Articles tagged with Colorectal Cancer
Researchers have found four key red flags for early-onset colorectal cancer, including abdominal pain and rectal bleeding, which can indicate an increased risk in younger adults. Early detection through timely endoscopy and follow-up is crucial to improve survival rates.
A recent study has shown that obesity is a significant risk factor for colorectal cancer, with overweight individuals having a one-third higher risk of developing the disease. The study also found that unintentional weight loss in the years leading up to diagnosis may be an early indicator of colorectal cancer.
Researchers have highlighted the importance of stromal vitamin A pathway in regulating IL-6 expression in colorectal cancer-associated fibroblasts. The study found that disrupting retinol-mediated IL-6 expression could be a potential approach to target CAFs during CRC treatment.
A new study found that remote outreach involving interactive education and follow-up support via telephone increased breast, cervical, and colorectal cancer screening rates among rural women. The combination of a remotely delivered interactive DVD and patient navigation services resulted in a six-fold increase in screenings.
A recent study led by Dr Rachael Rigby from Lancaster University found that delays in stoma reversal surgery do not impact on risk of complications or commensal microflora loss, atrophy, or scarring. However, a higher degree of microflora loss is associated with an increased risk of complications.
A new AI model, MOMA, accurately predicts colon cancer survival, treatment response and disease recurrence for patients. It can guide clinicians to follow up more closely or consider aggressive treatments for patients with worse predicted prognoses.
Memorial Sloan Kettering Cancer Center experts to present significant advances in cancer research at the American Association for Cancer Research Annual Meeting. MSK faculty will also receive prestigious awards and lectureships, highlighting their contributions to precision medicine and tumor biology.
A new study found that financial toxicity of cancer impacts partners' health-related quality of life, causing anxiety, depression, fatigue, and sleep disturbances. Younger partners were more likely to report financial burden and debt.
A study led by Tokyo University of Science researchers identified Dectin-1's role in promoting colorectal cancer by enhancing PGE2 production and suppressing IL-22BP expression. The study used mouse models and clinical samples to validate the findings, which have immediate clinical implications for CRC patients.
Researchers propose a new method of clustering colorectal cancer patients using differential presence of exons (DPE) sequencing, which can provide valuable information on CRC progression and response to therapy. This analysis may also reduce costs and time required for staging CRC patients.
Partners of colorectal cancer survivors experience long-term financial toxicity leading to worse health-related quality of life. Multilevel interventions are needed to address individual and systemic factors affecting both patients and their partners.
A UNIGE team created customizable treatments by testing drugs on artificial tumors derived from patients' cancer tissue. The approach opens the way for optimized and tailored therapies against various cancers and diseases.
Researchers at the Forsyth Institute have discovered a molecule naturally produced by the human host that targets and inhibits Fusobacteria, an opportunistic oral pathogen linked to colorectal cancer. The findings suggest a chemically modified version of this molecule could be used as a potential therapeutic to prevent colorectal cance...
The LSU Health New Orleans Louisiana Tumor Registry released the sixth report of statewide cancer incidence rates by census tract, finding that 81% of tracts met criteria for all cancers combined. Census tracts with statistically higher incidence rates were found in parishes including Orleans, Lafourche, and St. Bernard.
Researchers found that neutrophils can be pro- or anti-tumour depending on their surface markers, and those fighting tumours share cytotoxic power with neutrophils in bacterial infections. Blocking these anti-tumour neutrophils eliminates treatment benefits.
Researchers propose conjugating a cell-penetrating peptide to oxaliplatin to overcome chemotherapy resistance in colorectal cancer. The new approach reduces platinum accumulation in tumour microenvironment and healthy tissues.
Researchers found that cells in the colon undergo a type of molecular time travel, reverting back to an embryonic state and creating immature, non-functional cells that can form benign growths called adenomas. Blocking Sox9 in mouse models prevented adenoma formation and resulted in mature cell maturation.
Researchers used explainable AI to analyze gut microbiomes for CRC biomarkers, discovering four distinct subgroups with unique bacterial profiles. This approach shows promise for a more personalized microbiome exploration and potential disease subgroup identification.
Researchers from China have identified inosine as a potential broad-spectrum anti-inflammatory agent that improves survival in mice infected with SARS-CoV-2. The study also highlights TBK1 as a promising target for inhibiting cytokine storms and mitigating acute inflammatory lung injury.
Researchers found that physical activity can prevent cancer recurrence in stage III colon cancer patients by lowering the recurrence rate within the first year of treatment. This association persisted for approximately three years after surgery, suggesting a long-term survival benefit.
