Researchers discovered that immune cells change their behavior in response to a trigger, producing protein signals that cause skin lesions. This finding could lead to better treatment options for the disease by targeting early responder cells.
A team of UChicago chemists has developed a way to easily edit molecule structures, paving the way for faster and more efficient chemical discoveries. This breakthrough method allows for direct nitrogen deletion from molecules, bypassing traditional intermediate steps.
Scientists at UChicago and Argonne National Laboratory are developing AI-assisted systems to recover energy, nutrients, and freshwater from municipal wastewater. The goal is to reduce energy consumption and become energy positive at a national scale, benefiting underserved communities in Chicago's South Side and the Great Lakes region.
Researchers at UChicago have successfully brought multiple molecules into a single quantum state, a major technological feat. This achievement has the potential to open new fields in quantum physics and chemistry, enabling innovative applications such as unhackable networks and earthquake sensors.
Researchers develop Nanotraps that capture SARS-CoV-2 viruses within the body, utilizing the body's own immune system to destroy them. The therapy has shown promising results in early stages of testing and could potentially be administered via a nasal spray as a treatment for COVID-19.
A new simulation led by University of Chicago geoscientist Edwin Kite finds that high-altitude water ice clouds could have created a greenhouse effect on early Mars, enabling the presence of flowing rivers and lakes. The study challenges previous assumptions about the Martian climate and offers insights into the planet's habitability.
Researchers at the University of Chicago developed a new therapeutic vaccine that uses a patient's own tumor cells to train their immune system to find and kill cancer. The vaccine stopped melanoma tumor growth in mouse models and promoted a broad, robust immune response, preventing new tumor growth when tumor cells were re-introduced.
Researchers developed a new vaccine that uses a patient's own tumor cells to train the immune system to find and kill cancer, promoting a broad and robust immune response. The therapy has shown long-term efficacy against metastasis and relapse in mouse models, offering potential for treatment of various cancers.
Researchers at University of Chicago and Stanford University propose mechanism for formation and retention of water-dominated atmospheres on hot, rocky exoplanets. The model suggests these planets could have a water-rich atmosphere for long stretches, with some potentially keeping it for billions of years.
Scientists at the University of Chicago have developed a gel material that strengthens when exposed to vibration, increasing its strength by 66 times. The material selectively strengthens itself in specific areas where it is stressed to a higher degree.
Researchers at University of Chicago and Brookhaven National Laboratory develop a new method to improve photoelectrodes for producing solar fuels. By modifying the surface composition of bismuth vanadate electrodes, they found that surfaces with more bismuth atoms favor water splitting reactions.
Scientists at the University of Chicago have developed liquid crystals that can move on their own, enabling the creation of autonomous materials. By controlling the movement of defects within the crystals, researchers have demonstrated a microfluidic device that can transport fluids autonomously without pumps or pressure.
A team of researchers discovered that Tiktaalik roseae, a transitional fossil between fish and tetrapods, exhibited sliding joints in its skull that allowed for cranial kinesis, enabling the animal to expand its mouth and create suction. This adaptation is thought to have evolved in aquatic species before being adapted for use on land.
Researchers at the University of Chicago used computational simulations to understand how remdesivir works against SARS-CoV-2. They found that remdesivir binds strongly to the virus and destabilizes its protein complex, reducing replication. This study provides insights into the molecular mechanism of remdesivir and its potential for e...
Researchers at the University of Chicago have developed a new sensor design that allows stretchable electronics to collect and process faint signals from the body. The design, which incorporates a patterned material that optimizes strain distribution, enables transistors to maintain nearly the same electrical performance when stretched...
Theoretical researchers at the University of Chicago have found a way to make quantum sensors exponentially more sensitive by harnessing a unique physics phenomenon. This breakthrough could lead to improved detection and diagnosis of diseases, prediction of natural disasters, and exploration without digging.
Researchers at the University of Chicago have made significant breakthroughs in designing brain-like devices by predicting design rules for energy-efficient transition states. The study, published in npj Computational Materials, highlights the potential of oxide materials to mimic the behavior of neurons and synapses in the human brain.
The study found that repetitive cycles of wet-dry conditions led to progressive evolution of polymer compartments, affecting molecule exchange and composition. This research sheds light on prebiotic Earth and has implications for designing electronics and drug delivery systems.
Researchers have discovered a general property for understanding how immune cell receptors sense and respond to microbial signals. The result led to a more effective cancer immunotherapy in mice, which could lead to more effective vaccines for existing and novel viruses.
Researchers at the University of Chicago have developed a new method to design polymers with specific properties, such as degradable plastic bags or super-strong aircraft materials. By combining modeling and machine learning, they created a large database of hypothetical polymers and trained a neural network to predict their properties.
Researchers at the University of Chicago have designed a new therapy for multiple sclerosis by fusing a cytokine to a blood protein. This combination prevented destructive immune cells from infiltrating the central nervous system and decreased MS development, leading to fewer symptoms and disease prevention.
Researchers at the University of Chicago have discovered a new way to limit inflammation from adjuvants by adding a molecule that disrupts certain pathways in cells. This approach increases protective response against viruses and could lead to a new vaccine design for SARS-CoV-2, HIV, and other diseases.
The study proposes a new perspective on urban development, revealing the complex interplay of individual and collective actions that drive meaningful change. It highlights the slow pace of change in cities and the negative impact of uncertainty and policies promoting aggregate growth on innovation and inequality.
Researchers at the University of Chicago used computational analysis to identify ebselen as a potential treatment for COVID-19. The study found that ebselen can decrease Mpro's activity in two different ways, making it a promising lead for developing new therapeutic strategies against the virus.
