A team of researchers from Nottingham University has discovered a rare genetic variant associated with an increased risk of Alzheimer's disease. The study, which used data from over 25,000 people, found that a specific mutation in the TREM2 gene may play a key role in the development of the disease.
Scientists at the University of Nottingham have discovered that cordycepin, a compound found in rare parasitic fungi, has potential as an anti-inflammatory drug. The study shows that cordycepin reduces inflammatory gene products in airway smooth muscle cells, making it a potential treatment for asthma and other inflammatory conditions.
The UK BiLEVE study aims to discover the genes affecting lung function and susceptibility to COPD. Researchers will analyze data from 50,000 UK Biobank participants to identify genetic variants associated with COPD, shedding light on why some people are more prone to lung disease.
The University of Nottingham has been awarded £2.9m to develop low-carbon fuel and address global challenges through synthetic biology. Researchers aim to convert carbon monoxide into useful chemicals and fuels without competing with food resources.
A new report provides guidance on family involvement in serious case reviews following a child's death or serious injury due to abuse or neglect. The research explores personal experiences of professionals and families, making recommendations for best practice.
A new MRI model reveals why images are sensitive to nerve fiber direction and allows for detailed information about fiber size and direction. This discovery will help clinicians recognize lesions and tailor scans to patients with specific needs.
A study published in Archives of Disease in Childhood found that high birth weight, rapid weight gain, and maternal smoking are significant risk factors for childhood obesity. Conversely, breastfeeding and delayed introduction to solid food may reduce the risk.
A team of academics will compare screening programmes in some areas to establish the most effective way of spotting hearing loss in children aged four to six years old. The research aims to determine whether a nationwide approach would be successful and cost-effective.
A new University of Nottingham study will examine the incidence and impact of gluten intolerance in the UK, focusing on coeliac disease and dermatitis herpetiformis. The research aims to improve diagnosis rates and healthcare for affected individuals, with a goal of creating a more accurate estimate of the condition's prevalence.
Scientists at the University of Nottingham have discovered a low-cost new material called NOTT-300 that can capture CO2 and SO2 with high efficiency and selectivity. The material has the potential to reduce greenhouse gas emissions and contribute to a low-carbon economy.
Researchers at the University of Nottingham found that individuals with high tryptophan levels experience fewer quinine side effects. The study suggests that dietary changes could potentially alleviate toxic effects of quinine treatment, improving its effectiveness and reducing risk of adverse reactions.
Researchers have created a 'nanolaboratory' inside a hollow spherical C60 Buckminsterfullerene molecule, allowing them to study the quantum mechanical principles governing the motion of imprisoned hydrogen and water molecules. The experiments revealed wave-like behavior and 'quantum rattling' of the guest molecules within the C60.
Scientists at the University of Nottingham have developed new polymers resistant to bacterial attachment, reducing biofilm formation and infection rates. The breakthrough could lead to a significant reduction in hospital infections and medical device failures, with initial results showing up to 96.7% reduction in bacteria.
A joint study by University of Nottingham and Unilever found that fat in food reduces brain activity responsible for processing taste, aroma, and reward. The research provides insights into making healthier, less fatty food products with better taste and enjoyment.
Researchers will develop nanocomposites for medical implants that break down safely, replacing metal implants in bone surgery. The project tackles challenges in nanoparticle production, dispersion, degradation, and scaling up manufacture.
Scientists use thermal imaging to analyze brown fat reserves, which produce heat and aid in burning calories. The technique may help predict food labels' thermogenic index, aiding the fight against obesity.
The University of Nottingham is part of a €10 million European project to develop cost-effective solar generated electricity. The team aims to fabricate high-efficiency solar cells using advanced thin film technologies, solving issues with current commercialized cells.
A team of scientists discovered that spaceflight suppressed the accumulation of toxic proteins in a microscopic worm, Caenorhabditis elegans. When the expression of genes involved in aging was lowered, the worms lived longer, suggesting that spaceflight may slow the aging process.
Researchers at University of Nottingham are developing new injectable materials that stimulate stem cells to form new blood vessels, heart and bone tissue. The goal is to create radical new treatments for diseases with no cure, reducing the need for invasive surgery.
The University of Nottingham is developing a detailed picture of the Asian brain through a two-year project. The resulting road-map will help doctors in Asia diagnose age-related diseases like Alzheimer's and Parkinson's at an earlier stage, improving treatment outcomes.
Researchers at The University of Nottingham have successfully created a stable version of the elusive 'trophy molecule' using a novel method. The team's achievement offers a viable alternative to current nuclear fuels, with superior high densities, melting points, and thermal conductivities.
The project aims to improve professional translators and mediators in navigating cultural differences and minimizing misunderstandings. Experts investigate the impact of language, body language, and cultural variables on mediation processes.
Researchers at the University of Nottingham have discovered three sets of genetic markers that could improve diagnosis and treatment outcomes for children with a rare type of brain tumor. The study found distinct genetic signatures for each sub-type of tumor, which may lead to more effective tools for predicting patient outcomes.
Researchers have developed a novel porous material with unique carbon dioxide retention properties, which could be used in new carbon capture products to reduce emissions from fossil fuel processes. The material's structure allows selective adsorption of CO2, even at low temperatures.
A new project aims to increase hearing aid use by providing easy-to-use video tutorials that address common barriers to adoption. The tutorials offer practical tips, animations, and real-life experiences from users to support patients in making the most of their devices.
A parasitic flatworm called Fasciola hepatica hinders the diagnosis of bovine tuberculosis (TB) in cattle by reducing the sensitivity of skin tests. This study found that liver fluke infection can create false negatives for TB, allowing infected cattle to continue transmitting the disease.
