A UK study found that over a third of care home residents and a quarter of staff in England showed evidence of SARS-CoV-2 infection during the first two waves of the pandemic. The study also revealed that antibodies against the virus became undetectable in half of the population within eight months.
A large-scale review of anti-inflammatory drugs used for autoimmune disorders suggests that current treatments can worsen lipid metabolism, leading to increased cardiovascular disease risk. Researchers propose the development of combination therapies targeting lipid metabolism to reduce immune complications and CVD risk in patients.
Researchers found that male mosquitoes beat their wings up to 500-1,000 times a second, changing frequency to produce 'distortion tones' more audible to the male ear. This change is partly due to their circadian clock and allows males to detect females in swarms.
A large-scale international study found that simple health assessments can identify people with chronic lung conditions like COPD. The screening tools were effective in diverse low- and middle-income settings, highlighting a pressing need for global awareness and early diagnosis.
A global trial led by UCL found that a dolutegravir-based regimen reduced treatment failure among young people aged three to 18 by around 40% compared to standard treatments. The study also showed better growth and lipid profiles in children receiving dolutegravir, making it an effective option for treating HIV in children.
The SARS-CoV-2 Alpha variant adapted to avoid triggering the innate immune response by increasing expression of antagonism proteins, which disable the body's first line of defense. This allows the virus to replicate under the radar in early stages of infection, significantly increasing its chances of infecting a person.
Sauropod dinosaurs were restricted to warmer, drier habitats than other dinosaur types, which could thrive in Earth's polar regions. The researchers found that sauropods' range was more limited during colder periods, suggesting a unique physiology closer to being 'cold-blooded'.
Researchers identified 'pre-resistance' signs in bacteria, predicting future resistance to antibiotics. This discovery allows doctors to select the best treatments for bacterial infections and paves the way for personalized genomic therapy.
Researchers at University College London discovered that embryonic cells can navigate towards harder regions using chemical and mechanical signals, guiding the formation of facial features. This breakthrough could help prevent birth defects and infant mortality by improving understanding of cell migration mechanisms.
A new study by UCL researchers found that people's motivation to seek information falls into three categories: expected utility, emotional impact, and frequency of thought. Those who prioritize these factors tend to seek information more, with better mental health reported by those seeking info on frequently thought-about topics.
Researchers at University College London have successfully grown mini-stomach organoids, which could help study how SARS-CoV-2 affects the stomach. The study found that the virus replicates more noticeably in child and late fetal cells, leading to the death of delta cells that produce a hormone called somatostatin.
Researchers found that three minutes of morning exposure to 670nm deep red light improved color contrast vision by 17% and the effects lasted for at least a week. The study built on previous findings that daily longwave deep red light exposure boosts energy-producing mitochondria cells in the retina.
A new study suggests that unborn babies could contract Covid-19 if their gut is exposed to the SARS-CoV-2 virus. However, researchers say that this risk is extremely limited due to the placenta's protective shield. Vaccination against Covid-19 during pregnancy is still recommended as a way to protect the unborn baby.
A new UCL-led study found that people who survived childhood cancer have a higher risk of cardiovascular disease, infections, and disorders of the immune system by age 45. The study also suggests that cancer survivors treated with chemotherapy and radiotherapy face greater long-term health effects.
Researchers have discovered a new target for COVID-19 vaccines that could complement existing vaccines by inducing an immune response against 'replication proteins', essential for the viral cycle. The approach may lead to the creation of a pan-coronaviruses vaccine protecting against SARS-CoV-2 and other coronaviruses.
A new study found that human-caused bird extinctions lead to the loss of ecological roles, including pollination and seed dispersal. Introduced alien species do not fill these gaps, highlighting the disproportionate impact of human actions on biodiversity.
Researchers used a new X-ray technique to capture detailed images of lung vessels affected by COVID-19. The study revealed that severe infection causes 'shunting' of blood between oxygenated and nutrient-rich systems, leading to reduced oxygenation.
A therapeutic antibody has been shown to unblock and normalise blood vessels inside cancerous tumours, enabling the more effective delivery of targeted cancer treatments. The findings also suggest that inhibiting LRG1 protein production can enhance the effectiveness of immunotherapies, including checkpoint inhibitors and CAR T-cell the...
Researchers found that honeybee colonies modify their social interactions and movement patterns in response to parasite infestations, increasing social distance between young and old bees. This adaptation helps reduce the spread of diseases while maintaining beneficial social behaviors.
Researchers have recorded the sharpest images of living bacteria, revealing a complex architecture that makes them harder to kill by antibiotics. The study found that bacteria with protective outer layers may have stronger and weaker spots on their surface.
A UCL-led research team has identified an anti-viral gene that increases the risk of both Alzheimer's disease and severe Covid-19. The study found that a specific variant of the OAS1 gene amplifies inflammation in the brain, highlighting the importance of the immune system in both conditions.
Researchers at University College London discovered that worm mothers secrete a milk-like fluid to support their offspring's growth. This unique selfless act helps explain mysteries about the biology of ageing in nematode worms, which could have far-reaching implications for understanding human ageing.
A new study co-led by UCL researchers found that people with higher pre-pandemic levels of depression or anxiety were more severely affected by job and healthcare disruptions during the pandemic. Those with severe symptoms experienced a much greater likelihood of disruptions to jobs, income, and healthcare.
A new study by UCL researchers has found that staying on long-term antidepressants reduces the risk of relapse by 39% compared to those who stop taking them. The study involved 478 primary care patients and found that 56% experienced a relapse within a year if they discontinued their medication, while only 26% did so after a full year.
A study published in Academy of Management Discoveries found that visual information, including body language and facial expressions, plays a crucial role in investor decision-making. Researchers played silent videos of entrepreneurial pitches to expert investors and novices, who correctly identified the original winners. The study sug...
