Articles tagged with Blood Transfusion
A new study led by ISGlobal found that blood transfusions can increase the survival of children with severe malaria, even at higher haemoglobin levels than recommended thresholds. In cases with complications, such as impaired consciousness or acidosis, transfusion improved survival even at high haemoglobin levels.
The REALITY trial found that restricting blood transfusion to those with very low haemoglobin levels has no negative impact on clinical outcomes, while also saving blood. The trial showed that the restrictive strategy was non-inferior to the liberal strategy in preventing 30-day major adverse cardiac events (MACE) and was more cost-eff...
A retrospective cohort study in Sweden found ongoing transmission of hepatitis C before anti-HCV screening was implemented in 1992. The study identified undiagnosed hepatitis C patients living in Sweden who received transfusions pre-1992, emphasizing the need for testing and treatment.
A new microfluidics device has identified two super donors with long-lasting red blood cells, offering potential for improved transfusion safety. The study, published in Lab on a Chip, could benefit over 4.5 million patients requiring regular blood transfusions.
The global demand for blood transfusions exceeds the available supply by 30 million units annually, with the largest shortages found in lower-income countries. The estimated shortfall varies sharply between countries, with some requiring up to 75 times more blood than their supply can provide.
Researchers have developed a laser incubator for blood that can slash incubation time to just 40 seconds, improving pre-transfusion testing and saving lives. This technology has the potential to prevent fatal blood transfusions in critically ill patients and detect antibodies in pregnant women.
A new study found that postpartum transfusions carry a greater risk of adverse events, particularly among women with preeclampsia. The number of postpartum transfusions increased by 40% over 20 years, and the risk was twice as high for pregnant women compared to non-pregnant women.
A new UTSA study documents the war's casualty statistics, mortality trends, and treatment advances. Key findings include increased injury patterns and severity, as well as a significant reduction in mortality rates thanks to interventions such as tourniquets and rapid hospital transport times.
Gunshot victims require significantly more blood transfusions due to severe injury severity, with a 14-fold increased risk of death compared to non-GSW trauma patients. Blood products cost a lot and are scarce, making it crucial for hospitals to improve outcomes for trauma victims.
Researchers at Lund University have found a direct link between the gastrointestinal flora and lung disease in the setting of blood transfusions. The composition of the gut bacteria drives the pathogenic immune response in the lungs during Transfusion Related Acute Lung Injury (TRALI), a complication that can be fatal.
Researchers have developed a computer program that can comprehensively determine differences in individuals' blood types with over 99% accuracy. This breakthrough has the potential to prevent serious complications and fatalities from blood transfusion reactions.
Scientists have engineered red blood cell lines to express fewer antigens, making them less immunogenic for patients with rare blood types. This breakthrough could lead to the development of more universal blood sources for transfusion patients.
A $3.4 million grant will help researchers study endocrine-disrupting chemicals in medical devices, with a focus on improving transfusion safety and understanding the impact on cardiovascular health.
A study published in Mayo Clinic Proceedings reports significant improvements in HHT patients with severe bleeding treated with intravenous bevacizumab. The treatment reduced nose and gastrointestinal bleeds, allowing patients to stop or reduce blood transfusions, improving quality of life.
A study published in PLOS Medicine found that cell salvage did not significantly reduce the need for donor blood transfusions during caesarean sections. However, it showed promise in reducing transfusions in emergency caesareans. Further research is necessary to confirm these findings.
Experts recommend restrictive blood transfusion practices for stable patients with hemoglobin levels of 7 g/dL or higher, reducing mortality and blood clot risks. The study found significant reductions in blood use by 40-65% in largest randomized trials.
A global study of over 5,000 patients found that restrictive blood transfusion practices are safe and effective, reducing deaths, heart attacks, strokes, and kidney failures. The study also reduced the number of transfusions by 28% and the amount of blood transfused by 30%.
A study of US military combat casualties in Afghanistan found that prehospital blood transfusions within minutes of injury or prior to hospitalization resulted in greater 24-hour and 30-day survival rates compared to delayed or no transfusion. Early transfusion also showed a reduced risk of death over 24 hours when administered up to 1...
A recent study by Lund University researcher Mattias Möller has identified 1000 new genetic variants in blood group genes, which could have negative effects during blood transfusions. The discovery was made possible by developing a new computer program to process the genomes of 2504 people, providing insights into human genetic variation.
Researchers from Karolinska Institutet have conducted a study on the impact of sex-discordant blood transfusions on post-cardiac surgery survival. Despite initial findings suggesting a possible increased risk, the new study found no association between these types of transfusions and mortality rates.
