Articles tagged with Colorectal Cancer
New cancer projections highlight progress in reducing incidence rates for common cancers like lung, colorectal, and prostate, but also warn of rising rates for less common types such as liver, kidney, melanoma, and non-Hodgkin lymphoma.
Between 1999 and 2020, colorectal cancer incidence grew by 500% among children ages 10-14, 333% among teens aged 15-19, and 185% among young adults ages 20-24. Researchers highlight the need for tailored approaches to screening and awareness of signs and symptoms.
Researchers at Brigham and Women's Hospital found an association between appendix removal and a decreased risk of colorectal cancer positive for the bacterium Fusobacterium nucleatum. The study involved large prospective cohort studies and analyzed data from over 139,000 participants.
The ECOG-ACRIN Cancer Research Group has launched the ComboMATCH-E5 trial, evaluating the combination of sotorasib and panitumumab in patients with KRAS G12C-mutated advanced solid tumors. The study aims to assess the efficacy and safety of the combination in this patient population.
A study published by University of Pittsburgh researchers found that ACA insurance expansions led to an increase in patients receiving care at accredited cancer hospitals in Pennsylvania. The study suggests that these expansions make a difference in improving access to high-quality cancer care, particularly for those living in areas wi...
A cohort study found that individuals with a first colonoscopy with negative findings for colorectal cancer may benefit from longer screening intervals, potentially up to 15 years. This could lead to fewer unnecessary invasive examinations and improved patient outcomes.
Menopausal hormone therapy is appropriate to treat vasomotor symptoms in early menopause without contraindications. WHI evidence does not support routine supplementation with calcium plus vitamin D or a low-fat diet for preventing fractures and breast/colorectal cancer, respectively.
Scientists have developed mini-colon tissues that can simulate the complex process of tumorigenesis outside the body with high fidelity. These miniature organs mimic the physical structure and cellular diversity of colon tissue, allowing researchers to study colorectal cancer development and test potential therapies.
A new study reveals that aspirin boosts certain aspects of the immune system to detect and target cancer cells, reducing cancer spread to lymph nodes. Aspirin also increases expression of a protein called CD80 on immune cells, enhancing their ability to alert other immune cells of tumor-associated proteins.
A significant gap exists in the colorectal screening process, particularly after a positive stool-based test, where timely follow-up with colonoscopy is often lacking. This can lead to reduced incidence and mortality rates from colorectal cancer if addressed through education and quality measures.
The innovative Integrated Virtual Care (IVC) program successfully connected residents with family physicians in Renfrew County, addressing the rural shortage of primary care providers. Over 2,800 unique patient appointments were conducted, with 70% done virtually, offering comprehensive team-based primary care.
The study, presented at AACR Annual Meeting 2024, found the combination therapy to be effective with an objective response rate of 34% and a disease control rate of 85.1%. The regimen performed favorably compared to historical data for similar cohorts, indicating potential as a new standard of care.
Researchers developed a nanosized polymer that selectively delivers chemotherapeutic drugs to blood vessels supporting tumor growth. The treatment eliminates colorectal cancer liver metastases and prolongs mice survival after a single dose-therapy.
Researchers have identified specific gut microbiota signatures associated with KRAS mutations in colorectal cancer. The study suggests that these microbes may serve as non-invasive biomarkers for identifying subtypes of CRC and inform personalized treatment approaches.
A study of 9,740 surveillance colonoscopies found rare colorectal cancer detection and higher advanced neoplasia yields among those with prior advanced adenoma. These findings inform decision-making on continued screening in older adults with a history of colorectal adenomas.
A population-wide observational study found an association between tuberculosis (TB) and a higher incidence of various cancers. TB patients were more likely to be diagnosed with lung, blood, gynaecological, colorectal, thyroid, oesophagus, and stomach cancers compared to the general population.
A study published in the Journal of the American College of Surgeons found that hospitals accredited by the National Accreditation Program for Rectal Cancer (NAPRC) demonstrate significantly better outcomes for patients undergoing rectal cancer surgery. These institutions show lower rates of mortality, complications, and morbidity comp...
Researchers have found that combining DNMT and EZH2 inhibitors activates viral mimicry in cancer cells, making them more susceptible to attack by the immune system. The combination therapy has shown potential in treating colorectal cancers and other solid tumors, with an upcoming Phase I clinical trial planned.
New data suggest that blood-based colorectal cancer screening tests could lead to more cases and deaths than established methods, despite improving outcomes for unscreened individuals. The tests are predicted to be less effective and more costly, making them unsuitable replacements for current screening programs.
Researchers found that individuals with a single mutated copy of the MUTYH gene have a modest increase in susceptibility to a subset of solid tumors, including adrenal gland cancers and pancreatic islet cell tumors. This suggests that MUTYH variants may be involved in a broader range of cancers than previously known.