Researchers from Dana-Farber Cancer Institute have outlined a path toward understanding, preventing, and treating young-onset colorectal cancer. The study highlights the need for multidisciplinary research involving diverse populations to account for the complexity of the disease.
A study found that prenatal exposure to the anti-nausea drug Bendectin, containing dicyclomine, increased the risk of colorectal cancer in adult offspring. Incidence rates were three times higher among exposed children compared to those not exposed.
Researchers found that excessive iron absorption by tumor cells drives colorectal cancer growth, and a specific gene pathway is key. Inactivating this pathway can extend animal survival and potentially be used to treat cancer.
The HALP score, a novel immune-nutritional marker, has been linked to prognostic ability in different cancer types. It integrates indicators of immune status and nutritional status, showing promise as a cost-effective biomarker.
Lung cancer death rates are projected to decrease overall in the EU and UK in 2023, however, a concerning trend is observed among women in France, Italy, and Spain. Meanwhile, pancreatic cancer death rates are forecasted to rise among women due to continued smoking habits.
The use of AI is improving diagnostic accuracy for digestive cancers, but challenges in data sharing and standardization hinder its widespread application. Researchers surveyed recent applications of AI to these deadly cancers, finding that AI can automate complex processes and detect patterns not visible to humans.
Researchers at the University of Montreal Hospital Research Centre identified two bacterial strains that can either increase or decrease the risk of intestinal leakage after surgery. Modifying patients' gut microbiota before surgery may reduce postoperative complications and improve recovery.
A Tulane University study found that areas with paid sick leave mandates experienced significant increases in breast cancer (4%) and colorectal cancer (6-8%) screenings among private sector employees. The findings suggest that non-monetary barriers to healthcare access can have a meaningful impact on health outcomes.
A study published in Nature Communications reveals that platinum accumulates in healthy cells surrounding cancer cells, particularly fibroblasts, and induces gene activation associated with poor response to chemotherapy. Periostin levels serve as a marker of TGF-β activity in fibroblasts and predict treatment benefit.
Research identifies bovine meat and milk factor protein expression as possible cause of colorectal cancer. Monitoring Rep expression and inflammation in tissues may help identify individuals at risk. Early detection could offer new options for preventive and therapeutic intervention.
Researchers found that a combination of symptom and high-level viral rebound after untreated COVID-19 infection is rare, occurring in only 3 percent of study participants. This suggests that accounting for underlying rates of symptom relapse is crucial when evaluating antiviral treatment effects.
Researchers discovered that combining ferroptosis induction with immune checkpoint inhibition reduces liver tumour growth and metastases, offering a promising new approach for treating liver cancer
Replacing red and processed meat with Quorn's mycoprotein reduces intestinal genotoxins, a risk factor for bowel cancer, and increases beneficial gut bacteria. The study found significant reductions in harmful chemicals and improvements in gut health in participants consuming the mycoprotein diet.
Researchers at Uppsala University developed a prognostic method using a combination of immune cells to provide clearer disease prognoses and predict which patients will respond best to immunotherapy. The method was shown to be associated with patient fate in several types of cancer.
A study published in CANCER found that people's defensive beliefs can prevent them from taking at-home stool tests for colorectal cancer screening. Individuals who reacted defensively were more likely to believe that a healthy lifestyle or regular bowel movements mean they don't need to be screened.
Researchers found that arginine levels are limited in human cancers, prompting cancer cells to manipulate proteins to take up the amino acid. Starving cancer cells of arginine may lead to mutations that make them more recognizable to the immune system.
A phase 2 clinical trial combining immunotherapy and targeted therapy showed a 24.3% confirmed response rate and 5-month median progression-free survival among patients with BRAF V600 mutations. The treatment also demonstrated increased durability, with 57% of patients remaining on treatment for more than 6 months.
A UK study found that people with type 2 diabetes have substantially higher cancer mortality rates than the general population. Breast cancer mortality in younger women with T2D is rising, highlighting the need for extended screening, better management of diabetes and its complications, and improved cancer treatments.
A combination of two novel immunotherapy drugs has shown promising clinical activity in treating patients with refractory metastatic colorectal cancer. The study found that 23% of patients had a tumor reduction, and the disease control rate was 76%. The treatment was well-tolerated, but adverse events were common.
A team at Harvard Medical School has created large-scale 2D and 3D spatial maps of colorectal cancer, layering molecular information on top of histological features. The maps reveal the interconnectedness of traditional isolated structures in colorectal cancer, allowing researchers to explore differences within individual tumors.
A study of over 32,000 individuals reveals low follow-up colonoscopy rates among average-risk populations, with socioeconomic factors and the COVID-19 pandemic contributing to these gaps. These findings highlight opportunities for targeted interventions by clinicians and healthcare systems to improve colorectal cancer screening outcomes.
