A new registry-based study by the University of Eastern Finland found a significant association between season of birth and airway allergies, including asthma and allergic rhinitis. Being born in autumn or winter was associated with higher rates of these conditions, while summer births showed the lowest incidence.
A new study from the University of Eastern Finland shows that a healthy diet and regular exercise can reduce the risk of type 2 diabetes even in individuals with a high genetic risk. Lifestyle changes significantly improved glucose metabolism and reduced the prevalence of type 2 diabetes, regardless of genetic risk.
A new study found that early-onset dementia is more common than previously reported, with the incidence of Alzheimer's disease increasing by nearly double in the working-age population. The study analyzed patient data from Finland and found higher incidence rates of early-onset dementia compared to previous international studies.
A new study reveals that traffic-related ultrafine particles hinder mitochondrial functions in human olfactory mucosa cells, impairing oxidative phosphorylation and redox balance. Individuals with Alzheimer's disease showed altered responses to UFP exposure.
A new study from the University of Eastern Finland found that children's exposome scores, measuring environmental and lifestyle factors, are associated with altered serum levels of 31 metabolites. These metabolites were linked to cardiometabolic diseases such as obesity and type 2 diabetes in later life.
A combination treatment incorporating three drugs – tamsulosin, metoprolol, and bromocriptine – significantly slowed disease progression in four different animal models of IRD. The study suggests that drug repurposing could provide solutions for rare diseases like retinal degenerations, which are currently inaccessible therapeutically.
Researchers identified two distinct T-cell signatures in children with newly diagnosed type 1 diabetes and those at risk of developing the disease. These signatures may serve as potential biomarkers and targets for preventive immunotherapy treatments.
A new study at the University of Eastern Finland found that metacognitive knowledge is a key factor in the learning of mathematics. This awareness of one's cognitive processes enables students to face new challenges and adapt to changing environments.
A new study from the University of Eastern Finland finds that a healthy diet is associated with lower blood glucose levels and a reduced risk of prediabetes and type 2 diabetes. The association holds true for individuals with both low and high genetic risk, suggesting a universal benefit of healthy eating.
A Finnish study found that teaching AI basics to 4th and 7th graders improved their understanding of the technology. The students designed and created AI apps, which helped them develop conceptual understanding and critical thinking skills. The program also explored the impact and ethics of AI on children's daily lives.
A University of Eastern Finland study reveals top IT managers have differing views on face-to-face communication in the workplace. While some believe digital communication suffices for tasks, others emphasize its importance for complex projects and community building.
Researchers found that increased activity of the SIX2 protein contributes to increased cell plasticity and treatment resistance in prostate cancer cells. Silencing the SIX2 gene reduces malignancy and cancer spread in hormone therapy-resistant types of cancer.
The Planetary Inclusion Scale assesses life's connections to the environment, promoting experiences of belonging and inclusion. It offers a new perspective on sustainability by considering temporal, spatial, and ethical orientations.
Judges and physicians hold vastly different opinions on appointing legal guardians for people with dementia. Cognitive and neuropsychiatric symptoms, such as memory impairment and impulsivity, are evaluated differently by medical and legal professionals. Research emphasizes the need for consistency in assessments to ensure equal treatm...
A recent meta-analysis found that one in four patients with insulin-dependent diabetes exhibit eating disorder symptoms, including binge eating and food restriction. Intentional insulin omission is a unique form of disordered eating where insulin doses are restricted or skipped due to fears of weight gain.
A new study found that children who spent more time being sedentary in childhood had a higher risk of developing heart enlargement, which increases the risk of heart attacks and premature death. In contrast, light physical activity was shown to reduce this risk by 49%.
A new study among Finnish ninth-graders identified four perfectionistic profiles associated with varying levels of psychological well-being. The study found that perfectionistic profiles, particularly those characterized by high concerns, are linked to poorer well-being, including burnout and anxiety symptoms.
