Articles tagged with Medical Tests
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Research from Edith Cowan University highlights the need for accurate testing to prevent antibiotic allergies in children. Most suspected antibiotic allergies are inaccurate, with symptoms often caused by underlying illness. Testing once the child is well enough can help identify true allergies and ensure timely treatment.
The VICT3R project, led by UPF, uses data from pharmaceutical industry and AI to create virtual control groups for preclinical drug safety studies. The initiative aims to reduce animal usage by up to 25% and contribute to the 3Rs of animal testing.
A new study published in JAMA Health Forum found that machine learning can be more effective than traditional methods for distributing scarce treatments to patients most vulnerable during a public health crisis. The model reduces expected hospitalizations by about 27 percent compared to actual and observed care.
A highly accurate diagnostic blood test has been developed for amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease that affects neurons in the brain and spinal cord. The test requires only a simple blood draw and can distinguish between ALS patients and healthy controls with an overall accuracy of up to 98%.
Researchers from Aarhus University developed a new method to predict which patients with chronic kidney failure are at risk of losing kidney function over time. The method analyzes acid-base balances in urine samples, revealing early signs of acid buildup that can be harmful to kidney function.
A new preclinical blood test identifies adults most likely to develop severe respiratory conditions, including chronic obstructive pulmonary disease (COPD), by analyzing 32 proteins that accurately predict lung health data. The risk score indicates a high likelihood of hospital care, COPD development, and respiratory disease death.
Researchers at UCSF develop a method to target GTPases, enzymes involved in Parkinson's and many other diseases, by using drugs targeting the K-Ras oncogene. This approach reveals new drug binding sites that could not be predicted by computational tools.
Researchers developed an AI model to detect lung disease in premature babies by analyzing their breathing patterns while sleeping. The Long Short-Term Memory (LSTM) model achieved 96% accuracy in classifying flow values as belonging to a patient with BPD or not, enabling early diagnosis and treatment.
A novel synthetic biology platform enables rapid and cost-effective transformation of protein binders into high-contrast nanosensors for various applications. The platform uses fluorogenic amino acids to increase fluorescence up to 100-fold, enabling the detection of specific proteins, peptides, and small molecules.
A new study published by the American Academy of Neurology found a possible link between heavy metal cadmium exposure and cognitive impairment in white individuals, but not in Black people. The study showed that high levels of cadmium were associated with increased risk of thinking and memory problems among white participants.
Researchers have identified a unique biomarker in human blood serum that shows potential for early diagnosis of Alzheimer's disease. The study's findings suggest that this test could be used to diagnose AD before cognitive decline or symptoms become apparent, enabling earlier lifestyle changes and medication to slow disease progression.
A clinical trial led by UC San Francisco aims to develop new therapies for progressive supranuclear palsy, with a focus on reducing time to find effective treatments and increasing diverse participant enrollment. The five-year grant could lead to the first effective drugs for this incurable neurodegenerative disorder.
Researchers have developed a cost-effective and easily reproducible point-of-care testing device that can accurately measure cortisol levels in the blood. The device uses iridium oxide nanoparticles to improve stability, sensitivity, and selectivity, allowing for commercial use.
A novel, automated device has been developed to diagnose glioblastoma in under an hour using a biochip that detects biomarkers. The device requires only 100 microliters of blood and costs less than $2 to manufacture.
A study published in JAMA Network Open found that white patients are more likely to receive related diagnostic testing than Black patients after being discharged from the emergency department. This disparity raises concerns about potential overuse of tests in white patients versus undertesting and missed diagnoses in Black patients.
A cross-sectional study of 170 former football players found a strong association between repeated head impacts and increased perivascular space volume, as well as worse cognitive test performance. The findings suggest that PVS volume may contribute to the link between RHI exposure and neurodegeneration.
A recent study by WVU researchers found that smartwatches and clinical testing measures for heart rate variability have significant differences. The study used simulation analysis to determine the validity of wearable devices' calculations, revealing that some methods produce wider ranges of error in measurement.
A new non-hormonal hot flash treatment has been shown to significantly reduce symptom frequency and severity within weeks, while also improving sleep quality and overall well-being. The investigational drug elinzanetant was found to have a favorable safety profile with mild side effects.
Researchers at Osaka Metropolitan University found that AI model GPT-4 outperformed a weaker version of the model and was on par with radiology residents in diagnosing musculoskeletal conditions. However, it struggled to match the accuracy of board-certified radiologists.
A WVU researcher argues that more validation is needed for the increasing number of gallbladder surgeries performed for biliary dyskinesia, a functional gallbladder disorder. The researcher suggests that a combination of factors must come together to diagnose and select patients who would benefit from surgery.
