Research on asthma and respiratory disease. Covers brain-structure links, prevention trials, weight-loss drugs, and exercise for symptom control.
La Jolla Institute of Immunology and Seqster partner to accelerate discovery of personalized treatments for severe asthma through longitudinal data analysis. The collaboration enables 5000 participants to share medical records, genomic data, and wearable device data with researchers.
A Swedish study analyzed over 2.5 million births between 1973 and 1997 to examine the health outcomes of people born prematurely. The results show that 54.6% of those born preterm remained healthy without major conditions such as asthma, hypertension, or epilepsy by age 43, compared to 63% of full-term births.
A recent study published in the European Respiratory Journal has provided evidence that fatty tissue builds up in the airway walls of individuals who are overweight or obese. This accumulation alters the normal structure of the airways and leads to inflammation in the lungs, which may contribute to increased asthma symptoms.
Researchers found that ALS patients with a specific genetic variation in the IL6 receptor gene experience more severe symptoms and faster disease progression. The study suggests this polymorphism may serve as a target for new treatments and lay the groundwork for future clinical trials.
Research found that introducing fish or cod liver oil early in life significantly reduces the occurrence of eczema, wheezing and asthma at age six. Children who consumed fish weekly until two years old showed a 28-40% lower risk.
A Norwegian study by the University of Bergen found that obese boys between 8 and their voice break age have double the risk of having children with asthma compared to non-obese peers. The connection is attributed to the development of reproductive cells during this period.
Researchers at LSU Health New Orleans found that asthma status reversed the relationship between neighborhood disadvantage and obesity in African American adolescent females. The study analyzed data from 129 participants and found that those with asthma were less likely to be obese compared to those without asthma.
A study found that nearly a third of patients with severe asthma are taking harmful doses of oral steroids. Improving adherence to inhaled therapies and inhaler technique can help avoid this. However, only half of eligible patients receive biologic asthma drugs, which could reduce exposure to harmful oral steroids.
A recent study by UCSF researchers found that young adults with food insecurity are more likely to develop disorders associated with obesity and obstructive airway diseases like asthma. Chronic stress from food insecurity can lead to inflammation, insulin resistance and increased risk of mental health issues.
A new triple-therapy inhaler combining a steroid preventer, long-acting bronchodilator, and muscarinic antagonist significantly improved lung function and reduced moderate to severe asthma attacks. Patients with uncontrolled asthma who used the inhaler saw increased airway obstruction clearance and fewer exacerbations.
Researchers found that women with asthma are more likely to have lower levels of free testosterone and estradiol compared to those without asthma. Elevated sex hormone levels were associated with reduced odds of asthma in both men and women, particularly obese individuals.
Researchers found that African American children respond better to increasing inhaled corticosteroids or adding long-acting beta agonists compared to step-up therapies. The study highlights the need for tailored treatment approaches for subgroups of asthma patients, particularly those with African ancestry.
Children with asthma who also have depression and anxiety are more likely to visit the ER, with a rate of 28 visits per 100 child years compared to 16 for those without mental health diagnoses. This population may benefit from more intensive care coordination to improve medication compliance and symptom recognition.
A new study found that almost half of young African American children responded better to increasing inhaled corticosteroid doses than adding long-acting bronchodilators. For adolescents and adults, most showed improved responses with adding a long-lasting bronchodilator, but some had no difference.
Researchers identified links between genetic variants and early activation of memory T cells, suggesting problems with regulating this process could lead to immune diseases. The study's findings could help narrow down the search for molecular pathways involved in immune diseases.
Researchers found that certain flavored e-cigarette flavors, even without nicotine, can exacerbate asthma symptoms and increase tissue scarring. Flavors like Black Licorice and Banana Pudding were particularly problematic.
A Finnish study found that individuals with more allergic diseases are at higher risk for developing adult-onset asthma, especially among those born after 1940. The research suggests that even one allergic disease can approximately double the asthma risk, while three or more diseases can quadruple it.
Researchers discovered two distinct sub-populations of interstitial macrophages in the lung, which play a crucial role in preventing asthma development. These sub-populations exhibit different functions, origins, and morphologies, and have distinct local precursors.
A study by Karolinska Institutet shows that a mobile phone-based treatment adjustment algorithm can improve symptoms and medication adherence in uncontrolled asthma sufferers. The digital tool, AsthmaTuner, analyzes lung function and symptoms to provide personalized feedback and treatment recommendations.
