Articles tagged with Asthma
Research suggests that infant mice need a higher dose of bacterial LPS to prevent asthma, while adult mice can tolerate lower doses. This mechanism supports the hygiene hypothesis, which proposes that decreased exposure to microorganisms in childhood leads to increased allergies.
Researchers developed a decision tool called the Pediatric Asthma Risk Score (PARS) to predict asthma in young children. PARS is 11% more sensitive than existing tools and delivers personalized risk scores.
Children conceived via fertility treatment have up to 42% higher risk of asthma, while number of previous early miscarriages is also associated with increased risk. Research suggests that common factors underlying poorer fertility and recurrent miscarriages may influence asthma risk.
Researchers discovered that babies with a diverse range of nasal bacteria tend to recover faster from their first respiratory virus. Conversely, those dominated by certain bacterial families are more likely to experience prolonged symptoms.
Research suggests a link between PM2.5 exposure and higher daily rescue inhaler use in individuals with asthma. Reducing PM2.5 pollution could result in significant economic benefits, estimated at nearly $350 million annually.
Researchers analyzed data from over 500,000 children, finding a significant association between obesity and increased asthma incidence. Obesity was identified as a modest risk factor for asthma, with 23-27% of new cases directly attributable to obesity.
A study analyzing health data for over 500,000 children in the US suggests that obesity is a likely cause of approximately one-fourth of asthma cases in children who are obese. The research found that nearly 1 million cases of childhood asthma may be preventable by maintaining a healthy weight.
A new PhD thesis from the University of Eastern Finland reveals a link between early life environmental exposures, such as farming and air pollution, and altered immune responses. The study found that farming exposure decreases the risk of allergic diseases, while air pollution increases asthma prevalence in children.
A new treatment has been shown to help people with peanut allergies build up a tolerance to the allergen, allowing them to consume small amounts without experiencing severe reactions. The study found that two-thirds of participants were able to tolerate the equivalent of two peanuts per day after nine to 12 months of treatment.
Children of caregivers with poor asthma knowledge were four times more likely to have a prolonged hospital stay, according to new research. The study found that caregivers who received education on asthma management and inhaler technique showed significant improvements in their knowledge and ability to care for their child.
Research shows secondhand marijuana smoke can worsen asthma symptoms in children with cannabis allergies, even without direct exposure. After removing cannabis from the home, asthma symptoms improved significantly.
A Henry Ford Health System study found that babies whose parents cleaned their pacifiers with saliva had lower levels of IgE antibodies, associated with allergies and asthma. The researchers believe healthy oral bacteria may be passed from parents to their children, influencing immune system development.
A new study aims to investigate the origins of asthma in Puerto Rico by following 4,000 children from birth through early childhood. The team plans to use genetic techniques to identify biological drivers of disease and biomarkers that may predict outcomes.
A Swedish study found no correlation between growing up with hypoallergenic breeds and a lower risk of asthma in children. However, female dogs were associated with a 16% lower asthma risk, while living with two or more dogs reduced the risk by 21%.
A Rutgers University study found significant improvements in air quality after restricting heavy truck traffic on a residential street in Elizabeth, N.J. The research team tracked 60 trucks per hour and found a spike in black carbon from diesel exhaust pollution, which was linked to asthma and other health issues.
A study of 2,000 children suggests that London's diesel-dominated air pollution is restricting lung capacity, putting them at risk of lifelong breathing disorders. Despite improvements in air quality through the introduction of Low Emission Zones, there was no evidence of a reduction in small lungs or asthma symptoms.
A clinical trial found that eating fish twice a week as part of a Mediterranean diet can significantly decrease lung inflammation in children with mild asthma. The study involved 64 children from Greece and showed improved lung function after six months.
A study published in Environmental Health Perspectives found that air pollution from ozone and fine particulate matter may be responsible for nine to 33 million emergency room visits globally. The research suggests that policies aimed at cleaning up the air can reduce the global burden of asthma.
A study using single-cell transcriptomics reveals the cellular and functional changes underlying type 2-high asthma, which can lead to more severe disease. The research provides new insights into how airway epithelial cells produce mucus and could inform the development of targeted treatments for asthma and other airway diseases.
A new study published in Pediatric Research found that children with asthma growing up in polluted NYC neighborhoods need emergency medical treatment more often. The study suggests that these areas may have other environmental factors affecting urgent asthma treatment.
