Articles tagged with Chemotherapy
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A phase III trial has established the radiation/cisplatin combination as the standard of care for human papillomavirus (HPV)-related oral cancers, resulting in higher overall and progression-free survival rates compared to cetuximab/radiation. The treatment also showed a lower rate of serious side effects, particularly with cisplatin.
Researchers developed a targeted strategy to treat chemotherapy-resistant AML by targeting the MTF2-MDM2 axis, resulting in complete remission in all mouse models treated with the new combination. The findings hold promise for treating AML patients who would otherwise die from their disease.
A phase III clinical trial found immunotherapy pembrolizumab to be more effective than aggressive chemotherapy as a first-line treatment for advanced head and neck cancer. Patients with high PD-L1 levels saw significant improvements in survival and response rates.
A phase III study found that immunotherapy with pembrolizumab improves overall survival in patients with recurrent or metastatic head and neck cancer, particularly those expressing PD-L1. The treatment also showed longer response duration and median response duration compared to standard chemotherapy.
A randomized study shows erlotinib improves progression-free survival and tumor response rate compared to gemcitabine plus cisplatin in stage IIIA-N2 EGFR-mutated NSCLC. Median progression-free survival was significantly longer with erlotinib at 21·5 months versus 11.9 months with chemotherapy.
A phase 3 SOLO-1 trial found that olaparib maintenance therapy significantly improved progression-free survival (PFS) in newly diagnosed patients with advanced ovarian cancer and a BRCA1 or 2 mutation. The median PFS for those who received olaparib was approximately three years longer than the placebo group.
A combination of immunotherapy and chemotherapy significantly extends survival by up to ten months in patients with triple-negative breast cancer. The treatment reduces the risk of death or cancer progression by up to 40 per cent, offering new hope for young women affected by this aggressive form of breast cancer.
Atezolizumab, an antibody targeting PD-L1, improved survival in metastatic triple negative breast cancer patients by 20%, particularly those with PD-L1 positive tumors. The combination therapy also reduced disease worsening and death risk by 38% in PD-L1 positive subgroup
A study of breast cancer survivors found that natural pregnancies are possible after chemotherapy, but many no longer wish to have children. The study also showed that fertility preservation measures are not widely needed among young breast cancer patients.
A pooled analysis of four UK randomised controlled clinical trials found significant differences in chemotherapy side-effects between men and women with oesophagogastric cancer. Women experienced higher rates of nausea and vomiting, diarrhoea, mouth ulceration, and hair loss compared to men.
A study of oesophagogastric cancer patients found women experienced higher rates of nausea, vomiting, diarrhoea, mouth ulceration, and hair loss compared to men. The researchers analyzed data from four randomised trials involving over 1,600 patients.
A new blood test that detects circulating tumour DNA is being tested to determine if cancer patients need chemotherapy after surgery. The trial aims to identify high-risk patients who may benefit from aggressive treatment and low-risk patients who can avoid chemotherapy.
A study found that cancer patients are open to using complementary alternative medicines, but poorly informed about safety issues and risk of interactions with anti-cancer drugs. Vitamin D supplements were the most popular choice, followed by selenium plus zinc.
A new mouse study builds on human findings that link chemotherapy and the APOE4 gene variant to cognitive problems. The research, published in Neurotoxicity Research, reveals that APOE4 works with doxorubicin to cause significant brain changes and impair learning.
Scientists at University of Toronto's Leslie Dan Faculty of Pharmacy have developed a combination approach using nanoparticles to improve chemotherapy response and boost anti-tumor immunity in breast cancer. The treatment resulted in a 60% cure rate and enhanced life expectancy by five-fold compared to treating with chemotherapy alone.
Researchers found that daily lactoferrin supplementation can change salivary protein profiles in cancer patients, protecting their taste buds and odor perception. This could help patients recover from chemotherapy with improved nutrition and quality of life.
Researchers have developed a gel-based chemotherapy that can shrink melanoma skin tumors in mice by penetrating deep into the skin. The gel, called transfersome, was found to slow tumor growth when applied daily and administered intravenously every other day, with results showing a significant reduction in tumor size.
A new drug called Metavert has shown promising results in blocking pancreatic cancer growth in laboratory mice. The study also found that Metavert may prevent patients from developing resistance to currently used chemotherapies.
Researchers at UC Riverside have discovered a way to target migrating cancer cells, responsible for tumor metastases, using novel agents 135H11 and 135H12. These potent agents can block EphA2, an oncogene that spreads cancer, preventing cell migration and degradation.