The USPSTF finds that iron deficiency is the leading cause of anemia during pregnancy, affecting approximately 18% of pregnant individuals. Routine screening and supplementation are not recommended to prevent adverse maternal and infant health outcomes.
A new national study reveals significant regional variations in the likelihood of being diagnosed with Alzheimer's disease or another form of dementia. Despite controlling for demographic and population-level risk factors, the study found that differences in diagnostic intensity persist across regions.
A new study published in BMC Primary Care demonstrates the effectiveness of screening and intervention for unhealthy alcohol use in primary care settings. The quality improvement study increased screenings for unhealthy alcohol use from 0% to 83% using a validated tool and agile implementation process.
Researchers found that symptom-triggered testing can pick up early-stage aggressive ovarian cancer in 1 in 4 of those affected. The UK's protocol for picking up early-stage disease is an effective way to diagnose even early-stage ovarian cancer, with complete surgical removal possible in more than three quarters of women.
A saliva test has been found to be more accurate than a blood test in assessing the severity of recurrent respiratory infections in children. The test measures broadly protective antibodies in saliva, which indicate disease burden and predict treatment needs. Saliva testing also holds promise for new treatments and therapies.
The NHS is under scrutiny after investing $150m in a blood test called Galleri that promises to detect multiple types of cancer. Interim results have not been published, raising questions about the test's efficacy and the trial's ethics.
A new study published in Acta Paediatrica reports on the physical and psychological state of 19 children and 7 women who were released from Hamas captivity. The returnees suffered from various health complications, including gastrointestinal pathogens and infectious diseases, as well as trauma and poor hygiene-related issues.
A survey study estimates that 15.6 million US adults consume at least one potentially hepatotoxic botanical product within the past 30 days. Turmeric is the most commonly reported botanical, followed by green tea, ashwagandha, Garcinia cambogia, red yeast rice, and black cohosh products.
Researchers have developed a new therapy called PIPE-307 that targets an elusive receptor on certain cells in the brain, prompting them to mature into myelin-producing oligodendrocytes. This could potentially reverse damage caused by multiple sclerosis, leading to improved movement, balance, and vision.
A new study found that subclinical hypothyroidism diagnosed before 21 weeks of pregnancy is associated with higher rates of overt hypothyroidism or thyroid replacement therapy within 5 years after delivery. Women with high TSH values and elevated TPO antibodies were at increased risk.
A novel AI tool has been shown to accurately estimate gestational age from blind ultrasound sweeps, comparable to expert sonographers. The technology has the potential to democratize prenatal care in resource-limited settings by expanding access to quality diagnostic tools without the need for expensive equipment or specialized training.
A head-to-head comparison of six commercial blood tests found that some are accurate enough to replace spinal taps and brain scans in patients with cognitive impairment. The analysis, led by Suzanne Schindler at Washington University School of Medicine, identified reliable tests for diagnosing Alzheimer's disease.
Researchers propose a noninvasive method to track blood pressure using resonance sonomanometry, stimulating an artery with sound waves and measuring its response. The device showed promising results in initial human trials, with measurements closely matching those from traditional blood pressure cuffs.
Researchers found that when given accurate information about the anti-Mullerian hormone test, women had less interest in taking the test compared to those who viewed misleading online claims. The study highlights the importance of providing evidence-based information to women seeking fertility treatment.
A new video-processing technique developed at the University of Florida uses artificial intelligence to track Parkinson's disease progression in patients, allowing neurologists to better monitor their condition and quality of life. The system analyzes video recordings of patients performing the finger-tapping test, a standard test for ...
A qualitative study found that healthcare professionals disproportionately test Black newborns for prenatal drug exposure, contributing to Child Protective Services reporting and family separation. The study identified three primary themes: levels of racism beyond the hospital structure, inconsistent hospital policies, and healthcare p...
Researchers found a blood test to detect alpha-synuclein protein shows promise for diagnosing Parkinson's disease. The study, published in the Journal of Parkinson's Disease, confirmed that the biomarker is highly sensitive and changes over the course of the disease.
A nested case-control study found that completing fecal immunochemical tests lowers overall death risk from colorectal cancer, particularly in the left colon. The association was observed across racial and ethnic groups, supporting its use in population-based screening strategies.
The study found that exercise increased PEDF levels in skeletal muscles and suppressed senescence markers in the lungs. PEDF also reduced senescence markers in multiple tissues and attenuated decline in respiratory function in pulmonary emphysema mouse model, suggesting its potential as a therapeutic agent for age-related diseases.
Scientists have discovered a new hormone, CCN3, that helps maintain bone density and strength in breastfeeding women. In mice, CCN3 increased bone mass and strength, even when estrogen levels were low. The hormone also accelerated bone healing in fracture models, offering hope for treating osteoporosis and other bone conditions.