A USC-led study of over 20,000 European youths found that children with asthma are more likely to become obese. Asthma increases the risk of obesity by 50-66%, especially in those with persistent wheezing symptoms.
Researchers at UCalgary's Alberta Children's Hospital Research Institute and Hotchkiss Brain Institute discovered the nervous system plays a critical role in asthma attacks. By targeting treatment at the carotid bodies, they found that blocking receptors during an asthma attack can eliminate symptoms.
Researchers analyzed children's asthma management and found that environmental exposures like secondhand smoke and pet ownership were not significant factors in improving asthma control. Once asthma guidelines are followed, these exposures do not impact overall asthma improvement.
A University of Utah engineering study shows that smart controllers for home heating and cooling systems can clean pollution with minimal additional energy costs. The 'SmartAir' setting, which turns on the HVAC fan based on both temperature and air quality, cleaned the air almost as well as continuous operation but used 58% less energy.
A non-pathogenic fungus can expand in the intestines of antibiotic-treated mice and enhance the severity of allergic airways disease. The study suggests that alterations in gut microbiota induced by intestinal fungi might be a previously unrecognized but potentially important risk factor for patients with asthma.
A study published in Respirology found ten treatable traits predictive of future asthma attacks, including depression and vocal cord dysfunction. The findings may help clinicians tailor treatment plans for patients with severe asthma.
Research suggests that weight gain between childhood and puberty increases the risk of developing asthma later in life, including for future generations. The study found no correlation between weight gain before or after puberty, but rather a link to overall inflammation during this critical developmental period.
A new study found that children who have access to green spaces near their homes are less likely to experience respiratory problems as adults. The research, conducted by RHINESSA, analyzed data from over 5,400 participants and found a significant association between exposure to greenness and reduced respiratory symptoms.
A study found that paracetamol use in infancy may increase the risk of asthma in adolescents, particularly those with certain genetic variations of the glutathione S-transferase (GST) genes. Children who took paracetamol more frequently had a higher risk of developing asthma, especially if they carried the GSTP1 Ile/Ile variant.
Children with childhood asthma are at a disadvantage in education, leaving them more likely to drop out of university and struggle to enter non-manual occupations.
Researchers found high immunoglobulin E (IgE) levels among babies born in October and December in Melbourne, indicating a potential link between maternal exposure to grass pollen and increased risk of respiratory diseases. Conversely, being pregnant for an entire grass pollen season may have a protective effect on babies.
A new study has found that people with asthma are more likely to become obese, especially if their asthma begins in adulthood or if they have non-allergic asthma. The research, which followed over 8,600 participants for two decades, suggests the relationship between asthma and obesity is more complex than previously thought.
Researchers found that inhaled steroid use is associated with a higher risk of developing nontuberculous mycobacteria lung infections. The study analyzed medical records of patients diagnosed with NTM lung infections and found that the odds of infection were 2.7 times greater in those who used inhaled steroids.
Researchers have discovered a marker that can help identify patients with severe asthma who are likely to respond well to new treatments. The marker targets inflammatory cells called eosinophils, which play a key role in the condition.
Researchers at OHSU used 3D imaging to investigate airway nerves in asthma. They found that denser nerves are associated with more severe symptoms and increased eosinophils. This new insight could lead to better treatments for asthma.
Asthma patients with specific genetic profiles exhibit more intense symptoms following traffic pollution exposure. The study suggests that tailoring treatments to individual gene-environment interactions could enhance quality of life for people with asthma.
A new study found that early childhood weight gain velocity and body mass index are associated with lower lung function at age 10. Children who reached peak body mass index later had better lung function and a lower risk of asthma.
A study found that nearly 40% of women with asthma may develop COPD, but certain factors such as smoking, obesity, and socioeconomic status may lower this risk. The researchers identified individual risk factors playing a more significant role in the development of COPD overlap syndrome than exposure to air pollution.
A Johns Hopkins study found that fewer than half of Baltimore caregivers for preschool children with asthma can manage their child's chronic condition. The researchers evaluated caregiver preparedness through medication availability, identification, and dosing instructions.
A new study by Brigham and Women's Hospital researchers models allergic lung inflammation in mice, revealing the role of neutrophil extracellular traps (NETs) in triggering and amplifying an allergen-initiated immune response. The findings have implications for designing more precise clinical trials for severe asthma treatment.