Researchers at Wayne State University have developed a nanoplatform technology that works in combination with existing chemotherapeutic drugs to reverse drug-resistance in renal cell carcinoma. The technology uses tumor hypoxia-directed nanoparticles to target the root cause of the problem and has shown promising results in animal trials.
Scientists have discovered a way to enhance the effectiveness of artemisinin, a powerful antimalarial drug, by combining it with chemotherapy medicines that target the parasite's waste disposal system. The combination works by jamming the recycling process, leading to cell death in the parasite.
Scientists have demonstrated that adding aluminium atoms to active carbon delivery capsules increases the adsorption of chemotherapy drugs, like 5-Fluorouracil, onto targeted delivery devices. This could lead to more effective cancer treatments with fewer side effects by encapsulating chemo drugs into active carbon.
Researchers at University of Houston develop synthetic compound that inhibits two major pathways of pancreatic cancer. The drug, MA242, targets NFAT1 and MDM2, reducing tumor growth and progression.
Researchers at McMaster University have identified a previously unknown cell population that triggers the return of acute myeloid leukemia after remission. This discovery provides a potential new target for therapies and offers hope for improving treatment outcomes for patients with leukemia.
Skin cells can detect damaged DNA in the absence of infection and trigger an immune response similar to that observed during viral infections. This discovery could lead to new cancer treatments and preventive measures against skin cancers.
A Moffitt Cancer Center research team compared chemotherapy regimens and found that a combination called ddMVAC was associated with higher complete response rates and improved survival rates compared to standard care. The study analyzed data from over 800 surgical patients with advanced bladder cancer.
UTEP scientists have received a $6 million grant from the National Institutes of Health to develop new regimens and biomarkers for Chagas disease treatment. The researchers aim to improve the efficacy and safety of current treatments, which are toxic and have low effectiveness.
A study published in the Journal of the American Geriatrics Society found that short-term decline in physical function was common among older adults treated with chemotherapy for breast cancer. However, about half of patients were resilient and able to recover their ability to function within 12 months.
Scientists at Salk Institute and Purdue University discovered a key to mass-producing beneficial plant compounds, including terpenoids used in fragrances, flavorings, biofuels, and pharmaceuticals. They found that plants have an
Researchers at Washington State University discovered that cancer-fighting drugs can slow or stop fungal infections in plants by activating genes used to defend against pathogens. The study showed two different results from the applications of DNA-specific drugs on pea tissue, with differing mechanisms of action.
Researchers at University of Illinois Chicago discovered that a mutation in the NPM1 gene helps improve sensitivity to chemotherapy in patients. The study found that patients with this mutation tend to respond better to chemotherapy and have higher rates of remission.
Researchers developed a novel polymer conjugate to deliver anticancer drugs directly to cancer stem cells, significantly reducing tumor size. The combined use of standard anticancer drugs further enhanced the effect.
Researchers have discovered that antibodies in mother's milk can survive the digestive system and deliver intact molecules into a baby's bloodstream. Now, they hope to encapsulate chemotherapy drugs in milk particles to create a potential alternative to infusions.
Researchers found that doxorubicin targets enzymes controlling immune responses in the spleen and heart, disrupting metabolism and leading to impaired inflammation resolution. The drug also poisons specific immune cells, causing a loss of host defense and promoting chronic non-resolving inflammation.
A recent study found that 8.3% of trastuzumab-treated patients developed heart failure, highlighting the need for cardiac monitoring in high-risk breast cancer patients. The study also showed a consistent increase in heart failure risk with age, emphasizing the importance of prioritizing cardiac monitoring for younger patients.
The study identified four fungi species with high anti-cancer potential, including polyphenols, polysaccharides, and terpenoids. These compounds show selective targeting of malignant tumors with minimal harm to healthy cells.
Research published in eNeuro suggests that cannabidiol can prevent nausea in rats by increasing serotonin levels in the brain. The findings implicate the endocannabinoid system and its role in regulating nausea, opening up new therapeutic opportunities.
Researchers have developed a novel delivery system using magnetic nanoparticles to target chemotherapy drugs to spinal cord tumors, which are difficult to reach due to the blood-brain barrier. This approach shows promise in treating intramedullary spinal cord tumors with improved survival rates and reduced side effects.
Chemists at the University of Basel have developed a novel synthesis method for terpenes that uses molecular capsules to mimic nature. The method significantly reduces the number of steps and improves yield in the synthesis process.
A new study found that Cannabidiol (CBD) significantly improved the survival rate of mice with pancreatic cancer when used alongside chemotherapy. The treatment resulted in nearly tripled survival time compared to those receiving chemotherapy alone.
