Articles tagged with Blood Transfusion
Researchers at the University of Adelaide have made a promising breakthrough in reducing adverse inflammatory responses to blood transfusions in preterm babies. By understanding the mechanisms behind these responses, they aim to improve blood transfusion safety and reduce complications.
A recent study suggests that funding agencies should focus on providing a stable blood supply in sub-Saharan Africa. The authors argue that current policies and practices are not suitable for the region's emergency blood transfusion needs. This could lead to long-term reliance on external funding, making services unaffordable.
Patients who refuse transfusion following cardiac surgery, particularly Jehovah's Witnesses, experience lower morbidity and mortality rates compared to those who receive blood transfusions. They also show fewer complications such as heart attacks and longer hospital stays, while having better long-term survival rates.
A Johns Hopkins study reveals wide variation in blood transfusion use during surgery, with frequent unnecessary transfusions. Researchers suggest that patients only need a transfusion if their hemoglobin levels fall below seven or eight grams per deciliter.
Researchers have identified two proteins responsible for the Langereis and Junior blood types, shedding light on a long-standing medical mystery. The discovery may improve treatment options for breast cancer patients and enhance blood transfusion safety for rare blood type carriers.
Prevention strategies that included ultrasound screening and chronic blood transfusions for children with sickle cell anemia led to a significant decrease in racial disparities in stroke-related deaths. This change occurred after the Stroke Prevention Trial in Sickle Cell Anemia (STOP) was implemented in 1998.
A University of Maryland study found that restricting blood transfusions after hip surgery did not harm patients and may even be unnecessary for some. The research included over 2,000 patients with anemia after hip fracture and showed no significant difference in recovery rates between those who received moderate transfusions and those...
Preemies with AB blood type are nearly three times as likely to die from necrotizing enterocolitis (NEC) as those with other blood types. Changing blood transfusion practices could significantly reduce NEC incidence by providing specific blood types.
A study of over 100,000 patients found significant variability in US hospital blood transfusion rates for coronary artery bypass graft (CABG) surgery. Despite varying rates, there were no significant differences in mortality rates among hospitals with different transfusion practices.
A restrictive use of blood transfusions during cardiac surgery was associated with similar death and severe illness rates as a liberal approach, according to a study published in JAMA. The researchers found that limiting red blood cell transfusions did not increase the risk of complications or death at 30 days.
Loyola University Hospital reduced blood transfusions by 10% in 2009, saving $453,355, while improving patient safety without compromising care. The new blood management program implemented evidence-based indications and protocols to reduce unnecessary transfusions.
A new study aims to investigate whether delaying the clamping of a newborn's umbilical cord for two minutes after birth can improve their recovery from corrective heart surgery. The study hopes to determine if this practice can decrease the need for blood transfusions in critically ill babies.
A study published in the Journal of the National Cancer Institute found that erythropoiesis-stimulating agents increase the risk of venous thromboembolism in cancer patients. The use of these agents, approved to reduce blood transfusions during chemotherapy, may outweigh benefits due to associated risks.
A new study analyzing nearly 25,000 Medicare patients found that blood transfusions for hospitalized cardiac patients can be associated with increased risks of infection and death. The analysis also revealed substantial variation in transfusion practices among hospitals, highlighting the need for evidence-based guidelines.
A study of nearly 25,000 coronary artery bypass graft patients found that receiving blood from another person increased post-operative infection rates by two-fold. Hospital variation in transfusion practices was also significant, accounting for 30% of the variation.
A comprehensive review of medical literature by experts found no evidence supporting beneficial effects from blood transfusions. Studies show associations with higher rates of complications like heart attack, stroke, and kidney failure, highlighting the need for restricted practice and safer storage methods.
A study found that hospitals with low SSI incidence rates had shorter operations, fewer blood transfusions, and more efficient care delivery. These findings suggest strategies to reduce operation length and blood transfusion rates can complement basic aseptic techniques.
The use of anticoagulants, antiplatelet agents, and thrombolytics in acute coronary syndromes (ACS) increases the risk of bleeding, which has emerged as a major contributor to poor outcomes. Careful selection of drugs and measures to prevent gastrointestinal bleeding can help mitigate this risk.
A recent study found that blood transfusions can transmit a variant of mad cow disease (vCJD) to humans with high efficiency, particularly when donors are in the later stages of infection. The research suggests that blood from BSE- and scrapie-infected sheep could be used effectively in non-human experiments to develop diagnostic tests.
Researchers developed a special filter that quickly removes prion proteins, causing mad cow disease and Creutzfeldt-Jakob disease, from blood. The device has been approved for use in Europe and is expected to be commercialized in Ireland and the UK in mid 2008.
A Phase II study found that blood transfusion therapy helped shrink brain lesions caused by silent strokes in children with sickle cell disease. The therapy eliminated one lesion completely and showed no new silent strokes after two years. Researchers hope to preserve cognitive function in these children through prolonged transfusions.
Researchers discovered how bacteria produce desferrioxamines, leading to new ways to treat Fire Blight disease in orchards and human iron overload. The study also identified a more efficient method for producing the pharmaceutical desferrioxamine B.