A small pilot clinical trial shows eating two CHORI-Bars daily for eight weeks improves lung function in obese adolescents with asthma. The study's findings are provocative and suggest a need for larger trials.
A new study found that eczema is associated with a worse quality of life than several other chronic illnesses. Moderate and severe eczema were particularly burdensome, causing symptoms like blisters, pain, and sleep disturbance.
Adults with uncontrolled asthma have a moderately increased risk of developing atrial fibrillation, an irregular heart rhythm. Researchers are unsure of the underlying causes for this association and urge further investigation.
A new study published in the European Respiratory Journal found that healthy diets with high consumption of fruits, vegetables, and whole grain cereals are characterised by better asthma outcomes. Men who ate healthier diets had a 30% lower chance of experiencing asthma symptoms.
A £2 million project aims to improve asthma control in African schoolchildren, with a focus on 3,000 children aged 12-14. The study will use theatre performances to address asthma knowledge and stigma, and assess the barriers to achieving good control.
A review of 16 studies reveals a strong association between fast food intake and an increased risk of asthma, wheeze, and other allergic diseases. Hamburger consumption was found to be most prominently associated with these conditions in a dose-dependent manner, regardless of income level.
A study of nearly 50,000 New Zealand children found that greener neighborhoods are less likely to develop asthma, while low plant diversity is associated with a higher risk. Biodiversity conservation may provide concrete health benefits beyond its ecological significance.
Researchers develop novel small molecule, PM-43I, that specifically targets STAT6 pathway, reversing preexisting allergic airway disease in mice. This breakthrough approach offers unique advantages over monoclonal antibodies, with potential benefits for patients who may not need steroid treatments.
A new diagnostic test that uses a simple nasal brush to identify mild to moderate asthma has been developed by Mount Sinai researchers. The test, which uses machine learning algorithms and RNA sequencing, can differentiate asthma from other respiratory conditions and is less expensive than traditional pulmonary function testing.
A new study suggests that vaccinating asthmatic children against the flu could significantly reduce their risk of needing hospitalization for an asthma attack. The study found that kids with influenza or parainfluenza had a 37-per-cent or more chance of not responding to treatment, compared to 13 per cent for children without a virus.
Researchers from the University of Pennsylvania School of Medicine have identified the source of IL-25, an inflammatory cytokine linked to chronic rhinosinusitis and asthma. The study found that solitary chemosensory cells in the sinuses produce IL-25, which can recruit immune cells and lead to inflammation.
Asthma management is complicated by heterogeneity and variability, making it difficult to implement optimal strategies. The role of physicians in managing asthma complexity is particularly challenging, requiring knowledge, dedication, and experience.
A study found that patients hospitalized for asthma who received antibiotics had longer hospital stays and higher costs, but no reduced risk of treatment failure. Antibiotic-related diarrhea was also more common in treated patients.
Researchers found a new treatment, dupilumab, effective in treating severe asthma by blocking key drivers of inflammation. The study showed improved asthma symptoms, lung function, and reduced need for corticosteroids.
Dupilumab alleviates asthma symptoms and improves lung function in moderate to severe asthma patients. The drug significantly reduced asthma exacerbations by half in some patients, with improved rates of emergency room visits and hospitalizations.
A long-term study has found that exposure to ozone at birth is associated with an increased risk of developing asthma, allergic rhinitis, and eczema in childhood. The study, which followed 1,881 children from birth to age 17, found that even small increases in ozone exposure were linked to a higher risk of developing these conditions.
Researchers have found a patient-centric treatment that works for people with mild asthma, using an as-needed combined-drug inhaler. The study, led by Paul O'Byrne, showed the inhaler was superior to conventional treatment strategies in reducing asthma attacks and improving symptom control.
A high-fiber diet increases survival in influenza-infected mice by setting the immune system at a healthy level of responsiveness. It also boosts antiviral immunity by activating T cells, mediated by changes in gut bacteria composition.
A recent study published in Pediatrics found that no single category of intervention was effective in reducing hospital readmission for children with asthma. However, multimodal interventions that combined multiple categories showed promise in reducing the risk of readmission between 30 days and one year after initial discharge.
A study found that asthma mortality rates are falling among younger people in the poorest areas compared to the wealthiest, but remain higher in older adults. Regional variations persist, with significant differences in outcomes across England.