A study evaluating contract treatment in Sweden found that this sanction significantly reduces recidivism and substance-related adverse health events compared to community sanctions or prison sentences. Providing treatment yields better results than punishment, addressing the root causes of criminality often linked to substance misuse.
Researchers at the University of Eastern Finland have identified coregulator proteins as an alternative target to prevent drug resistance in prostate cancer. By inhibiting these proteins, the growth of drug-resistant cancer cells can be inhibited, and the activity of the glucocorticoid receptor can be limited.
A new study found that increased childhood sedentary time is associated with higher blood insulin concentration and a greater risk of excess insulin and insulin resistance. Light physical activity was shown to reduce the risk of excess insulin by 20%, while moderate-to-vigorous physical activity had a smaller effect.
A Finnish study found that only 10% of newly diagnosed type 2 diabetics lost weight, while 3% gained weight, highlighting the challenges of achieving weight loss in these patients. The study also showed a strong association between weight gain and increased risk of microvascular and macrovascular complications.
A new study found that increased childhood sedentary time accelerates vascular damage, while light physical activity reverses it. Arterial stiffness is a key factor in this process, with moderate-to-vigorous physical activity slightly increasing stiffness.
The University of Eastern Finland has published a chromosomally assembled reference genome for the European brown hare, consisting of 2.9 billion base pairs and 30,833 genes. This represents a significant breakthrough in genomic research for Finnish species.
Researchers at the University of Eastern Finland have developed a new therapeutic strategy to combat multidrug-resistant Salmonella enterica. The dual-pronged treatment combines colistin with a quinazoline compound to target resistance mechanisms and disrupt bacterial envelope electrochemical equilibrium.
A new study found that waist circumference-to-height ratio detects excess fat mass and distinguishes it from muscle mass in children and adolescents significantly better than body mass index (BMI). The measure is inexpensive and accurate, making it a promising alternative to BMI for diagnosing childhood obesity.
Researchers used MRI to investigate the effects of Phytophthora cactorum on strawberry plants, discovering elevated relaxation times and visible pathogen presence. The study suggests MRI can monitor plant health, investigate disease progression, and inform strategies for preventing plant diseases.
A new study by University of Eastern Finland identifies four main drivers for home care worker turnover: mismatch between client needs and available resources, digital systems taking up time, inflexible work demands, and ethical burden. Home care workers seek personal management and consideration of employee and client needs.
A recent study from Finland found that children's initial positive attitude towards mathematics gradually fades during the first three years of school, negatively impacting their competence perception. The researchers suggest that teaching practices supporting children's interest and experiences of success can help mitigate this effect.
A recent study at the University of Eastern Finland gathered information on psychotherapy-associated adverse events, their content and scope. The researchers found no significant negative outcomes in included studies, but highlighted the need for standardised methods to assess adverse effects.
A recent study by the University of Eastern Finland found associations between high age, low education, and poor lifestyle habits with increased allostatic load. The study suggests that effective depression prevention strategies at a population level could help reduce allostatic load.
Researchers discovered that depletion of the protein DPYSL5 can restore drug-responsive neuroendocrine prostate cancer cells, promoting cell transformation and lineage plasticity. This finding could lead to the development of new cancer drugs.
Scientists have identified two fungi, Beauveria pseudobassiana and Metarhizium brunneum, with high insecticidal activity against the Eucalyptus snout beetle. These naturally occurring pathogenic fungi could be used to develop a bio-pesticide for controlling the beetle in forest plantations.
A risk model based on routine blood work can identify cancer patients who are more likely to benefit from immune checkpoint inhibitors, increasing treatment efficacy and cost-effectiveness. The study found that patients in the low-risk group had a higher response rate and longer overall survival compared to those in the high-risk group.
A study found a clear connection between light levels and mental health in Finland, with more sick days taken due to depression, anxiety, and sleep disorders during autumn and winter. Climate change may worsen these conditions, while brighter summers could alleviate some symptoms of bipolar disorder.
