Articles tagged with Asthma
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A new study has found that temporarily quadrupling the dose of inhaled steroids during severe episodes of asthma can reduce the risk of serious attacks by 20% and hospital admissions. The study involved nearly 2000 patient volunteers and showed promising results for patients with long-term asthma.
Researchers at UC Davis Health have identified a new molecular target, vascular endothelial growth factor A (VEGFA), that plays a major role in inflammation and airway obstruction associated with asthma. Targeting VEGFA may lead to new treatments.
Researchers found that short-term increases in inhaled steroid doses do not effectively prevent severe asthma flare-ups in children. Instead, they may be associated with a small decrease in growth rate, echoing previous studies on the topic.
A new study published in Hospital Pediatrics shows that improved pediatric asthma care can be achieved through the use of personalized inpatient assessments and streamlined patient care decision tools. The study found that clinicians who used these tools had a significant improvement in the accuracy of prescribed medication, with an in...
Research by Weill Cornell Medicine scientists reveals that the nervous system can dampen excessive inflammation in the gut and lungs, which may lead to new treatments for diseases like asthma and inflammatory bowel disease. The study also found that beta-adrenergic receptors play a crucial role in controlling the immune response.
A special receptor called dectin-1 recognizes a protein found in house dust mites, cockroaches, shellfish, and other invertebrates, suppressing immune reactions to these common allergy triggers. The discovery suggests new ways to treat or prevent allergies and asthma, which affect tens of millions in the US.
Researchers at Purdue University found that microRNA miR-223 can help control inflammatory disease by regulating the NF-kB pathway, which is critical in human bronchial epithelial cells. Supplementing this microRNA to epithelial cells may provide a new treatment option for asthma and cancer.
A subset of T cells identified as an early childhood immune signature predicts the risk of developing asthma later on. The presence of house dust components stimulating the innate immune system decreases asthma risk, supporting the hygiene hypothesis. Researchers found MAIT cells to be protective against asthma.
Women with asthma who use short-acting asthma relievers take longer to become pregnant than those without asthma. In contrast, long-acting asthma preventers do not appear to reduce fertility, suggesting that improved asthma control could lead to faster conception rates.
A major review of evidence highlights a link between fluctuations in female sex hormones and the development of allergies and asthma. Analysis of over 500,000 women found that starting periods before age 11 and irregular periods were associated with a higher rate of asthma.
Women with asthma who use short-acting asthma relievers take longer to become pregnant than those without asthma, but using long-acting asthma preventers has no impact on fertility. The study of over 5,000 women in Australia, New Zealand, and Ireland shows a significant difference between short-acting and long-acting treatments.
A multicenter retrospective cohort study found that comprehensive education prior to discharge significantly lowers readmission rates in children hospitalized for acute asthma. Discharge components such as medication provision, communication with primary medical doctors, and post-discharge activities also show promise in reducing readm...
A new device developed by Rutgers University and UCLA can measure the physical strength of individual cells up to 100 times faster than current technology. This allows for easier testing and evaluation of new drugs for diseases associated with abnormal cell strength, including hypertension, asthma, and muscular dystrophy.
Researchers identified a new treatment that relaxes muscles and opens airways in asthma, preventing pulmonary resistance. The treatment, TSG12, is non-toxic and more effective than current treatments, providing relief for millions with asthma.
The study found that cleaner shipping fuels will result in a significant reduction of childhood asthma cases, with an estimated 14 million annual cases related to global ship pollution using current fuels. The new IMO rule will decrease the allowable amount of sulphur in fuel oil from 35,000 ppm to 5,000 ppm.
Researchers at Houston Methodist have identified an interaction between two molecules that can be manipulated to prevent airway closure in asthma. By targeting super-enhancers, they may develop more efficacious treatments than current steroids.
A new database, CHILDdb, is being developed by SFU researchers to help identify genetic and environmental factors contributing to childhood asthma. The database will enable precision medicine to diagnose and prevent the disease earlier, reducing healthcare costs.
The UA-led international research consortium aims to determine the role of CC16 in persistent childhood asthma and its potential as a therapeutic intervention. The study will analyze thousands of participants followed from birth into adulthood, providing unique data on asthma persistence.
A study by Columbia University's Mailman School of Public Health found that despite the Clean Heat Program, many buildings continued to burn residual diesel fuel oil, releasing high levels of particulate matter and linked health problems. The researchers recommend new incentives and a building energy rating system to encourage conversion.
Researchers have discovered a potential new therapy for eczema that also reduces asthma severity, offering hope for effective treatments for both conditions. The study found that alleviating skin inflammation can significantly reduce asthma symptoms.
