Articles tagged with Vaccination
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Researchers found that individuals with multiple social connections, or hub nodes, are more likely to vaccinate themselves and contain the spread of epidemics. This voluntary vaccination method can lead to periodic outbreaks, but ultimately settle into a stable state due to the majority of individuals choosing vaccination.
Researchers have proven that subneutralizing levels of dengue virus antibodies exacerbate the disease, contradicting the normal function of antibodies. This finding has major implications for developing a vaccine against dengue virus, which annually infects 50-100 million people worldwide.
High-coverage HPV vaccination among adolescents and young women has been shown to rapidly reduce the risk of genital warts, cervical cell abnormalities, and diagnostic procedures. The study found significant reductions in risk across all HPV types, paving the way for a notable decrease in cancer rates.
Scientists have developed an experimental VLP vaccine that protects macaques and mice against chikungunya virus, a debilitating disease with no current treatment. The vaccine, using non-infectious virus-like particles, elicits immune responses and provides complete protection from infection.
The rotavirus vaccine has been shown to prevent severe diarrhoea in African children, with a 61.2% reduction in incidence. The vaccine's efficacy was lower in Malawi compared to South Africa, but it still demonstrated significant impact in reducing mortality rates.
Researchers at Scripps Research Institute have discovered a potential new way to stimulate the immune system to prevent or clear a viral infection by blocking a key protein in mouse immune systems. This approach may enhance the effectiveness of human vaccines designed to prevent viral infections.
Researchers at NIST found that standard-sized refrigerators without freezers outperform smaller, dormitory-style refrigerators in storing vaccines. The study identified several best practices for vaccine storage, including keeping vaccines away from the door shelves and walls to prevent temperature drifts.
A clinical trial shows that patients with metastatic prostate cancer who received a vaccine lived substantially longer than those who received a placebo, with a median survival time of 24.5 months compared to 16 months. The study found encouraging evidence for a clinically meaningful benefit from this vaccine approach.
A new study by Imperial College London discovered a virus called vaccinia spreading four times more quickly than previously believed. The virus uses a novel mechanism to spread rapidly between cells, making it harder to target with antiviral drugs.
Alexander Ksendzovsky, a third-year medical student, has been awarded the Lucien Rubenstein Award for his groundbreaking research on a potential vaccine to fight malignant brain tumors. The American Brain Tumor Association recognized his outstanding work as part of their annual Research Award Program.
Researchers found that RA patients treated with rituximab in combination with methotrexate had the same immune response to the tetanus vaccine as those treated with methotrexate alone. However, patients on rituximab had a reduced response to the pneumonia vaccine compared to those on methotrexate alone.
Researchers have developed a vaccine that appears to reduce leukemia cells in some chronic myeloid leukemia (CML) patients taking the drug Gleevec. The study found significant reductions in residual cancer cells and complete remission in seven patients.
A study found that refusing the varicella vaccine is associated with a nine-fold increased risk of developing the disease in children. This finding suggests that declining vaccination rates could lead to an increase in the incidence of chickenpox and related complications.
Research reveals that quitting smoking can increase type 2 diabetes risk in the short term due to weight gain. Additionally, spoon size affects dosing accuracy with liquid medicine, leading to errors. The latest adult immunization schedule emphasizes HPV and influenza vaccinations, while antiretroviral adherence is linked to lower heal...
Researchers identified significant gaps in HPV vaccine uptake among low-income minority groups, with disparities in knowledge, awareness, and healthcare provider recommendations. Tailored interventions are necessary to address these barriers and increase vaccination rates.
University of Missouri researchers found that aspirin and Tylenol block enzymes that inhibit vaccines. This could lead to reduced antibody responses and decreased protection against infections.
The Elsevier journal Vaccine has released a supplement dedicated to vaccines for biodefense, showcasing significant advancements in vaccine development against diverse human and veterinary pathogens. The publication acknowledges the shift from traditional military focus to protecting both civilian and military populations.
The Interagency Autism Coordinating Committee (IACC) has included vaccine research studies in its updated Strategic Plan for Autism Research, responding to Congressional calls to investigate the potential connection between vaccines and autism. The plan aims to explore risk factors contributing to autism, including environmental exposu...
Researchers identified 78 homegrown health biotechnology companies producing innovative products for all neglected diseases, including the Big 3. A proposed 'Global Health Accellerator' service aims to connect these firms with expertise and funding to reach additional villages worldwide.
A Phase II clinical study found that a vaccine candidate can cause a modest but sustained reduction in genital and gastrointestinal GBS bacterial colonization. The vaccine was also found to be safe and well-tolerated, eliciting a strong immune response.
