A new study by University of Notre Dame researchers found that the most abundant protein in the Ebola virus, VP40, mediates replication and interacts with human cell lipids. This discovery may lead to novel therapeutics for combating Ebola.
A new study from the University of Notre Dame develops a more sensitive and affordable tool for detecting Asian Carp DNA using environmental DNA (eDNA) monitoring. The new method detects Asian Carp eDNA 95% of the time, compared to less than 5% with current methods.
Researchers have sequenced the genomes of 16 Anopheles mosquito species, revealing genetic differences between deadly parasite-transmitting species and their harmless cousins. The study offers new insights into how these species adapt to new environments and interact with humans, potentially advancing malaria control efforts.
Researchers at Notre Dame designed a highly accurate traffic prediction model that considers both time-based and distance-based costs. The model outperformed previous models when predicting commuter flows, demonstrating its potential to predict the impact of network disruptions.
A new study by Andriy Bodnaruk and Andrei Simonov found that financial experts, including mutual-fund managers, do not outperform ordinary investors in making investment decisions. The researchers suggest that focusing on passive strategies can help minimize trading costs.
Researchers at the University of Notre Dame have discovered a new class of hybrid perovskites with exceptional performance in solid-state thin film solar cells. The materials demonstrate high light-to-electricity conversion efficiencies approaching 20% and are easy to process using coating and printing techniques.
A study published by University of Notre Dame scientists estimates that bighead and silver carp biomass in Lake Erie could be up to 25 metric-tons/km2, potentially increasing Yellow perch biomass by 15-50% but decreasing Walleye biomass by 10-40%. The experts emphasize the importance of considering uncertainty in decision-making.
A new study published in the American Sociological Review finds that counties with high levels of residential segregation based on education levels are more likely to have Tea Party organizations. The research also shows that college graduates living in these segregated areas are more likely to support the Tea Party. These findings hig...
Research by University of Notre Dame sociologist Elizabeth McClintock shows the 'trophy wife' stereotype is largely a myth. She found that handsome men partner with pretty women, while successful men partner with successful women, controlled for physical attractiveness.
The University of Notre Dame's Marya Lieberman has received a Grand Challenges Explorations grant to develop printed test cards for rapid field screening of human and animal medications. The test cards can detect low-quality medications, applying economic pressure to companies that manufacture or distribute them.
Researchers from the University of Notre Dame have uncovered a novel mechanism by which carcinoma-associated fibroblasts (CAFs) contribute to tumor progression. CAFs block cell death through insulin-like growth factor-binding proteins, highlighting potential therapeutic targets for slowing breast cancer metastasis. Further pre-clinical...
Researchers from NASA working with the University of Notre Dame have detected an Earth-like planet, Kepler-186f, in the habitable zone of a cool star. The planet has conditions suitable for liquid water to exist on its surface, increasing the likelihood of supporting life.
Researchers at the University of Notre Dame have developed the largest data set on developmental proteomics for any organism, analyzing nearly 4,000 proteins in African clawed frog embryos. The study reveals unexpected discordance between messenger RNA and protein levels, shedding light on key events during early development.
University of Notre Dame biologists Nicole Achee and Neil Lobo are leading a five-year project to develop spatial repellent products for mosquito control, aiming to prevent malaria and dengue fever. The grant will generate data on the effectiveness of this new paradigm in mosquito control.
A team of researchers from Notre Dame has discovered a new class of oxadiazole antibiotics effective against MRSA and other drug-resistant bacteria, offering a promising treatment option. The discovery is based on the inhibition of penicillin-binding proteins and shows promise in mouse models of infection.
The University of Notre Dame has established a state-of-the-art research center for drug discovery and development, with the aim of improving lives worldwide. The Warren Family Research Center will support the translation of basic scientific discoveries into new therapeutics.
A new research paper from the University of Notre Dame researchers Holly Goodson and Mark Alber resolves an ongoing debate about the assembly of a subcellular network that plays a critical role in cell function and disease. The study explains how stathmin, a key regulator, works by binding and destabilizing segments of microtubules.
Experts estimate that hydrologic separation and electric barriers can prevent up to 95-100% and 85-95% of Asian carp introductions, respectively. Physical separation is found to be the most effective method, with a high probability of preventing introduction into Lake Michigan.
A new study by Matthew Ravosa and colleagues at the University of Notre Dame reveals that dietary influences play a crucial role in shaping the human skull. Contrary to long-held assumptions about hard object feeding, the research suggests that early human ancestors, such as Australopithecus, relied on tough foods year-round.
Researchers from University of Notre Dame and Indiana University School of Medicine have revealed a link between the circadian clock and alcohol-induced liver disease. The study found that disturbances in the liver's daily rhythms can lead to fatty liver disease, suggesting a potential target for treatment.
A paper proposes a novel understanding of brain architecture using a network representation of connections within the primate cortex. The researchers describe the cortex as a network of connections with a bow tie structure, characterized by a dense core connecting to feed-forward and feedback pathways. This arrangement is found in self...
Researchers at University of Notre Dame identified enzymes detrimental and beneficial to wound repair in diabetic individuals. Selective MMP-9 inhibitors showed 92% wound healing rate after 14 days, compared to 74% in untreated mice.
Researchers at the University of Notre Dame have made progress toward a treatment for dangerous allergies by designing a special molecule that can out-compete allergens in their race to attach to mast cell receptors. The team has demonstrated the effectiveness of their inhibitor molecule on allergic reactions using animal models.
Notre Dame researchers discovered how MRSA regulates its cell wall in response to beta-lactam antibiotics, enabling drug resistance. They also found a way for a new antibiotic, ceftaroline, to target and inhibit the enzyme responsible for resistance.
