Scientists are exploring the potential of bacteriophages, which target specific bacteria, to prevent and treat intestinal illnesses like Salmonella, Campylobacter, and E. coli in children. The research aims to develop a new approach for treating food poisoning in developing countries.
Researchers observe 'comet-shaped' structures forming on agar plates, indicating active motility in MRSA, a spherical bacterium with no propulsive tail or appendages. This discovery could have implications for future clinical treatments and open up new avenues of research into Gram-positive bacteria.
A clinical trial found that stem cell transplantation did not provide significant improvement in sustained disease remission after one year for patients with difficult-to-treat Crohn's disease. However, some patients showed objective signs of disease disappearance and discontinued active treatment more frequently in the stem cell group.
Scientists at the University of Nottingham have discovered a small molecule called nicotinamide mononucleotide (NMN) that causes a chain reaction of destruction within neuron cell processes. This finding may lead to new therapies for age-related neurodegenerative disorders such as Parkinson's and Alzheimer's disease.
Research reveals how Bdellovibrio bacteriovorus uses an ankyrin-type protein called Bd3460 as a shield to protect itself against its own enzymes. The study found that the protein binds to the tip of the enzyme weapons, nullifying their action until they are safely secreted out of the Bdellovibrio and into the prey bacteria.
The top 10 research priorities for tackling mild to moderate hearing loss include addressing aspects of hearing aid provision, with the majority concerned with improving treatment outcomes. The list aims to re-focus future studies on areas with the greatest potential impact in furthering understanding and developing successful treatments.
Scientists at the University of Nottingham are exploring the use of car driving simulators to train and test drivers, aiming to reduce road traffic accidents. The research uses a new facility that records eye movements and brain activity while participants drive in both simulated and real-world environments.
Researchers from University of Nottingham uncover cyclin's crucial role in malaria parasite development within mosquitoes and mammal hosts. The study identifies three types of cyclin, shedding light on the disease's complex life cycle.
Researchers developed two new risk prediction tools to identify patients with diabetes at high risk of blindness and amputation, using existing patient data. The tools aim to personalize care and advice for those in greatest need.
A new genetic discovery has identified a significant gene called miR137 that is switched off in prostate cancer cells, contributing to the disease's initiation and progression. The study also identified potential targets for next-generation drugs to treat prostate cancer.
A new international study is recruiting over 8,000 UK parkrun participants to assess the link between recreational running and osteoarthritis. The HALO study will follow participants for 15 years to identify potential benefits and risks of regular running.
A recent study published in Proceedings of the National Academy of Sciences found that climbing vines are significantly reducing carbon storage in tropical forests by crowding out and killing trees. The researchers discovered that woody climbing plants, or lianas, substantially reduce forest-level carbon uptake and storage.
GABA's role in dampening hyperactivity has led researchers to believe that increased production during adolescence improves symptoms for the majority of people with TS. This finding could offer a new approach to treatments targeting GABA levels in brain areas controlling motor function.
A UK Biobank study has identified genetic differences that affect lung health, including those who smoke and never smoked. The research may lead to improved treatments for diseases like COPD and help smokers quit.
The University of Nottingham leads a £6.5m research project to create bespoke biomaterials for specific applications in regenerative medicine, drug delivery, and medical devices. The team aims to identify new materials that can control cell response and address unmet clinical needs.
A recent study published in PNAS journal suggests that collaborative settings can provide fertile ground for corrupt behavior, including lying and dishonesty. The researchers found that levels of corruption were highest when profits were shared equally among group members.
Researchers identified the molecular mechanism behind H. pylori's adhesion protein using powerful x-rays, revealing a specific 'groove' that enables attachment to stomach sugars. This discovery could lead to the development of novel strategies to clear H. pylori from the stomach.
Researchers at the University of Nottingham have created a fully synthetic substrate to grow billions of human pluripotent stem cells. This breakthrough could lead to the creation of 'stem cell factories' for clinical use in treating heart, liver and brain conditions.
A team of wildlife experts has successfully revealed the black leopard's spots using a modified infrared flash on automatic camera traps, allowing scientists to study and monitor this unique population. The research provides a new tool for conservation efforts, which are critical due to widespread poaching and habitat loss in Malaysia.
Scientists have developed a rapid method to distinguish between left- and right-handed molecules in a mixture, offering potential breakthroughs in drug development and disease diagnosis. The Mass-Selected PhotoElectron Circular Dichroism technique can identify molecule handedness with high accuracy, even in complex mixtures.
Researchers developed the smallest and most accurate thermometer that can detect tiny fluctuations in microscopic regions, enabling applications in various fields. The study provides a full characterization of temperature estimators with maximum accuracy, shedding light on their margin of error.
Researchers at University of Nottingham launch new app BabyFace to collect images of newborn babies' feet, face, and ears for premature baby research. The app aims to improve survival rates in developing countries with smartphone technology.
Research suggests that children displaying increasing levels of inattention at age 7 are at risk of worse academic outcomes in their GCSE examinations. The study found a linear relationship between inattention symptoms and reduced GCSE scores, with every one-point increase in symptoms leading to a two-to-three point decrease in scores.
A new study found that while most people are willing to reduce their personal energy consumption, many are hesitant to share their energy data with third parties. Climate change awareness and cost concerns play a significant role in shaping public acceptance of demand-side management systems.
Elephant soundscapes tested for effectiveness in deterring night-time raids on farmland in southern India, with results showing 90% success rate using tiger sounds and 73% using leopard sounds. The study's findings suggest a potential solution to the growing problem of human-elephant conflict in agriculture.