Researchers have developed a method to amplify prions from brain tissue samples using normal blood cells, improving detection test sensitivity. This breakthrough may lead to a blood test for screening individuals at risk of passing variant CJD through blood transfusion or surgery.
Researchers analyzed data on blood donations and recipients in Sweden and Denmark over 34 years, finding no link between cancer risk and blood from precancerous donors. The study provides valuable insights into the safety of blood transfusions and highlights the need for further research on chronic diseases.
A new study suggests that blood transfusions during heart bypass surgery may be linked to a higher risk of developing potentially dangerous infections and dying in the first few months after operation. Women are more likely to receive blood transfusions than men, which may explain their increased mortality risk.
A new case of variant Creutzfeldt-Jakob disease (vCJD) linked to a blood transfusion has been confirmed in the UK. The patient developed symptoms six years after receiving a contaminated blood sample from a donor who later died from vCJD. Early diagnosis and monitoring are crucial for affected individuals.
Research finds blood type and age may be pivotal in transfusion success. Blood transfusions are associated with a markedly increased risk of mortality in patients suffering from ST-elevation myocardial infarction.
Research at Duke University Medical Center found that US heart patients receive blood transfusions 84% more often than Europeans and 38% more often than Asians. The study revealed wide differences in bleeding and transfusion rates among heart patients globally, with the US having significantly higher rates.
Researchers found high HCV rates among former plasma/blood donors and villagers who received blood transfusions. Unhygienic plasma donation and blood transfusion are strong risk factors for HCV infection in rural central China.
Scientists are using genomics to create a new type of hemoglobin that can be used in blood transfusions. This innovation has the potential to reduce contamination risks and make blood transfusions safer for people in emerging countries.
A new study confirms the filter's effectiveness in reducing prions by up to 99.9%, providing a critical safety measure against vCJD transmission through blood transfusion. The technology has the potential to safeguard the global blood supply and prevent future outbreaks.
Recent studies have shown a significant decrease in multiple organ failure (MOF) incidence among severely injured patients over the last decade. Advances in trauma and critical care, including more judicious use of blood transfusions, have led to improved MOF outcomes.
A meta-analysis of 27 clinical trials found that erythropoietin treatment lowers the likelihood of needing a blood transfusion and improves hematologic response in cancer patients. However, results on overall survival are inconclusive, suggesting erythropoietin should not be used to increase survival outside clinical trials.
The NHLBI halted a clinical trial on periodic blood transfusions for patients with sickle cell anemia due to the treatment's proven effectiveness in preventing strokes. However, the trial also highlighted potential long-term side effects such as iron overload and the need for ongoing monitoring.
A study published in JAMA Network found that heart attack patients who received blood transfusions had a significantly higher death rate compared to those who did not. The study included 24,111 participants and showed that blood transfusion was associated with nearly four times increased risk for 30-day death.
A study of over 24,000 patients found that blood transfusions during hospitalization for acute coronary syndrome increase mortality rates. Patients who received transfusions were also more likely to suffer a heart attack within 30 days.
The study identifies a heterozygous genotype for the prion protein, suggesting that individuals with this genetic subgroup may be at higher risk of vCJD transmission. The findings highlight the need for continued surveillance and leucoreduction policies to reduce the risk of blood-borne transmission.
The Emory University Health Sciences Center, AABB, and Red Cross will work together to reduce HIV transmission in developing countries by improving blood supply systems, testing for HIV, and creating safe transfusion centers.
A UK-based study found that individuals who received blood components from donors later diagnosed with vCJD were at increased risk. Researchers also discovered that the BSE agent can be transmitted through intravenous routes, highlighting concerns for possible transfusion cases.
Researchers found that recombinant activated factor VIIA significantly reduced blood loss during abdominal prostate removal surgery. Patients given the drug required no blood transfusions, whereas those receiving placebo did.
Researchers found that administering recombinant human erythropoietin (rHuEPO) resulted in a 19% reduction in red blood cell transfusion. The study showed improved hemoglobin levels and reduced exposure to RBC tranfusions, with potential benefits including morbidity and mortality reductions.
A team of physicians at the University of Toronto successfully treated a pediatric patient with an autoimmune disease using a cell-free hemoglobin solution. This alternative provides oxygen-carrying capacity similar to blood cells, making it a viable option for children and Jehovah's Witnesses.
Researchers found that ATG significantly improved the ability of patients to produce healthy blood cells, allowing them to stop blood transfusions. The treatment has also shown potential in preventing progression to leukemia and improving quality of life for patients with myelodysplastic syndromes.
Research suggests that individuals with coronary artery disease are less tolerant to anaemia during non-cardiac surgery. A study of 2059 patients found those with anaemia had a five-fold higher in-hospital mortality rate after bypass surgery despite blood transfusions, indicating the need for further investigation before surgery.
Researchers found that a unique blood plasma volume expander can resuscitate rats after severe hemorrhage and apnea, with some surviving up to 7 days without blood transfusions. Hyperbaric oxygen appears to confer advantages in resuscitation and maintenance of circulation.
The study found that 43.4% of elderly heart attack patients are anemic, and those with lower blood counts have higher mortality rates. Blood transfusions significantly reduce mortality risk in these patients, even at higher blood count levels than previously thought.