A study by Finnish Institute for Health and Welfare found that large amounts of certain bacteria from outdoors may protect children from asthma. High diversity of microbes is important in protecting against asthma, but certain soil microbes provide more effective protection.
By creating a microdevice that mimics the behavior of human airways, researchers have discovered how muscle contraction in the airway causes breathing difficulties in people with asthma. This breakthrough could lead to new treatment strategies for respiratory diseases.
Children with mild asthma can effectively manage their condition by using inhalers when symptoms occur, reducing steroid medication use by almost 75%.
Researchers are developing technology to predict when a child will have an asthma attack and provide prevention and treatment suggestions. The system tracks geographical location, physical activity, air quality, and health data using smart phones, watches, and sensors.
A study published by the Barcelona Institute for Global Health found that air pollution from particulate matter (PM2.5), nitrogen dioxide (NO2), and black carbon is responsible for 33% of new childhood asthma cases in Europe, highlighting the need to update WHO air quality guidelines to better protect children's health.
A new study has identified 141 genetic regions associated with the risk of developing asthma, hay fever and eczema. The research also found that many patients diagnosed with one disease develop the others at some stage in life.
A new multi-national survey found that nearly one-tenth of work hours are missed by asthma sufferers, resulting in significant productivity loss. Additionally, workers reported feeling embarrassed, ashamed, and inferior when using inhalers at work.
A team of international scientists uncovered a previously unclear inflammatory mechanism caused by airborne particles that worsen asthma symptoms. Diesel fumes activate AhR receptors in immune cells, leading to increased production of inflammatory molecules.
A study found that reducing nitrogen dioxide levels can lower childhood asthma incidence rates by up to 27.6%. The analysis estimated benefits of fine particulate matter reduction were smaller but still significant, suggesting stricter air quality standards could lead to public health gains.
A new Northwestern University study found that positive family relationships can buffer children from the negative effects of difficult neighborhood conditions on asthma management. Children living in high-danger neighborhoods with better family relationships had fewer symptoms and improved pulmonary function.
Infants with eczema are at risk of developing food allergies, hay fever, and asthma as they grow older. Moisturizers can help prevent these conditions by protecting the skin barrier.
A chaotic household environment is associated with worse asthma control in urban minority children, according to a new study published in Pediatrics. The researchers found that parent and childhood depressive symptoms are linked to poorer asthma outcomes, while family chaos explained part of this relationship.
Researchers from Mount Sinai highlight the importance of multidimensional data for stratifying a complex disease like asthma. Carefully designed, integrated multi-'omic' studies could accelerate precision medicine for asthma patients by defining asthma subtypes through transcriptomics and other omic approaches.
Research reveals 'back to school asthma' peaks in September, with higher rates of GP consultations for worsening bouts among under 5s and boys. The study suggests multiple factors may be involved, including changes in weather, air pollution, and stress.
A study discovered that farm-like indoor microbiota protects children from asthma in urban homes, with a key characteristic being large abundance of outdoor environment bacteria. The presence of these beneficial microbes may help develop mechanisms protecting against asthma.
Scientists have created a detailed anatomical map of the respiratory airways, producing the first draft Human Cell Atlas of the lung. The study revealed an entirely new cell state that produces mucus in asthma patients, and large differences between normal and asthmatic lungs.
A Mount Sinai study found improved asthma control and quality of life in older patients, with a significant reduction in emergency department visits. The study tested a patient-tailored self-management support intervention, which targeted social determinants of health and achieved meaningful improvements.
A joint ATS and European Respiratory Society statement reveals that occupational hazards contribute to over 1 in 10 cases of non-cancerous lung diseases, including asthma and COPD. The study estimates the burden of these conditions, highlighting a need for policy makers to prioritize prevention among working women and men worldwide.
A new study found that prenatal exposure to paternal tobacco smoking is associated with increased methylation of immune genes, which alters how the genetic code is read. This leads to a higher risk of developing childhood asthma.
A pilot program using smartphones to detect asthma triggers is launching in Washington D.C., aiming to improve child well-being and create healthier homes. The project, led by Children's National Hospital, will use video conferencing to identify potential housing triggers with families.
Researchers discovered Charcot-Leyden Crystals are abundant in airway mucus, stimulate immune system and promote inflammation, which can be treated with newly developed antibodies. These antibodies can dissolve the crystals to reduce asthma features.
