Articles tagged with Colorectal Cancer
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Researchers at the Salk Institute discovered that high-fat diets change gut bacteria and bile acids, leading to inflammation and affecting intestinal stem cell replenishment. The altered bile acids cause inflammation and increase cancer risk in mice.
A new commentary suggests that vitamin D supplementation can improve survival outcomes for patients with digestive tract cancers, particularly those with a high-risk genetic makeup. The study found that patients with antibodies to control the production of mutated p53 protein saw improved survival rates when taking daily vitamin D3 sup...
A new study estimates that cancer screenings have saved the US at least $6.5 trillion and led to 12 million more years of life, with significant economic impact from breast, colon, cervical, and lung cancer screenings.
Researchers identified 2476 nonsynonymous mutations in SA-CRC, including four newly discovered driver genes. The study also found distinct genomic profiles of SA-CRC compared to other colorectal cancers.
A Harvard T.H. Chan School of Public Health study found that chronic exposure to fine particulate air pollutants (PM2.5) and nitrogen dioxide (NO2) increases the risk of colorectal and prostate cancers in older adults. NO2 exposure was also associated with an increased risk of breast cancer, while PM2.5 exposure had mixed results.
A meta-analysis of multiple studies found no association between depression and anxiety and most types of cancer. However, the study found a link between depression and anxiety with a 6% higher risk of developing lung cancer and smoking-related cancers.
A study by Harvard T.H. Chan School of Public Health found that chronic exposure to fine particulate air pollutants (PM2.5) and nitrogen dioxide (NO2) may increase non-lung cancer risk in older adults, with significant associations with colorectal and prostate cancers.
A new study found that 81% of women report persistent GI symptoms years after diagnosis, with abdominal bloating and gas being the most common. The analysis also showed that severe GI symptoms are linked to poor quality of life, social activities, and body image satisfaction.
The American College of Physicians recommends starting colorectal cancer screening at age 50 for asymptomatic adults with average risk. The guideline aims to balance benefits and harms of screening in this population. Screening in younger adults may not offer significant net benefit due to lower incidence rates.
Researchers found that expression of transcription factors contributes to different subtypes of colorectal cancers. The degree of DNA methylation varies across tissue types, with some cancers having high and others low frequency of methylation gains. Studying transcription factor expression may help determine overall survival in patien...
Researchers identified methylation in normal tissues in some patients with mismatch repair deficiency, leading to undiagnosed Lynch syndrome. This study suggests revising current screening guidelines to include this poorly recognized cause of hereditary cancer.
Researchers discovered that Nerofe and Doxorubicin can downregulate KRAS signaling, leading to enhanced apoptosis in colorectal cancer cells. The combination also activates the immune system against tumor cells, increasing immunostimulatory cytokines and recruiting NK cells and M1 macrophages.
A study found disparities in Hispanic cancer mortality rates, with higher rates for men in certain age groups and women for liver, pancreatic, and uterine cancers. The researchers highlight the need for targeted education and screening efforts to address these disparities.
Researchers developed a biodegradable nanoparticle that reaches dendritic cells in mice with melanoma and colon cancer, activating an immune response. The nanoparticle improves survival rates for these cancers, with half of mice surviving long-term after treatment.
A study by Regenstrief Institute has identified seven risk factors for early onset colorectal cancer in males, providing a framework for clinicians to consider screening recommendations for younger men. The model may help estimate relative risk and identify individuals at higher risk for colorectal cancer.
Researchers have developed a new technique to generically treat several kinds of cancer, showing tumors grew almost three times less and survival rates reached 100% after just one injection. The method targets cancer cells with alpha radiation, sparing healthy tissue.
A newly discovered radionuclide-based agent (CB-2PA-NT) has shown high tumor uptake, sustained retention, and contrast in preclinical models. Targeting neurotensin receptors, CB-2PA-NT expands precision medicine for cancer diagnosis and treatment.
The FRESCO-2 phase III study demonstrated statistically significant improvements in overall survival and progression-free survival in patients with refractory metastatic colorectal cancer treated with fruquintinib. Fruquintinib showed a favorable safety profile, with patients staying on treatment almost twice as long as those on placebo.
Researchers developed a new tool called Orion that integrates histologic and molecular information to improve cancer diagnosis and treatment. The tool uses a digital imaging platform to analyze tumor samples, identifying biomarkers that predict patient outcomes.
A preclinical study has uncovered the role of Y chromosome gene KDM5D in regulating anti-tumor immune responses and promoting metastasis in male patients with KRAS-mutated colorectal cancer. The study reveals that mutant KRAS drives upregulation of KDM5D, leading to reduced cell adhesion and immune recognition by the immune system.