A new University of Notre Dame study reveals the molecular genetic and physiological basis for metabolic diseases related to circadian function. The research found that a specific gene, Id2, plays a crucial role in glucose metabolism and circadian control of feeding and locomotor activity.
Researchers found that mosquitoes have higher olfactory sensitivity and protein abundance of odorant-binding proteins (OBPs) at night, making them more effective at detecting human hosts. This discovery has significant implications for developing novel insect control methods to reduce malaria transmission.
Scientists at the University of Notre Dame have identified a protein called SIK1 that can help regulate the body's internal clock. By blocking its activity, researchers found that mice adjusted faster to changes in their environment, suggesting that SIK1 could be a target for treating jet lag and shift work disorders.
Researchers from Notre Dame and Moi University are examining the unique manifestation of breast cancer in Kenya. The collaboration aims to identify novel insights into the mechanisms of breast cancer progression, which could ultimately help women worldwide.
The Collaborative Assessment and Recommendation Engine (CARE) system uses electronic medical records to offer rapid advances in personalized health care, disease management, and wellness. CARE generates personalized disease risk profiles based on collaborative filtering method and Big Data science.
A new study by University of Notre Dame researchers found that unattractive colleagues are more likely to be subjected to cruel treatment at work. The study, published in Human Performance, suggests that physical attractiveness plays a significant role in how employees are perceived and treated in the workplace.
Researchers at the University of Notre Dame have identified the importance of Wnt proteins and ARF6 in cancer cell signaling. The studies found that ARF6 can propagate Wnt signaling, leading to proliferation in epithelial tumors and melanoma spread. This understanding offers potential target molecules for cancer drug development.
A study by University of Notre Dame researchers found that cancer cells use antioxidant enzymes to survive detachment from the extracellular matrix. This discovery may lead to targeted therapies for metastatic cancers.
College-age women rate overweight peers with positive body talk as most likeable, while those engaging in 'fat talk' are deemed less likable. The study highlights the negative impact of self-abasing remarks on social perception and potential eating disorder risks.
Mothers who experienced childhood trauma exhibit traumatic avoidance symptoms, leading to shorter conversations and less child participation. This phenomenon has negative impacts on cognitive and emotional development in children.
Researchers have identified five planets within the habitable zone of a Sun-like star, including two planets similar in size to Earth. The discovery was made using data from the Kepler spacecraft and validated by high statistical confidence.
New research from the University of Notre Dame suggests that child learning and performance in counting tasks is affected by the type of object used. The study found that objects with high perceptual detail hindered performance when children already had established knowledge, but improved it when they didn't.
Researchers found no evidence of widespread Asian carp presence in the Great Lakes, but detected DNA from bighead and silver carp. Live fish are considered the most likely source of the DNA, contradicting reports of bird or boat spread.
Researchers at the University of Notre Dame have developed a method to create three-dimensional anatomical models from CT scans using 3D printing, holding promise for medical professionals and their patients. The technology enables the rapid production of detailed skeletal and soft tissue structures from X-ray CT data.
Researchers from the University of Notre Dame have created a method using environmental DNA (eDNA) and Light Transmission Spectroscopy (LTS) to detect invasive aquatic species in real-time. This innovative approach enables rapid identification of high-risk species before they cause significant damage.
Researchers at the University of Notre Dame used genetic analysis to identify a harmless fruit fly in Washington state, preventing costly quarantine measures. The study's findings demonstrate the potential for rapid and accurate identification of insect species, which could have significant implications for agriculture and public health.
A new study by the University of Notre Dame examines the impact of bridal registries on traditional wedding rituals and gift-giving practices. The research reveals that these registries have become a lucrative industry, with $19 billion in gifts purchased by invited guests in 2010.
Researchers have discovered significant amounts of water in Apollo samples, indicating the early Moon was wet and the water wasn't substantially lost during formation. The detection of hydroxyl groups suggests a prolonged solidification of the lunar magma ocean.
University of Notre Dame Sociologist Elizabeth McClintock's research offers new insights into physical attractiveness and age on mate selection. Her studies show that very physically attractive women are more likely to form exclusive relationships, while thinner women report fewer sexual partners.
A new Notre Dame study examines the dual-use aspect of nanotechnology research, exploring both its benefits and threats. The report discusses the potential for nano-sized particles to breach the blood-brain barrier and deliver targeted medicines, while also posing a serious threat in combat situations.
A study by Kevin D. Bradford and his team examined 28 thousand pages of court documents to understand how guns move from legal channels into the hands of criminals. They found that one percent of gun dealers are responsible for 45 to 60 percent of guns involved in crimes, highlighting the need for more vigilance over gun distribution.
The University of Notre Dame has been selected to lead the Center for Low Energy Systems Technology (LEAST), a $6 million research center funded by DARPA and SRC. The center aims to develop new devices that consume less energy, which will enable the creation of smaller and faster computer chips.
Researchers led by Nicolas Lehner found large quantities of cool gas with low heavy element content surrounding modern galaxies. This gas has not been strongly processed through stars, providing a substantial reservoir for fueling continued star formation in modern galaxies.
University of Notre Dame biochemist Anthony S. Serianni's research provides new perspectives on sugar breakdown in the human body, particularly for diabetic patients. The study discovered an unexpected reaction pathway involving a novel rearrangement of the carbon backbone, undermining prevailing assumptions about sugar degradation.
Researchers at Notre Dame are developing mathematical algorithms to integrate plug-in hybrid electric vehicles into the power grid, anticipating optimization problems for various parties. The goal is to create an efficient system that benefits consumers, companies, and the environment.
Research reveals that Great Lakes salmon carry industrial pollutants into streams and tributaries as they migrate upstream to spawn. This can lead to the bioconcentration of pollutants in stream fish, posing a risk to human health, particularly for pregnant women and children.