A team of UChicago scientists developed a technique that allows quantum systems to stay operational for up to 22 milliseconds, four orders of magnitude higher than before. This breakthrough has the potential to revolutionize quantum communication, computing, and sensing by enabling new research opportunities in quantum engineering.
A team of researchers at the University of Chicago has developed an AI-led process to design artificial proteins using big data and machine learning models. The breakthrough reveals relatively simple design rules for building artificial proteins, which performed chemistries rivalling those found in nature.
Researchers at the University of Chicago have developed a way to stretch and strain liquid crystals to generate different colors, leading to a wide range of optical effects. This technology has potential applications in temperature and strain sensors, enabling remote measurement without contact.
Researchers have created complex computer simulations to study the properties of salt in water under high pressure and temperature conditions, similar to those found in the Earth's mantle. The models revealed key molecular changes that could impact understanding of chemical reactions at these extreme depths.
Scientists at the University of Chicago have developed a new quantum communication technique that bypasses traditional channels, allowing for secure information transfer without photon loss. This breakthrough enables faster and more efficient communication systems, opening up new possibilities for future technologies.
A new testing system developed by researchers at the University of Chicago can quantify bacteria, antibiotic-resistant genes, and immune molecule levels in sepsis patients, predicting patient outcomes with high accuracy. This innovative approach enables personalized treatment strategies and may improve patient survival rates.
Researchers have developed a new imaging analysis pipeline called LaMDA, which enables machine learning and complex analyses on high-dimensional microscopy data. This can reveal and predict T-cellular states, providing valuable insights for drug testing, vaccine development, and expanding knowledge of T-cell biology.
Researchers have developed a unique immunotherapy delivery system that can turn cold tumors into 'hot' tumors, making it effective in cancers such as breast and melanoma. The system uses a protein called interleukin 12 to inflame the tumor and activate the immune system.
A team of scientists used machine learning to speed up the process of identifying optimal self-assembling peptides for biocompatible electronic devices. By screening 8,000 candidates, they were able to rank each design and pave the way for experimentalists to test the most promising ones.
A new study suggests a nuclear conflict anywhere on Earth would lead to a decade of global cooling and a severe decline in crop production, compromising global food security. The study found that the sudden change in climate would cause significant crop losses, particularly in northern breadbasket regions.
A new study analyzes genome-wide DNA data from 70 ancient individuals, revealing that Sardinian genetic ancestry remained relatively stable until the Iron Age, when Phoenician, Punic, and Roman populations arrived. The research provides insight into the island's unique history and ancestral connections among Mediterranean peoples.
Researchers at the University of Chicago have predicted a new state of matter that could efficiently conduct both electricity and energy. They found that quantum entanglement enables the coexistence of these two properties in certain materials, which could lead to significant technological advancements.
Researchers at UChicago study birdsong to understand brain cell properties and their role in learning, revealing surprising similarities with human stuttering. The study uses zebra finch neurons to show that changes in intrinsic cell properties are closely tied to song patterns and stuttering behavior.
The new mouse model accurately reflects human genetic and immune system characteristics, enabling researchers to test new treatments. It can reverse damage to the small intestine once it has developed, providing a vital tool for improving quality of life for people with celiac disease.
Researchers have developed a new computer simulation to study carbon in deep Earth reservoirs, providing insights into the Earth's carbon cycle and climate change. The simulation reveals underestimated concentrations of bicarbonate ions under extreme pressure and temperature conditions.
Scientists at UChicago discovered a previously unknown mechanism where RNA itself affects DNA transcription using a chemical process. This breakthrough has significant implications for understanding human disease and drug design.
A study by University of Chicago Medicine found that hospitals caring for patients in disadvantaged areas may garner lower quality scores due to social risk factors. Hospitals' ability to improve certain quality outcomes is hindered by these factors, such as income and education levels in the community.
Researchers found that only 57.5% of falls were accounted for in Nursing Home Compare's ratings, with racial disparities and higher rates for long-term stays. The study suggests that the Centers for Medicare & Medicaid Services should change their evaluation criteria to use objective sources like claims data.
A new study by University of Chicago biologists found that Mediterranean mussels with existing genetic variation can adapt to declining pH levels in seawater caused by carbon emissions. The surviving population in the low pH environment differed genetically from others, suggesting a faster adaptation process if no new mutation arises.
A new study estimates heritability and maps relationships among thousands of diseases using electronic health record data. Disease prevalence curves show early onset vs late onset patterns, revealing genetic links between diseases. The team identifies new patterns, including parasitic infections aligning with noninfectious diseases.
Analysis of US heart transplant data reveals large discrepancies in how sick patients are when they receive transplants at different hospitals. The study finds that high-survival-benefit hospitals prioritize sicker patients, while low-survival-benefit centers give organs to less critical patients.
A new study from UChicago identifies 44 drugs that may prevent suicide attempts, including folic acid and several antidepressants. The research used a statistical tool to analyze data on 922 prescription medications and found that just 10 were associated with an increased rate of suicide attempts.
New research from UChicago shows how genetic differences in the immune system shape the collections of bacteria that colonize the digestive system. Genetic variations in innate immunity play a key role in determining microbial composition.
A new study by biologists at the University of Chicago and University of North Carolina reveals how species that form long-term pair-bonds raise their young more efficiently. By investing in love and affection, males stimulate females to work harder, leading to increased reproductive success.
The Bacterial and Viral Bioinformatics Resource Center combines two independent resources to support richer scientific data and more powerful analytic tools. The hub will provide rapid access to genomic datasets, computational tools, and artificial intelligence techniques to analyze data and make predictions.
A new study describes a 2-foot long shark with jaws capable of suction feeding, 50 million years older than the earliest evidence in bony fishes. The fossil, analyzed using CT imaging and modeling software, shows that ancient sharks responded quickly to ecological opportunities after major extinctions.