, income, and healthcare.
A new study by UCL researchers has found that staying on long-term antidepressants reduces the risk of relapse by 39% compared to those who stop taking them. The study involved 478 primary care patients and found that 56% experienced a relapse within a year if they discontinued their medication, while only 26% did so after a full year.
A study published in Academy of Management Discoveries found that visual information, including body language and facial expressions, plays a crucial role in investor decision-making. Researchers played silent videos of entrepreneurial pitches to expert investors and novices, who correctly identified the original winners. The study sug...
A UCL-led research team has discovered a new gene causing hypertrophic cardiomyopathy, an inherited heart condition. The study found that variants in the ALPK3 gene are responsible for 1-2% of adults with the condition, affecting approximately 1,250-2,500 people in the UK.
A new study found that children who experienced sexual or physical abuse or neglect are more likely to die prematurely as adults. Adults who reported experiencing sexual abuse had a 2.6 times higher risk, while those who experienced physical abuse had a 1.7 times higher risk of premature death.
A new study by UCL researchers found that social inequality can incite collective violence, including vandalism, even with weak social identification. The findings suggest that reducing economic inequality could play a role in maintaining public safety.
A new trial run by UCL researchers shows promise in slowing the regrowth of tumors among some bowel cancer patients. The drug adavosertib was found to delay tumour growth by about two months on average and had relatively few side effects, particularly in left-sided/rectal tumours.
Researchers found that primate mothers across 50 species carried their infant corpses for months, suggesting an awareness of death. Younger mothers and those with strong maternal bonds were more likely to exhibit this behavior.
A recent study published in Cell Metabolism found that reducing naturally occurring errors in protein synthesis improves both health and lifespan. By engineering a mutation in ribosomes, researchers observed fewer protein mistakes and improved heat resistance, leading to longer lifespans in yeast, worms, and fruit flies.
Scientists at UCL and Francis Crick Institute developed a novel tool that rapidly estimates the number of T cells in cancerous tumors, helping predict patient response to immunotherapy. This method uses DNA sequencing data from patients' cancerous tumours to quantify T cell abundance.
A new study found that young adults aged 18 to 24 are four times more likely to become overweight or develop obesity over the next 10 years than those aged 65 to 74. The study suggests that age is the most important sociodemographic factor for BMI change, and that targeted interventions for young adults may be necessary to prevent obes...
A new study by UCL researchers highlights the significant mental health burden on frontline healthcare workers during the Covid-19 pandemic. The study calls for increased mental health awareness training, more assertive outreach to identify those in need, and sustained funding for psychological support services.