A new study published in PLOS Pathogens found that whooping cough immunity typically lasts at least 30 years and perhaps as long as 70 years after natural infection. The research suggests that repeat infections contribute relatively little to transmission and may even boost immunity in individuals with waning protection.
The first ever World Pneumonia Day highlights the potential for renewed global action against this forgotten killer of children. The Global Action Plan for Prevention and Control of Pneumonia aims to reduce child pneumonia mortality through exclusive breastfeeding, vaccine use, and community-level management.
The American College of Physicians (ACP) has issued clinical practice guidelines for treating erectile dysfunction (ED), recommending the use of phosphodiesterase type 5 (PDE-5) inhibitors and individualizing decisions on hormonal tests. For patients with stable ischemic heart disease, adding ACE inhibitors to standard care improves ou...
A systematic review of six randomized trials found pneumococcal conjugate vaccines reduced vaccine-type IPD by 80%, all-serotype IPD by 58% and x-ray defined pneumonia by 27%. The vaccines also prevented 11% of child deaths.
Researchers at UC Davis MIND Institute report that after adjusting for factors, typically developing children and those with autism have similar blood-mercury levels. The study, conducted as part of the CHARGE Study, looked at various sources of mercury in participants' environments, including fish consumption and vaccinations.
Veterinary scientists harnessing 'barcodes' of microbes to develop a single, effective vaccine for all mammals. Tiny variations in TLRs could be key to adapting vaccines across species.
A national survey found that most girls and young women were aware of the HPV vaccine's benefits, but lacked knowledge about the HPV virus and other sexually transmitted infections. The study suggests that education on the HPV virus itself is crucial for informed decision-making.
A University of North Carolina at Chapel Hill researcher has been awarded a four-year grant to study the effectiveness of rotavirus vaccines in Nicaragua. The study aims to determine how well the vaccine works in developing countries and identify shifts in rotavirus strains as a result of immunization programs.
The National Institute of Allergy and Infectious Diseases (NIAID) has awarded contracts to discover novel vaccine adjuvants. The goal is to enhance the immune response and extend vaccine supply. Researchers will test new compounds in animal models and human cells.
A new article reviews published research and finds no convincing evidence supporting a relationship between vaccines and autism. The onset of autism occurs prior to age three, with various possible associations examined but no clear cause identified.
A new method of delivering measles vaccines, using an inhalable powder, has shown promise in test animals. The powder is produced by mixing a weakened measles virus with high-pressure carbon dioxide and can remain stable for at least eight weeks at room temperature.
Vaccination against HPV, combined with national screening programmes, could lead to the eradication of cervical cancer in countries that implement such measures. HPV screening is more effective than Pap smear tests and can detect the virus in smears rather than relying on visual examination.
A team of researchers led by Dr. Alon Monsonego has created a humanized mouse model that responds specifically to an A-beta-peptide vaccine, reducing plaque and inflammation in the brain. The study provides a basis for developing individualized immunotherapeutic approaches to Alzheimer's disease.
A new rabies vaccine has shown to induce a rapid and efficient immune response in mice and non-human primates, potentially reducing the six-shot post-exposure regimen to just one inoculation. The experimental vaccine lacks a key gene called the matrix (M) gene, inhibiting the virus from completing its life cycle.
The MSD Wellcome Trust Hilleman Laboratories aims to develop new vaccines to prevent diseases affecting low-income countries. The not-for-profit joint venture will work on optimizing existing vaccines and developing new ones, with the goal of increasing vaccine impact in resource-limited settings.
A 20-year study revealed a significant drop in liver cancer cases among vaccinated 6- to 19-year-olds. The universal vaccination program in Taiwan has been shown to extend its effectiveness into young adulthood.
A study published in The Lancet found that vaccination against bacterial infections, such as Streptococcus pneumoniae and Haemophilus influenzae type b, can substantially improve survival rates in African children with sickle-cell anaemia. The researchers also found that these bacteria are the same cause of infection in both developed ...
A new protein conjugate vaccine, PCV7, has been found to produce superior immune responses in patients with chronic obstructive pulmonary disease (COPD) compared to the currently accepted vaccine, PPSV23. The study suggests that PCV7 may offer improved protection against respiratory disease in COPD patients at risk for pneumonia.
Researchers at the University of British Columbia have developed a system that turns harmless bacterium Caulobacter crescentus into a protein production factory, making useful proteins for vaccines and therapeutic purposes. The technology could be used to manufacture HIV-blocking agents cheaply and with minimal expertise.
Einstein scientists have identified two small protein fragments that could be developed into an anthrax vaccine, potentially causing fewer side effects than the current vaccine. The research focuses on the protein toxin used in the current vaccine, looking for peptides that can trigger protective antibodies when injected into animals.