Residents of historically redlined neighborhoods are more than twice as likely to visit emergency rooms for asthma, with significantly higher levels of diesel particulate matter in the air. Poverty and psychosocial stresses associated with living in divested neighborhoods also contribute to the disparity.
Research reveals a surprising connection between redlining practices and increased asthma-related emergency room visits in affected neighborhoods. Residents of redlined areas experienced 13.9 more asthma-related ER visits annually per 10,000 people compared to non-redlined communities.
Patients with severe asthma have reduced microbiome diversity, highlighting a potential relationship between neutrophils and the microbiome. This finding may lead to new targeted asthma therapies by better understanding the link between these two factors.
Research presented at ATS 2019 suggests that violence exposure and depression may contribute to the development of asthma in high school students. Additionally, promoting healthy lifestyle habits such as a balanced diet and regular exercise may help reduce the risk of asthma in adolescents.
A review of nearly 2.5 million patient records found that regions with greater primary care usage had lower respiratory failure admissions, particularly among patients with chronic diseases like asthma and COPD. This suggests that more primary care may reduce rates of respiratory failure and ICU admissions.
A USC study tracking Southern California children over 20 years found a 20% decrease in new asthma cases due to reduced PM2.5 levels. Nitrogen dioxide and particulate matter reductions also led to lower asthma rates.
Research suggests DGKζ enzyme plays a role in suppressing runaway inflammation in asthma. The enzyme's deletion in mouse T cells led to reduced inflammation and airway hyper-responsiveness, two hallmarks of the disease.
Patients with severe eosinophilic asthma continued to experience fewer exacerbations and improved pulmonary function with long-term benralizumab treatment. The BORA study found that the risk of infection did not increase over time, and long-term use was well-tolerated.
In a Phase 2 trial, RTB101 reduced the incidence of respiratory tract infections by 68.9% in adults with asthma over 16 weeks. The therapy was well-tolerated and effective during winter cold and flu season.
A recent study of nearly 300 patients with mild persistent asthma found that inhaled steroids were no more effective than placebo in nearly three-fourths of the study patients. However, for those with high levels of eosinophils, inhaled steroids were better than placebo, suggesting a potential new approach to targeting specific therapies.
A new £2m project, ACACIA, aims to improve asthma control in African children aged 12-16. The study will design and test a school-based intervention to address asthma knowledge and stigma.
A study published in Pediatrics found that children using the eAsthma Tracker app had improved asthma control, reduced emergency department visits, and increased school attendance. The app helps parents and doctors monitor symptoms and intervene early to prevent flare-ups, leading to better disease management and quality of life.
A recent genome-wide association study found that childhood-onset asthma is associated with nearly three times as many genes as adult-onset asthma. The study identified 61 independent asthma-related genes, with most being specific to childhood onset. The findings suggest different mechanisms cause the inception of asthma in childhood c...
A recent study found that nearly half of children hospitalized for asthma demonstrate improper inhaler use, with adolescents being the most common offenders. The study highlights the importance of proper inhaler technique in managing asthma, particularly among older teens who may feel they no longer need a spacer device.
A large GWAS study identified novel loci associated with asthma susceptibility, including the gene IL1RL1 and HLA-DQA1, in four major ethnic groups. The study suggests unique biological pathways contribute to asthma susceptibility across different ethnicities.
A recent study estimates that 4 million children worldwide develop asthma each year due to exposure to nitrogen dioxide pollution. The study found that urban areas account for 64% of these new cases, and cities with high NO2 concentrations also experience high levels of greenhouse gas emissions.
A study published in The Lancet Planetary Health estimates that traffic-related air pollution is associated with 170 new cases of traffic pollution-related asthma per 100,000 children every year. Globally, 13% of childhood asthma cases diagnosed each year are linked to traffic pollution.
Researchers tracked grass pollen for seasonal variations and found it was released into the atmosphere later in areas further from the equator. The study aims to create a unique profile of each grass pollen species to determine the most harmful strains.
The study reveals that different grass pollens can cause varying reactions in allergy sufferers and people with asthma. By analyzing environmental DNA, researchers identified links between certain pollen types and days with increased asthma attacks or intense hay fever symptoms.
Researchers created an interactive heat map and city-by-city table detailing the distribution of childhood asthma due to traffic-related air pollution across the United States. Between 2000 and 2010, asthma cases attributable to traffic-related air pollution decreased by 33%, with over 140,000 cases reported in 2010.