A large international study of almost 31,500 patients showed that using older blood for transfusions does not increase the risk of death. The research, published in the New England Journal of Medicine, provides strong evidence that stored blood can be safely used to ensure a stable blood supply.
The Perioperative Surgical Home (PSH) model has been shown to decrease imaging tests by 9%, lab tests by 22%, and blood transfusions by 87%. Hospital stays are also reduced, with a 50% decrease in length of stay. Patient satisfaction improves through better pain management and physician communication.
Researchers propose combining multiple methods to identify cheating athletes, including hemoglobin mass, gene expression changes, ironomics, and blood storage-related biomarkers. These new tools offer a potential solution to detecting autologous blood transfusions.
Researchers at Vanderbilt University Medical Center implemented blood utilization practice guidelines, resulting in a 30% reduction in blood transfusions and $2 million savings. The new guidelines also reduced blood wastage by 75%, from 300 to 80 units, improving patient outcomes and optimizing the use of this limited resource.
Researchers found that combining TXA delivery methods reduced blood loss by 37% compared to IV alone following TKR. The study showed no thromboembolic complications, with one patient requiring a postoperative blood transfusion.
Researchers identified predictors of postoperative complications after partial nephrectomy and found a significant reduction in perioperative blood transfusions with the use of tranexamic acid. Additionally, men who underwent primary artificial urinary sphincter implantation for stress incontinence had improved long-term outcomes.
Researchers developed a technique to reduce infectious malaria parasites in whole blood, significantly reducing the risk of transmission through blood transfusion. The Mirasol pathogen reduction technology system has shown promising results in treating whole blood using ultraviolet light energy and riboflavin.
A study by University of Cincinnati researchers found that trauma patients receiving blood quickly after severe injuries have a decreased death risk. The delay in blood transfusion increased the chances of death, with each 10-minute delay resulting in higher mortality rates.
Researchers found that TXA reduced the need for a blood transfusion by more than 50% in hip and knee replacement surgery. Topical versus intravenous administration of TXA showed similar effectiveness in reducing blood loss and transfusion rates.
A recent study found that nearly 5,000 trauma patients sustain major haemorrhage each year in England and Wales, with one-third dying due to delays in blood transfusion practices. The study highlights the need for more rapid and consistent delivery of blood components to trauma patients, as this can halve mortality rates.
Patients undergoing urologic surgery who are frail have a 1.7-times higher risk of complications. Frailty is an independent predictor of postoperative complications across most procedures.
A new study suggests that hydroxyurea can be effective in reducing the risk of stroke for some children with sickle cell disease. The Transcranial Doppler with Transfusions Changing to Hydroxyurea (TWiTCH) study, stopped early due to positive preliminary results, showed that transitioning from regular blood transfusions to daily doses ...
A large registry study of almost 50,000 patients in Sweden found that transfusion with stored blood does not influence patient outcomes after heart surgery. The study provides firm reassurance that current blood storage practices are safe.
Intermountain Healthcare implemented a blood ordering and tracking system, reducing blood transfusions by 30% and infections by 50%, saving $2.5 million over two years. The program also decreased the need for dual-unit blood orders, a common practice that suppressed recipients' immune systems.
The study found a lower rate of blood transfusions in overweight and obese patients undergoing hip and knee replacement surgery compared to those with normal weight. Researchers also discovered no correlation between BMI and post-surgical complications such as blood clots and heart attacks.
A new review presents a patient-specific plan to predict blood loss and address it, highlighting the commonality of anemia in surgical practice. The approach relies on detecting and treating anemia before surgery, reducing blood loss during surgery, and optimizing management after surgery.
A large clinical trial found no significant difference in mortality between fresh and older blood in critically ill patients. The Age of Blood Evaluation (ABLE) study, conducted across 64 centers, showed that 423 patients died within 90 days with fresh blood compared to 398 with older blood.
Researchers found that patients who received blood transfusions at a higher haemoglobin level had fewer serious complications and deaths after cardiac surgery. The study challenges current guidelines and health policy, suggesting that a more liberal approach to transfusion may be safer and more cost-effective
Patients undergoing non-emergency cardiac surgery were given either a low or high haemoglobin threshold for transfusion, with the researchers finding that more patients died in the 'low' group. Health care costs and serious complications were similar in both groups, challenging prevailing guidelines.
The Georgia Health Policy Center has received a $2.7 million grant from the CDC to study transfusion-related complications in patients with hemoglobin disorders, aiming to improve their outcomes. Researchers will explore approaches for reducing complications, developing data-driven solutions, and empowering patients and providers.