Researchers suggest a follow-up colonoscopy within defined periods after abnormal stool-based screening test results. The proposed measure aims to address low current performance rates and produce reliable results.
The COVID-19 pandemic caused a significant decrease in colorectal cancer surgeries, with patients undergoing procedures having more advanced stages of cancer compared to those treated in 2019. The study found that approximately 10,000 fewer patients did not have surgery for colorectal cancer in 2020.
Researchers at Fred Hutchinson Cancer Center found that a specific subtype of Fusobacterium nucleatum is responsible for tumor growth in up to 50% of human colorectal cancers. The study identifies the exact bacterial lineage associated with colorectal cancer, offering opportunities for developing microbial cellular therapies.
The study found that 90.98% of participants obtained a definitive result from colorectal cancer screening, with 31.71% being normal and 5.49% having non-neoplastic polyps. The results suggest the importance of primary care physicians in promoting secondary prevention and informing the population about the program.
A new study suggests that removing barriers to cervical cancer screening, surveillance, and diagnostic procedures can save lives and reduce disparities. If every eligible person gets the full screening and follow-up tests recommended, up to 23% fewer people would be diagnosed with cervical cancer and 20% fewer would die from it.
A new link has been discovered between FBXW7 mutations and EGFR signaling activity in colorectal cancer. The study found that the mutated form of the FBXW7 gene could no longer degrade the EGFR protein, leading to increased signaling activity and a decreased response to anti-EGFR treatment.
Research highlights new findings on social vulnerability and survivorship after colorectal cancer resection, as well as disparities in kidney recovery among Black donors. Additionally, studies reveal cost savings from implementing quality interventions and explore eligibility for transplants in obese patients with end-stage renal disease.
Researchers linked red/processed meat consumption to increased colorectal cancer risk, highlighting two genetic markers (HAS2 and SMAD7) that alter cancer risk levels based on meat intake. The study analyzed data from nearly 70,000 people and found a 30-40% increased risk for those with high red or processed meat intake.
A clinical study published in the New England Journal of Medicine found that a blood test can detect colorectal cancer in 83% of people confirmed to have the disease. The test, which analyzes circulating tumor DNA, offers an alternative to current screening options for patients who may decline traditional methods.
A new study published in New England Journal of Medicine found that a next generation multi-target stool DNA colorectal cancer screening test detects 94 percent of colorectal cancers, outperforming other noninvasive tests. The test has the best detection rate for both colorectal cancer and advanced precancerous polyps.
A study found that up to 87% of childhood cancer survivors are not following recommended screening guidelines, leaving them vulnerable to late effects such as heart disease and certain cancers. The lack of awareness and barriers to adherence may contribute to this low rate, highlighting the need for improved support and education.
A recent study investigated eating habits and physical activity in colorectal cancer (CRC) patients with overweight/obesity. The results show that these patients have higher prevalence of metastasis, recurrence, and death compared to eutrophic patients.
A pilot study has confirmed the feasibility and acceptability of a bowel symptom intervention for rectal cancer survivors. The intervention, which included dietary changes and phone-based support, showed some benefits in reducing symptoms such as frequent bowel movements and bloating.
Research reveals micro- and nanoplastics can persist in the human body for longer than previously thought, being passed on to newly formed cells during cell division. The study also suggests these tiny plastic particles may promote the spread of cancer by increasing tumor migration.
A bioinformatics analysis identified 71 differentially expressed genes in colorectal cancer, with Krüppel-like factor 4 (KLF4) emerging as a key player. KLF4 was associated with immune cell infiltration and poor prognosis in overall survival analyses.
Researchers define a 'core senescent profile' in human colon fibroblasts, revealing potential driver proteins involved in CRC. The study's findings provide insights into therapies for improving overall health and preventing CRC.
A study of routine fecal occult blood testing found a significant decrease in colorectal cancer mortality in Sweden. The association between screening and reduced mortality is expected to be higher due to co-existing testing and delayed diagnoses.
A new off-the-shelf vaccine has shown promise in treating pancreatic and colorectal cancers in patients with KRAS mutations. The study found that the vaccine significantly decreased tumor biomarkers and produced strong T-cell responses, leading to a reduced risk of relapse and death.
A new AI-powered system has been shown to detect 40% more polyps during colonoscopies, a crucial step in preventing colorectal cancer. This breakthrough technology uses artificial intelligence to examine every pixel in the image and alert doctors to potential issues, allowing for more accurate diagnoses.
A recent study reveals the lack of colorectal cancer screening programs in low-middle-income countries, but successful implementation in high-middle-income Latin American nations. High-middle-income countries achieved high uptake of screening, with over 75% receiving colonoscopies following positive stool test results.