Researchers have discovered new enzymes that convert nitric oxide into stopgap molecules, modulating proteins and achieving diverse cellular functions. The newly found enzymes may serve as prime therapeutic targets for treating a range of diseases, including Alzheimer's, heart failure, cancer, asthma, and infection.
Research estimates that asthma costs the US economy $81.9 billion per year, with 15.4 million people affected annually. The study also found significant disparities in healthcare costs between insured and uninsured individuals.
A new study found that babies' crawling movements kick up high levels of dirt, skin cells, bacteria, pollen, and fungal spores, which can be detrimental to adult health. However, researchers suggest that this exposure may actually stimulate the immune system and reduce the risk of asthma and allergies later in life.
New research from the University of Rochester Medical Center shows that children with asthma who received a combination of telemedicine support and school-based medication therapy were almost half as likely to need an emergency room or hospital visit. The program, which expanded on previous research, demonstrated its effectiveness in r...
An international study discovered five new regions of the genome associated with increased asthma risk, characterized by epigenetic marks on gene enhancers. The genetic variants also show associations with auto-immune diseases and inflammatory component diseases, highlighting the importance of pleiotropy in multifactorial diseases.
A meta-analysis published in Mayo Clinic Proceedings shows that the FeNO test has moderate accuracy for diagnosing asthma, particularly in patients aged 5 and older. The test's sensitivity and specificity vary depending on the cutoff value used.
A new study from Duke University Medical Center finds that obesity can add five weeks of asthma symptoms per year in preschoolers. The research suggests that maintaining a healthy weight may be an effective strategy for controlling asthma, and that inhalers work effectively for all preschoolers.
Researchers at Johns Hopkins University found that exposure to coarse particulate matter increases the risk of asthma and hospitalizations in children. For each microgram/cubic meter increase in coarse particulate matter, asthma diagnosis increased by 1.3 percent, emergency room visits for asthma by 3.3 percent, and hospitalizations by...
New research found that coarse particulate matter increases the risk of asthma diagnosis, ER visits for asthma, and hospitalizations in children. The study analyzed records of over 7 million children in Medicaid and found a strong association between PM10-2.5 exposure and asthma-related outcomes.
A study by the University of Southampton found that breathing exercises can significantly improve the quality of life for people with asthma. The interventions, which included DVD and face-to-face physiotherapy, reduced asthma attacks and lower NHS healthcare costs.
A self-taught breathing retraining program shows similar results to face-to-face training with a physiotherapist in improving symptoms, mood, and ability to conduct day-to-day activities. The program is cheaper and less resource-intensive than physiotherapist training.
Research found that consuming high amounts of fructose during pregnancy and early childhood increases the risk of developing asthma in mid-childhood. Mothers who drank a lot of sugar-sweetened beverages while pregnant were more likely to have children with asthma.
A new study by Children's National Hospital suggests that severely premature children are more susceptible to human rhinovirus infections and may require earlier and more intensive supportive care. The research found a 'dose effect' of prematurity, with children born more prematurely having a higher risk of wheezing and retractions.
A Pediatric Pulmonology study of 376 infants found that increasing hair nicotine levels were associated with prior parent-reported smoking exposure and potential increased risks of wheeze and asthma. Higher levels of hair nicotine were also linked to smoking in pregnancy, although associations at older ages were non-significant.
High levels of polyunsaturated fatty acids, particularly omega-3 and arachidonic acid, are associated with a reduced risk of asthma and rhinitis in children. The study found that children with higher blood levels of these fatty acids at age 8 were less likely to develop the diseases by age 16.
Researchers at the University of Bergen found that young people with intestinal worms have a 4 times higher risk of developing asthma and allergies than others. Interestingly, their parents are generally unaffected by the parasite.
Midlife women are disproportionately affected by asthma due to testosterone's impact on ILC2 proliferation and airway inflammation. The study highlights the importance of sex hormones in treating respiratory diseases.
A study by Vanderbilt University and Johns Hopkins researchers found that testosterone hinders an immune cell linked to asthma symptoms in women. This is due to the effects of testosterone on lung cells, which are more prevalent in asthmatic women than men.
A University of Alberta study found that infant boys born to mothers with asthma have a reduced gut microbiome, particularly lower levels of Lactobacillus, which could lead to a preventative approach to reduce the risk of asthma. The study also suggests sex-specific differences in the impact of maternal asthma on infant gut microbes.