A study published in Journal of the American College of Surgeons confirms the effectiveness of pre-trauma center blood transfusions in increasing one-day survival rates and reducing shock among air-lifted trauma patients. The UPMC protocol involves giving guidelines on when to administer transfusions, resulting in improved outcomes.
Researchers found that postoperative TRALI is significantly underreported but occurs in 1.4 percent of surgical patients, while TACO remains a risk at 4 percent, particularly in those with increased volume of blood transfused and advanced age. The studies provide new insights into the incidence of these life-threatening complications.
A NIH-funded study found that regular monthly blood transfusions prevented recurrent brain blood vessel blockage in children with sickle cell anemia, reducing the risk of long-term cognitive problems and poor academic performance. The study suggests early screening for silent strokes can help manage the disease and prevent complications.
Monthly blood transfusions significantly lower the risk of recurrent strokes in children with sickle cell disease who have already suffered a silent stroke. Children receiving regular transfusions had a 58% lower risk of suffering repeat silent or overt strokes compared to those without treatment.
Researchers found that monthly transfusions reduced the risk of silent strokes and subsequent brain damage in children with sickle cell anemia. The treatment, which raises circulating blood levels and lowers sickled cells, also decreased the occurrence of painful crises.
Researchers found a significant reduction in blood transfusions with tranexamic acid, with no increased risk of complications. The study involved over 872,000 patients and found that the drug was effective in reducing blood loss during and after major joint surgery.
A UH biomedical engineer is working on a device to separate well-preserved red blood cells from potentially harmful materials in blood transfusions. The system uses microfluidic technology to scale up the separation process, making it safer and more efficient.
A study published in JAMA found that restricting blood transfusions reduces healthcare-associated infections by 18%, saving lives and costs. The research suggests that a more restrictive approach to transfusions could alleviate patient suffering and reduce hospital costs.
A randomized trial found that a 1:1:1 blood transfusion protocol is feasible but associated with higher waste of plasma. The study suggests that widespread adoption may lead to significant resource and safety implications due to the scarcity of plasma.
Researchers at Case Western Reserve University have developed a therapeutic approach to restore nitric oxide levels in donated blood, improving tissue oxygen delivery and kidney function. The treatment, called renitrosylation therapy, may hold great promise for millions of patients who receive regular blood transfusions.
The Lancet Series on transfusion medicine examines the use of restrictive transfusion practices, innovative solutions to address the growing demand for blood products, and alternative ways to manage the blood supply. The series aims to reduce unnecessary blood transfusions, improve patient safety, and cut costs.
A new protocol using single, high-dose erythropoietin administered two days prior to surgery reduces transfusion requirements by one-third and improves patient outcomes.
A team of scientists from the University of Vermont and France has discovered the tiny protein SMIM1, which causes the rare 'Vel-negative' blood type. This breakthrough allows for fast DNA-based tests to identify Vel-negative individuals, enabling them to receive life-saving transusions.
A study published in the Canadian Journal of Anesthesia found that hospitals treating patients with anemia before surgery had better outcomes, including reduced blood transfusions, infections, and shorter hospital stays. Early diagnosis and treatment of anemia are crucial to avoid unnecessary transfusions and improve patient care.
A meta-analysis of 10 studies suggests that blood transfusions are associated with increased all-cause mortality in patients with myocardial infarction. The analysis found a weighted absolute risk increase of 12% and a higher risk for subsequent myocardial infarction, highlighting the need for further research.
Researchers at the University of Adelaide have made a promising breakthrough in reducing adverse inflammatory responses to blood transfusions in preterm babies. By understanding the mechanisms behind these responses, they aim to improve blood transfusion safety and reduce complications.
A recent study suggests that funding agencies should focus on providing a stable blood supply in sub-Saharan Africa. The authors argue that current policies and practices are not suitable for the region's emergency blood transfusion needs. This could lead to long-term reliance on external funding, making services unaffordable.
Patients who refuse transfusion following cardiac surgery, particularly Jehovah's Witnesses, experience lower morbidity and mortality rates compared to those who receive blood transfusions. They also show fewer complications such as heart attacks and longer hospital stays, while having better long-term survival rates.
A Johns Hopkins study reveals wide variation in blood transfusion use during surgery, with frequent unnecessary transfusions. Researchers suggest that patients only need a transfusion if their hemoglobin levels fall below seven or eight grams per deciliter.
Researchers have identified two proteins responsible for the Langereis and Junior blood types, shedding light on a long-standing medical mystery. The discovery may improve treatment options for breast cancer patients and enhance blood transfusion safety for rare blood type carriers.