Scientists at the University of Nottingham have proven a long-held theory about bacterial communication by showing that quorum sensing's effectiveness depends on bacterial population density. This discovery can inform research into disrupting QS and stopping toxin production in pathogenic organisms like Pseudomonas aeruginosa.
Researchers are studying the genetic link to pre-eclampsia, aiming to predict and prevent the disease. By understanding which genes cause pre-eclampsia, it may be possible to improve treatment and provide additional ante-natal care for high-risk women.
Researchers at University of Nottingham use math to study gibberellin hormone affecting plant growth, identifying key interactions between feedback loops. This work aims to improve crop varieties and address global food security concerns.
A study led by experts at the University of Nottingham has discovered a link between chromosomal abnormalities and survival rates in children with brain cancer. The research identified increased copies of chromosome 1q25 as associated with poorer outcomes, paving the way for a new diagnostic test.
A new clinical trial aims to determine whether intravenous antibiotics are more effective than traditional therapies in tackling Pseudomonas aeruginosa, a common germ causing destructive lung infections in CF patients. The study will assess the treatment's success over a year and potentially inform national guidelines.
A study published in the British Medical Journal found that offering free nicotine patches and proactive counselling to smokers calling an NHS quitline did not increase the number of people who successfully quit smoking. The trial compared the effectiveness of this extra support against standard reactive quitline support, with no signi...
Scientists at the University of Nottingham used next-generation DNA sequencing to correct a patient's genetic diagnosis from incorrect to accurate. The new technique enables fast and affordable analysis of human genomes, providing hope for thousands of people living with muscle-wasting diseases in the UK.
A study found that shortcuts in subsidy scheme design risk environmental benefits, promising conservation gains are often lost. The researchers suggest designing more targeted schemes to efficiently use public funds.
A team led by Professor Kevin Shakesheff has created an artificial 'womb' that allows for the growth of embryos outside the body, revealing new aspects of embryonic development. By observing critical stages in real-time, scientists have gained insights into the process of head formation and the role of pioneer cells in leading migration.
Academics at the University of Nottingham are recruiting patients with relapsing remitting multiple sclerosis to test the effect of a low dose of the helminth parasite Necator americanus on their immune system. The study aims to prove that hookworms can reduce MS symptoms and prevent relapses.
Planarian worms, a species of flatworm, have been found to maintain telomere length indefinitely, allowing them to regenerate tissues and cells without aging. This discovery sheds light on the mechanisms underlying their immortality and may shed new insights into alleviating aging in human cells.
Researchers have discovered a vital player in the sexual phase of the malaria parasite's reproduction that could prove an effective target for new treatments. The new protein, CDC20, plays a crucial role in cell division and the development of male sex cells, essential for parasite transmission between humans and mosquitoes.
A new study by University of Nottingham researchers found that systematically collecting family medical history is a significant tool in helping GPs spot patients at high risk of heart disease. The study identified an additional five percent of patients who would benefit from prevention measures, highlighting the potential for low-cost...
A study led by University of Nottingham found that pharmacist-led intervention schemes can significantly reduce prescribing errors in general practices. The scheme involves a pharmacist working with GPs to identify and correct medication errors, resulting in reductions of up to 50 percent in errors related to specific medications.
Researchers at the University of Nottingham have developed a revolutionary technique using X-ray Micro Computed Tomography (Micro-CT) to analyze plant roots with unprecedented accuracy. This breakthrough enables the identification of root architecture in three dimensions, paving the way for improved crop breeding and food security.
Scientists at the University of Nottingham developed a mathematical model of calcium activity in atrial heart cells, improving our understanding of heart disease and stroke. The model provides clinically relevant insights into sub-cellular calcium signals, allowing for new treatments for conditions like atrial fibrillation.
Researchers at the University of Nottingham have discovered a way to accelerate salt delivery to the tongue, allowing for significant salt reduction in snack foods while maintaining flavor. This breakthrough has the potential to tackle high salt intake, linked to health issues like high blood pressure and cardiovascular disease.
A nano-enabled intranasal formulation of teriparatide is being developed to treat osteoporosis, with the potential to provide easier administration and enhance efficacy. The project combines Critical Pharmaceuticals' nanotechnology expertise with the University of Nottingham's world-leading research capabilities.
Scientists at the University of Nottingham discovered a new mechanism that explains how infections can trigger multiple sclerosis relapses. Regulatory T cells, which regulate immune responses, become less inhibitory when stimulated by bacterial or viral molecules, leading to increased inflammation.
Scientists at The University of Nottingham have identified a new molecule DC-SIGN that plays a role in damping down the body's allergic response to house dust mites. This discovery could pave the way for developing new therapies or treatments for preventing allergies.
A study published in BMJ Open found that baby-led weaning promotes healthy food preferences and may protect against obesity. The research suggests that infants who are weaned through this method learn to regulate their food intake, leading to a lower BMI and a preference for healthy foods like carbohydrates.
Researchers have identified a new family of hypoxic regulator proteins that malfunction when dysregulated, contributing to the progression of serious diseases like cancer. This discovery may lead to the development of novel drug therapeutics to combat cancer and other oxygen-related disorders.
Scientists at the University of Nottingham have successfully altered root growth in plants by controlling a key regulatory protein, WRKY23. This breakthrough could lead to improved crop yields and resistance to parasites under varying environmental conditions.
Researchers found that Malaysian Chinese use a unique mixed strategy to recognize faces, focusing on the eyes and nose more than the mouth, which proved advantageous for accurate recognition of Chinese and Caucasian faces.