Researchers developed an AI model that can estimate lung function from chest radiographs with high accuracy, potentially expanding options for pulmonary function assessment in patients who have difficulty performing spirometry. The study found a remarkably high agreement rate between the AI model's estimates and actual spirometric data.
A recent study published in BMJ Military Health found that female conscripts' iron deficiency more than doubled from 25% to 55% after five months of basic military training. The study also showed a significant decrease in ferritin levels, which can lead to anemia and fatigue.
The NTU team created a compact and flexible light-based sensing device, like a plaster, to provide highly accurate biomarker readings within minutes. The device detects glucose, lactate, and urea levels in sweat with ultra-high sensitivity and dynamic range.
A Swedish researchers have created a questionnaire test that quickly identifies individuals at high risk of heart attack. The test has been shown to be as accurate as blood tests and blood pressure measurements, detecting 65% of those at the highest risk of cardiovascular disease.
Researchers have discovered a new diagnostic method for PSP by analyzing protein biomarkers in spinal fluid, which could lead to earlier diagnosis and targeted therapies. The high-throughput technology allows for the measurement of thousands of proteins in a tiny drop of fluid, providing a promising solution for identifying the condition.
Researchers discovered that young adults with higher levels of inflammation were more likely to experience reduced cognitive function in midlife. Higher inflammation was associated with lower performance on skills testing and differences in executive functioning.
A study by Pusan National University researchers found that repeated item development training enhances faculty members' accuracy in predicting and adjusting item difficulty levels, leading to better educational outcomes. The training improved the quality of MCQ assessments in medical education.
A phase 2 study found fluorine-18 PSMA-1007 PET/computed tomography to be superior to multiparametric MRI for locoregional staging of prostate cancer. The technology supports its use in the preoperative workflow for intermediate-risk and high-risk tumors.
A recent study published in JAMA found that transgender women on hormone therapy have drastically lower PSA levels, which may lead to delayed diagnosis and treatment of prostate cancer. The researchers analyzed Veterans Health Administration records and recommended caution when interpreting PSA values in transgender women.
A new approach to testing for Clostridioides difficile (C. diff) has been shown to reduce unnecessary testing by 20%. The study, published in the American Journal of Infection Control, introduces a clearly defined, evidence-based test ordering process that targets specific patient groups and reduces inappropriate testing.
Researchers identified a kissing bug in Delaware with the Chagas disease-causing parasite Trypanosoma cruzi. Entomologists confirmed the insect's presence and found it was infected with the parasite, which can lead to serious heart problems if left untreated.
The WVU researchers developed a non-invasive, at-home sleep apnea detection device that uses artificial intelligence technology to measure oxygen levels in the blood. Early detection can help prevent worsening of underlying comorbid conditions and reduce healthcare costs, according to Dr. Sunil Sharma.
Researchers found associations between childhood cognition, adolescent crystalized intelligence, and midlife fluid intelligence with DNA methylation age acceleration. A 1-unit increase in adolescent PPVT was associated with a 0.048-year decrease in aging.
Scientists have developed a new method to detect antibiotics in finger sweat, showing high accuracy for tuberculosis treatment monitoring. The technique allows for less invasive testing, making it easier to monitor treatment and preventing drug-resistant TB.
A prospective study found that medication abortion via no-test telehealth and mailing of medications was comparable in effectiveness to in-person care with ultrasonography. The research also revealed low adverse event rates across all groups.
Xiaohu Xia's research focuses on enhancing diagnostic efficacy of enzyme-linked immunosorbent assay (ELISA) testing using specially tailored nickel-platinum nanoparticles. His goal is to improve disease detection accuracy by more than 300 times, enabling early diagnosis of cancers like prostate and colorectal cancer.
Patients with CLL and NHL who received frequent immunoglobulin G tests had fewer infections, required fewer antimicrobial medications, and higher blood levels of IgG. Increased IgG testing is associated with a lower risk of severe infections, suggesting that clear clinician guidance may save lives.
A new, streamlined urine DNA test detects primary bladder cancer more accurately than current methods, potentially reducing the need for invasive cystoscopy. The test shows high sensitivity and specificity, even for detecting high-grade noninvasive papillary carcinoma.
Researchers analyzed three tumor markers for associations with radiographic response and clinical outcomes in NSCLC patients. The study found that CEA, CA-125, and CA-19-9 were associated with progression and radiographic responses in NSCLC.
A recent study has identified three subgroups of gestational diabetes with different treatment needs, enabling personalized therapy and reducing complications for mothers and children. The analysis used cluster methods and machine learning to analyze data from 2682 women with gestational diabetes.