Researchers discovered that pre-surgery immunotherapy significantly improved patient outcomes for locally advanced colorectal cancer. The treatment showed substantial longer survival benefits, including low recurrence rates, in patients with mismatch repair-deficient or microsatellite instability-high (dMMR/MSI-H) CRC.
A new University of Kentucky Markey Cancer Center study found that people in Kentucky's Black communities may not be aware of all available colorectal cancer screening options, particularly stool-based tests. Regular screening beginning at age 45 is key to preventing and finding colorectal cancer early.
Researchers developed predictive models using serum microRNAs to identify patients at risk of requiring early palliative care. The study used serum samples from 178 patients with various types of cancer and found that miRNA-based models had higher accuracy than clinical models in predicting referral to a palliative care unit.
A new software developed by researchers at Cold Spring Harbor Laboratory can accurately infers continental ancestry from tumor DNA and RNA. This technology has the potential to lead to more targeted and personalized cancer treatments by identifying genetic connections between cancer and race or ethnicity.
Researchers found that AI-assisted colonoscopy significantly improved adenoma detection rates in patients with Lynch syndrome, detecting flat adenomas more effectively than standard examinations. The study suggests that AI-assisted real-time colonoscopy is a promising approach to optimize endoscopic surveillance for LS patients.
Research from Michigan Medicine reveals that high levels of ammonia in colon tumors can lead to reduced T cell growth and immunotherapy resistance. A study published in Cell Metabolism found that using an FDA-approved drug to lower ammonia levels made tumors more sensitive to treatment.
A massive international data analysis uncovered hundreds of signals for new treatment and prevention targets in colorectal cancer. The study identified 250 independent risk associations, including 50 newly discovered ones, through analyzing genomic, transcriptomic, and methylomic data.
A comprehensive analysis of over 100,000 colorectal cancer cases identified 100 new genetic risk factors strongly linked with the disease. These findings could help clinicians determine who's at highest risk for early detection and potentially identify candidates for preventive treatments.
Researchers discovered PDGF cross-signaling through alternative receptors in colorectal cancer cells, enabling bypassed signaling. This finding supports anti-PDGF therapy as a combination strategy alongside VEGF and EGF targeting.
A new study has identified a potential therapy for metastatic colon cancer by targeting the molecule hyaluronan, which accumulates in tumors and shuts down immune cells that can kill tumor cells. The experimental therapy, hyaluronidase, shrinks tumors and allows immune cells to attack tumor cells.
The National Cancer Institute awards $10.5 million to USC's Division of Biostatistics to develop statistical methods for uncovering new risk factors associated with cancer by integrating large volumes of health, genomic, and exposure data. The project aims to provide new insights into complex biological processes and discoveries of nov...
Researchers found that muscle wasting severity is related to the type, size and location of tumors in mice, with different tumors causing varying levels of wasting. The study's findings have crucial implications for understanding how different cancers affect muscle mass and developing effective treatments.
Researchers discovered three essential amino acids - leucine, valine, and tryptophan - as potential metabolic biomarkers for HCC. The study used metabolomics to analyze the differences in tumor and non-tumor tissue metabolomes, revealing striking differences that could aid in diagnosis.
A new study found that a three-year interval between screenings using non-invasive multi-target stool DNA testing is clinically appropriate for individuals with average risk of colorectal cancer. The study, led by Thomas F. Imperiale, M.D., identified no colorectal cancers in participants after an initial negative test.
Eating a diet rich in whole grains, vegetables, and legumes is associated with a reduced risk of colorectal cancer in men. The study found that men who consumed the highest amounts of healthy plant-based foods had a 22% lower risk of colorectal cancer compared to those who ate the lowest amounts.
Population-based cancer screening rates declined during the pandemic, only to recover rapidly in initial stages; however, long-term follow-up reveals ongoing gaps in preventive care. The study suggests that prolonged disruptions in screening can have lasting effects on public health.
The ESMO Asia Congress 2022 will focus on the latest scientific and clinical advances in oncology, with a special emphasis on the Asia-Pacific region. Media representatives can register for coverage through the official media registration form.
Researchers at Goethe University Frankfurt found that dying colon cancer cells release ATP to neighboring tumor cells, activating a survival signaling pathway. Interrupting this communication can significantly increase the effectiveness of chemotherapy against resistant tumors.
Researchers at the Fred Hutchinson Cancer Center discovered that oral bacteria like Fusobacterium nucleatum can infiltrate tumors, influencing their growth and response to treatment. The findings suggest a link between oral health and cancer, highlighting the potential for microbiome-based therapies to combat cancer.