A new trial will evaluate strategies to improve attention and memory for people with multiple sclerosis, aiming to boost everyday life activities. The 10-week group intervention will focus on improving attention and reducing memory problems in daily life.
The app will use distinctive features on newborns to estimate gestation and identify those at risk of urgent medical care. Computer scientists aim to harness smartphone technology to transform mobile phones into medical devices for low-access communities.
A study found that pollution has led to a significant increase in cyanobacteria populations in lakes across North America and Europe over the last 200 years. The research highlights the importance of controlling nutrient inputs from industrial fertilizers and sewage discharge.
A new study published in PNAS found that people who focus on the success of their peers are more likely to act selfishly in group decisions. This is because success-oriented individuals prioritize information about which behavior pays off best, leading to a greater likelihood of selfish actions.
Scientists at The University of Nottingham have developed new breeding techniques to enhance flood tolerance in barley and other crops. They identified the mechanism used by plants to sense low oxygen levels and reduced yield loss in water-logged conditions, leading to improved crop resilience.
A study reveals children with 'biallelic mismatch repair deficiency' (bMMRD) experience a rapid wave of genetic mutations, dubbed the 'great flood', which causes aggressive cancer. The research identifies a previously undiscovered mechanism for cancer progression and potential targets for treatment.
Researchers have developed a fluorescent hormone biosensor that reveals the dynamics of jasmonate signalling in plants, allowing for the imaging of plant defence mechanisms in real time. This breakthrough enables the study of how plants coordinate their defence responses to mechanical damage and disease.
Scientists at the University of Nottingham used magnetic levitation to manufacture wax models of tektites, which are tiny glass objects formed by asteroid impacts. The research validates numerical models of spinning droplets and provides new information on tektite formation.
Researchers found associations between extraversion and pro-inflammatory genes, as well as conscientiousness and reduced pro-inflammatory gene expression. These findings support the idea that personality traits influence health and longevity.
A recent study by Dr. Ahmed Dahir Mohamed found that Modafinil slowed down reaction times and impaired the ability to respond in a timely manner in healthy participants. The drug did not improve cognitive performance or enhance creativity, contrary to its marketed claims.
A large international clinical trial has shown that current hospital protocols for managing blood pressure in stroke patients may not be effective. The ENOS trial found that early treatment with glyceryl trinitrate patches improved outcomes in patients who received treatment within 6 hours of symptom onset.
A new approach to disease outbreak management proposes using real-time information to adapt interventions, potentially saving up to £20 million in livestock losses. This flexible approach aims to improve outcomes by incorporating scientific discovery with policy making.
Researchers found that regular poor trimming can cause residual stress in nails, leading to shape changes and serious conditions. They suggest optimising nail shapes to reduce stress and promote health in both humans and animals.
Researchers at The University of Nottingham have shed new light on the interaction between two proteins, laminin receptor (LAMR1) and galectin-3, and the human pathogen Neisseria meningitidis. This study provides critical components that cause the formation of pairs of molecules targeted by the bacterium.
Scientists at The University of Nottingham have made a major medical discovery that could lead to the development of an entirely new type of painkiller for chronic pain conditions like traumatic nerve injury. They found that a signal protein called VEGF promotes pain while its inhibiting form prevents it.
A study by University of Nottingham researchers found that higher levels of GABA in the supplementary motor area (SMA) help dampen down hyperactivity, allowing stronger signals to produce movement. This could lead to targeted approaches controlling tics using transcranial direct-current stimulation (tdcs).
A study by University of Nottingham researchers found that smart meters displaying individual and communal energy usage can lead to feelings of shame, anger, and guilt among housemates. This may result in increased conflict and negative emotions, particularly when one or more housemates are free-riding on others' energy usage.
Despite significant increases in R&D expenditure as a percentage of GDP, China has seen a decline in funding for applied research, with basic research funding plummeting from 5.2% to 4.7%. The authors argue that further reforms are needed to bring transparency and coordination to the country's R&D spending.
Researchers have discovered new materials capable of repelling bacteria, which could lead to a significant reduction in hospital infections acquired through implanted medical devices. The polymers have been licensed to a UK SME for clinical trials, aiming to inform rational design of improved bacteria-resistant polymers.
Researchers have completed a comprehensive study on the role of protein phosphatases in malaria parasite development and differentiation. The study, published in Cell Host and Microbe, identifies 16 genes that are crucial for parasite growth and could be future drug targets.
A first-year Environmental Science student at the University of Nottingham Malaysia Campus published a literature review on the Southeast Asian monsoon in Geoscience Frontiers. The study found that future climate warming could lead to a 15-day delay in the monsoon onset by the start of the next century.
A breakthrough in diagnostic technology could make it easier to detect pathogenic bacteria, particularly in developing nations. The innovative approach involves hijacking bacterial metabolic machinery to grow polymers that selectively bind to specific bacteria.
Researchers have identified a new and accurate test for Parkinson's disease using 3T MRI scanning technology, known as the 'swallow tail' appearance of the healthy nigrosome. This sign is absent in Parkinson's disease, making it a potential diagnostic tool for clinicians.
Children and young adults with epilepsy are more likely to suffer broken bones, burns, and poisonings compared to those without the condition. Young people with epilepsy are at significantly greater risk of being poisoned by medication, especially in the age group of 19-24 years old.
Scientists discovered that species with germ plasm, a cell lineage responsible for producing gametes, evolve faster than those without. This accelerated rate of evolution leads to 'explosive radiations' of species and challenges traditional views on the process.