A large-scale study has identified 136 genetic loci that increase the risk of developing atopic dermatitis, hay fever, and asthma. These variants are associated with genes involved in regulating the immune system, suggesting a shared genetic origin for the three diseases.
A study found that trees and green space are associated with a decrease in people admitted to hospital with asthma. In the most polluted urban areas, trees had a strong association with fewer emergency asthma cases.
A new Northwestern Medicine study found that water baths were just as effective as bleach baths in reducing eczema symptoms, with no added benefits to using bleach. Regular bathing can help control bacterial infections and prevent dryness, making it a better alternative for patients with eczema.
A study finds that children with eczema or atopic dermatitis and sensitization to an allergen at age 1 are significantly more likely to develop asthma and a food allergy by age three. The CHILD Study also found that early introduction of common allergenic foods may reduce the risk of allergic sensitization and food allergy.
The Navajo Nation will receive a six-year, $8.5 million grant to improve asthma care, with two proven programs being implemented in Tuba City, Chinle, and Fort Defiance. The projects aim to reduce health disparities and lower asthma exacerbations.
Severe asthma defined as asthma requiring high-dose long-acting B2-agonists and/or additional controller medication or frequent oral corticosteroid use, emphasizing patient adherence verification before diagnosis.
A breastfeeding program was associated with reduced atopic eczema risk in adolescents, but no protective effect on lung function or asthma. The study involved over 13,500 children born to mothers participating in a breastfeeding promotion trial.
A recent study published in the Journal of Allergy and Clinical Immunology found that breastfeeding may increase the risk of developing hay fever and eczema, while not having a clear effect on asthma. Lifestyle factors such as socioeconomic status and body mass index also played a role in the study.
Pregnant women who consume high-dose omega-3 fatty acids daily during the 3rd trimester are less likely to develop asthma in their children. Researchers recommend 8-12 ounces of low mercury fish per week for similar benefits.
The American College of Allergy, Asthma, and Immunology is developing guidelines for allergists on using telemedicine to provide high-quality care. This approach leverages technology to improve access to medical care and maximize patient experience. The goal is to have an exceptional user experience, putting the patient at the center.
A new study by the American College of Allergy, Asthma, and Immunology found that almost half of adult food allergies occur in adulthood, with shellfish allergy prevalence increasing by 44% among US adults. The risk of developing a food allergy to certain foods is higher among black, Asian, and Hispanic adults compared to whites.
A study found that children with eczema and a family history of asthma had more severe hospital experiences, including increased oxygen use and longer stays. The research suggests these factors may help identify children at higher risk for severe asthma hospitalizations.
Two studies present evidence suggesting that exposure to dogs during pregnancy and early childhood may reduce the risk of developing eczema and asthma. While exposure to dog allergens can exacerbate symptoms in children with allergies, non-allergen-related factors associated with dogs may provide a protective effect.
A study found that asthma prevalence and emergency department visits vary widely among different NYC neighborhoods. Pollutants like nitrogen dioxide and elemental carbon are associated with greater urgent asthma care in lower-prevalence areas, especially among children.
Researchers at the University of Illinois Chicago have identified two asthma phenotypes linked to distinct lung microbiomes, suggesting a potential for more precise treatments. The study found that targeting specific bacterial compositions may help control asthma severity and development.
Researchers found that an experimental drug stimulates alpha-7 nicotinic receptors, reducing inflammation and improving lung function in mice with chronic allergic conditions. The treatment also activated M2 macrophages, associated with tissue repair, and reduced pro-inflammatory molecules.
Scientists have discovered a key protein controlling ferroptosis, a highly regulated cell death process that plays a role in health and disease. The research links ferroptosis to diseases such as asthma, kidney injury, and brain trauma, suggesting potential drug targets for treatment.
A study of 38,679 hospitalized children with asthma found obesity to be a risk factor for repeated hospital admissions and longer stays. Those who were obese required more intensive care and had higher total hospitalization costs compared to normal-weight children.
Taking oral vitamin D supplements alongside standard asthma medication may halve the risk of severe asthma attacks that require hospital care. Research found a 30% reduction in steroid treatment and a 50% decrease in hospitalizations due to asthma exacerbations.
A large epidemiological study conducted in Québec found no link between the BCG vaccine and childhood asthma. The research team analyzed data from a comprehensive vaccination registry and public health records, adjusting for various confounders to ensure accurate findings.
Researchers at Cleveland Clinic found that TRPV1 protein plays a critical role in airway disease through mucus production, cough reflex stimulation and airway narrowing. The study suggests that targeting this protein may lead to new strategies to reduce the impact of RSV infections in both asthmatic and non-asthmatic children.