Researchers found that patients with aggressive leukemia had few complications and mounted a strong immune system attack after receiving a cancer vaccine shortly after a stem cell transplant. The study suggests that the approach may be more effective than traditional transplant alone, with higher survival rates.
The study analyzed reports of adverse events following HPV vaccination and found a higher proportion of reports of fainting and blood clots. However, the rates were still consistent with pre-licensing data and background rates of other vaccines.
New vaccines, drug regimens, and diagnostics under development have the potential to significantly impact tuberculosis. The study predicts a 39-52% decrease in TB incidence through vaccination, while new drug regimens could reduce incidence by 10-27%. Diagnostic tools may also contribute to improved outcomes.
A new monitoring system developed by Johns Hopkins researchers allows for the non-invasive pinpointing of Mycobacterium tuberculosis in mouse lungs, speeding up preclinical testing of TB drugs and vaccines. This innovation enables fewer animals to be used, reducing the need for lengthy and complicated regimens.
A new study by IVI-NICED found that the Vi polysaccharide vaccine is highly effective in protecting young children against typhoid fever, with 80% protection rate in children under five years old. The vaccine also conferred substantial herd protection, reducing typhoid risk among unvaccinated neighbors by 44%.
Researchers at La Jolla Institute have discovered the specific gene that triggers antibody production, a key step in mounting an immune response against viruses and pathogens. The finding has significant implications for developing new and more effective vaccines.
The study shows that the timing of rotavirus epidemics depends on birth rates in the population, with higher birth rates leading to earlier outbreaks. New vaccines may reduce the frequency and severity of these outbreaks, potentially shifting the age at which infection appears in children.
A study found that reduced-dose schedules of pneumococcal conjugate vaccine (PCV-7) significantly reduce vaccine serotype pneumococcal carriage in children. The 2-dose and 2 + 1-dose schedules were shown to be effective in reducing pneumonia and infection risks in infants.
A study published in JNCI found HPV vaccination to be non-cost-effective in the Netherlands due to low cervical cancer cases and deaths. The authors suggest vaccine price reduction could make it more cost-effective, but only if the vaccine's effectiveness increases.
Researchers have mapped the structure of an antiviral antibody clamped onto rotavirus protein VP7, revealing intimate details about how it interferes with virus infection. The discovery may lead to the development of a new generation of rotavirus vaccines that are easier to store and administer.
Researchers at the University of Pennsylvania School of Medicine have found that metformin can enhance the effectiveness of vaccines by boosting numbers of cancer-fighting T cells. This resulted in a larger population of memory immune cells that were able to fight off a tumor at a later time.
Researchers have found that CSA-13, a synthetic compound, can kill vaccinia virus in cell cultures and mice, while also stimulating the innate immune system. The study showed that CSA-13 reduced skin lesions caused by vaccinia virus in infected mice.
Researchers discovered that metformin increases the efficiency of T-cells, which boosts infection- and cancer-fighting treatments. This discovery could lead to novel strategies for vaccine and anti-cancer therapies, potentially enhancing immunological memory.
A recent Florida State University study found that informing men about the HPV vaccine's benefit for their female partners did not increase their interest in getting the vaccine. The researchers suggest that men may need more direct information on the vaccine's benefits for their own health to consider vaccination.
A randomized trial found the HPV vaccine to be 91% effective against all four virus strains in women aged 24-45 who hadn't been infected. The vaccine efficacy was lower when including those with pre-existing HPV infection, highlighting the importance of vaccinating susceptible individuals.
The study found that those who received the vaccine had a significant response rate of 22.1% and progression-free survival of 2.9 months compared to 9.7% and 1.6 months respectively in those that did not. The median overall survival for those receiving vaccine trended positive at 17.6 months.
The vaccine-autism debate persists despite scientific consensus, fueled by internet misinformation and declining public trust. Pediatrician Paul Offit's efforts to set the record straight have been hindered by celebrity anti-vaccine advocates like Jenny McCarthy.
A new multimeric-L2 protein vaccine shows robust antibody responses and protection against human papillomavirus (HPV) infection in mice and rabbits. The vaccine has the potential to address the limited protection of current HPV vaccines against other HPV types, which cause cancer.
Researchers at La Jolla Institute have identified a cellular defect that increases the risk of severe reactions to the smallpox vaccine in people with eczema. Boosting Natural Killer cell activity may help prevent such reactions.
Researchers have developed a new computer simulation model that captures the human immune response to influenza type A, predicting treatment design and pandemic preparedness. The model reveals that drugs and vaccines targeting dendritic cell presentation of antigens have a significant impact on patient outcomes.