A new study from the University of Ottawa proposes using vanoxerine, a drug initially developed for cocaine addiction, to potentially treat advanced colon cancer. Vanoxerine has been found to suppress cancer stem cell activity in colon cancer patients' tissues and tumours implanted in laboratory animals. The drug works by interfering w...
A new stool test, multitargetFIT-test (mtFIT), detects cancer precursors more effectively than the current FIT test, predicting a reduction in new cases of colorectal cancer and mortality. The new test yields more true-positive results without an increase in 'false-positive' results.
Researchers found that combining chemotherapy drugs triggers 'cell blasters' to kill cancer, leading to longer survival rates in patients with tumors having increased NETs. The study's novel discovery paves the way for designing new cancer treatments.
Researchers found elevated PROX1 levels in advanced colon adenocarcinoma, correlating with poor prognosis. PROX1 modulates CRC cell behavior, influencing invasiveness and survival outcomes. The combined PROX1/α-SMA gene set emerges as a potential CRC prognostic marker.
Researchers mapped changes in tumor-related bacteria to uncover potential strategies to combat the rise of young-onset colorectal cancer. Unique bacterial signatures were found in tumors from younger patients, including Akkermansia and Bacteroides, which are more likely to have left-sided, rectal, and advanced stage tumors.
A growing number of rectal cancer patients are choosing a watch-and-wait approach over surgery, with the number increasing nearly 10% between 2006 and 2020. This approach requires frequent follow-ups but may allow patients to avoid long-term bowel dysfunction.
Cancer kills more Black people than White individuals in the Barretos region, whereas in São Paulo city, it is the opposite, according to a study published in Cancer Causes & Control. The disparity is most pronounced for breast and cervical cancer among Black women.
Experts predict a significant increase in bowel cancer death rates among young adults in the EU and UK, driven by rising obesity and heavy alcohol consumption. Death rates are predicted to rise by 26% in men and nearly 39% in women in the UK, with similar increases seen in Italy and other European countries.
A study from Dana-Farber Cancer Institute found that unintentional weight loss is associated with an increased risk of cancer diagnosis within the coming year. The research suggests that patients experiencing unexpected weight loss should see their doctor to consider possible causes, including cancer. Healthy weight loss can come from ...
Despite declining overall US cancer mortality rates, substantial racial disparities persisted for many common cancers, including breast and colorectal cancer. Structural racism, medical mistrust, and health care access inequities contribute to these disparities.
A Phase I trial demonstrated that a vaccine targeting KRAS mutations delayed relapse in patients with high-risk pancreatic and colorectal cancer. The vaccine induced significant T cell responses, which correlated with reduced risk of relapse.
A study in the JAMA Network Open found that Hispanic and American Indian individuals with breast, colorectal, lung, and prostate cancer were undercaptured in the National Cancer Database, but representation improved over time. Further investigation is needed to understand where these populations seek cancer care.
A study of 64 patients with MSI-H/dMMR metastatic colorectal cancer found that 88% had not experienced a recurrence two years after stopping immunotherapy. The progression-free survival rate was 98% at one year and 84% at three years post-treatment.
Researchers found that blocking cholesterol production prevented progression of serrated-type intestinal tumors in mice, suggesting a potential new strategy for treating these aggressive cancers. The study's findings support the use of cholesterol-lowering drugs to prevent or treat these tumors.
Researchers found that probiotics can limit CRC-promoting bacteria, rebalance the microbial profile, and induce targeted cancer cell death. Postbiotics derived from probiotic bacteria have also been shown to prevent CRC by limiting tumor proliferation and modulating the balance of anti-apoptotic and pro-apoptotic factors.
Researchers found that GLP-1 RAs significantly reduced the incidence of colorectal cancer in patients with diabetes, compared to those treated with other anti-diabetic drugs. The study's findings support the need for clinical trials to determine whether these medications could prevent one of the deadliest types of cancers.
A recent study from Drexel University's College of Nursing and Health Professions aimed to understand the challenges and supports affecting individuals with GI cancer and their caregivers when it comes to maintaining a healthy diet and avoiding malnutrition. The research highlighted the importance of creating dietary interventions that...
Researchers have developed gene-specific classification criteria for assessing the medical relevance of unclear genetic variants that can lead to hereditary colorectal cancer. The new criteria are expected to reclassify a significant proportion of these variants as harmless, providing relief to carriers worldwide.
Researchers found that cancer cells with multiple mutations alter cell competition, allowing them to infiltrate and form highly invasive tumors. The study identified a key mechanism, MMP21, which promotes the production of diffusely invasive cancer cells.
A meta-analysis of five randomised controlled trials shows that giving iron intravenously before colorectal surgery improves outcomes for patients, reducing the need for blood transfusion. The study found a significant reduction in blood transfusions by 33% in patients with colorectal cancer.