Researchers at the University of Illinois Chicago developed a magnetic surgical cement that can guide nanoparticles to lesions near spinal fractures, providing targeted drug delivery. The technology has the potential to become a surgical option for patients with primary spinal column tumors or metastasizing tumors.
Australian researchers found that follistatin, a naturally occurring hormone, can enhance the effectiveness of platinum-based chemotherapy and prevent kidney damage in lung cancer patients. The 'two birds, one stone' approach has shown promising results in mouse models.
Researchers developed a method to create 3D cultures of clustered cancer cells that better mimic tumors, enabling more accurate drug testing. A new NIH grant will model the response of colon cancer cells to anticancer drugs, aiming to identify molecular mechanisms of drug resistance and develop new treatment strategies.
Researchers developed a technique to measure drug-target engagement in individual cancer cells, revealing variation in effectiveness between cells within a tumour. The findings could help clinicians choose the best course and delivery of treatment for cancer patients, improving treatment outcomes.
Researchers developed an algorithm that combines genomic information to predict individual responses to anticancer drugs. The new tool, pGENMi, uses gene expression, DNA sequence and epigenetic factors to identify key characteristics associated with specific drug responses.
A study published in Science Translational Medicine found that acetazolamide increases sensitivity to treatment and enhances survival in mice with glioblastoma. The drug, which is also used to treat altitude sickness, was able to restore the effectiveness of chemotherapy by blocking a protein called BCL-3.
A study published in Antimicrobial Agents and Chemotherapy found that nearly half of all prescriptions reviewed were prescribed unnecessarily, with a third of cases involving non-face-to-face encounters. The research highlights the need for improved antibiotic stewardship in outpatient clinics.
The California Institute for Regenerative Medicine (CIRM) has awarded City of Hope $3.7 million to develop a phase 1 clinical trial for glioblastoma patients that will genetically engineer their stem cells to better tolerate chemotherapy's side effects, allowing them to receive higher doses of the therapy. The trial is expected to star...
Macrophage receptors trigger intestinal contractions, leading to severe diarrhea in cancer patients undergoing chemotherapy. The discovery opens up new avenues for developing targeted treatments for this debilitating side effect.
Scientists at Scripps Research have discovered a previously unknown mechanism by which bacteria protect themselves from toxic substances, providing new clues for improving chemotherapies. The study reveals that three genes encode proteins that bind to toxins, keeping them separate from the rest of the organism.
Researchers found that PARP inhibitors, such as rucaparib, showed promise in treating pancreatic cancer in patients with BRCA mutations. In a small study, 32% of patients experienced disease control after treatment.
A Phase II study found that over half of women with early-stage BRCA+ breast cancer who took talazoparib once daily prior to surgery had no evidence of disease at the time of surgery. The oral medication showed high response rates and manageable toxicities, offering an alternative to chemotherapy for this patient population.
A landmark study published in the New England Journal of Medicine found that most breast cancer patients with intermediate scores on a 21-gene test can safely avoid chemotherapy. The study's results have significant implications for doctors and patients, allowing for more personalized treatment options.
A new trial presented at ASCO18 shows that PET scans can improve treatment outcomes for esophageal cancer patients. Patients who responded to induction chemotherapy had a median overall survival of 46 months, while those who did not respond had a 27-month median survival, significantly better than previous studies.
According to a new analysis of over 8,000 patients, African-American men with advanced prostate cancer who received docetaxel-based therapies had a lower risk of death than white men. This finding is significant, as it challenges the long-held notion that racial disparities in prostate cancer survival are due to biological differences.
Researchers discovered a naturally occurring protein called apolipoprotein A-I binding protein (AIBP) that inhibits inflammatory response underlying chronic pain processing. A single spinal injection of AIBP alleviated chemotherapy pain in mice for two months with no side effects.
Children with leukemia experience frequent vertebral fractures during chemotherapy, often persisting into adulthood. Vertebral deformities are more common in older children and those with severe collapse.
A small study of adults with pancreatic cancer reveals that patients with BRCA1 or BRCA2 gene mutations have poorer overall survival rates compared to those without the mutations. However, those with BRCA1 or BRCA2 had better survival rates with platinum-based chemotherapy.
Researchers have developed new treatment regimens that significantly boost survival rates for children and young adults with rare forms of leukemia and lymphoma, such as T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LL). The trial showed that 90% of patients lived at least four years after starting tre...
Cancer cells express specific sugar receptors that can be targeted for better drug delivery. Researchers are developing nanocarrier formulations to accumulate in tumor sites and minimize side effects.