The FRESCO-2 trial shows that fruquintinib significantly improved overall survival and progression-free survival in patients with refractory metastatic colorectal cancer. The median OS was 7.4 months with fruquintinib versus 4.8 months in the placebo arm.
A study by Martin-Luther-University Halle-Wittenberg found a link between high levels of IGF2BP2 and faster-growing bowel cancer tumours with chemotherapy resistance. The protein's role in cell growth and metabolism may lead to the development of new diagnostic procedures and therapeutic strategies.
A keto diet may help reduce body weight and slow tumor growth in cancer patients. However, research found that this diet can cause early-onset cachexia, a lethal wasting disease, in mice with pancreatic and colorectal cancer. Pairing keto with corticosteroids prevented cachexia in mice, allowing them to live longer.
A new study found significant reductions in breast, colorectal and prostate cancers as well as melanoma diagnoses in Alberta during the COVID-19 pandemic. Diagnoses dropped by 43% for melanoma, 36% for colorectal and prostate, and 33% for breast cancer during the 'state of emergency' phase.
A new study found that obesity is associated with an increased risk of certain cancers, with stronger links in female patients for gallbladder and endometrial cancer. The study also revealed differential effects between sexes on colorectal, esophageal, and liver cancer.
Researchers have developed a polygenic risk score for colorectal cancer, which can estimate an individual's likely disease risk and identify those who may benefit from earlier screening. The score can also help determine more appropriate ages to start screening based on genetic risk.
Research from Johns Hopkins Medicine found that Black and Hispanic female breast cancer survivors have higher death rates from second cancers compared to other ethnic groups. The risk of death from a second cancer is 12% higher among non-Hispanic Black survivors and 8% higher among Hispanic survivors.
Researchers found that only 6.8% of cancer patients underwent genetic testing within two years of diagnosis, with lower rates among Black, Hispanic, and Asian patients. The low rates are attributed to lack of integration of test results into cancer management and prevention.
The study found that people younger than age 50 with colorectal cancer had lower levels of citrate and differed in protein and carbohydrate metabolism compared to older patients. Red meat consumption and sugar intake are potential risk factors for young-onset colorectal cancer. Higher levels of 4-hydroxyhippuric acid correlated with im...
Researchers found specific bacterial species significantly associated with the development of tubular adenomas and sessile serrated adenomas. The study suggests a potential opportunity to intervene through diet or probiotics to prevent colorectal cancer.
A new study published in the Journal of the American College of Surgeons predicts a significant increase in cancer cases due to COVID-19 screening delays, with lung, breast, and colorectal cancers most affected. The study found that missed diagnoses during the pandemic may lead to delays in treatment and upstaging of disease.
Researchers found varying microbiome compositions in early-onset (age 45 or younger) and late-onset (age 65 or older) colorectal cancer tumors, with distinct species present in each group. The discovery may help explain the rise in young-onset disease cases without known risk factors.
Researchers have developed new methods to analyze dry-coated drug particles using 3D Raman mapping, which can effectively slow down dissolution rates. Another study introduces a novel technique for detecting complex traditional Chinese medicines, preventing adulteration and counterfeiting.
Researchers have discovered that HER3 plays a crucial role in promoting cell survival in metastatic colorectal and pancreatic cancer. The surrounding liver microenvironment activates HER3, making it an emerging therapeutic target for these types of cancer.
A new study by researchers from the University of Edinburgh found that double testing with a faecal immunochemical test (FIT) increases the detection rate of bowel cancer to nearly 100%. This approach ensures more cases are identified and can potentially reduce demand for colonoscopies.
Researchers have created a new measure called the LRRC–QoL to assess health-related quality of life in patients with locally recurrent rectal cancer. The tool captures a wide range of issues affecting these patients, providing a more comprehensive understanding of their experiences.
Researchers found that fatty liver cells secrete proteins and genetic material that promote the spread of colorectal cancer to the liver. This condition is likely underdiagnosed, affecting over 40% of patients with colorectal cancer, according to a new study published in Cell Metabolism.
Researchers at Baylor College of Medicine found that silencing gene p16 can drive colorectal cancer progression in animal models. A combined treatment strategy involving two drugs improved survival rates in tumor-bearing mice, offering new possibilities for targeted therapies.
Overweight and obesity in early adulthood are associated with increased risks of colorectal cancer and non-colorectal gastrointestinal cancers. The study highlights the need for further exploration into the mechanisms driving these associations.
A new study finds that one-time genomic screening of adults aged 20-60 for hereditary breast and ovarian cancer syndrome, Lynch syndrome, and familial hypercholesterolemia is cost-effective based on quality-adjusted life-year measures. The study suggests that this approach could improve disease management and reduce healthcare costs.