A study by University of Eastern Finland finds that integrating AI systems into service teams increases demands on middle management, requiring balancing acts and new skills. The study also highlights the need for human managers to focus on innovations and development while AI handles routine tasks.
A new study reveals altered gene activity in Alzheimer's patients' olfactory mucosa after SARS-CoV-2 infection, potentially leading to exacerbated COVID-19 outcomes. The research found heightened oxidative stress and altered immune responses in infected cells.
A new study found that increased childhood sedentary time significantly increases cholesterol levels in young adulthood. However, light physical activity (LPA) has been shown to completely reverse this effect, while moderate-to-vigorous physical activity (MVPA) may also reduce cholesterol levels but with diminished impact due to body f...
A new study found that light physical activity (LPA) can completely reverse childhood obesity caused by sedentary behavior, but moderate-to-vigorous physical activity (MVPA) has limited effect. LPA reduced total body fat mass by 950 grams during growth from childhood to young adulthood.
A study at the University of Eastern Finland reveals how digital multi-sided platforms are changing the way businesses approach B2B service sales. The research finds that platform owners play a crucial role in orchestrating value networks, enabling them to manage larger networks with fewer staff and use various interaction methods.
A new study from the University of Eastern Finland found that individuals with higher wealth levels had greater hospital care and medication costs before diagnosis. However, after diagnosis, wealth was associated with lower healthcare costs due to differences in comorbidities among different wealth groups.
Researchers found a unique resonance phenomenon in the crevice cave that amplifies and lengthens sound at a specific frequency, which may have impacted beliefs associated with it. The study suggests that this resonance could be an exceptional sound phenomenon for the people living in the region centuries ago.
A new study from the University of Eastern Finland highlights the potential for non-profit organisations to promote sustainable practices in multinational businesses. By using a Strategic Confrontation and Collaboration Interaction Model (SCCIM), non-profits can influence stakeholders such as employees, investors, and politicians to ad...
Researchers at University of Eastern Finland developed a new method for accurate determination of water content in water-soluble compounds, utilizing solution-state nuclear magnetic resonance spectroscopy. The method is simple, accurate and quick, with results comparable to traditional methods like TGA and X-ray crystallography.
The study found significant variation in maximum allowable GVW limits for timber trucking across countries, with Japan having the strictest limits. Road transport accounted for 89% of total industrial roundwood moved over long distances, and average transportation costs ranged from 4-24 euros per tonne. The results highlight the need f...
A new study by an international team of researchers found that common oral infections and periodontal diseases are associated with inflammatory metabolic profiles. Oral infections were also predicted to cause future adverse changes in metabolic profiles.
A new study reveals that exposure to ultrafine particles from traffic alters the expression of many genes in human olfactory mucosa cells. The study found that different fuels and engines cause distinct effects on cell function, with renewable diesel causing less adverse effects than fossil diesel.
A recent study published in Scandinavian Journal of Medicine and Science in Sports found that physical fitness since childhood is associated with increased cerebellar grey matter volume in adolescents. Those with better neuromuscular fitness had larger Crus I grey matter volume, while those with cardiorespiratory fitness had smaller to...
Researchers developed prodrugs that temporarily incorporate thyroxine or a thyroxine-like molecule to enhance brain drug delivery. These prodrugs were efficiently delivered into glial cells via the OATP1C1 transporter, targeting chronic inflammation in the brain.
A recent study by the University of Eastern Finland found that workplace ostracism weakens job satisfaction and perceived health in healthcare workers, increasing stress. Ostracism was most frequently experienced by social workers, with doctors and managers experiencing the least.
A holistic transformation is needed for a sustainable future, and a new study by an international team of researchers explores the Theory of Planetary Social Pedagogy as a driver. This theory applies to all societal sectors and aims to make life meaningful by increasing experiences of belonging and inclusion.