A UCL-led research team has discovered a new gene causing hypertrophic cardiomyopathy, an inherited heart condition. The study found that variants in the ALPK3 gene are responsible for 1-2% of adults with the condition, affecting approximately 1,250-2,500 people in the UK.
A new study found that children who experienced sexual or physical abuse or neglect are more likely to die prematurely as adults. Adults who reported experiencing sexual abuse had a 2.6 times higher risk, while those who experienced physical abuse had a 1.7 times higher risk of premature death.
A new study by UCL researchers found that social inequality can incite collective violence, including vandalism, even with weak social identification. The findings suggest that reducing economic inequality could play a role in maintaining public safety.
A new trial run by UCL researchers shows promise in slowing the regrowth of tumors among some bowel cancer patients. The drug adavosertib was found to delay tumour growth by about two months on average and had relatively few side effects, particularly in left-sided/rectal tumours.
Researchers found that primate mothers across 50 species carried their infant corpses for months, suggesting an awareness of death. Younger mothers and those with strong maternal bonds were more likely to exhibit this behavior.
A recent study published in Cell Metabolism found that reducing naturally occurring errors in protein synthesis improves both health and lifespan. By engineering a mutation in ribosomes, researchers observed fewer protein mistakes and improved heat resistance, leading to longer lifespans in yeast, worms, and fruit flies.
Scientists at UCL and Francis Crick Institute developed a novel tool that rapidly estimates the number of T cells in cancerous tumors, helping predict patient response to immunotherapy. This method uses DNA sequencing data from patients' cancerous tumours to quantify T cell abundance.
A new study found that young adults aged 18 to 24 are four times more likely to become overweight or develop obesity over the next 10 years than those aged 65 to 74. The study suggests that age is the most important sociodemographic factor for BMI change, and that targeted interventions for young adults may be necessary to prevent obes...
A new study by UCL researchers highlights the significant mental health burden on frontline healthcare workers during the Covid-19 pandemic. The study calls for increased mental health awareness training, more assertive outreach to identify those in need, and sustained funding for psychological support services.
A large-scale review of clinical evidence suggests that losing significant weight through diet or surgery can bring about type 2 diabetes remission. Meal-replacement diets and low-carbohydrate diets were found to be effective in achieving remission, with people who lost the most weight being more likely to succeed.
Researchers identified a new mechanism preventing toxic DNA lesions in cells, which could lead to therapies for Huntington's disease. The study found that FAN1 can block the accumulation of DNA mismatch repair factors, alleviating toxicity in cells derived from patients.
A new study led by UCL researchers confirms that genetic inheritance has a significant impact on educational outcomes. However, the study also reveals that parent genes that aren't directly inherited can shape parents' education levels and subsequently influence their children's learning environment, affecting their academic success.
A new dietary supplement, K.Vita, has been shown to reduce seizures in children and adults with drug-resistant epilepsy, with a mean 50% reduction in seizures or paroxysmal events. The study found that the supplement was well-tolerated and palatable, with fewer than 10% of participants producing significant ketones.
A study of 3,568 children aged 9-15 found that proximity to woodlands was linked to better cognitive development and lower risk of emotional problems. Higher exposure to woodland was associated with higher scores in cognitive development and a 16% lower risk of emotional and behavioural problems.
A new study published in Nature found that the arrival of plants on land about 400 million years ago may have altered the Earth's natural climate regulation. The researchers discovered a shift in the global formation of clay, which led to reduced carbon dioxide levels and a cooler planet.
A large international study has identified over 200 symptoms of long COVID, affecting multiple organ systems. The research calls for widening medical guidelines and a national screening programme to address the complex range of symptoms and their impact on daily life.
Researchers have solved a decades-old mystery as to how Jupiter produces spectacular bursts of X-rays every few minutes. The X-rays are triggered by periodic vibrations of Jupiter's magnetic field lines, creating waves of plasma that send charged particles towards the planet's atmosphere.
Researchers at UCL and the London School of Hygiene & Tropical Medicine argue that modern society's emphasis on cleanliness does not impede childhood immunity. Instead, they suggest exposing children to beneficial microorganisms through maternal contact, family members, and natural environments is crucial for immune system development.
A study by UCL researchers suggests that levelling up access to finance for poorer countries can accelerate the transition to renewable energy, allowing Africa to reach net-zero emissions approximately 10 years earlier than current projections. This would require policy interventions to lower the weighted average cost of capital (WACC)...
Neuroscientists at UCL have identified abnormalities in the way memories are 'replayed' in the brains of people with schizophrenia. The study found that individuals with schizophrenia were less able to build a structure of the task, with impaired neural replay linked to their symptoms.
Scientists at UCL GOS ICH and Great Ormond Street Hospital have developed a precision gene therapy that has been shown to relieve defects in DTDS brain cells, potentially offering a cure for the condition. The therapy was tested on laboratory models and mice, showing promising results and paving the way for a clinical trial.
A new study suggests that cosmic dawn, when stars formed for the first time, occurred between 250 and 350 million years after the beginning of the universe. The study used data from the Hubble and Spitzer Space Telescopes to estimate the age of distant galaxies.
A new modelling report calls for cities to reduce private car use and promote walking, cycling, and public transport. By decreasing car use, cities can lower congestion, improve air quality, and create faster, more sustainable urban environments.
Researchers developed an AI-powered app to improve the accuracy of HIV test results, particularly for laypeople. The app achieved 98.9% accuracy in classifying images, reducing errors compared to traditional interpretation.
The Milky Way's galactic bar has slowed down its spin by at least 24% since its formation, according to a study published in Monthly Notices of the Royal Astronomical Society. Dark matter acts as a counterweight slowing the spin.