Researchers created organoids from patient tissues to test chemotherapy drugs and identified genetic signatures that predict treatment response, offering high accuracy in personalized drug screening. This breakthrough may help select effective drugs for individual patients, reducing trial and error.
Researchers have found four key red flags for early-onset colorectal cancer, including abdominal pain and rectal bleeding, which can indicate an increased risk in younger adults. Early detection through timely endoscopy and follow-up is crucial to improve survival rates.
A recent study has shown that obesity is a significant risk factor for colorectal cancer, with overweight individuals having a one-third higher risk of developing the disease. The study also found that unintentional weight loss in the years leading up to diagnosis may be an early indicator of colorectal cancer.
Researchers have highlighted the importance of stromal vitamin A pathway in regulating IL-6 expression in colorectal cancer-associated fibroblasts. The study found that disrupting retinol-mediated IL-6 expression could be a potential approach to target CAFs during CRC treatment.
A new study found that remote outreach involving interactive education and follow-up support via telephone increased breast, cervical, and colorectal cancer screening rates among rural women. The combination of a remotely delivered interactive DVD and patient navigation services resulted in a six-fold increase in screenings.
A recent study led by Dr Rachael Rigby from Lancaster University found that delays in stoma reversal surgery do not impact on risk of complications or commensal microflora loss, atrophy, or scarring. However, a higher degree of microflora loss is associated with an increased risk of complications.
A new AI model, MOMA, accurately predicts colon cancer survival, treatment response and disease recurrence for patients. It can guide clinicians to follow up more closely or consider aggressive treatments for patients with worse predicted prognoses.
Memorial Sloan Kettering Cancer Center experts to present significant advances in cancer research at the American Association for Cancer Research Annual Meeting. MSK faculty will also receive prestigious awards and lectureships, highlighting their contributions to precision medicine and tumor biology.
A new study found that financial toxicity of cancer impacts partners' health-related quality of life, causing anxiety, depression, fatigue, and sleep disturbances. Younger partners were more likely to report financial burden and debt.
A study led by Tokyo University of Science researchers identified Dectin-1's role in promoting colorectal cancer by enhancing PGE2 production and suppressing IL-22BP expression. The study used mouse models and clinical samples to validate the findings, which have immediate clinical implications for CRC patients.
Researchers propose a new method of clustering colorectal cancer patients using differential presence of exons (DPE) sequencing, which can provide valuable information on CRC progression and response to therapy. This analysis may also reduce costs and time required for staging CRC patients.
Partners of colorectal cancer survivors experience long-term financial toxicity leading to worse health-related quality of life. Multilevel interventions are needed to address individual and systemic factors affecting both patients and their partners.
A UNIGE team created customizable treatments by testing drugs on artificial tumors derived from patients' cancer tissue. The approach opens the way for optimized and tailored therapies against various cancers and diseases.
Researchers at the Forsyth Institute have discovered a molecule naturally produced by the human host that targets and inhibits Fusobacteria, an opportunistic oral pathogen linked to colorectal cancer. The findings suggest a chemically modified version of this molecule could be used as a potential therapeutic to prevent colorectal cance...
The LSU Health New Orleans Louisiana Tumor Registry released the sixth report of statewide cancer incidence rates by census tract, finding that 81% of tracts met criteria for all cancers combined. Census tracts with statistically higher incidence rates were found in parishes including Orleans, Lafourche, and St. Bernard.
Researchers found that neutrophils can be pro- or anti-tumour depending on their surface markers, and those fighting tumours share cytotoxic power with neutrophils in bacterial infections. Blocking these anti-tumour neutrophils eliminates treatment benefits.
Researchers propose conjugating a cell-penetrating peptide to oxaliplatin to overcome chemotherapy resistance in colorectal cancer. The new approach reduces platinum accumulation in tumour microenvironment and healthy tissues.
Researchers found that cells in the colon undergo a type of molecular time travel, reverting back to an embryonic state and creating immature, non-functional cells that can form benign growths called adenomas. Blocking Sox9 in mouse models prevented adenoma formation and resulted in mature cell maturation.
Researchers used explainable AI to analyze gut microbiomes for CRC biomarkers, discovering four distinct subgroups with unique bacterial profiles. This approach shows promise for a more personalized microbiome exploration and potential disease subgroup identification.
Researchers from China have identified inosine as a potential broad-spectrum anti-inflammatory agent that improves survival in mice infected with SARS-CoV-2. The study also highlights TBK1 as a promising target for inhibiting cytokine storms and mitigating acute inflammatory lung injury.